Drug & supplement interaction

Scopolia + Probenecid

Probenecid brand names: Benemid, Benuryl, Probecid.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Scopolia and Probenecid in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Scopolia and Probenecid

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Probenecid and Scopolia in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Scopolia safety at a glance

Scopolia overall Avoid Scopolia is toxic and unsafe for self-medication because of its potent anticholinergic alkaloids.
Pregnancy Likely Unsafe When the root or rhizome is used orally as a medicine; avoid using. Read the full pregnancy detail
Breastfeeding Likely Unsafe When the root or rhizome is used orally as a medicine; avoid using. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Probenecid and Scopolia? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Probenecid

Interactions in our licensed database are recorded against drug classes, not just single drug names. Probenecid is filed under 6 classifications — including antigout drugs, organic anion transporter 3 (oat3) substrates, organic anion transporter 1 (oat1) substrates. Scopolia has documented interactions with 3 drug classes — the most serious being anticholinergic drugs (major), quinidine (major) and tricyclic antidepressants (tcas) (major) — and none of Probenecid’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Scopolia Does Interact With Other Medications

Scopolia has 200 major, known drug interactions in our database — Probenecid isn’t one of them. If you take anything else, check it against the full list below.

Major 200 No known interaction 2,630 (incl. Probenecid)
Taking anything else?

Check Another of Your Medications Against Scopolia

Covers the 2,830 medications we’ve checked against Scopolia. Pick one to open its full report.

What to actually watch for

What Scopolia Itself Has Been Linked To

This is not an interaction — nothing below involves Probenecid. It is the side-effect record for Scopolia on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Scopolia, this list is the first place to look. One entry is worth acting on rather than waiting out — marked below.

  • Trouble passing urine / Hallucinations / Confusion Worth acting on Additional detail

    “Scopolia is generally regarded as unsafe for use. Any benefits of therapy may not outweigh the risk of toxicity. Orally, scopolia root acts on the central nervous system and can cause dry mouth, dry and reddened skin, hyperthermia, disturbance of ocular accommodation, tachycardia, difficulty urinating, glaucoma attacks (2), and constipation (18).”

    Scopolia · Natural Medicines adverse-effect record, reported in arrhythmia.

    2 sources cited
    1. 2. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
    2. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

    “Orally, adverse effects of scopolia are generally related to the central nervous system. Scopolia root can cause dry mouth, dry and reddened skin, hyperthermia, disturbance of ocular accommodation, tachycardia, difficulty urinating, glaucoma attacks (2), and constipation (18). Early symptoms of scopolia poisoning include reddened skin, dry mouth, and tachycardic arrhythmias (18).”

    Scopolia · Natural Medicines adverse-effect record, reported in arrhythmia.

    2 sources cited
    1. 2. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
    2. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  • Dry mouth / A fast or pounding heartbeat / Anxiety or restlessness / Constipation Additional detail

    Recorded for Scopolia in the same Natural Medicines adverse-effect record shown under Trouble passing urine / Hallucinations / Confusion above.

Everything above comes from the Natural Medicines adverse-effect record for Scopolia — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Probenecid’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Probenecid column appears here.

Special populations

Scopolia in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Unsafe

When the root or rhizome is used orally as a medicine; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Scopolia or Probenecid

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Scopolia or Probenecid, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Probenecid

This page covers Scopolia only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Probenecid page lists 30 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Siberian Cocklebur (major), African Wild Potato (moderate) and Aristolochia (moderate).

By severity: 3 major · 17 moderate · 10 minor.

From our pharmacist’s overview on the Probenecid page

“Probenecid does its work through the kidneys, pulling uric acid out of the blood to control gout, and that is exactly why the 30 supplement and herbal interactions on file deserve genuine care rather than a quick skim. The three rated major strike where this drug is most vulnerable: two are herbs, Siberian cocklebur among them, that ca…”

Reviewed by 2 · Jul 18, 2026

Open the Probenecid interaction page

How much people look this up

Where Scopolia and Probenecid Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Scopolia
Steady interest

#1,073 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Probenecid
Steady interest

#1,425 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Scopolia reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Scopolia and Probenecid records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Scopolia

What is Scopolia?

Scopolia
  • Stomach and intestinal cramps
  • Motion sickness
  • Spasms and colic
  • Excess saliva or secretions
  • Pain relief (traditional)

Scopolia is a poisonous plant in the nightshade family that contains powerful anticholinergic alkaloids like atropine, hyoscyamine, and scopolamine. While these compounds are used in carefully measured prescription medicines, the raw plant is dangerous for self-treatment and should never be used without a doctor's supervision.

Scopolia carniolica · Solanaceae · Rhizome (root) and leaves · Standardized extracts, tinctures, and as a source for isolated alkaloid drugs (rarely sold as a stand-alone supplement)

An interaction check asks whether these two react with each other — it does not ask whether Scopolia is a good idea for someone in your situation. Here is what our Scopolia record says about it on its own.

Scopolia: dosing

There is no established safe over-the-counter dose of Scopolia for self-care. Because the plant contains powerful and toxic alkaloids, even small differences in amount can be the difference between an effect and a poisoning.The purified alkaloids found in Scopolia are dosed precisely in prescription products by trained professionals. When in doubt, do not use it.

From our Scopolia monograph — the full record covers uses, side effects and every documented interaction.

Read the full Scopolia monograph & all interactions
Medication

About Probenecid

What Is Probenecid Used For?

Brand names: Benemid, Benuryl, Probecid

Probenecid tablets are used to treat hyperuricemia (high uric acid levels in the blood) associated with gout and gouty arthritis. By helping the kidneys remove more uric acid, it lowers uric acid levels over time and helps prevent painful gout attacks.

Probenecid tablets are also used alongside certain penicillin-type antibiotics — including penicillin, ampicillin, methicillin, oxacillin, cloxacillin, and nafcillin — to raise and sustain the antibiotic's level in the bloodstream, making the antibiotic work more effectively.

See full Probenecid drug information
Keep checking

Other Drugs & Scopolia

Browse every other medication we’ve checked against Scopolia — both the ones with a known interaction and the ones without. Select any drug for the full detail.

200Major
0Moderate
0Minor
2,629No known interaction
200 Major 2,629 No interaction
Major

200 interactions

Showing 60 of 200 major interactions — see all 200 on the Scopolia page.

No interaction 2,629 drugs checked — show the list

We also checked Scopolia against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,629 medications checked with no known interaction — see the full Scopolia list.

See the full Scopolia interactions page
See every supplement checked against Probenecid, ranked by severity
Evidence & sources

Scopolia References

The 4 references that drive our Scopolia monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  4. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Scopolia and Probenecid Together: Common Questions

Is it safe to take Scopolia with Probenecid?
We do not list a known interaction between Scopolia and Probenecid. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Scopolia and Probenecid combination checked?
Interactions in our licensed database are recorded against drug classes. Probenecid is filed under 6 classifications, and Scopolia has documented interactions with 3 drug classes — none of Probenecid's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Scopolia interact with any other medications?
Yes. Scopolia has 200 documented drug interactions in our database — Probenecid is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Probenecid interact with any supplements?
Yes. Probenecid has documented interactions with 30 supplements in our database — Scopolia is not one of them. The Probenecid interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Scopolia monograph Uses, safety profile, and every drug interaction in one place Probenecid drug information The full plain-English guide to this medication Probenecid supplement interactions Every supplement checked against Probenecid, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 4 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Probenecid and Scopolia?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.