Drug & supplement interaction

Kratom + dabigatran

dabigatran brand names: Pradaxa, Pradax.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Kratom and dabigatran in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for dabigatran states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Kratom and dabigatran

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between dabigatran and Kratom in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Kratom safety at a glance

Kratom overall Avoid Kratom carries risks of dependence, serious side effects, and contaminated products, and is not regulated as a safe supplement.
Pregnancy Possibly Unsafe When used orally. There have been multiple case reports of neonatal abstinence syndrome in the infants of those who used kratom during pregnancy. Animal researc... Read the full pregnancy detail
Breastfeeding Avoid Kratom compounds may pass into breast milk and should be avoided while nursing.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining dabigatran and Kratom? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for dabigatran

Interactions in our licensed database are recorded against drug classes, not just single drug names. dabigatran is filed under 3 classifications — anticoagulant/antiplatelet drugs, p-glycoprotein substrates, oral drugs. Kratom has documented interactions with 11 drug classes — the most serious being cns depressants (moderate), cytochrome p450 1a2 (cyp1a2) substrates (moderate) and cytochrome p450 2d6 (cyp2d6) substrates (moderate) — and none of dabigatran’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Kratom Does Interact With Other Medications

Kratom has 983 moderate, 12 minor known drug interactions in our database — dabigatran isn’t one of them. If you take anything else, check it against the full list below.

Moderate 983 Minor 12 No known interaction 1,835 (incl. dabigatran)
Taking anything else?

Check Another of Your Medications Against Kratom

Covers the 2,830 medications we’ve checked against Kratom. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Kratom and dabigatran May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 2 of them are worth acting on rather than waiting out — marked below.

  • A stroke or mini-stroke Worth acting on Additional detail

    Kratom

    “Orally, kratom can cause tachycardia and changes in blood pressure, especially when used in doses of 8 grams or more. In one Poison Control Center report of 3484 exposures to kratom, the majority of which involved oral single-substance exposures, 45% of cases reported cardiovascular effects.”

    Kratom · Natural Medicines adverse-effect record, reported in arrhythmia.

    6 sources cited
    1. 95819. Kruegel AC, Grundmann O. The medicinal chemistry and neuropharmacology of kratom: A preliminary discussion of a promising medicinal plant and analysis of its potential for abuse.Neuropharmacology. 2017. pii: S0028-3908(17)30393-3. PubMed
    2. 108565. Graves JM, Dilley JA, Terpak L, et al. Kratom exposures among older adults reported to U.S. poison centers, 2014-2019. J Am Geriatr Soc 2021;69(8):2176-2184. PubMed
    3. 114575. Krantz MJ, Rudo TJ, Haigney MCP, et al. Ventricular Arrhythmias Associated With Over-the-Counter and Recreational Opioids. J Am Coll Cardiol 2023;81(23):2258-2268. PubMed
    4. 104636. Leong Abdullah MFI, Tan KL, Narayanan S, et al. Is kratom (Mitragyna speciosa Korth.) use associated with ECG abnormalities? Electrocardiogram comparisons between regular kratom users and controls. Clin Toxicol (Phila). 2020:1-9.
    5. 108566. Leong Bin Abdullah MFI, Singh D. Assessment of Cardiovascular Functioning Among Regular Kratom (Mitragyna speciosa Korth) Users: A Case Series. Front Pharmacol 2021;12:723567. PubMed
    6. 101706. Abdullah HMA, Haq I, Lamfers R. Cardiac arrest in a young healthy male patient secondary to kratom ingestion: is this 'legal high' substance more dangerous than initially thought ? BMJ Case Rep. 2019 Jul 19;12(7). pii: e229778. PubMed

    “Data from the US Food and Drug Administration (FDA) Adverse Event Reporting System shows that from 2004 to 2021, out of 489 kratom-related adverse reaction reports, 102 deaths and 34 accidental deaths were reported, accounting for 21% and 7% of total adverse events reported. However, only 45% of reported adverse events listed kratom as the only drug ingested.”

    Kratom · Natural Medicines adverse-effect record, reported in epilepsy.

