Drug & supplement interaction

Solomon's Seal + Etomidate

Etomidate brand name: Amidate.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Solomon's Seal and Etomidate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Solomon's Seal and Etomidate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Etomidate and Solomon's Seal in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Solomon's Seal safety at a glance

Solomon's Seal overall Use caution Limited safety data exists in people, so use carefully and choose reputable products.
Pregnancy Avoid Safety has not been established, so it is best to avoid use during pregnancy.
Breastfeeding Avoid There is not enough information to consider it safe while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Etomidate and Solomon's Seal? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Etomidate

Interactions in our licensed database are recorded against drug classes, not just single drug names. Etomidate is filed under a single classification — anesthesia. Solomon's Seal has documented interactions with 3 drug classes — the most serious being antidiabetes drugs (moderate), chlorpropamide (diabinese) (moderate) and insulin (moderate) — and none of Etomidate’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Solomon's Seal Does Interact With Other Medications

Solomon's Seal has 86 moderate known drug interactions in our database — Etomidate isn’t one of them. If you take anything else, check it against the full list below.

Moderate 86 No known interaction 2,744 (incl. Etomidate)
Taking anything else?

Check Another of Your Medications Against Solomon's Seal

Covers the 2,830 medications we’ve checked against Solomon's Seal. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Solomon's Seal and Etomidate May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Nausea Additional detail

    Solomon's Seal

    “A thorough evaluation of safety outcomes has not been conducted. Orally, long-term use of Solomon's seal has been reported to cause gastrointestinal irritation. Use of large doses or overdoses may cause nausea, diarrhea, and other gastrointestinal complaints (18).”

    Solomon's Seal · Natural Medicines adverse-effect record, reported in diarrhea.

    1 source cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

    “Orally, Solomon's seal may cause gastrointestinal irritation when used long-term. Use of large doses or overdoses may cause nausea, diarrhea, and other gastrointestinal complaints (18).”

    Solomon's Seal · Natural Medicines adverse-effect record, reported in diarrhea.

    1 source cited
    1. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

    Etomidate

    Listed in the ADVERSE REACTIONS section of the FDA label for Etomidate. Read the label on DailyMed ›

Reported for Solomon's Seal but not commonly for Etomidate: diarrhea.

Effects for Etomidate come from the ADVERSE REACTIONS section of its FDA label; effects for Solomon's Seal come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Everything else you take

See Every Supplement That Interacts With Etomidate

This page covers Solomon's Seal only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Etomidate page lists 5 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Fever Bark (major), Cannabis (moderate), Cowhage (moderate), Datura Wrightii (moderate) and Delta-9-tetrahydrocannabinol (thc) (moderate).

By severity: 1 major · 4 moderate.

From our pharmacist’s overview on the Etomidate page

“Etomidate is not a pill you take at home. It is an intravenous drug used to put you under quickly for surgery or emergency procedures, and that shapes what this short list of five interacting supplements means.”

Reviewed by 2 · Jul 18, 2026

Open the Etomidate interaction page

One more smart check

Taking Solomon's Seal as Part of a Dietary Supplement Product? Check It for Interactions

We hold 113 real supplement products containing Solomon's Seal, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Solomon's Seal. Even though Solomon's Seal itself has no known interaction with Etomidate, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Solomon's Seal and Etomidate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Solomon's Seal
Top half

#603 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Etomidate
Top half

#948 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Solomon's Seal reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Solomon's Seal and Etomidate records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Solomon's Seal

What is Solomon's Seal?

Solomon's Seal
  • Joint and muscle discomfort
  • Tendon and ligament injuries
  • Inflammation
  • Digestive complaints
  • Skin and wound care
  • Dry cough and throat irritation

Solomon's Seal is a traditional herb whose root has long been used for joint, tendon, and muscle complaints, but high-quality human studies are largely lacking. There is not enough reliable evidence to confirm it works for any specific condition, so use it cautiously and talk with your pharmacist or doctor first.

Polygonatum multiflorum · Asparagaceae · Rhizome (root) and sometimes the whole plant · Capsules, dried root, teas, tinctures, powders, and topical salves

An interaction check asks whether these two react with each other — it does not ask whether Solomon's Seal is a good idea for someone in your situation. Here is what our Solomon's Seal record says about it on its own.

Solomon's Seal: dosing

There is no standardized, scientifically established dose for Solomon's Seal. Products vary widely in strength and form, so amounts on labels are not based on strong clinical research.If you choose to use it, follow the directions on the product label and do not exceed the suggested amount. Because doses are not well studied, it is wise to start low.

From our Solomon's Seal monograph — the full record covers uses, side effects and every documented interaction.

Read the full Solomon's Seal monograph & all interactions
Medication

About Etomidate

What Is Etomidate Used For?

Brand name: Amidate

Etomidate — available as Amidate and under the generic name Etomidate — is given by intravenous (IV) injection to induce general anesthesia before surgery or other procedures. It brings on unconsciousness rapidly, usually within about one minute.

Amidate and etomidate injection products are also used to supplement weaker anesthetic agents, such as nitrous oxide in oxygen, during short operative procedures — for example, dilation and curettage (D&C) or cervical conization. This supplemental use is supported only for adult patients in short procedures; it is not recommended for longer procedures or for pediatric patients.

See full Etomidate drug information
Keep checking

Other Drugs & Solomon's Seal

Browse every other medication we’ve checked against Solomon's Seal — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
86Moderate
0Minor
2,743No known interaction
86 Moderate 2,743 No interaction
Moderate

86 interactions

Showing 60 of 86 moderate interactions — see all 86 on the Solomon's Seal page.

No interaction 2,743 drugs checked — show the list

We also checked Solomon's Seal against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,743 medications checked with no known interaction — see the full Solomon's Seal list.

See the full Solomon's Seal interactions page
See every supplement checked against Etomidate, ranked by severity
Evidence & sources

Solomon's Seal References

The 2 references that drive our Solomon's Seal monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Solomon's Seal and Etomidate Together: Common Questions

Is it safe to take Solomon's Seal with Etomidate?
We do not list a known interaction between Solomon's Seal and Etomidate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Solomon's Seal and Etomidate have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Solomon's Seal and Etomidate combination checked?
Interactions in our licensed database are recorded against drug classes. Etomidate is filed under 1 classification, and Solomon's Seal has documented interactions with 3 drug classes — none of Etomidate's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Solomon's Seal interact with any other medications?
Yes. Solomon's Seal has 86 documented drug interactions in our database — Etomidate is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Etomidate interact with any supplements?
Yes. Etomidate has documented interactions with 5 supplements in our database — Solomon's Seal is not one of them. The Etomidate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Solomon's Seal monograph Uses, safety profile, and every drug interaction in one place Etomidate drug information The full plain-English guide to this medication Etomidate supplement interactions Every supplement checked against Etomidate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Etomidate and Solomon's Seal?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.