Drug & supplement interaction

Phenpromethamine + Sodium Phenylbutyrate

Sodium Phenylbutyrate brand names: Buphenyl, Pheburane, Olpruva.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 27, 2026
The bottom line No known interaction

We found no known interaction between Phenpromethamine and Sodium Phenylbutyrate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Sodium Phenylbutyrate states a food rule worth keeping to.

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Interaction report

Phenpromethamine and Sodium Phenylbutyrate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Sodium Phenylbutyrate and Phenpromethamine in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Phenpromethamine safety at a glance

Phenpromethamine overall Avoid This is an unapproved synthetic stimulant that should not be used as a supplement.
Pregnancy Possibly Unsafe When used orally. Certain stimulants, especially when used in combination with other stimulants or intensive exercise, have been associated with cardiovascular... Read the full pregnancy detail
Breastfeeding Possibly Unsafe When used orally. Certain stimulants, especially when used in combination with other stimulants or intensive exercise, have been associated with cardiovascular... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Sodium Phenylbutyrate and Phenpromethamine? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Sodium Phenylbutyrate

Interactions in our licensed database are recorded against drug classes, not just single drug names. Sodium Phenylbutyrate is filed under 2 classifications — sodium-containing drugs, oral drugs. Phenpromethamine has documented interactions with 1 drug class — the most serious being stimulant drugs (moderate) — and none of Sodium Phenylbutyrate’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Phenpromethamine Does Interact With Other Medications

Phenpromethamine has 172 moderate known drug interactions in our database — Sodium Phenylbutyrate isn’t one of them. If you take anything else, check it against the full list below.

Moderate 172 No known interaction 2,658 (incl. Sodium Phenylbutyrate)
Taking anything else?

Check Another of Your Medications Against Phenpromethamine

Covers the 2,830 medications we’ve checked against Phenpromethamine. Pick one to open its full report.

What to actually watch for

What Sodium Phenylbutyrate’s Own FDA Label Lists

This is not an interaction — none of it involves Phenpromethamine. These are the most notable effects listed in the ADVERSE REACTIONS section of Sodium Phenylbutyrate’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • Hearing loss Worth acting on
  • Memory problems Worth acting on
  • Bleeding in the gut Worth acting on
  • Low potassium Worth acting on
  • Pancreatitis Worth acting on
  • Fainting Worth acting on
  • An irregular heartbeat Worth acting on
  • Confusion Worth acting on
  • Low mood Worth acting on
  • A low platelet count Worth acting on

Showing the 10 most notable of 28 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Sodium Phenylbutyrate. Read the label on DailyMed › Where a percentage is shown, it is the share of 411 voluntary FDA FAERS reports for Sodium Phenylbutyrate that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Phenpromethamine’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Phenpromethamine side to compare — that is a limit of the record, not a statement that Phenpromethamine has no side effects.

Special populations

Phenpromethamine in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Unsafe

When used orally. Certain stimulants, especially when used in combination with other stimulants or intensive exercise, have been associated with cardiovascular events such as stroke and cardiac arrest. Avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Sodium Phenylbutyrate Products Have a Food Rule — Phenpromethamine Should Not Break It

At least one FDA label for a product containing Sodium Phenylbutyrate says to take it with food. If you take Phenpromethamine on an empty stomach out of habit, keep them separate — and take Sodium Phenylbutyrate with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Sodium Phenylbutyrate products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

The powder is to be mixed with food (solid or liquid) for immediate use; however, when dissolved in water, BUPHENYL Powder has been shown to be stable for up to one week at room temperature or refrigerated.

From the Dosage and Administration section of the FDA label we read for Sodium Phenylbutyrate — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Sodium Phenylbutyrate

This page covers Phenpromethamine only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Sodium Phenylbutyrate page lists 19 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).

By severity: 1 major · 9 moderate · 9 minor.

From our pharmacist’s overview on the Sodium Phenylbutyrate page

“Sodium phenylbutyrate (Buphenyl, Pheburane, Olpruva) keeps ammonia in check in people with urea cycle disorders, so a supplement that blunts its absorption is not a small problem, it is the difference between a controlled ammonia level and a dangerous one. Seventeen of the 19 ingredients on this page, mostly fibers, gums, and mucilages…”

Reviewed by 2 · Jul 18, 2026

Open the Sodium Phenylbutyrate interaction page

How much people look this up

Where Phenpromethamine and Sodium Phenylbutyrate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Phenpromethamine
Steady interest

#733 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Sodium Phenylbutyrate
Steady interest

#1,549 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Phenpromethamine reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 27, 2026. The Phenpromethamine and Sodium Phenylbutyrate records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Phenpromethamine

What is Phenpromethamine?