    6 sources cited
    1. 113067. Li X, Ndungu P, Taneja SB, et al. An evaluation of adverse drug reactions and outcomes attributed to kratom in the US Food and Drug Administration Adverse Event Reporting System from January 2004 through September 2021. Clin Transl Sci 2023.
    2. 95804. FDA Adverse Event Reporting System: Kratom Deaths. February 6, 2018. https://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/CDERFOIAElectronicReadingRoom/UCM595575.pdf. Accessed March 6, 2018.
    3. 99182. Olsen EO, O'Donnell J, Mattson CL, Schier JG, Wilson N. Notes from the field: Unintentional drug overdose deaths with kratom detected - 27 States, July 2016-December 2017. MMWR Morb Mortal Wkly Rep. 2019;68(14):326-327.
    4. 108565. Graves JM, Dilley JA, Terpak L, et al. Kratom exposures among older adults reported to U.S. poison centers, 2014-2019. J Am Geriatr Soc 2021;69(8):2176-2184. PubMed
    5. 113069. Mata DC, Chang HH. Postmortem Mitragynine Distribution in a Single Drug Fatality Case. Acad Forensic Pathol 2023;13(1):34-40. PubMed
    6. 99811. Gershman K, Timm K, Frank M, et al. Deaths in Colorado Attributed to Kratom. N Engl J Med. 2019 Jan 3;380(1):97-98. PubMed

    dabigatran

    Listed in the ADVERSE REACTIONS section of the FDA label for dabigatran. Read the label on DailyMed ›

  • Blood clots Worth acting on Additional detail

    Kratom

    Recorded for Kratom in the same Natural Medicines adverse-effect record shown under A stroke or mini-stroke above.

    dabigatran

    Listed in the ADVERSE REACTIONS section of the FDA label for dabigatran. Read the label on DailyMed ›

  • Swelling Additional detail

    Kratom

    “Orally, kratom has been linked to respiratory depression, particularly when used in combination with other mu-opioid agonists. In one case report, a 36-year-old male with a history of substance abuse and smoking was diagnosed with kratom-induced acute respiratory distress syndrome (ARDS) after presenting with progressive respiratory failure, hypoxemia, and bilateral lung infiltrates.”

    Kratom · Natural Medicines adverse-effect record, reported in acute respiratory distress syndrome (ards).

    6 sources cited
    1. 27119. Backstrom BG, Classon G, Lowenhielm P, Thelander G. [Krypton--new, deadly Internet drug. Since October 2009 have nine young persons died in Sweden]. Lakartidningen 2010;107(50):3196-3197.
    2. 27120. Kronstrand R, Roman M, Thelander G, Eriksson A. Unintentional fatal intoxications with mitragynine and O-desmethyltramadol from the herbal blend Krypton. J Anal Toxicol 2011;35(4):242-247. PubMed
    3. 27136. US Food and Drug Administration (2014). SNI National is Voluntarily recalling Kratom XL 4 Pack, Maeng Da Kratom 10 Pack, Max Kratom 20 Pack, and Bali Kratom 40 pack Due to Undeclared Drug Ingredients [Press Release].
    4. 104637. Davidson C, Cao D, King T, et al. A comparative analysis of kratom exposure cases in Thailand and the United States from 2010-2017. Am J Drug Alcohol Abuse. 2020:1-10. PubMed
    5. 108565. Graves JM, Dilley JA, Terpak L, et al. Kratom exposures among older adults reported to U.S. poison centers, 2014-2019. J Am Geriatr Soc 2021;69(8):2176-2184. PubMed
    6. 113071. Peran D, Stern M, Cernohorsky P, Sykora R, Popela S, Duska F. Mitragyna speciosa (Kratom) poisoning: Findings from ten cases. Toxicon 2023;225:107054. PubMed

    “In one Poison Control Center report of 3484 exposures to kratom, the majority of which involved oral single-substance exposures, 75% of cases reported neurologic effects, including agitation, coma, confusion, dizziness, drowsiness, hallucinations, seizures, and tremor.”

    Kratom · Natural Medicines adverse-effect record, reported in alcohol-related liver disease.

