Drug & supplement interaction

Phenpromethamine + Niraparib Tosylate

Niraparib Tosylate brand name: Zejula.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Phenpromethamine and Niraparib Tosylate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Phenpromethamine and Niraparib Tosylate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Niraparib Tosylate and Phenpromethamine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Phenpromethamine safety at a glance

Phenpromethamine overall Avoid This is an unapproved synthetic stimulant that should not be used as a supplement.
Pregnancy Possibly Unsafe When used orally. Certain stimulants, especially when used in combination with other stimulants or intensive exercise, have been associated with cardiovascular... Read the full pregnancy detail
Breastfeeding Possibly Unsafe When used orally. Certain stimulants, especially when used in combination with other stimulants or intensive exercise, have been associated with cardiovascular... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Niraparib Tosylate and Phenpromethamine? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Niraparib Tosylate

Interactions in our licensed database are recorded against drug classes, not just single drug names. Niraparib Tosylate is filed under 2 classifications — p-glycoprotein substrates, oral drugs. Phenpromethamine has documented interactions with 1 drug class — the most serious being stimulant drugs (moderate) — and none of Niraparib Tosylate’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Phenpromethamine Does Interact With Other Medications

Phenpromethamine has 172 moderate known drug interactions in our database — Niraparib Tosylate isn’t one of them. If you take anything else, check it against the full list below.

Moderate 172 No known interaction 2,658 (incl. Niraparib Tosylate)
Taking anything else?

Check Another of Your Medications Against Phenpromethamine

Covers the 2,830 medications we’ve checked against Phenpromethamine. Pick one to open its full report.

What to actually watch for

What Niraparib Tosylate’s Own FDA Label Lists

This is not an interaction — none of it involves Phenpromethamine. These are the most notable effects listed in the ADVERSE REACTIONS section of Niraparib Tosylate’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 8 of them are worth acting on rather than waiting out — marked below.

  • Low magnesium Worth acting on
  • Raised blood pressure Worth acting on mentioned in 5.9% of FDA reports for Niraparib Tosylate
  • A low platelet count Worth acting on
  • Kidney problems Worth acting on
  • Anemia Worth acting on
  • Shortness of breath Worth acting on
  • A low white blood cell count Worth acting on
  • A higher chance of infection Worth acting on
  • A change in taste
  • Reduced appetite mentioned in 7.8% of FDA reports for Niraparib Tosylate

Showing the 10 most notable of 27 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Niraparib Tosylate. Read the label on DailyMed › Where a percentage is shown, it is the share of 51 voluntary FDA FAERS reports for Niraparib Tosylate that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Phenpromethamine’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Phenpromethamine side to compare — that is a limit of the record, not a statement that Phenpromethamine has no side effects.

Special populations

Phenpromethamine in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Unsafe

When used orally. Certain stimulants, especially when used in combination with other stimulants or intensive exercise, have been associated with cardiovascular events such as stroke and cardiac arrest. Avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Everything else you take

See Every Supplement That Interacts With Niraparib Tosylate

This page covers Phenpromethamine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Niraparib Tosylate page lists 54 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), St. John's Wort (major), Bitter Melon (moderate), Black Pepper (moderate) and Bulbine Natalensis (moderate).

By severity: 2 major · 35 moderate · 17 minor.

From our pharmacist’s overview on the Niraparib Tosylate page

“Activated charcoal, popular for bloating and so-called detox routines, can trap niraparib (Zejula) in the gut before it absorbs, and St. John's wort can drive levels of the drug down another way.”

Reviewed by 2 · Jul 18, 2026

Open the Niraparib Tosylate interaction page

How much people look this up

Where Phenpromethamine and Niraparib Tosylate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Phenpromethamine
Steady interest

#1,151 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Niraparib Tosylate
Steady interest

#2,108 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Phenpromethamine reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Phenpromethamine and Niraparib Tosylate records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Phenpromethamine

What is Phenpromethamine?

  • Nasal decongestion (historical)
  • Stimulant effects (misuse)
  • Pre-workout 'energy' (illegally added to some products)

Phenpromethamine is a synthetic stimulant drug, not a herb or legitimate dietary supplement. It has been found illegally added to some sports and weight-loss supplements, and it is not approved for use in the United States. You should avoid any product that lists it as an ingredient and talk to a pharmacist or doctor.

