Drug & supplement interaction

Red Raspberry + Sodium Oxybate

Sodium Oxybate brand name: Xyrem.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Red Raspberry and Sodium Oxybate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Sodium Oxybate states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Red Raspberry and Sodium Oxybate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Sodium Oxybate and Red Raspberry in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Red Raspberry safety at a glance

Red Raspberry overall Use caution Generally well tolerated by most adults, but evidence on safety is limited.
Pregnancy Likely Safe When the fruit is used orally in amounts commonly found in foods. Read the full pregnancy detail
Breastfeeding Likely Safe When the fruit is used orally in amounts commonly found in foods. There is insufficient reliable information available about the safety of red raspberry leaf; a... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Sodium Oxybate and Red Raspberry? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Sodium Oxybate

Interactions in our licensed database are recorded against drug classes, not just single drug names. Sodium Oxybate is filed under 3 classifications — sodium-containing drugs, seizure threshold lowering drugs, oral drugs. Red Raspberry has documented interactions with 2 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate) and insulin (moderate) — and none of Sodium Oxybate’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Red Raspberry Does Interact With Other Medications

Red Raspberry has 135 moderate known drug interactions in our database — Sodium Oxybate isn’t one of them. If you take anything else, check it against the full list below.

Moderate 135 No known interaction 2,695 (incl. Sodium Oxybate)
Taking anything else?

Check Another of Your Medications Against Red Raspberry

Covers the 2,830 medications we’ve checked against Red Raspberry. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Red Raspberry and Sodium Oxybate May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Diarrhea Additional detail

    Red Raspberry

    “Orally, red raspberry may cause gastrointestinal upset, diarrhea, and epigastric pain.”

    Red Raspberry · Natural Medicines adverse-effect record, reported in diarrhea.

    1 source cited
    1. 112127. Henrotin Y, Cozannet RL, Fança-Berthon P, et al. Rubus idaeus extract improves symptoms in knee osteoarthritis patients: results from a phase II double-blind randomized controlled trial. BMC Musculoskelet Disord 2022;23(1):650. PubMed

    Sodium Oxybate

    Listed in the ADVERSE REACTIONS section of the FDA label for Sodium Oxybate. Read the label on DailyMed ›

Reported for Red Raspberry but not commonly for Sodium Oxybate: stomach upset, shortness of breath and wheezing.

Effects for Sodium Oxybate come from the ADVERSE REACTIONS section of its FDA label; effects for Red Raspberry come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 65,315 voluntary FDA FAERS reports for Sodium Oxybate that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Red Raspberry in Pregnancy & Breastfeeding

Pregnancy Likely Safe

When the fruit is used orally in amounts commonly found in foods.

Pregnancy Possibly Safe

When red raspberry leaf is used orally and appropriately in medicinal amounts during late pregnancy under the supervision of a healthcare provider. Red raspberry leaf is used by nurse midwives to facilitate delivery. There is some evidence that red raspberry leaf in doses of up to 2.4 grams daily, beginning at 32 weeks' gestation and continued until delivery, can be safely used for this purpose. Make sure patients do not use red raspberry leaf without the guidance of a healthcare professional.

Pregnancy Likely Unsafe

When red raspberry leaf is used orally in medicinal amounts throughout pregnancy or for self-treatment. Red raspberry leaf might have estrogenic effects. These effects can adversely affect pregnancy. Tell pregnant patients not to use red raspberry leaf at any time during pregnancy without the close supervision of a healthcare provider.

Lactation Likely Safe

When the fruit is used orally in amounts commonly found in foods. There is insufficient reliable information available about the safety of red raspberry leaf; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Sodium Oxybate Products Have a Food Rule — Red Raspberry Should Not Break It

At least one FDA label for a product containing Sodium Oxybate says to take it with food. If you take Red Raspberry on an empty stomach out of habit, keep them separate — and take Sodium Oxybate with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Sodium Oxybate products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

• Allow 2 hours after eating before dosing ( 2.3 ).

From the Dosage and Administration section of the FDA label we read for Sodium Oxybate — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

From our Q&A

Questions About Red Raspberry or Sodium Oxybate

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Red Raspberry or Sodium Oxybate, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Sodium Oxybate

This page covers Red Raspberry only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Sodium Oxybate page lists 25 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Biofeedback (moderate), Coffee Charcoal (moderate), Dendrobium (moderate) and European Mandrake (moderate).

By severity: 1 major · 15 moderate · 9 minor.

From our pharmacist’s overview on the Sodium Oxybate page

“Activated charcoal is the single major-rated interaction with sodium oxybate (Xyrem), and it earns that rating because the drug only works if each dose is fully absorbed; charcoal can bind it in the gut and weaken the nighttime control it provides for narcolepsy. Treat this list with genuine care, since 17 of the 25 ingredients on file…”

Reviewed by 2 · Jul 18, 2026

Open the Sodium Oxybate interaction page

One more smart check

Taking Red Raspberry as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,303 real supplement products containing Red Raspberry, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Red Raspberry. Even though Red Raspberry itself has no known interaction with Sodium Oxybate, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Red Raspberry and Sodium Oxybate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Red Raspberry
Top 25%

#170 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Sodium Oxybate
Top 25%

#609 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Red Raspberry reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Red Raspberry and Sodium Oxybate records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Red Raspberry

What is Red Raspberry?

  • Pregnancy and labor support
  • Menstrual cramps
  • Digestive upset and diarrhea
  • Sore throat and mouth rinse
  • Antioxidant support

Red raspberry leaf is a traditional herbal remedy most often used as a tea in late pregnancy and for menstrual discomfort, but solid scientific evidence for these uses is limited. It is generally considered well tolerated by most adults, but pregnant people should talk with their doctor or midwife before using it.