    6 sources cited
    1. 108565. Graves JM, Dilley JA, Terpak L, et al. Kratom exposures among older adults reported to U.S. poison centers, 2014-2019. J Am Geriatr Soc 2021;69(8):2176-2184. PubMed
    2. 95798. Cumpston KL, Carter M, Wills BK. Clinical outcomes after Kratom exposures: A poison center case series. Am J Emerg Med. 2018;36(1):166-168. PubMed
    3. 101707. Eggleston W, Stoppacher R, Suen K, Marraffa JM, Nelson LS. Kratom Use and Toxicities in the United States. Pharmacotherapy. 2019 Jul;39(7):775-777. doi: 10.1002/phar.2280. Epub 2019 Jun 13. PubMed
    4. 104637. Davidson C, Cao D, King T, et al. A comparative analysis of kratom exposure cases in Thailand and the United States from 2010-2017. Am J Drug Alcohol Abuse. 2020:1-10. PubMed
    5. 113071. Peran D, Stern M, Cernohorsky P, Sykora R, Popela S, Duska F. Mitragyna speciosa (Kratom) poisoning: Findings from ten cases. Toxicon 2023;225:107054. PubMed
    6. 103214. Afzal H, Esang M, Rahman S. A case of kratom-induced seizures. Cureus. 2020;12(1):e6588. PubMed

    dabigatran

    Listed in the ADVERSE REACTIONS section of the FDA label for dabigatran. Read the label on DailyMed ›

  • Diarrhea Additional detail

    Kratom

    “Kratom ingestion has been associated with nausea, vomiting, dry mouth, tongue numbness, increased appetite, and constipation. In one Poison Control Center report of 3484 exposures to kratom, the majority of which involved oral single-substance exposures, 25% of cases reported gastrointestinal effects.”

    Kratom · Natural Medicines adverse-effect record, reported in constipation.

    6 sources cited
    1. 27130. Jansen KL, Prast CJ. Ethnopharmacology of kratom and the Mitragyna alkaloids. J Ethnopharmacol 1988;23(1):115-119. PubMed
    2. 27136. US Food and Drug Administration (2014). SNI National is Voluntarily recalling Kratom XL 4 Pack, Maeng Da Kratom 10 Pack, Max Kratom 20 Pack, and Bali Kratom 40 pack Due to Undeclared Drug Ingredients [Press Release].
    3. 95797. Castillo A, Payne JD, Nugent K. Posterior reversible leukoencephalopathy syndrome after kratom ingestion. Proc (Bayl Univ Med Cent). 2017;30(3):355-357. PubMed
    4. 95818. Trakulsrichai S, Sathirakul K, Auparakkitanon S, et al. Pharmacokinetics of mitragynine in man. Drug Des Devel Ther. 2015;9:2421-9. PubMed
    5. 104637. Davidson C, Cao D, King T, et al. A comparative analysis of kratom exposure cases in Thailand and the United States from 2010-2017. Am J Drug Alcohol Abuse. 2020:1-10. PubMed
    6. 113067. Li X, Ndungu P, Taneja SB, et al. An evaluation of adverse drug reactions and outcomes attributed to kratom in the US Food and Drug Administration Adverse Event Reporting System from January 2004 through September 2021. Clin Transl Sci 2023.

    dabigatran

    Listed in the ADVERSE REACTIONS section of the FDA label for dabigatran. Read the label on DailyMed ›

  • Nausea Additional detail

    Kratom

    “Orally, kratom is possibly unsafe. Topically, no adverse effects have been reported; however, a thorough evaluation of safety outcomes has not been conducted.

    Most Common Adverse Effects:

    Orally: Constipation, dependence (chronic use), dry mouth, frequent urination, nausea, tongue numbness, and vomiting.

    Serious Adverse Effects (Rare):

    Orally: Cardiac arrest, death, encephalopathy syndrome, hallucinations, hypertensi…”

    Kratom · Natural Medicines adverse-effect record, reported in cardiac arrest.

    dabigatran

    Listed in the ADVERSE REACTIONS section of the FDA label for dabigatran. Read the label on DailyMed ›

Reported for Kratom but not commonly for dabigatran: liver problems, raised blood pressure, dependence or withdrawal symptoms and confusion.

Effects for dabigatran come from the ADVERSE REACTIONS section of its FDA label; effects for Kratom come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Kratom in Pregnancy & Breastfeeding

Pregnancy Possibly Unsafe

When used orally. There have been multiple case reports of neonatal abstinence syndrome in the infants of those who used kratom during pregnancy. Animal research suggests that kratom crosses the placenta.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some dabigatran Products Have a Food Rule — Kratom Should Not Break It

At least one FDA label for a product containing dabigatran says to take it with food. If you take Kratom on an empty stomach out of habit, keep them separate — and take dabigatran with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two dabigatran products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

Consider administration with food if gastrointestinal distress occurs with dabigatran etexilate capsules.