  • Nasal decongestion (historical)
  • Stimulant effects (misuse)
  • Pre-workout 'energy' (illegally added to some products)

Phenpromethamine is a synthetic stimulant drug, not a herb or legitimate dietary supplement. It has been found illegally added to some sports and weight-loss supplements, and it is not approved for use in the United States. You should avoid any product that lists it as an ingredient and talk to a pharmacist or doctor.

Not applicable; phenpromethamine is a synthetic chemical, not a plant part · Historically found as a nasal inhaler; not a legitimate dietary supplement ingredient

An interaction check asks whether these two react with each other — it does not ask whether Phenpromethamine is a good idea for someone in your situation. Here is what our Phenpromethamine record says about it on its own.

Phenpromethamine: dosing

There is no established or recommended dose of phenpromethamine for supplement use. It is not an approved supplement ingredient, and any amount found in products is unregulated and potentially unsafe.Because the amount in spiked products is unknown and uncontrolled, no dose can be considered safe. The best advice is to avoid products that contain it entirely.

From our Phenpromethamine monograph — the full record covers uses, side effects and every documented interaction.

Read the full Phenpromethamine monograph & all interactions
Medication

About Sodium Phenylbutyrate

Most-Reported Side Effects for Sodium Phenylbutyrate

From FAERS, the FDA’s public side-effect reporting system (420 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Hyperammonaemia 56 reports
Vomiting 42 reports
Ammonia increased 32 reports
Nausea 28 reports
Diarrhea 27 reports
Keep checking

Other Drugs & Phenpromethamine

Browse every other medication we’ve checked against Phenpromethamine — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
172Moderate
0Minor
2,657No known interaction
172 Moderate 2,657 No interaction
Moderate

172 interactions

Showing 60 of 172 moderate interactions — see all 172 on the Phenpromethamine page.

No interaction 2,657 drugs checked — show the list

We also checked Phenpromethamine against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,657 medications checked with no known interaction — see the full Phenpromethamine list.

See the full Phenpromethamine interactions page
See every supplement checked against Sodium Phenylbutyrate, ranked by severity
Evidence & sources

Phenpromethamine References

The 2 references that drive our Phenpromethamine monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Venhuis B, Keizers P, van Riel A, de Kaste D. A cocktail of synthetic stimulants found in a dietary supplement associated with serious adverse events. Drug Test Anal. 2014 Jun;6(6):578-81. doi: 10.1002/dta.1664. Epub 2014 May 6. PubMed
  2. Cohen PA, Travis JC, Vanhee C, Ohana D, Venhuis BJ. Nine prohibited stimulants found in sports and weight loss supplements: deterenol, phenpromethamine (Vonedrine), oxilofrine, octodrine, beta-methylphenylethylamine (BMPEA), 1,3-dimethylamylamine (1,3-DMA

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Phenpromethamine and Sodium Phenylbutyrate Together: Common Questions

Is it safe to take Phenpromethamine with Sodium Phenylbutyrate?
We do not list a known interaction between Phenpromethamine and Sodium Phenylbutyrate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Phenpromethamine and Sodium Phenylbutyrate at the same time of day?
At least one FDA label for a product containing Sodium Phenylbutyrate says to take it with food. If you take Phenpromethamine on an empty stomach out of habit, keep them separate and take Sodium Phenylbutyrate with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Sodium Phenylbutyrate products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Phenpromethamine and Sodium Phenylbutyrate combination checked?
Interactions in our licensed database are recorded against drug classes. Sodium Phenylbutyrate is filed under 2 classifications, and Phenpromethamine has documented interactions with 1 drug class — none of Sodium Phenylbutyrate's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Phenpromethamine interact with any other medications?
Yes. Phenpromethamine has 172 documented drug interactions in our database — Sodium Phenylbutyrate is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Sodium Phenylbutyrate interact with any supplements?
Yes. Sodium Phenylbutyrate has documented interactions with 19 supplements in our database — Phenpromethamine is not one of them. The Sodium Phenylbutyrate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Phenpromethamine monograph Uses, safety profile, and every drug interaction in one place Sodium Phenylbutyrate supplement interactions Every supplement checked against Sodium Phenylbutyrate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Sodium Phenylbutyrate and Phenpromethamine?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.