Drug & supplement interaction

Linden + Tolcapone

Tolcapone brand name: Tasmar.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Linden and Tolcapone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Linden and Tolcapone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Tolcapone and Linden in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Linden safety at a glance

Linden overall Use caution Generally well tolerated as a tea, but human safety data are limited.
Pregnancy Avoid Not enough safety information, so avoiding it is the safer choice.
Breastfeeding Use caution Safety is not well studied; check with your doctor before use.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Tolcapone and Linden? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Tolcapone

Interactions in our licensed database are recorded against drug classes, not just single drug names. Tolcapone is filed under 3 classifications — dopamine agonists, hepatotoxic drugs, oral drugs. Linden has documented interactions with 1 drug class — the most serious being lithium (moderate) — and none of Tolcapone’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Linden Does Interact With Other Medications

Linden has 1 moderate known drug interaction in our database — Tolcapone isn’t one of them. If you take anything else, check it against the full list below.

Moderate 1 No known interaction 2,829 (incl. Tolcapone)
Taking anything else?

Check Another of Your Medications Against Linden

Covers the 2,830 medications we’ve checked against Linden. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Linden and Tolcapone May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. 2 of them are worth acting on rather than waiting out — marked below.

  • Hives / An allergic reaction Worth acting on Additional detail

    Linden

    “Orally, there is one case report of allergic reaction to linden pollen in a linden flower tea (12). Topically, there is one case report of contact urticaria following the use of a linden extract-containing shampoo (12).”

    Linden · Natural Medicines adverse-effect record, reported in urticaria.

    1 source cited
    1. 12. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.

    Tolcapone

    Listed in the ADVERSE REACTIONS section of the FDA label for Tolcapone. Read the label on DailyMed ›

Effects for Tolcapone come from the ADVERSE REACTIONS section of its FDA label; effects for Linden come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Everything else you take

See Every Supplement That Interacts With Tolcapone

This page covers Linden only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Tolcapone page lists 58 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Siberian Cocklebur (major), Wine (major) and Ashwagandha (moderate).

By severity: 4 major · 45 moderate · 9 minor.

Open the Tolcapone interaction page

One more smart check

Taking Linden as Part of a Dietary Supplement Product? Check It for Interactions

We hold 178 real supplement products containing Linden, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Linden. Even though Linden itself has no known interaction with Tolcapone, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Linden and Tolcapone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Linden
Top half

#559 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Tolcapone
Steady interest

#2,243 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Linden reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Linden and Tolcapone records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Linden

What is Linden?

  • Anxiety and stress
  • Trouble sleeping
  • Colds and flu symptoms
  • Cough and sore throat
  • Mild digestive upset
  • Promoting sweating during fever

Linden (also called lime flower) is a traditional herbal tea long used to calm nerves, ease cold symptoms, and support restful sleep. Strong human evidence for these uses is lacking, but the flowers are generally considered safe as an occasional tea for most healthy adults. Talk with your pharmacist or doctor before using it regularly, especially during pregnancy, breastfeeding, or if you have a health condition.

Tilia cordata, Tilia platyphyllos · Malvaceae · Dried flowers (and bracts), sometimes leaves · Tea (infusion), tincture, liquid extract, capsules

An interaction check asks whether these two react with each other — it does not ask whether Linden is a good idea for someone in your situation. Here is what our Linden record says about it on its own.

Linden: dosing

There is no official standardized dose for linden. Traditionally it is taken as a tea made by steeping a small amount of the dried flowers in hot water, often once or a few times a day.Because products vary in strength, the best approach is to follow the directions on the product label.

From our Linden monograph — the full record covers uses, side effects and every documented interaction.

Read the full Linden monograph & all interactions
Medication

About Tolcapone

What Is Tolcapone Used For?

Brand name: Tasmar

Tolcapone tablets are used as an add-on treatment to levodopa and carbidopa for idiopathic Parkinson's disease (Parkinson's disease with no known cause). Both Tasmar and tolcapone tablets (generic) carry this indication.

Because of a serious risk of liver failure, tolcapone is ordinarily reserved for patients who are experiencing symptom fluctuations — such as "wearing-off" episodes between doses — and who are not responding satisfactorily to, or are not appropriate candidates for, other add-on therapies.

Most-Reported Side Effects for Tolcapone

From FAERS, the FDA’s public side-effect reporting system (349 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Fall 30 reports
Hallucination 27 reports
Dyskinesia 26 reports
Pneumonia 20 reports
General physical health deterioration 19 reports
See full Tolcapone drug information
Keep checking

Other Drugs & Linden

Browse every other medication we’ve checked against Linden — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
1Moderate
0Minor
2,828No known interaction
1 Moderate 2,828 No interaction
Moderate

1 interaction

No interaction 2,828 drugs checked — show the list

We also checked Linden against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,828 medications checked with no known interaction — see the full Linden list.

See the full Linden interactions page
See every supplement checked against Tolcapone, ranked by severity
Evidence & sources

Linden References

The 2 references that drive our Linden monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Linden and Tolcapone Together: Common Questions

Is it safe to take Linden with Tolcapone?
We do not list a known interaction between Linden and Tolcapone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Linden and Tolcapone have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Linden and Tolcapone combination checked?
Interactions in our licensed database are recorded against drug classes. Tolcapone is filed under 3 classifications, and Linden has documented interactions with 1 drug class — none of Tolcapone's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Linden interact with any other medications?
Yes. Linden has 1 documented drug interaction in our database — Tolcapone is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Tolcapone interact with any supplements?
Yes. Tolcapone has documented interactions with 58 supplements in our database — Linden is not one of them. The Tolcapone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Linden monograph Uses, safety profile, and every drug interaction in one place Tolcapone drug information The full plain-English guide to this medication Tolcapone supplement interactions Every supplement checked against Tolcapone, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Tolcapone and Linden?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.