From the Dosage and Administration section of the FDA label we read for dabigatran — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

From our Q&A

Questions About Kratom or dabigatran

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Kratom or dabigatran, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With dabigatran

This page covers Kratom only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the dabigatran page lists 235 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Danshen (major), Piracetam (major), St. John's Wort (major) and Aconite (moderate).

By severity: 4 major · 201 moderate · 30 minor.

From our pharmacist’s overview on the dabigatran page

“Dabigatran (Pradaxa) is a blood thinner prescribed to prevent strokes and dangerous clots, which makes the stakes for mixing in supplements higher than for most medicines, and I would go through this list with real care. Of the 235 ingredients on file, 202 could add to dabigatran's blood-thinning effect and increase bruising or bleedin…”

Reviewed by 2 · Jul 18, 2026

Open the dabigatran interaction page

One more smart check

Taking Kratom as Part of a Dietary Supplement Product? Check It for Interactions

We hold 8 real supplement products containing Kratom, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Kratom. Even though Kratom itself has no known interaction with dabigatran, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Kratom and dabigatran Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Kratom
Top half

#401 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication dabigatran
Top 10%

#159 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Kratom reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Kratom and dabigatran records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Kratom

What is Kratom?

Kratom
  • Pain relief
  • Opioid withdrawal symptoms
  • Anxiety and stress
  • Low energy or fatigue
  • Mood enhancement

Kratom is a Southeast Asian plant whose leaves act on the brain's opioid receptors and can produce both stimulant-like and opioid-like effects. It is not approved or proven safe by health regulators, carries real risks of dependence and serious harm, and its legal status varies widely. Talk to a pharmacist or doctor before considering it.

Mitragyna speciosa · Rubiaceae · Leaves · Dried leaf powder, capsules, tablets, brewed tea, liquid extracts, and concentrated gummies

An interaction check asks whether these two react with each other — it does not ask whether Kratom is a good idea for someone in your situation. Here is what our Kratom record says about it on its own.

Kratom: dosing

There is no established safe or standardized dose for kratom. The strength of products varies widely, and the amount of active compounds can differ greatly from one batch to another, even within the same brand.Because of these unknowns and the real risks of dependence and harm, we cannot recommend a specific amount. Avoid mixing it with alcohol, opioids, sedatives, or other substances.

From our Kratom monograph — the full record covers uses, side effects and every documented interaction.

Read the full Kratom monograph & all interactions
Medication

About Dabigatran

What Is Dabigatran Used For?

Brand names: Pradaxa, Pradax

Dabigatran etexilate capsules are approved for adults to reduce the risk of stroke and systemic embolism (blood clots traveling through the body) in non-valvular atrial fibrillation (an irregular heart rhythm not caused by a heart valve problem). Capsules are also used to treat deep vein thrombosis (DVT — a blood clot in a deep vein, usually the leg) and pulmonary embolism (PE — a clot in the lungs), to prevent those clots from coming back, and to prevent DVT and PE in adults who have had hip replacement surgery.

For children, the capsule form is approved for treating VTE (venous thromboembolism — blood clots in veins) and reducing recurrence in patients aged 8 to under 18. Pradaxa Oral Pellets are approved specifically for children aged 3 months to under 12 years for the same treatment and recurrence-prevention purposes.

See full Dabigatran drug information
Keep checking

Other Drugs & Kratom

Browse every other medication we’ve checked against Kratom — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
983Moderate
12Minor
1,834No known interaction
983 Moderate 12 Minor 1,834 No interaction
Moderate

983 interactions

Showing 60 of 983 moderate interactions — see all 983 on the Kratom page.

Minor

12 interactions

No interaction 1,834 drugs checked — show the list

We also checked Kratom against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 1,834 medications checked with no known interaction — see the full Kratom list.

