Drug & supplement interaction

Kombucha + Amylase, Lipase, Protease

Amylase, Lipase, Protease brand names: Pangestyme MT 16, Pangestyme CN 10, Pangestyme CN 20, Pangestyme EC, Pangestyme UL 12, and others.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Kombucha and Amylase, Lipase, Protease in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Kombucha and Amylase, Lipase, Protease

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Amylase, Lipase, Protease and Kombucha in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Kombucha safety at a glance

Kombucha overall Use caution Usually fine in moderation for healthy adults, but contamination and acidity can cause problems.
Pregnancy Possibly Unsafe When used orally; avoid using. Read the full pregnancy detail
Breastfeeding Possibly Unsafe When used orally; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Amylase, Lipase, Protease and Kombucha? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Amylase, Lipase, Protease

Interactions in our licensed database are recorded against drug classes, not just single drug names. Amylase, Lipase, Protease is filed under a single classification — oral drugs. Kombucha has documented interactions with 2 drug classes — the most serious being antidiabetes drugs (moderate) and disulfiram (antabuse) (minor) — and none of Amylase, Lipase, Protease’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Kombucha Does Interact With Other Medications

Kombucha has 86 moderate, 1 minor known drug interactions in our database — Amylase, Lipase, Protease isn’t one of them. If you take anything else, check it against the full list below.

Moderate 86 Minor 1 No known interaction 2,743 (incl. Amylase, Lipase, Protease)
Taking anything else?

Check Another of Your Medications Against Kombucha

Covers the 2,830 medications we’ve checked against Kombucha. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Kombucha and Amylase, Lipase, Protease May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Nausea Additional detail

    Kombucha

    “Orally, use of kombucha has been associated with reports of stomach problems, nausea, and vomiting. The acidic content of kombucha increases with the duration of fermentation during preparation, which may contribute to development of stomach ulcers.”

    Kombucha · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    5 sources cited
    1. 2652. Kombucha-toxicity alert. Crit Path AIDS Proj, 1994;30:31-32 1994-5.
    2. 2656. Srinivasan R, Smolinske S, Greenbaum DJ. Probable gastrointestinal toxicity of Kombucha tea: is this beverage healthy or harmful? J Gen Intern Med 1997;12:643-4. PubMed
    3. 57733. Ernst, E. Kombucha: a systematic review of the clinical evidence. Forsch.Komplementarmed.Klass.Naturheilkd. 2003;10(2):85-87. PubMed
    4. 57742. Sabouraud, S., Coppere, B., Rousseau, C., Testud, F., Pulce, C., Tholly, F., Blanc, M., Culoma, F., Facchin, A., Ninet, J., Chambon, P., Medina, B., and Descotes, J. [Environmental lead poisoning from lead-glazed earthenware used for storing drinks]. Rev
    5. 103179. Jakubczyk K, Kałduńska J, Kochman J, Janda K. Chemical Profile and Antioxidant Activity of the Kombucha Beverage Derived from White, Green, Black and Red Tea. Antioxidants (Basel). 2020;9(5):E447. doi: 10.3390/antiox9050447. PubMed

    Amylase, Lipase, Protease

    Listed in the ADVERSE REACTIONS section of the FDA label for Amylase, Lipase, Protease. Read the label on DailyMed ›

Reported for Kombucha but not commonly for Amylase, Lipase, Protease: bleeding in the gut, kidney problems, dizziness and vomiting.

Effects for Amylase, Lipase, Protease come from the ADVERSE REACTIONS section of its FDA label; effects for Kombucha come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Kombucha in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Unsafe

When used orally; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Amylase, Lipase, Protease

This page covers Kombucha only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Amylase, Lipase, Protease page lists 17 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 7 moderate · 9 minor.