Rubus idaeus · Rosaceae · Leaves and fruit · Tea, capsules, tablets, dried leaf, liquid extract

An interaction check asks whether these two react with each other — it does not ask whether Red Raspberry is a good idea for someone in your situation. Here is what our Red Raspberry record says about it on its own.

Red Raspberry: dosing

There is no official or standardized dose for red raspberry leaf. It is most commonly taken as a tea made from dried leaves, and also comes in capsules, tablets, and liquid extracts.Because products vary in strength, the best approach is to follow the directions on the product label.

From our Red Raspberry monograph — the full record covers uses, side effects and every documented interaction.

Read the full Red Raspberry monograph & all interactions
Medication

About Sodium Oxybate

What Is Sodium Oxybate Used For?

Brand name: Xyrem

Sodium oxybate treats two major symptoms of narcolepsy: cataplexy (sudden muscle weakness triggered by emotion) and excessive daytime sleepiness (EDS). It is available in several products, each approved for these uses.

Xyrem (oral solution) and the generic sodium oxybate oral solution are approved for cataplexy or EDS in patients with narcolepsy. Lumryz (extended-release oral suspension) is specifically approved for cataplexy or EDS in patients 7 years of age and older with narcolepsy. The generic sodium oxybate oral solution label does not include the pediatric indication due to marketing exclusivity held by Xyrem.

Most-Reported Side Effects for Sodium Oxybate

From FAERS, the FDA’s public side-effect reporting system (65,536 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Nausea 4,928 reports
Anxiety 3,979 reports
Somnolence 3,965 reports
Insomnia 3,371 reports
Feeling abnormal 3,223 reports
See full Sodium Oxybate drug information
Keep checking

Other Drugs & Red Raspberry

Browse every other medication we’ve checked against Red Raspberry — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
135Moderate
0Minor
2,694No known interaction
135 Moderate 2,694 No interaction
Moderate

135 interactions

Showing 60 of 135 moderate interactions — see all 135 on the Red Raspberry page.

No interaction 2,694 drugs checked — show the list

We also checked Red Raspberry against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,694 medications checked with no known interaction — see the full Red Raspberry list.

See the full Red Raspberry interactions page
See every supplement checked against Sodium Oxybate, ranked by severity
Evidence & sources

Red Raspberry References

The 8 references that drive our Red Raspberry monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Eagon PK, Elm MS, Hunter DS, et al. Medicinal herbs: modulation of estrogen action. Era of Hope Mtg, Dept Defense; Breast Cancer Res Prog, Atlanta, GA 2000;Jun 8-11.
  2. Parsons M, Simpson M, Ponton T. Raspberry leaf and its effects on labour: safety and efficacy. Aust Coll Midwives Inc J 1999;12:20-5.
  3. Simpson M, Parsons M, Greenwood J, Wade K. Raspberry leaf in pregnancy: its safety and efficacy in labor. J Midwifery Womens Health 2001;46:51-9.. PubMed
  4. Mullen W, McGinn J, Lean ME, et al. Ellagitannins, flavonoids, and other phenolics in red raspberries and their contribution to antioxidant capacity and vasorelaxation properties. J Agric Food Chem 2002;50:5191-6.. PubMed
  5. Sherson, D., Andersen, B., Hansen, I., and Kjoller, H. Occupational asthma due to freeze-dried raspberry. Ann Allergy Asthma Immunol. 2003;90(6):660-663. PubMed
  6. Cheang KI, Nguyen TT, Karjane NW, Salley KE. Raspberry Leaf and Hypoglycemia in Gestational Diabetes Mellitus. Obstet Gynecol. 2016;128(6):1421-4. PubMed
  7. Dudzinska D, Bednarska K, Boncler M, Luzak B, Watala C. The influence of Rubus idaeus and Rubus caesius leaf extracts on platelet aggregation in whole blood. Cross-talk of platelets and neutrophils. Platelets. 2016;27(5):433-9.
  8. Henrotin Y, Cozannet RL, Fança-Berthon P, et al. Rubus idaeus extract improves symptoms in knee osteoarthritis patients: results from a phase II double-blind randomized controlled trial. BMC Musculoskelet Disord 2022;23(1):650. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Red Raspberry and Sodium Oxybate Together: Common Questions

Is it safe to take Red Raspberry with Sodium Oxybate?
We do not list a known interaction between Red Raspberry and Sodium Oxybate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Red Raspberry and Sodium Oxybate have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Red Raspberry and Sodium Oxybate at the same time of day?
At least one FDA label for a product containing Sodium Oxybate says to take it with food. If you take Red Raspberry on an empty stomach out of habit, keep them separate and take Sodium Oxybate with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Sodium Oxybate products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Red Raspberry and Sodium Oxybate combination checked?
Interactions in our licensed database are recorded against drug classes. Sodium Oxybate is filed under 3 classifications, and Red Raspberry has documented interactions with 2 drug classes — none of Sodium Oxybate's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Red Raspberry interact with any other medications?
Yes. Red Raspberry has 135 documented drug interactions in our database — Sodium Oxybate is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Sodium Oxybate interact with any supplements?
Yes. Sodium Oxybate has documented interactions with 25 supplements in our database — Red Raspberry is not one of them. The Sodium Oxybate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Red Raspberry monograph Uses, safety profile, and every drug interaction in one place Sodium Oxybate drug information The full plain-English guide to this medication Sodium Oxybate supplement interactions Every supplement checked against Sodium Oxybate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 8 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Sodium Oxybate and Red Raspberry?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.