Drug & supplement interaction

Job's Tears + Troglitazone

Troglitazone brand name: Rezulin.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Job's Tears has a moderate interaction with Troglitazone. Preliminary evidence shows that constituents of Job's tears might have hypoglycemic effects.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Job's Tears and Troglitazone

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTIDIABETES DRUGS

Why this applies to Troglitazone

Troglitazone falls under ANTIDIABETES DRUGS — the group Job's Tears interacts with.

Preliminary evidence shows that constituents of Job's tears might have hypoglycemic effects. Theoretically, concomitant use with drugs that decrease blood glucose levels might increase the risk of hypoglycemia. Some antidiabetes drugs include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the simple version. Troglitazone (Rezulin) lowers your blood sugar to help manage type 2 diabetes. Job's Tears, the grain-like seed, may also nudge blood sugar a little lower on its own. Put the two together and, in theory, your numbers could dip further than expected, which raises the chance of low blood sugar (think shakiness, sweating, dizziness, confusion, or feeling suddenly weak).

I want to be honest with you, though: this concern is theoretical, based on how Job's Tears behaves rather than solid human studies. Eating it as a normal food is unlikely to cause trouble. Concentrated supplements are the bigger question mark. If you'd like to try one, check with your pharmacist or doctor first and keep an eye on your blood sugar.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Chiang W, Cheng C, Chiang M, Chung KT. Effects of dehulled adlay on the culture count of some microbiota and their metabolism in the gastrointestinal tract of rats. J Agric Food Chem 2000;48:829-32. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Job's Tears Also Interacts With Other Medications

Job's Tears has 127 moderate known drug interactions in our database — the Troglitazone one above is one of them. If you take anything else, check it against the full list below.

Moderate 127 No known interaction 2,703 (incl. Troglitazone)
Taking anything else?

Check Another of Your Medications Against Job's Tears

Covers the 2,830 medications we’ve checked against Job's Tears. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Troglitazone

This page covers Job's Tears only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Troglitazone page lists 280 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Siberian Cocklebur (major), Wine (major) and Acai (moderate).

By severity: 4 major · 239 moderate · 37 minor.

From our pharmacist’s overview on the Troglitazone page

“Most people taking troglitazone (Rezulin) are managing type 2 diabetes, and this list reflects that. The great majority of the 280 flagged ingredients act on blood sugar, most lowering it and a few raising it, so pairing them with a diabetes medication makes glucose control less predictable and can tip it too low.”

Reviewed by 2 · Jul 18, 2026

Open the Troglitazone interaction page

One more smart check

Taking Job's Tears as Part of a Dietary Supplement Product? Check It for Interactions

We hold 111 real supplement products containing Job's Tears, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Job's Tears. Your product may carry other ingredients that interact with Troglitazone too, on top of Job's Tears — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Job's Tears and Troglitazone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Job's Tears
Steady interest

#1,237 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Troglitazone
Top 25%

#621 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Job's Tears

What is Job's Tears?

  • Digestive support
  • Skin health and smoothness
  • Mild swelling or water retention
  • General nourishing food/tonic
  • Joint discomfort (traditional use)

Job's Tears is a grain-like seed long used as a food and in traditional medicine, especially in East Asia. While it is generally safe as a food and is being studied for possible effects on metabolism, inflammation, and immunity, strong human evidence for its health claims is limited. Talk with your pharmacist or doctor before using concentrated supplements, especially during pregnancy.

Read the full Job's Tears monograph & all interactions
Keep checking

Other Drugs & Job's Tears

Browse every other medication we’ve checked against Job's Tears — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
127Moderate
0Minor
2,702No known interaction
127 Moderate 2,702 No interaction
Moderate

127 interactions

Showing 60 of 127 moderate interactions — see all 127 on the Job's Tears page.

No interaction 2,702 drugs checked — show the list

We also checked Job's Tears against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,702 medications checked with no known interaction — see the full Job's Tears list.

See the full Job's Tears interactions page
See every supplement checked against Troglitazone, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Job's Tears monograph › Uses, safety, and every drug interaction in one place Troglitazone supplement interactions › Every supplement checked against Troglitazone, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Job's Tears and Troglitazone Together: Common Questions

Can you take Job's Tears with Troglitazone?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Job's Tears and Troglitazone interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Troglitazone and Job's Tears?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.