Drug & supplement interaction

Saffron + Latanoprost

Latanoprost brand names: Xalatan, Xelpros, Iyuzeh.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Saffron and Latanoprost in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Saffron and Latanoprost

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Latanoprost and Saffron in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Saffron safety at a glance

Saffron overall Use caution Likely safe in food amounts, but supplement doses should be used carefully and high doses can be toxic.
Pregnancy Likely Unsafe When used orally in amounts exceeding those commonly found in foods. Larger amounts of saffron have uterine stimulant and abortifacient effects; avoid using. Read the full pregnancy detail
Breastfeeding Use caution Not enough reliable safety information, so it is best to avoid supplement amounts.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Latanoprost and Saffron? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
Keep it in perspective

Saffron Does Interact With Other Medications

Saffron has 521 moderate known drug interactions in our database — Latanoprost isn’t one of them. If you take anything else, check it against the full list below.

Moderate 521 No known interaction 2,309 (incl. Latanoprost)
Taking anything else?

Check Another of Your Medications Against Saffron

Covers the 2,830 medications we’ve checked against Saffron. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Saffron and Latanoprost May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • Wheezing Worth acting on Additional detail

    Saffron

    “Allergy to oral saffron has been reported in clinical trials. Anaphylactic reactions can occur within minutes of eating food prepared with saffron. Occupational exposure to saffron has been associated with the development of rhinoconjunctivitis and allergy-induced asthma.”

    Saffron · Natural Medicines adverse-effect record, reported in allergic rhinitis (hay fever).

    4 sources cited
    1. 93404. Mazidi M, Shemshian M, Mousavi SH, Norouzy A, Kermani T, Moghiman T, Sadeghi A, Mokhber N, Ghayour-Mobarhan M, Ferns GA. A double-blind, randomized and placebo-controlled trial of Saffron (Crocus sativus L.) in the treatment of anxiety and depression. J C
    2. 4107. Wuthrich B, Schmid-Grendelmeyer P, Lundberg M. Anaphylaxis to saffron. Allergy 1997;52:476-7. PubMed
    3. 72555. Wuthrich, B., Schmid-Grendelmeyer, P., and Lundberg, M. Anaphylaxis to saffron. Allergy 1997;52(4):476-477. PubMed
    4. 4106. Feo F, Martinez J, Martinez A, et al. Occupational allergy in saffron workers. Allergy 1997;52:633-41. PubMed

    Latanoprost

    Listed in the ADVERSE REACTIONS section of the FDA label for Latanoprost. Read the label on DailyMed ›

  • Dizziness / Headache Additional detail

    Saffron

    “Orally, saffron has been reported to cause drowsiness, headache, agitation, and sedation when given at doses of 30 mg twice daily for up to 26 weeks or when crocin is given as 15 mg twice daily for 12 weeks. At doses of 30 mg daily for 6 weeks, the side effect occurrence rate was similar to placebo. Saffron poisoning can occur with oral intake of doses of 5 grams or more; symptoms include vertigo and numbness (2,11).”

    Saffron · Natural Medicines adverse-effect record, reported in cluster headache.

    5 sources cited
    1. 18102. Safarinejad MR, Shafiei N, Safarinejad S. A prospective double-blind randomized placebo-controlled study of the effect of saffron (Crocus sativus Linn.) on semen parameters and seminal plasma antioxidant capacity in infertile men with idiopathic oligoasth
    2. 105616. Abbaszadeh-Mashkani S, Hoque SS, Banafshe HR, Ghaderi A. The effect of crocin (the main active saffron constituent) on the cognitive functions, craving, and withdrawal syndrome in opioid patients under methadone maintenance treatment. Phytother Res. 2021; PubMed
    3. 13103. Akhondzadeh S, Tahmacebi-Pour N, Noorbala AA, et al. Crocus sativus L. in the treatment of mild to moderate depression: a double-blind, randomized and placebo-controlled trial. Phytother Res 2005;19:148-51.
    4. 2. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
    5. 11. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.

    Latanoprost

    Listed in the ADVERSE REACTIONS section of the FDA label for Latanoprost. Read the label on DailyMed ›

  • Vomiting / Nausea Additional detail

    Saffron

    “Orally, saffron has been associated with changes in appetite, nausea, and vomiting when given at doses of 30 mg twice daily for 26 weeks, or when the saffron constituent crocin was given as 15 mg twice daily for 12 weeks. At lower doses of 30 mg daily, the occurrence rate of these and other adverse events such as dry mouth, dyspepsia, diarrhea, and constipation was rare or similar to placebo.”

    Saffron · Natural Medicines adverse-effect record, reported in constipation.

