Drug & supplement interaction

Manna + Tenapanor Hydrochloride

Tenapanor Hydrochloride brand name: Ibsrela.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Manna and Tenapanor Hydrochloride in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Manna and Tenapanor Hydrochloride

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Tenapanor Hydrochloride and Manna in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Manna safety at a glance

Manna overall Use caution Generally mild but can cause loose stools, gas, and cramping, especially at higher amounts.
Pregnancy Use caution Not well studied in pregnancy; use only under medical supervision.
Breastfeeding Use caution Little safety information exists, so caution is advised while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Tenapanor Hydrochloride and Manna? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Tenapanor Hydrochloride

Interactions in our licensed database are recorded against drug classes, not just single drug names. Tenapanor Hydrochloride is filed under 2 classifications — cytochrome p450 3a4 (cyp3a4) substrates, oral drugs. Manna has documented interactions with 4 drug classes — the most serious being digoxin (lanoxin) (moderate), diuretic drugs (moderate) and stimulant laxatives (moderate) — and none of Tenapanor Hydrochloride’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Manna Does Interact With Other Medications

Manna has 99 moderate known drug interactions in our database — Tenapanor Hydrochloride isn’t one of them. If you take anything else, check it against the full list below.

Moderate 99 No known interaction 2,731 (incl. Tenapanor Hydrochloride)
Taking anything else?

Check Another of Your Medications Against Manna

Covers the 2,830 medications we’ve checked against Manna. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Manna and Tenapanor Hydrochloride May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Bloating or gas reported in 5.8% of FDA reports for Tenapanor Hydrochloride Additional detail

    Manna

    “Orally, manna has been reported to cause flatulence and nausea (2,18).”

    Manna · Natural Medicines adverse-effect record, reported in flatulence.

    2 sources cited
    1. 2. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
    2. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

    Tenapanor Hydrochloride

    Listed in the ADVERSE REACTIONS section of the FDA label for Tenapanor Hydrochloride, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Reported for Manna but not commonly for Tenapanor Hydrochloride: nausea.

Effects for Tenapanor Hydrochloride come from the ADVERSE REACTIONS section of its FDA label; effects for Manna come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 1,216 voluntary FDA FAERS reports for Tenapanor Hydrochloride that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Overlapping uses

What Tenapanor Hydrochloride Is Prescribed For, and What Manna Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Tenapanor Hydrochloride is a prescription medicine with approved uses on its FDA label. Manna is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Tenapanor Hydrochloride is prescribed for: Tenapanor is approved for two distinct conditions, each under a separate brand. Ibsrela is used to treat irritable bowel syndrome with constipation (IBS-C) in adults. XPHOZAH is used to reduce high phosphorus levels (hyperphosphatemia) in adults with chronic kidney disease (CKD) who are on dialysis — specifically as an add-on when phosphate binders haven't worked well enough or aren't tolerated.

Manna has been studied for:

  • Constipation studied, not established Manna has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Manna for constipation

    Although there has been interest in using oral manna for constipation, there is insufficient reliable information about the clinical effects of manna for this purpose.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Tenapanor Hydrochloride on your own; if you are taking Manna for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Tenapanor Hydrochloride

This page covers Manna only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Tenapanor Hydrochloride page lists 138 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 94 moderate · 41 minor.

From our pharmacist’s overview on the Tenapanor Hydrochloride page

“Tenapanor hydrochloride (Ibsrela) works in the gut to relieve irritable bowel syndrome with constipation, and its supplement interaction list deserves genuine care rather than a quick skim. Three of the 138 ingredients on file rate major: grapefruit, St.”

Reviewed by 2 · Jul 18, 2026

Open the Tenapanor Hydrochloride interaction page

One more smart check

Taking Manna as Part of a Dietary Supplement Product? Check It for Interactions

We hold 27 real supplement products containing Manna, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Manna. Even though Manna itself has no known interaction with Tenapanor Hydrochloride, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Manna and Tenapanor Hydrochloride Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Manna
Top half

#663 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Tenapanor Hydrochloride
Top 5%

#83 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Manna reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Manna and Tenapanor Hydrochloride records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Manna

What is Manna?

