Drug & supplement interaction

Phlorizin + Leniolisib

Leniolisib brand name: Joenja.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Phlorizin and Leniolisib in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Phlorizin and Leniolisib

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Leniolisib and Phlorizin in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Phlorizin safety at a glance

Phlorizin overall Not established Human safety data for phlorizin supplements are very limited.
Pregnancy Avoid There is no reliable safety data, so it is best avoided in pregnancy.
Breastfeeding Avoid No safety information exists for nursing, so avoid use.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Leniolisib and Phlorizin? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Leniolisib

Interactions in our licensed database are recorded against drug classes, not just single drug names. Leniolisib is filed under 3 classifications — cytochrome p450 1a2 (cyp1a2) inhibitors, cytochrome p450 3a4 (cyp3a4) substrates, oral drugs. Phlorizin has documented interactions with 1 drug class — the most serious being antidiabetes drugs (moderate) — and none of Leniolisib’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Phlorizin Does Interact With Other Medications

Phlorizin has 86 moderate known drug interactions in our database — Leniolisib isn’t one of them. If you take anything else, check it against the full list below.

Moderate 86 No known interaction 2,744 (incl. Leniolisib)
Taking anything else?

Check Another of Your Medications Against Phlorizin

Covers the 2,830 medications we’ve checked against Phlorizin. Pick one to open its full report.

What to actually watch for

What Leniolisib’s Own FDA Label Lists

This is not an interaction — none of it involves Phlorizin. These are the most notable effects listed in the ADVERSE REACTIONS section of Leniolisib’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 4 of them are worth acting on rather than waiting out — marked below.

  • A severe allergic reaction Worth acting on
  • A low white blood cell count Worth acting on
  • A higher chance of infection Worth acting on
  • An allergic reaction Worth acting on
  • Weight gain
  • Hair loss
  • Back pain
  • A fast or pounding heartbeat
  • Fever
  • Tiredness

Showing the 10 most notable of 13 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Leniolisib. Read the label on DailyMed › Phlorizin’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Phlorizin side to compare — that is a limit of the record, not a statement that Phlorizin has no side effects.

Everything else you take

See Every Supplement That Interacts With Leniolisib

This page covers Phlorizin only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Leniolisib page lists 145 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), St. John's Wort (major), Acacia Rigidula (moderate) and Adrafinil (moderate).

By severity: 3 major · 100 moderate · 42 minor.

From our pharmacist’s overview on the Leniolisib page

“Leniolisib (Joenja) treats APDS, a rare immune disorder, and it is cleared by the CYP3A4 enzyme, a pathway that runs through nearly this whole page: 121 of the 145 supplements and herbs on file can push its blood level up or down that way. That deserves genuine vigilance, starting with the three major entries.”

Reviewed by 2 · Jul 18, 2026

Open the Leniolisib interaction page

One more smart check

Taking Phlorizin as Part of a Dietary Supplement Product? Check It for Interactions

We hold 6 real supplement products containing Phlorizin, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Phlorizin. Even though Phlorizin itself has no known interaction with Leniolisib, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Phlorizin and Leniolisib Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Phlorizin
Top half

#485 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Leniolisib
Top half

#1,320 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Phlorizin reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Phlorizin and Leniolisib records this page draws on were last updated July 3, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Phlorizin

What is Phlorizin?

  • Blood sugar support
  • Diabetes research
  • Antioxidant
  • Weight management interest

Phlorizin is a natural plant compound (a dihydrochalcone) found in apple tree bark and other plants that has been studied mostly in the laboratory for its effects on blood sugar handling. There is no good human evidence that taking it as a supplement is safe or effective, and it is poorly absorbed when swallowed. Talk with your pharmacist or doctor before using any product containing it.

Root bark, bark, and leaves of apple trees and related Rosaceae plants · Purified compound (research chemical), capsules, powders

An interaction check asks whether these two react with each other — it does not ask whether Phlorizin is a good idea for someone in your situation. Here is what our Phlorizin record says about it on its own.

Phlorizin: dosing

There is no established or standardized dose of phlorizin for supplement use in humans. It has mainly been used in research settings at carefully controlled amounts, not as a routine oral supplement.If you choose to use a product that contains phlorizin or apple bark extract, follow the directions on the product label and do not exceed the recommended amount.

From our Phlorizin monograph — the full record covers uses, side effects and every documented interaction.

Read the full Phlorizin monograph & all interactions
Medication

About Leniolisib

What Is Leniolisib Used For?

Brand name: Joenja

Joenja (leniolisib) is approved to treat activated phosphoinositide 3-kinase delta syndrome, commonly called APDS — a rare genetic immune disorder in which certain immune cells (B and T cells) don't work properly. It is approved for adults and pediatric patients who are at least 12 years old.

APDS is caused by gene variants that make a specific enzyme (PI3K-delta) overactive, leading to immune system dysfunction. Joenja is the brand name for leniolisib in tablet form, taken by mouth.

See full Leniolisib drug information
Keep checking

Other Drugs & Phlorizin

Browse every other medication we’ve checked against Phlorizin — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
86Moderate
0Minor
2,743No known interaction
86 Moderate 2,743 No interaction
Moderate

86 interactions

Showing 60 of 86 moderate interactions — see all 86 on the Phlorizin page.

No interaction 2,743 drugs checked — show the list

We also checked Phlorizin against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,743 medications checked with no known interaction — see the full Phlorizin list.

See the full Phlorizin interactions page
See every supplement checked against Leniolisib, ranked by severity
Evidence & sources

Phlorizin References

The 1 references that drive our Phlorizin monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Chao EC, Henry RR. SGLT2 inhibition--a novel strategy for diabetes treatment. Nat Rev Drug Discov. 2010;9(7):551-9. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Phlorizin and Leniolisib Together: Common Questions

Is it safe to take Phlorizin with Leniolisib?
We do not list a known interaction between Phlorizin and Leniolisib. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Phlorizin and Leniolisib combination checked?
Interactions in our licensed database are recorded against drug classes. Leniolisib is filed under 3 classifications, and Phlorizin has documented interactions with 1 drug class — none of Leniolisib's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Phlorizin interact with any other medications?
Yes. Phlorizin has 86 documented drug interactions in our database — Leniolisib is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Leniolisib interact with any supplements?
Yes. Leniolisib has documented interactions with 145 supplements in our database — Phlorizin is not one of them. The Leniolisib interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Phlorizin monograph Uses, safety profile, and every drug interaction in one place Leniolisib drug information The full plain-English guide to this medication Leniolisib supplement interactions Every supplement checked against Leniolisib, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Leniolisib and Phlorizin?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.