Drug & supplement interaction

Manna + Risedronate Sodium

Risedronate Sodium brand names: Actonel, Actonel Once a Week.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Oct 4, 2026
The bottom line No known interaction

We found no known interaction between Manna and Risedronate Sodium in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Manna and Risedronate Sodium

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Risedronate Sodium and Manna in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Manna safety at a glance

Manna overall Use caution Generally mild but can cause loose stools, gas, and cramping, especially at higher amounts.
Pregnancy Use caution Not well studied in pregnancy; use only under medical supervision.
Breastfeeding Use caution Little safety information exists, so caution is advised while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Risedronate Sodium and Manna? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Risedronate Sodium

Interactions in our licensed database are recorded against drug classes, not just single drug names. Risedronate Sodium is filed under 2 classifications — bisphosphonates, oral drugs. Manna has documented interactions with 4 drug classes — the most serious being digoxin (lanoxin) (moderate), diuretic drugs (moderate) and stimulant laxatives (moderate) — and none of Risedronate Sodium’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Manna Does Interact With Other Medications

Manna has 99 moderate known drug interactions in our database — Risedronate Sodium isn’t one of them. If you take anything else, check it against the full list below.

Moderate 99 No known interaction 2,731 (incl. Risedronate Sodium)
Taking anything else?

Check Another of Your Medications Against Manna

Covers the 2,830 medications we’ve checked against Manna. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Manna and Risedronate Sodium May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Nausea reported in 10.0% of FDA reports for Risedronate Sodium Additional detail

    Manna

    “Orally, manna has been reported to cause flatulence and nausea (2,18).”

    Manna · Natural Medicines adverse-effect record, reported in flatulence.

    2 sources cited
    1. 2. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
    2. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

    Risedronate Sodium

    Listed in the ADVERSE REACTIONS section of the FDA label for Risedronate Sodium, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Reported for Manna but not commonly for Risedronate Sodium: bloating or gas.

Effects for Risedronate Sodium come from the ADVERSE REACTIONS section of its FDA label; effects for Manna come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 30,902 voluntary FDA FAERS reports for Risedronate Sodium that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Everything else you take

See Every Supplement That Interacts With Risedronate Sodium

This page covers Manna only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Risedronate Sodium page lists 23 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Calcium (moderate), Coffee Charcoal (moderate), Dolomite (moderate) and European Mandrake (moderate).

Open the Risedronate Sodium interaction page

One more smart check

Taking Manna as Part of a Dietary Supplement Product? Check It for Interactions

We hold 27 real supplement products containing Manna, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Manna. Even though Manna itself has no known interaction with Risedronate Sodium, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Manna and Risedronate Sodium Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Manna
Top half

#645 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Risedronate Sodium
Steady interest

#2,145 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Manna reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Manna and Risedronate Sodium records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Manna

What is Manna?

Manna
  • Gentle constipation relief
  • Mild laxative for children and elderly
  • Natural sweetener
  • Occasional bowel softening

Manna is the dried, sweet sap of the flowering ash tree (Fraxinus ornus) and is best known as a gentle, mild laxative because it contains a sugar alcohol called mannitol. It is generally considered mild and is sometimes used for occasional constipation, but high-quality modern studies are limited, so talk with your pharmacist or doctor before using it.

Fraxinus ornus · Oleaceae · Dried sap (exudate) from the bark and stems · Dried flakes or pieces, syrup, powder, and as an ingredient in laxative products

An interaction check asks whether these two react with each other — it does not ask whether Manna is a good idea for someone in your situation. Here is what our Manna record says about it on its own.

Manna: dosing

There is no official standardized dose of manna for supplement use. Amounts have traditionally varied based on the person's age and how strong a laxative effect is needed, with smaller amounts used for children.If you choose to use a manna product, follow the directions on the label and start with the lowest amount.

From our Manna monograph — the full record covers uses, side effects and every documented interaction.

Read the full Manna monograph & all interactions
Medication

About Risedronate

What Is Risedronate Used For?

Brand names: Actonel, Actonel Once a Week

Risedronate treats and prevents postmenopausal osteoporosis (thinning bones after menopause). In postmenopausal women with osteoporosis, it lowers the chance of spine fractures and certain other osteoporosis-related fractures.

Some uses belong only to certain products. Risedronate sodium film-coated tablets are also used to increase bone mass in men with osteoporosis. They also treat and prevent glucocorticoid-induced osteoporosis (bone loss from steroid medicines) and treat Paget's disease of bone. Risedronate sodium delayed-release tablets (including Atelvia) are labeled only for treating postmenopausal osteoporosis.

Most-Reported Side Effects for Risedronate Sodium

From FAERS, the FDA’s public side-effect reporting system (30,902 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Arthralgia 3,876 reports
Nausea 3,085 reports
Dyspnea 3,028 reports
Fatigue 3,025 reports
Vomiting 2,949 reports
See full Risedronate drug information
Keep checking

Other Drugs & Manna

Browse every other medication we’ve checked against Manna — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
99Moderate
0Minor
2,730No known interaction
99 Moderate 2,730 No interaction
Moderate

99 interactions

Showing 60 of 99 moderate interactions — see all 99 on the Manna page.

No interaction 2,730 drugs checked — show the list

We also checked Manna against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,730 medications checked with no known interaction — see the full Manna list.

See the full Manna interactions page
See every supplement checked against Risedronate Sodium, ranked by severity
Evidence & sources

Manna References

The 3 references that drive our Manna monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  3. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Manna and Risedronate Sodium Together: Common Questions

Is it safe to take Manna with Risedronate Sodium?
We do not list a known interaction between Manna and Risedronate Sodium. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Manna and Risedronate Sodium have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Manna and Risedronate Sodium combination checked?
Interactions in our licensed database are recorded against drug classes. Risedronate Sodium is filed under 2 classifications, and Manna has documented interactions with 4 drug classes — none of Risedronate Sodium's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Manna interact with any other medications?
Yes. Manna has 99 documented drug interactions in our database — Risedronate Sodium is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Risedronate Sodium interact with any supplements?
Yes. Risedronate Sodium has documented interactions with 23 supplements in our database — Manna is not one of them. The Risedronate Sodium interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Manna monograph Uses, safety profile, and every drug interaction in one place Risedronate drug information The full plain-English guide to this medication Risedronate Sodium supplement interactions Every supplement checked against Risedronate Sodium, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Risedronate Sodium and Manna?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.