From our pharmacist’s overview on the Amylase, Lipase, Protease page

“Pancreatic enzyme replacements (amylase, lipase, and protease, the Pangestyme brands) only work if the capsules reach your gut and mix with food, and all 17 supplements listed here can interfere with that, so the list deserves real care. Activated charcoal is the one major-rated entry; it soaks up medicines in the digestive tract befor…”

Reviewed by 2 · Jul 18, 2026

Open the Amylase, Lipase, Protease interaction page

One more smart check

Taking Kombucha as Part of a Dietary Supplement Product? Check It for Interactions

We hold 30 real supplement products containing Kombucha, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Kombucha. Even though Kombucha itself has no known interaction with Amylase, Lipase, Protease, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Kombucha and Amylase, Lipase, Protease Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Kombucha
Top half

#565 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Amylase, Lipase, Protease
Top 10%

#264 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Kombucha reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Kombucha and Amylase, Lipase, Protease records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Kombucha

What is Kombucha?

  • General wellness and gut health
  • Digestion
  • Immune support
  • Energy and detox claims
  • Source of probiotics

Kombucha is a fermented tea that many people enjoy as a probiotic-rich beverage, but solid human research proving specific health benefits is lacking. It is generally fine in moderate amounts for healthy adults, though homemade or unpasteurized versions can carry contamination risks. Pregnant people, those who are breastfeeding, and people with weakened immune systems should be cautious or avoid it.

Fermented sweetened tea (made with Camellia sinensis tea and a SCOBY culture) · Bottled drink, homemade fermented tea, occasionally powders or supplements

An interaction check asks whether these two react with each other — it does not ask whether Kombucha is a good idea for someone in your situation. Here is what our Kombucha record says about it on its own.

Kombucha: dosing

There is no established standard dose for kombucha. Many people drink a small glass (a few ounces) once a day or less, and start with a small amount to see how their body reacts.Follow the serving size on the product label, and choose reputable, commercially made brands rather than untested homemade versions.

From our Kombucha monograph — the full record covers uses, side effects and every documented interaction.

Read the full Kombucha monograph & all interactions
Medication

About Pancrelipase

What Is Pancrelipase Used For?

Brand names: Pangestyme MT 16, Pangestyme CN 10, Pangestyme CN 20, Pangestyme EC, Pangestyme UL 12, Pangestyme UL 18, Pangestyme UL 20, Pancrelipase, Pancrelipase 10,000, Lipram 10,000, Pancrecarb Ms-4, Ku-Zyme, Kutrase, Digepepsin, Pancrecarb Ms-8, Pancrelipase 16,000, Pancrelipase 20,000, Pancron 20, Festal II, Microspheres, Zymase, Entozyme, Ku-Zyme HP, Protilase, Ilozyme, Plaretase, Ultresa

Pancrelipase is used to treat exocrine pancreatic insufficiency (EPI) — a condition where the pancreas doesn't produce enough digestive enzymes. Without these enzymes, the body struggles to break down and absorb nutrients from food.

It is indicated for adults with EPI caused by chronic pancreatitis (long-term pancreas inflammation) or pancreatectomy (surgical removal of the pancreas, in whole or in part). It is also used in people with cystic fibrosis who develop EPI.

See full Pancrelipase drug information
Keep checking

Other Drugs & Kombucha

Browse every other medication we’ve checked against Kombucha — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
86Moderate
1Minor
2,742No known interaction
86 Moderate 1 Minor 2,742 No interaction
Moderate

86 interactions

Showing 60 of 86 moderate interactions — see all 86 on the Kombucha page.

Minor

1 interaction

No interaction 2,742 drugs checked — show the list

We also checked Kombucha against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,742 medications checked with no known interaction — see the full Kombucha list.

See the full Kombucha interactions page
See every supplement checked against Amylase, Lipase, Protease, ranked by severity
Evidence & sources

