Drug & supplement interaction

Piracetam + Ibuprofen, Acetaminophen

Ibuprofen, Acetaminophen brand name: Advil Dual Action.

Major Interaction
Medically reviewed by · Updated September 2026
The bottom line Major

Piracetam has a major interaction with Ibuprofen, Acetaminophen. Theoretically, concomitant use of piracetam and anticoagulant/antiplatelet drugs might increase the risk of bleeding.

Read the full interaction report
SeverityMajor
LikelihoodProbable
EvidenceB
What do Severity, Likelihood & Evidence mean?
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Interaction report

Piracetam and Ibuprofen, Acetaminophen

Here is the interaction we found between these two, with the evidence behind it.

Major

ANTICOAGULANT/ANTIPLATELET DRUGS

Why this applies to Ibuprofen, Acetaminophen

Ibuprofen, Acetaminophen falls under ANTICOAGULANT/ANTIPLATELET DRUGS — the group Piracetam interacts with.

Theoretically, concomitant use of piracetam and anticoagulant/antiplatelet drugs might increase the risk of bleeding.
Preliminary clinical research shows that a single dose of piracetam inhibits platelet aggregation.
Severity Major Likelihood Probable Evidence B

Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the thing to keep in mind with Advil Dual Action, which combines ibuprofen (an NSAID) and acetaminophen. The ibuprofen part already has a mild blood-thinning effect because it dampens platelets, the little cells that help your blood clot. Early research suggests piracetam can also make platelets less sticky on its own.

Stack those two together and you may nudge up your bleeding risk a bit. Watch for things like easy bruising, nosebleeds, bleeding gums, or stomach upset and dark stools, since ibuprofen can already irritate the stomach. This is more of a theoretical, add-up concern than a proven danger, but I'd run it by your pharmacist or doctor first, especially if you take it often or use other blood thinners.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Moriau M, Crasborn L, Lavenne-Pardonge E, et al. Platelet anti-aggregant and rheological properties of piracetam. A pharmacodynamic study in normal subjects. Arzneimittelforschung. 1993;43(2):110-8.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Piracetam Also Interacts With Other Medications

Piracetam has 121 major, known drug interactions in our database — the Ibuprofen, Acetaminophen one above is one of them. If you take anything else, check it against the full list below.

Major 121 No known interaction 2,709 (incl. Ibuprofen, Acetaminophen)
Taking anything else?

Check Another of Your Medications Against Piracetam

Covers the 2,830 medications we’ve checked against Piracetam. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Ibuprofen, Acetaminophen

This page covers Piracetam only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ibuprofen, Acetaminophen page lists 342 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Danshen (major) and Siberian Cocklebur (major).

By severity: 7 major · 290 moderate · 45 minor.

From our pharmacist’s overview on the Ibuprofen, Acetaminophen page

“Advil Dual Action pairs ibuprofen, an NSAID with built-in stomach-bleeding risk, and acetaminophen, which the liver processes, so this interaction list deserves a careful read, not a skim. Most of the entries can add to bleeding risk, while smaller clusters put extra strain on the liver or kidneys.”

Reviewed by 2 · Jul 18, 2026

Open the Ibuprofen, Acetaminophen interaction page

One more smart check

Taking Piracetam as Part of a Dietary Supplement Product? Check It for Interactions

We hold 6 real supplement products containing Piracetam, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Piracetam. Your product may carry other ingredients that interact with Ibuprofen, Acetaminophen too, on top of Piracetam — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Piracetam and Ibuprofen, Acetaminophen Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Piracetam
Steady interest

#856 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Ibuprofen, Acetaminophen
Top 25%

#409 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Piracetam

What is Piracetam?

  • Memory and cognition ('nootropic')
  • Cognitive decline and dementia
  • Myoclonus
  • Dyslexia in children
  • Vertigo

Piracetam is a synthetic 'nootropic' drug studied mainly for cognitive decline, myoclonus, and certain neurological conditions, but evidence for boosting memory in healthy people is weak. It is a prescription medicine in many countries and is not an approved drug or dietary supplement in the United States, so quality and safety of products sold online vary. Talk to a doctor or pharmacist before using it.

Read the full Piracetam monograph & all interactions
Keep checking

Other Drugs & Piracetam

Browse every other medication we’ve checked against Piracetam — both the ones with a known interaction and the ones without. Select any drug for the full detail.

121Major
0Moderate
0Minor
2,708No known interaction
121 Major 2,708 No interaction
Major

121 interactions

Showing 60 of 121 major interactions — see all 121 on the Piracetam page.

No interaction 2,708 drugs checked — show the list

We also checked Piracetam against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,708 medications checked with no known interaction — see the full Piracetam list.

See the full Piracetam interactions page
See every supplement checked against Ibuprofen, Acetaminophen, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Piracetam monograph › Uses, safety, and every drug interaction in one place Ibuprofen, Acetaminophen supplement interactions › Every supplement checked against Ibuprofen, Acetaminophen, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Piracetam and Ibuprofen, Acetaminophen Together: Common Questions

Can you take Piracetam with Ibuprofen, Acetaminophen?
This is rated a major interaction, so the combination is best avoided unless your doctor or pharmacist has specifically told you otherwise. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Piracetam and Ibuprofen, Acetaminophen interaction?
We rate it Major. This is a clinically significant combination that is generally best avoided, or used only under the direct supervision of your physician or pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Ibuprofen, Acetaminophen and Piracetam?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.