Manna
  • Gentle constipation relief
  • Mild laxative for children and elderly
  • Natural sweetener
  • Occasional bowel softening

Manna is the dried, sweet sap of the flowering ash tree (Fraxinus ornus) and is best known as a gentle, mild laxative because it contains a sugar alcohol called mannitol. It is generally considered mild and is sometimes used for occasional constipation, but high-quality modern studies are limited, so talk with your pharmacist or doctor before using it.

Fraxinus ornus · Oleaceae · Dried sap (exudate) from the bark and stems · Dried flakes or pieces, syrup, powder, and as an ingredient in laxative products

An interaction check asks whether these two react with each other — it does not ask whether Manna is a good idea for someone in your situation. Here is what our Manna record says about it on its own.

Manna: dosing

There is no official standardized dose of manna for supplement use. Amounts have traditionally varied based on the person's age and how strong a laxative effect is needed, with smaller amounts used for children.If you choose to use a manna product, follow the directions on the label and start with the lowest amount.

From our Manna monograph — the full record covers uses, side effects and every documented interaction.

Read the full Manna monograph & all interactions
Medication

About Tenapanor

What Is Tenapanor Used For?

Brand name: Ibsrela

Tenapanor is approved for two distinct conditions, each under a separate brand. Ibsrela is used to treat irritable bowel syndrome with constipation (IBS-C) in adults. XPHOZAH is used to reduce high phosphorus levels (hyperphosphatemia) in adults with chronic kidney disease (CKD) who are on dialysis — specifically as an add-on when phosphate binders haven't worked well enough or aren't tolerated.

Most-Reported Side Effects for Tenapanor Hydrochloride

From FAERS, the FDA’s public side-effect reporting system (0 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Diarrhea 1,239 reports
Therapy interrupted 292 reports
Abdominal distension 234 reports
Insurance issue 184 reports
Intentional underdose 167 reports
See full Tenapanor drug information
Keep checking

Other Drugs & Manna

Browse every other medication we’ve checked against Manna — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
99Moderate
0Minor
2,730No known interaction
99 Moderate 2,730 No interaction
Moderate

99 interactions

Showing 60 of 99 moderate interactions — see all 99 on the Manna page.

No interaction 2,730 drugs checked — show the list

We also checked Manna against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,730 medications checked with no known interaction — see the full Manna list.

See the full Manna interactions page
See every supplement checked against Tenapanor Hydrochloride, ranked by severity
Evidence & sources

Manna References

The 3 references that drive our Manna monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  3. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Manna and Tenapanor Hydrochloride Together: Common Questions

Is it safe to take Manna with Tenapanor Hydrochloride?
We do not list a known interaction between Manna and Tenapanor Hydrochloride. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Manna and Tenapanor Hydrochloride have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Are Manna and Tenapanor Hydrochloride used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Manna in each. That is a conversation for your prescriber, especially if Tenapanor Hydrochloride is being adjusted to a target.
How was the Manna and Tenapanor Hydrochloride combination checked?
Interactions in our licensed database are recorded against drug classes. Tenapanor Hydrochloride is filed under 2 classifications, and Manna has documented interactions with 4 drug classes — none of Tenapanor Hydrochloride's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Manna interact with any other medications?
Yes. Manna has 99 documented drug interactions in our database — Tenapanor Hydrochloride is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Tenapanor Hydrochloride interact with any supplements?
Yes. Tenapanor Hydrochloride has documented interactions with 138 supplements in our database — Manna is not one of them. The Tenapanor Hydrochloride interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Manna monograph Uses, safety profile, and every drug interaction in one place Tenapanor drug information The full plain-English guide to this medication Tenapanor Hydrochloride supplement interactions Every supplement checked against Tenapanor Hydrochloride, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Tenapanor Hydrochloride and Manna?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.