Kombucha References

The 15 references that drive our Kombucha monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Phan TG, Estell J, Duggin G, et al. Lead poisoning from drinking Kombucha tea brewed in a ceramic pot. Med J Aust 1998;169:644-6. PubMed
  2. FDA Talk Paper. FDA Cautions Consumers on "Kombucha Mushroom Tea." Available at: www.vm.cfsan.fda.gov/~lrd/TPMUSHRM.html
  3. Kombucha-toxicity alert. Crit Path AIDS Proj, 1994;30:31-32 1994-5.
  4. CDC. Unexplained severe illness possibly associated with consumption of Kombucha tea-Iowa, 1995. MMWR Morb Mortal Wkly Rep 1995;44:892-3,899-900.
  5. Srinivasan R, Smolinske S, Greenbaum DJ. Probable gastrointestinal toxicity of Kombucha tea: is this beverage healthy or harmful? J Gen Intern Med 1997;12:643-4. PubMed
  6. Ernst, E. Kombucha: a systematic review of the clinical evidence. Forsch.Komplementarmed.Klass.Naturheilkd. 2003;10(2):85-87. PubMed
  7. Derk, C. T., Sandorfi, N., and Curtis, M. T. A case of anti-Jo1 myositis with pleural effusions and pericardial tamponade developing after exposure to a fermented Kombucha beverage. Clin.Rheumatol. 2004;23(4):355-357. PubMed
  8. Sabouraud, S., Coppere, B., Rousseau, C., Testud, F., Pulce, C., Tholly, F., Blanc, M., Culoma, F., Facchin, A., Ninet, J., Chambon, P., Medina, B., and Descotes, J. [Environmental lead poisoning from lead-glazed earthenware used for storing drinks]. Rev
  9. SungHee, Kole A., Jones, H. D., Christensen, R., and Gladstein, J. A case of Kombucha tea toxicity. J.Intensive Care Med. 2009;24(3):205-207. PubMed
  10. Aloulou, A., Hamden, K., Elloumi, D., Ali, M. B., Hargafi, K., Jaouadi, B., Ayadi, F., Elfeki, A., and Ammar, E. Hypoglycemic and antilipidemic properties of kombucha tea in alloxan-induced diabetic rats. BMC.Complement Altern.Med. 2012;12:63. PubMed
  11. McNaughton, C. and Eidsness, L. M. Ethics of alternative therapies. S.D.J.Med. 1995;48(7):209-211.
  12. No author. Unexplained severe illness possibly associated with consumption of Kombucha tea--Iowa, 1995. From the Centers for Disease Control and Prevention. JAMA 1-10-1996;275(2):96-98.
  13. Jakubczyk K, Kałduńska J, Kochman J, Janda K. Chemical Profile and Antioxidant Activity of the Kombucha Beverage Derived from White, Green, Black and Red Tea. Antioxidants (Basel). 2020;9(5):E447. doi: 10.3390/antiox9050447. PubMed
  14. Jang SS, McIntyre L, Chan M, Brown PN, Finley J, Chen SX. Ethanol concentration of kombucha teas in British Columbia, Canada. J Food Prot 2021;84(11):1878-83. PubMed
  15. Xu S, Wang Y, Wang J, Geng W. Kombucha reduces hyperglycemia in type 2 diabetes of mice by regulating gut microbiota and Its metabolites. Foods 2022;11(5):754. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Kombucha and Amylase, Lipase, Protease Together: Common Questions

Is it safe to take Kombucha with Amylase, Lipase, Protease?
We do not list a known interaction between Kombucha and Amylase, Lipase, Protease. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Kombucha and Amylase, Lipase, Protease have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Kombucha and Amylase, Lipase, Protease combination checked?
Interactions in our licensed database are recorded against drug classes. Amylase, Lipase, Protease is filed under 1 classification, and Kombucha has documented interactions with 2 drug classes — none of Amylase, Lipase, Protease's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Kombucha interact with any other medications?
Yes. Kombucha has 87 documented drug interactions in our database — Amylase, Lipase, Protease is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Amylase, Lipase, Protease interact with any supplements?
Yes. Amylase, Lipase, Protease has documented interactions with 17 supplements in our database — Kombucha is not one of them. The Amylase, Lipase, Protease interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Kombucha monograph Uses, safety profile, and every drug interaction in one place Pancrelipase drug information The full plain-English guide to this medication Amylase, Lipase, Protease supplement interactions Every supplement checked against Amylase, Lipase, Protease, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 15 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Amylase, Lipase, Protease and Kombucha?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.