Drug & supplement interaction

Swallowroot + Ingenol Mebutate

Ingenol Mebutate brand name: Picato.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Oct 4, 2026
The bottom line No known interaction

We found no known interaction between Swallowroot and Ingenol Mebutate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Swallowroot and Ingenol Mebutate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Ingenol Mebutate and Swallowroot in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Swallowroot safety at a glance

Swallowroot overall Not established Human safety data are limited, so use cautiously and under professional guidance.
Pregnancy Avoid Not enough safety information exists, so it is best avoided during pregnancy.
Breastfeeding Avoid Safety while breastfeeding is unknown, so avoid use.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Ingenol Mebutate and Swallowroot? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Ingenol Mebutate

Interactions in our licensed database are recorded against drug classes, not just single drug names. Ingenol Mebutate is filed under a single classification — topical drugs. Swallowroot has documented interactions with 1 drug class — the most serious being anticoagulant/antiplatelet drugs (moderate) — and none of Ingenol Mebutate’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Swallowroot Does Interact With Other Medications

Swallowroot has 122 moderate known drug interactions in our database — Ingenol Mebutate isn’t one of them. If you take anything else, check it against the full list below.

Moderate 122 No known interaction 2,708 (incl. Ingenol Mebutate)
Taking anything else?

Check Another of Your Medications Against Swallowroot

Covers the 2,830 medications we’ve checked against Swallowroot. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Ingenol Mebutate

This page covers Swallowroot only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Ingenol Mebutate page lists 3 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Dimethylsulfoxide (dmso) (moderate), Turpentine Oil (moderate) and Alchemilla (minor).

By severity: 2 moderate · 1 minor.

From our pharmacist’s overview on the Ingenol Mebutate page

“Ingenol mebutate (Picato) is a gel applied to the skin for actinic keratosis, the rough precancerous patches caused by sun damage, and it is deliberately harsh, producing redness, flaking, and stinging as part of how it works. The few supplement interactions on record are all skin-level ones.”

Reviewed by 2 · Jul 18, 2026

Open the Ingenol Mebutate interaction page

How much people look this up

Where Swallowroot and Ingenol Mebutate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Swallowroot
Top half

#614 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Ingenol Mebutate
Steady interest

#1,799 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Swallowroot reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Swallowroot and Ingenol Mebutate records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Swallowroot

What is Swallowroot?

  • Digestive complaints
  • General tonic and appetite stimulant
  • Blood purifier in folk medicine
  • Antimicrobial and food preservative
  • Cooling drink in hot weather

Swallowroot (Decalepis hamiltonii) is a root used in South Indian folk medicine and as a food flavoring, often pickled or made into a cooling drink. Modern scientific evidence for its health benefits in people is very limited, resting mostly on laboratory and animal studies, so its effectiveness is not proven. If you are considering it, talk with your pharmacist or doctor first, especially during pregnancy or breastfeeding.

Decalepis hamiltonii · Apocynaceae · Roots and root tubers · Dried root, root powder, pickles, syrups, and traditional decoctions

An interaction check asks whether these two react with each other — it does not ask whether Swallowroot is a good idea for someone in your situation. Here is what our Swallowroot record says about it on its own.

Swallowroot: dosing

There is no established standardized dose for Swallowroot. Traditional use varies widely depending on whether it is taken as a pickle, a drink, or a powder.If you choose to use a commercial product, follow the directions on the label and do not exceed them.

From our Swallowroot monograph — the full record covers uses, side effects and every documented interaction.

Read the full Swallowroot monograph & all interactions
Medication

About Ingenol Mebutate Topical

What Is Ingenol Mebutate Topical Used For?

Brand name: Picato

  • Ingenol mebutate gel is used to treat actinic keratosis (flat, scaly growths on the skin caused by too much sun exposure). Ingenol mebutate is in a class of medications called cytotoxic agents. It works by killing fast-growing cells such as the abnormal cells associated with actinic keratoses.

See full Ingenol Mebutate Topical drug information
Keep checking

Other Drugs & Swallowroot

Browse every other medication we’ve checked against Swallowroot — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
122Moderate
0Minor
2,707No known interaction
122 Moderate 2,707 No interaction
Moderate

122 interactions

Showing 60 of 122 moderate interactions — see all 122 on the Swallowroot page.

No interaction 2,707 drugs checked — show the list

We also checked Swallowroot against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,707 medications checked with no known interaction — see the full Swallowroot list.

See the full Swallowroot interactions page
See every supplement checked against Ingenol Mebutate, ranked by severity
Evidence & sources

Swallowroot References

The 1 references that drive our Swallowroot monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Suneetha WJ, Krishnakantha TP. Effect of swallowroot extract on functions of platelets in vitro. J Thromb Thrombolysis 2005;19:133-4. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Swallowroot and Ingenol Mebutate Together: Common Questions

Is it safe to take Swallowroot with Ingenol Mebutate?
We do not list a known interaction between Swallowroot and Ingenol Mebutate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Swallowroot and Ingenol Mebutate combination checked?
Interactions in our licensed database are recorded against drug classes. Ingenol Mebutate is filed under 1 classification, and Swallowroot has documented interactions with 1 drug class — none of Ingenol Mebutate's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Swallowroot interact with any other medications?
Yes. Swallowroot has 122 documented drug interactions in our database — Ingenol Mebutate is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Ingenol Mebutate interact with any supplements?
Yes. Ingenol Mebutate has documented interactions with 3 supplements in our database — Swallowroot is not one of them. The Ingenol Mebutate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Swallowroot monograph Uses, safety profile, and every drug interaction in one place Ingenol Mebutate Topical drug information The full plain-English guide to this medication Ingenol Mebutate supplement interactions Every supplement checked against Ingenol Mebutate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Ingenol Mebutate and Swallowroot?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.