Drug & supplement interaction

Latilactobacillus Sakei + Fidaxomicin

Fidaxomicin brand name: Dificid.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Latilactobacillus Sakei has a moderate interaction with Fidaxomicin. Theoretically, taking Latilactobacillus sakei with antibiotic drugs might decrease the effectiveness of L.

Read the full interaction report
SeverityModerate
LikelihoodProbable
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Latilactobacillus Sakei and Fidaxomicin

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTIBIOTIC DRUGS

Why this applies to Fidaxomicin

Fidaxomicin falls under ANTIBIOTIC DRUGS — the group Latilactobacillus Sakei interacts with.

Theoretically, taking Latilactobacillus sakei with antibiotic drugs might decrease the effectiveness of L. sakei.
Latilactobacillus sakei preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. sakei preparations by at least two hours.
Severity Moderate Likelihood Probable Evidence D

Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the thing to keep in mind with this pair: it's not that the probiotic harms your medication, it's the other way around. Fidaxomicin is an antibiotic, and antibiotics don't know the difference between good and bad bacteria. Since Latilactobacillus sakei is a live, active organism, taking it at the same time as fidaxomicin could simply kill off a good chunk of those probiotic bugs before they ever get a chance to work. Your fidaxomicin keeps doing its job against C. difficile just fine, so it won't hurt your treatment.

This is a theoretical concern based on how the two work together, not hard proof. If you still want to take the probiotic, a simple fix is to space them out by at least two hours. Run it by your pharmacist or doctor first, especially while you're being treated for C. diff.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Latilactobacillus Sakei Also Interacts With Other Medications

Latilactobacillus Sakei has 181 moderate known drug interactions in our database — the Fidaxomicin one above is one of them. If you take anything else, check it against the full list below.

Moderate 181 No known interaction 2,649 (incl. Fidaxomicin)
Taking anything else?

Check Another of Your Medications Against Latilactobacillus Sakei

Covers the 2,830 medications we’ve checked against Latilactobacillus Sakei. Pick one to open its full report.

From our Q&A

Questions About Latilactobacillus Sakei or Fidaxomicin

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Latilactobacillus Sakei or Fidaxomicin, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Fidaxomicin

This page covers Latilactobacillus Sakei only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Fidaxomicin page lists 92 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Oleander (major), St. John's Wort (major), Bacillus Coagulans (moderate) and Bacillus Subtilis (moderate).

By severity: 3 major · 71 moderate · 18 minor.

From our pharmacist’s overview on the Fidaxomicin page

“If you are taking fidaxomicin (Dificid) for a Clostridioides difficile infection, supplements are not a side issue, because anything that weakens this drug risks letting a hard-to-treat infection come back. Three entries rated major top my concerns.”

Reviewed by 2 · Jul 18, 2026

Open the Fidaxomicin interaction page

How much people look this up

Where Latilactobacillus Sakei and Fidaxomicin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Latilactobacillus Sakei
Top half

#601 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Fidaxomicin
Top 25%

#693 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Latilactobacillus Sakei

What is Latilactobacillus Sakei?

  • Chronic rhinosinusitis and nasal congestion
  • Atopic dermatitis (eczema)
  • Allergies
  • Gut and immune support
  • Skin health

Latilactobacillus sakei is a probiotic bacterium found in fermented foods like kimchi and certain meats, studied mostly for nasal sinus problems and eczema. Early research looks interesting, but evidence is still limited, so it should not replace proven treatments. Talk with a pharmacist or doctor before using it, especially if you have a weakened immune system.

Read the full Latilactobacillus Sakei monograph & all interactions
Medication

About Fidaxomicin

What Is Fidaxomicin Used For?

Brand name: Dificid

Fidaxomicin treats C. difficile-associated diarrhea (CDAD) — a bacterial infection in the gut caused by Clostridioides difficile that leads to significant diarrhea and intestinal inflammation. Fidaxomicin tablets are approved for adult patients. Dificid (as tablets or oral suspension) is approved for both adults and children 6 months of age and older.

Because fidaxomicin works almost entirely inside the gut and is barely absorbed into the bloodstream, it is only effective against C. difficile and should not be used for any other type of infection.

See full Fidaxomicin drug information
Keep checking

Other Drugs & Latilactobacillus Sakei

Browse every other medication we’ve checked against Latilactobacillus Sakei — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
181Moderate
0Minor
2,648No known interaction
181 Moderate 2,648 No interaction
Moderate

181 interactions

Showing 60 of 181 moderate interactions — see all 181 on the Latilactobacillus Sakei page.

No interaction 2,648 drugs checked — show the list

We also checked Latilactobacillus Sakei against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,648 medications checked with no known interaction — see the full Latilactobacillus Sakei list.

See the full Latilactobacillus Sakei interactions page
See every supplement checked against Fidaxomicin, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Latilactobacillus Sakei monograph › Uses, safety, and every drug interaction in one place Fidaxomicin supplement interactions › Every supplement checked against Fidaxomicin, ranked by severity Fidaxomicin drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Latilactobacillus Sakei and Fidaxomicin Together: Common Questions

Can you take Latilactobacillus Sakei with Fidaxomicin?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Latilactobacillus Sakei and Fidaxomicin interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Fidaxomicin and Latilactobacillus Sakei?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.