    6 sources cited
    1. 18102. Safarinejad MR, Shafiei N, Safarinejad S. A prospective double-blind randomized placebo-controlled study of the effect of saffron (Crocus sativus Linn.) on semen parameters and seminal plasma antioxidant capacity in infertile men with idiopathic oligoasth
    2. 105616. Abbaszadeh-Mashkani S, Hoque SS, Banafshe HR, Ghaderi A. The effect of crocin (the main active saffron constituent) on the cognitive functions, craving, and withdrawal syndrome in opioid patients under methadone maintenance treatment. Phytother Res. 2021; PubMed
    3. 13103. Akhondzadeh S, Tahmacebi-Pour N, Noorbala AA, et al. Crocus sativus L. in the treatment of mild to moderate depression: a double-blind, randomized and placebo-controlled trial. Phytother Res 2005;19:148-51.
    4. 93395. Akhondzadeh S, Sabet MS, Harirchian MH, Togha M, Cheraghmakani H, Razeghi S, Hejazi SSh, Yousefi MH, Alimardani R, Jamshidi A, Zare F, Moradi A. Saffron in the treatment of patients with mild to moderate Alzheimer's disease: a 16-week, randomized and plac
    5. 93402. Kashani L, Eslatmanesh S, Saedi N, Niroomand N, Ebrahimi M, Hosseinian M, Foroughifar T, Salimi S, Akhondzadeh S. Comparison of Saffron versus Fluoxetine in Treatment of Mild to Moderate Postpartum Depression: A Double-Blind, Randomized Clinical Trial. Ph PubMed
    6. 93409. Safarinejad MR, Shafiei N, Safarinejad S. An open label, randomized, fixed-dose, crossover study comparing efficacy and safety of sildenafil citrate and saffron (Crocus sativus Linn.) for treating erectile dysfunction in men naïve to treatment. Int J Impo PubMed

    Latanoprost

    Listed in the ADVERSE REACTIONS section of the FDA label for Latanoprost. Read the label on DailyMed ›

Reported for Saffron but not commonly for Latanoprost: loss of bladder control, constipation, a severe allergic reaction and drowsiness.

Effects for Latanoprost come from the ADVERSE REACTIONS section of its FDA label; effects for Saffron come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Saffron in Pregnancy & Breastfeeding

Pregnancy Likely Unsafe

When used orally in amounts exceeding those commonly found in foods. Larger amounts of saffron have uterine stimulant and abortifacient effects; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Overlapping uses

What Latanoprost Is Prescribed For, and What Saffron Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Latanoprost is a prescription medicine with approved uses on its FDA label. Saffron is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Latanoprost is prescribed for: Latanoprost ophthalmic solution — available as Xalatan, Xelpros, and Iyuzeh — is used to reduce elevated intraocular pressure (IOP, the pressure inside your eye) in people with open-angle glaucoma or ocular hypertension (high eye pressure without glaucoma symptoms yet). Keeping eye pressure under control is important because high pressure is a major risk factor for damage to the optic nerve and loss of vision.

Saffron has been studied for:

  • Hypertension studied, not established Saffron has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows

    Saffron for hypertension

    It is unclear if oral saffron reduces blood pressure; the available research is conflicting.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Latanoprost on your own; if you are taking Saffron for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

From our Q&A

Questions About Saffron or Latanoprost

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Saffron or Latanoprost, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

One more smart check

Taking Saffron as Part of a Dietary Supplement Product? Check It for Interactions

We hold 418 real supplement products containing Saffron, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Saffron. Even though Saffron itself has no known interaction with Latanoprost, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Saffron and Latanoprost Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Saffron
Top 25%

#235 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Latanoprost
Steady interest

#2,281 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Saffron reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Saffron and Latanoprost records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Saffron

What is Saffron?

Saffron
  • Depression and low mood
  • Anxiety
  • PMS symptoms
  • Memory and cognition
  • Eye health (age-related macular degeneration)

Saffron is a costly spice that has shown promise in early studies for mild-to-moderate depression and some mood and PMS symptoms, but most research uses small trials, so results are not definitive. It is generally well tolerated in food and small supplement amounts, but high doses can be harmful and it should be avoided in pregnancy. Talk to your pharmacist or doctor before using saffron supplements.

Crocus sativus · Iridaceae · Dried stigmas of the flower · Capsules, tablets, dried spice, extracts, tea

An interaction check asks whether these two react with each other — it does not ask whether Saffron is a good idea for someone in your situation. Here is what our Saffron record says about it on its own.

Saffron: dosing

There is no official, standardized dose of saffron for any health condition. Many supplement studies have used standardized extracts, but products vary widely in strength and quality.The best approach is to follow the directions on the product label and not exceed the recommended amount. Because high doses can be harmful, more is not better with saffron.

From our Saffron monograph — the full record covers uses, side effects and every documented interaction.

Read the full Saffron monograph & all interactions
Medication

About Latanoprost Ophthalmic

What Is Latanoprost Ophthalmic Used For?