See the full Kratom interactions page
See every supplement checked against dabigatran, ranked by severity
Evidence & sources

Kratom References

The 77 references that drive our Kratom monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Singh D, Müller CP, Vicknasingam BK. Kratom (Mitragyna speciosa) dependence, withdrawal symptoms and craving in regular users. Drug Alcohol Depend 2014 Jun 1;139:132-7. PubMed
  2. Backstrom BG, Classon G, Lowenhielm P, Thelander G. [Krypton--new, deadly Internet drug. Since October 2009 have nine young persons died in Sweden]. Lakartidningen 2010;107(50):3196-3197.
  3. Kronstrand R, Roman M, Thelander G, Eriksson A. Unintentional fatal intoxications with mitragynine and O-desmethyltramadol from the herbal blend Krypton. J Anal Toxicol 2011;35(4):242-247. PubMed
  4. Boyer EW, Babu KM, Adkins JE, McCurdy CR, Halpern JH. Self-treatment of opioid withdrawal using kratom (Mitragynia speciosa korth). Addiction 2008;103(6):1048-1050.
  5. Jansen KL, Prast CJ. Ethnopharmacology of kratom and the Mitragyna alkaloids. J Ethnopharmacol 1988;23(1):115-119. PubMed
  6. Nelsen JL, Lapoint J, Hodgman MJ, Aldous KM. Seizure and coma following Kratom (Mitragynina speciosa Korth) exposure. J Med Toxicol 2010;6(4):424-426. PubMed
  7. Sheleg SV, Collins GB. A coincidence of addiction to "Kratom" and severe primary hypothyroidism. J Addict Med 2011;5(4):300-301. PubMed
  8. Kapp FG, Maurer HH, Auwarter V, Winkelmann M, Hermanns-Clausen M. Intrahepatic cholestasis following abuse of powdered kratom (Mitragyna speciosa). J Med Toxicol 2011;7(3):227-231. PubMed
  9. Kong WM, Chik Z, Ramachandra M, et al. Evaluation of the effects of Mitragyna speciosa alkaloid extract on cytochrome P450 enzymes using a high throughput assay. Molecules. 2011;16(9):7344-7356. PubMed
  10. US Food and Drug Administration (2014). SNI National is Voluntarily recalling Kratom XL 4 Pack, Maeng Da Kratom 10 Pack, Max Kratom 20 Pack, and Bali Kratom 40 pack Due to Undeclared Drug Ingredients [Press Release].
  11. Castillo A, Payne JD, Nugent K. Posterior reversible leukoencephalopathy syndrome after kratom ingestion. Proc (Bayl Univ Med Cent). 2017;30(3):355-357. PubMed
  12. Cumpston KL, Carter M, Wills BK. Clinical outcomes after Kratom exposures: A poison center case series. Am J Emerg Med. 2018;36(1):166-168. PubMed
  13. FDA Adverse Event Reporting System: Kratom Deaths. February 6, 2018. https://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/CDERFOIAElectronicReadingRoom/UCM595575.pdf. Accessed March 6, 2018.
  14. Trakulsrichai S, Sathirakul K, Auparakkitanon S, et al. Pharmacokinetics of mitragynine in man. Drug Des Devel Ther. 2015;9:2421-9. PubMed
  15. Kruegel AC, Grundmann O. The medicinal chemistry and neuropharmacology of kratom: A preliminary discussion of a promising medicinal plant and analysis of its potential for abuse.Neuropharmacology. 2017. pii: S0028-3908(17)30393-3. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Kratom and dabigatran Together: Common Questions

Is it safe to take Kratom with dabigatran?
We do not list a known interaction between Kratom and dabigatran. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Kratom and dabigatran have any of the same side effects?
Yes — our sources link each of them separately to 5 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Kratom and dabigatran at the same time of day?
At least one FDA label for a product containing dabigatran says to take it with food. If you take Kratom on an empty stomach out of habit, keep them separate and take dabigatran with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two dabigatran products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Kratom and dabigatran combination checked?
Interactions in our licensed database are recorded against drug classes. dabigatran is filed under 3 classifications, and Kratom has documented interactions with 11 drug classes — none of dabigatran's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Kratom interact with any other medications?
Yes. Kratom has 995 documented drug interactions in our database — dabigatran is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does dabigatran interact with any supplements?
Yes. dabigatran has documented interactions with 235 supplements in our database — Kratom is not one of them. The dabigatran interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Kratom monograph Uses, safety profile, and every drug interaction in one place Dabigatran drug information The full plain-English guide to this medication dabigatran supplement interactions Every supplement checked against dabigatran, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 77 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About dabigatran and Kratom?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.