Medication interaction hub

What Supplements Interact with Troglitazone?

Troglitazone brand name: Rezulin. Every interaction below applies to the brands too.

280 Interactions 4 Major 239 Moderate 37 Minor
Curated & coded by · Clinical Pharmacist · Updated September 25, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Troglitazone? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Troglitazone against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Most people taking troglitazone (Rezulin) are managing type 2 diabetes, and this list reflects that. The great majority of the 280 flagged ingredients act on blood sugar, most lowering it and a few raising it, so pairing them with a diabetes medication makes glucose control less predictable and can tip it too low. Overall, 239 entries rate moderate and 37 minor, but the four majors are what earn this page genuine caution. Troglitazone can stress the liver on its own, and Siberian cocklebur, along with everyday alcohol, wine or beer included, stacks liver risk on top of that.

The fourth major is activated charcoal, which can soak up the medication in the gut, and a smaller cluster of thick fibers blunts absorption the same way, so keep those well apart from your dose. Closer glucose checks cover most of the moderates, but the liver is where I would focus first.

— , Clinical Pharmacist · July 18, 2026

Major 4 Moderate 239 Minor 37 No known interaction 1,172

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Troglitazone: Top Interactions at a Glance

The Troglitazone supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 280 interacting ingredients — plus 1,172 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Troglitazone Combinations Today

The Troglitazone + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Cudweed + Troglitazonei

Preliminary research in rats shows that cudweed might lower blood glucose levels.

Read the full interaction Moderate Likelihood Possible Cissus Quadrangularis + Troglitazonei

Theoretically, Cissus quadrangularis might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Read the full interaction Moderate Likelihood Possible Chicory + Troglitazonei

Theoretically, chicory might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Read the full interaction Minor Likelihood Possible Apple Cider Vinegar + Troglitazonei

Theoretically, taking apple cider vinegar with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full interaction Moderate Likelihood Possible Chirata + Troglitazonei

Theoretically, taking chirata concomitantly with antidiabetes drugs may increase the risk of hypoglycemia.

Read the full interaction Moderate Likelihood Possible Kombucha + Troglitazonei

Theoretically, kombucha might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Read the full interaction
The complete list

Every Supplement Checked Against Troglitazone

All 1,452 ingredients in our database, ranked by severity — 280 with a Troglitazone interaction on file and 1,172 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Troglitazone?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Cudweed with Troglitazone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Preliminary research in rats shows that cudweed might lower blood glucose levels.

Full Cudweed + Troglitazone answer

Can you take Cissus Quadrangularis with Troglitazone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Cissus quadrangularis might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Cissus Quadrangularis + Troglitazone answer

Can you take Chicory with Troglitazone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, chicory might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Chicory + Troglitazone answer

Can you take Apple Cider Vinegar with Troglitazone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking apple cider vinegar with antidiabetes drugs might increase the risk of hypoglycemia.

Full Apple Cider Vinegar + Troglitazone answer

Can you take Chirata with Troglitazone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking chirata concomitantly with antidiabetes drugs may increase the risk of hypoglycemia.

Full Chirata + Troglitazone answer

Can you take L-arginine with Troglitazone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of L-arginine might have additive effects with antidiabetes drugs.

Full L-arginine + Troglitazone answer

Can you take L-cysteine with Troglitazone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking L-cysteine supplements with antidiabetes drugs might increase the risk of hypoglycemia.

Full L-cysteine + Troglitazone answer

Can you take Ligandrol with Troglitazone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might have additive hepatotoxic effects.

Full Ligandrol + Troglitazone answer

Can you take Lion's Mane Mushroom with Troglitazone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, lion's mane mushroom may have additive effects when used with antidiabetes drugs.

Full Lion's Mane Mushroom + Troglitazone answer

Can you take Lotus with Troglitazone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, lotus might have additive effects with antidiabetes drugs and increase the risk of hypoglycemia.

Full Lotus + Troglitazone answer

Can you take Lychee with Troglitazone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, lychee seed might increase the risk of hypoglycemia when used with antidiabetes drugs.

Full Lychee + Troglitazone answer

Can you take Madagascar Periwinkle with Troglitazone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research shows that Madagascar periwinkle lowers blood glucose levels in diabetic rats.

Full Madagascar Periwinkle + Troglitazone answer

Can you take Maitake Mushroom with Troglitazone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, combining maitake mushroom with antidiabetes drugs might increase the risk of hypoglycemia.

Full Maitake Mushroom + Troglitazone answer

Can you take Manchurian Thorn with Troglitazone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research suggests that high doses of Manchurian thorn can induce liver damage.

Full Manchurian Thorn + Troglitazone answer

Can you take Maritime Pine with Troglitazone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, maritime pine bark extract might increase the risk of hypoglycemia when used with antidiabetes drugs.

Full Maritime Pine + Troglitazone answer

Can you take Melatonin with Troglitazone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking melatonin with antidiabetes drugs might increase the risk of hypoglycemia.

Full Melatonin + Troglitazone answer

Can you take Milk Thistle with Troglitazone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Taking milk thistle with antidiabetes drugs may increase the risk of hypoglycemia.

Full Milk Thistle + Troglitazone answer

Can you take Miracle Fruit with Troglitazone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, miracle fruit leaf might have an additive effect with antidiabetes drugs and increase the risk of hypoglycemia.

Full Miracle Fruit + Troglitazone answer

Can you take Myrrh with Troglitazone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, myrrh might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Myrrh + Troglitazone answer

Can you take Neem with Troglitazone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Neem might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Neem + Troglitazone answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Troglitazone is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Troglitazone, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Troglitazone sits in 3 interaction categories. Open any one to see what the group means:

Antidiabetes Drugs 239 ingredients

Blood-sugar-lowering medications. Supplements that also lower glucose can push blood sugar too low when combined.

239 of the supplement ingredients on this page reach Troglitazone through this category.

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Troglitazone through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Troglitazone through this category.

Related: does Troglitazone deplete any nutrients?

Troglitazone has 1 reported nutrient association in the research literature — see the Troglitazone nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Troglitazone

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Troglitazone.

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Pharmacist Counseling Corner

Troglitazone & Supplements: Common Questions

What supplements interact with Troglitazone?
In our interaction database, 280 supplement and herbal ingredients have an interaction with Troglitazone on file — 4 rated major, 239 moderate, and 37 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Siberian Cocklebur, Activated Charcoal, Beer.
Which Troglitazone supplement interactions are the most serious?
The 4 major-rated combinations — led by Siberian Cocklebur, Activated Charcoal, Beer and Wine — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Troglitazone?
That depends entirely on which supplement. The honest answer for Troglitazone is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Rezulin have the same supplement interactions as Troglitazone?
Yes — Rezulin all contain Troglitazone, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Troglitazone deplete any vitamins or nutrients?
It might — Troglitazone has 1 reported nutrient-depletion association in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Troglitazone nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Troglitazone and my other medications?
This page covers Troglitazone against supplements and herbal ingredients. Checking Troglitazone against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 25, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.