Brand names: Xalatan, Xelpros, Iyuzeh

Latanoprost ophthalmic solution — available as Xalatan, Xelpros, and Iyuzeh — is used to reduce elevated intraocular pressure (IOP, the pressure inside your eye) in people with open-angle glaucoma or ocular hypertension (high eye pressure without glaucoma symptoms yet). Keeping eye pressure under control is important because high pressure is a major risk factor for damage to the optic nerve and loss of vision.

See full Latanoprost Ophthalmic drug information
Keep checking

Other Drugs & Saffron

Browse every other medication we’ve checked against Saffron — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
521Moderate
0Minor
2,308No known interaction
521 Moderate 2,308 No interaction
Moderate

521 interactions

Showing 60 of 521 moderate interactions — see all 521 on the Saffron page.

No interaction 2,308 drugs checked — show the list

We also checked Saffron against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,308 medications checked with no known interaction — see the full Saffron list.

See the full Saffron interactions page
See every supplement checked against Latanoprost, ranked by severity
Evidence & sources

Saffron References

The 22 references that drive our Saffron monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  3. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  4. Feo F, Martinez J, Martinez A, et al. Occupational allergy in saffron workers. Allergy 1997;52:633-41. PubMed
  5. Wuthrich B, Schmid-Grendelmeyer P, Lundberg M. Anaphylaxis to saffron. Allergy 1997;52:476-7. PubMed
  6. Akhondzadeh S, Tahmacebi-Pour N, Noorbala AA, et al. Crocus sativus L. in the treatment of mild to moderate depression: a double-blind, randomized and placebo-controlled trial. Phytother Res 2005;19:148-51.
  7. Safarinejad MR, Shafiei N, Safarinejad S. A prospective double-blind randomized placebo-controlled study of the effect of saffron (Crocus sativus Linn.) on semen parameters and seminal plasma antioxidant capacity in infertile men with idiopathic oligoasth
  8. Fatehi, M., Rashidabady, T., and Fatehi-Hassanabad, Z. Effects of Crocus sativus petals' extract on rat blood pressure and on responses induced by electrical field stimulation in the rat isolated vas deferens and guinea-pig ileum. J Ethnopharmacol. 2003; PubMed
  9. Modaghegh, M. H., Shahabian, M., Esmaeili, H. A., Rajbai, O., and Hosseinzadeh, H. Safety evaluation of saffron (Crocus sativus) tablets in healthy volunteers. Phytomedicine. 2008;15(12):1032-1037. PubMed
  10. Imenshahidi, M., Hosseinzadeh, H., and Javadpour, Y. Hypotensive effect of aqueous saffron extract (Crocus sativus L.) and its constituents, safranal and crocin, in normotensive and hypertensive rats. Phytother.Res 12-9-2009;
  11. Zhang, Y., Shoyama, Y., Sugiura, M., and Saito, H. Effects of Crocus sativus L. on the ethanol-induced impairment of passive avoidance performances in mice. Biol.Pharm Bull. 1994;17(2):217-221. PubMed
  12. Wuthrich, B., Schmid-Grendelmeyer, P., and Lundberg, M. Anaphylaxis to saffron. Allergy 1997;52(4):476-477. PubMed
  13. Akhondzadeh S, Sabet MS, Harirchian MH, Togha M, Cheraghmakani H, Razeghi S, Hejazi SSh, Yousefi MH, Alimardani R, Jamshidi A, Zare F, Moradi A. Saffron in the treatment of patients with mild to moderate Alzheimer's disease: a 16-week, randomized and plac
  14. Kashani L, Eslatmanesh S, Saedi N, Niroomand N, Ebrahimi M, Hosseinian M, Foroughifar T, Salimi S, Akhondzadeh S. Comparison of Saffron versus Fluoxetine in Treatment of Mild to Moderate Postpartum Depression: A Double-Blind, Randomized Clinical Trial. Ph PubMed
  15. Kianbakht S, Ghazavi A. Immunomodulatory effects of saffron: a randomized double-blind placebo-controlled clinical trial. Phytother Res. 2011 Dec;25(12):1801-5. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Saffron and Latanoprost Together: Common Questions

Is it safe to take Saffron with Latanoprost?
We do not list a known interaction between Saffron and Latanoprost. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Saffron and Latanoprost have any of the same side effects?
Yes — our sources link each of them separately to 5 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Are Saffron and Latanoprost used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Saffron in each. That is a conversation for your prescriber, especially if Latanoprost is being adjusted to a target.
Does Saffron interact with any other medications?
Yes. Saffron has 521 documented drug interactions in our database — Latanoprost is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Saffron monograph Uses, safety profile, and every drug interaction in one place Latanoprost Ophthalmic drug information The full plain-English guide to this medication Latanoprost supplement interactions Every supplement checked against Latanoprost, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 22 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Latanoprost and Saffron?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.