Not applicable; phenpromethamine is a synthetic chemical, not a plant part · Historically found as a nasal inhaler; not a legitimate dietary supplement ingredient

An interaction check asks whether these two react with each other — it does not ask whether Phenpromethamine is a good idea for someone in your situation. Here is what our Phenpromethamine record says about it on its own.

Phenpromethamine: dosing

There is no established or recommended dose of phenpromethamine for supplement use. It is not an approved supplement ingredient, and any amount found in products is unregulated and potentially unsafe.Because the amount in spiked products is unknown and uncontrolled, no dose can be considered safe. The best advice is to avoid products that contain it entirely.

From our Phenpromethamine monograph — the full record covers uses, side effects and every documented interaction.

Read the full Phenpromethamine monograph & all interactions
Medication

About Niraparib

What Is Niraparib Used For?

Brand name: Zejula

Zejula is used as maintenance therapy — meaning it is taken after chemotherapy to help keep the cancer from coming back — for adults with advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer. For first-line maintenance, Zejula is approved for patients whose cancer is HRD-positive (has certain DNA-repair defects, including BRCA mutations or genomic instability) and who have responded to their first round of platinum-based chemotherapy.

Zejula is also approved for maintenance treatment in adults with recurrent ovarian, fallopian tube, or primary peritoneal cancer that carries a germline BRCA mutation (an inherited change in the BRCA gene), when the cancer has responded to platinum-based chemotherapy. In both cases, a companion diagnostic test is required to confirm eligibility before starting Zejula.

Most-Reported Side Effects for Niraparib Tosylate

From FAERS, the FDA’s public side-effect reporting system (51 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Constipation 4 reports
Decreased appetite 4 reports
Fatigue 4 reports
Nausea 4 reports
Prostatic specific antigen increased 4 reports
See full Niraparib drug information
Keep checking

Other Drugs & Phenpromethamine

Browse every other medication we’ve checked against Phenpromethamine — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
172Moderate
0Minor
2,657No known interaction
172 Moderate 2,657 No interaction
Moderate

172 interactions

Showing 60 of 172 moderate interactions — see all 172 on the Phenpromethamine page.

No interaction 2,657 drugs checked — show the list

We also checked Phenpromethamine against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,657 medications checked with no known interaction — see the full Phenpromethamine list.

See the full Phenpromethamine interactions page
See every supplement checked against Niraparib Tosylate, ranked by severity
Evidence & sources

Phenpromethamine References

The 2 references that drive our Phenpromethamine monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Venhuis B, Keizers P, van Riel A, de Kaste D. A cocktail of synthetic stimulants found in a dietary supplement associated with serious adverse events. Drug Test Anal. 2014 Jun;6(6):578-81. doi: 10.1002/dta.1664. Epub 2014 May 6. PubMed
  2. Cohen PA, Travis JC, Vanhee C, Ohana D, Venhuis BJ. Nine prohibited stimulants found in sports and weight loss supplements: deterenol, phenpromethamine (Vonedrine), oxilofrine, octodrine, beta-methylphenylethylamine (BMPEA), 1,3-dimethylamylamine (1,3-DMA

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Phenpromethamine and Niraparib Tosylate Together: Common Questions

Is it safe to take Phenpromethamine with Niraparib Tosylate?
We do not list a known interaction between Phenpromethamine and Niraparib Tosylate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Phenpromethamine and Niraparib Tosylate combination checked?
Interactions in our licensed database are recorded against drug classes. Niraparib Tosylate is filed under 2 classifications, and Phenpromethamine has documented interactions with 1 drug class — none of Niraparib Tosylate's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Phenpromethamine interact with any other medications?
Yes. Phenpromethamine has 172 documented drug interactions in our database — Niraparib Tosylate is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Niraparib Tosylate interact with any supplements?
Yes. Niraparib Tosylate has documented interactions with 54 supplements in our database — Phenpromethamine is not one of them. The Niraparib Tosylate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Phenpromethamine monograph Uses, safety profile, and every drug interaction in one place Niraparib drug information The full plain-English guide to this medication Niraparib Tosylate supplement interactions Every supplement checked against Niraparib Tosylate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Niraparib Tosylate and Phenpromethamine?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.