Octacosanol - Inderide (Hydrochlorothiazide, Propranolol) Interaction
Herbal: Octacosanol
Drug: Hydrochlorothiazide, Propranolol
Brand names:
Inderide
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 25, 2025
Interaction Details
Hydrochlorothiazide, Propranolol is classified as belonging to the following category: Beta-Blockers
Theoretically, concomitant use of octacosanol with beta-blockers might result in additive hypotensive effects.
Octacosanol is the main component of policosanol. Clinical research shows that policosanol 5 mg daily can have additive blood pressure-lowering effects in patients with hypertension who are taking beta-blockers. Also, animal research shows that policosanol can increase the hypotensive effects of propranolol. It is not clear if these effects occur with the use of octacosanol.
Interaction Rating
Likelihood of Occurrence
ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
References
- Molina, Cuevas, V, Arruzazabala, M. L., Carbajal, Quintana D., Mas, Ferreiro R., and Valdes, Garcia S. Effect of policosanol on arterial blood pressure in rats. Study of the pharmacological interaction with nifedipine and propranolol. Arch Med Res 1998;29
- Castano G, Mas R, Gamez R, et al. Concomitant use of policosanol and beta-blockers in older patients. Int J Clin Pharmacol.Res 2004;24:65-77.
Interaction Details
Hydrochlorothiazide, Propranolol is classified as belonging to the following category: Propranolol (Inderal)
Theoretically, octacosanol might enhance the hypotensive effects of propranolol.
Octacosanol is the main component of policosanol. Animal research shows that taking policosanol along with propranolol can increase the blood pressure-lowering effects of propranolol. It is not clear if these effects occur with the use of octacosanol.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Molina, Cuevas, V, Arruzazabala, M. L., Carbajal, Quintana D., Mas, Ferreiro R., and Valdes, Garcia S. Effect of policosanol on arterial blood pressure in rats. Study of the pharmacological interaction with nifedipine and propranolol. Arch Med Res 1998;29
Octacosanol Overview
Octacosanol is a long-chain alcohol that is found in a variety of plant sources, including wheat germ oil, rice bran oil, and sugar cane wax. It is a white, waxy substance that is used as a dietary supplement and is purported to have a number of potential health benefits.
Octacosanol has been studied for its effects on physical performance and exercise endurance. Some research suggests that it may improve muscle strength and endurance, as well as increase oxygen utilization during exercise. However, these findings are mixed and more research is needed to confirm the effects of octacosanol on physical performance.
Octacosanol is also thought to have antioxidant and anti-inflammatory properties, and it is sometimes used to treat a variety of conditions, including high cholesterol, anxiety, and multiple sclerosis. However, the effectiveness of octacosanol for these conditions has not been established, and more research is needed to understand its potential benefits and risks.
Octacosanol - More Interactions
Octacosanol interacts with 245 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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