Drug & supplement interaction

Swallowroot + Pimavanserin Tartrate

Pimavanserin Tartrate brand name: Nuplazid.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Swallowroot and Pimavanserin Tartrate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Swallowroot and Pimavanserin Tartrate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Pimavanserin Tartrate and Swallowroot in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Swallowroot safety at a glance

Swallowroot overall Not established Human safety data are limited, so use cautiously and under professional guidance.
Pregnancy Avoid Not enough safety information exists, so it is best avoided during pregnancy.
Breastfeeding Avoid Safety while breastfeeding is unknown, so avoid use.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Pimavanserin Tartrate and Swallowroot? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Pimavanserin Tartrate

Interactions in our licensed database are recorded against drug classes, not just single drug names. Pimavanserin Tartrate is filed under 4 classifications — including antipsychotic drugs, qt interval-prolonging drugs, cytochrome p450 3a4 (cyp3a4) substrates. Swallowroot has documented interactions with 1 drug class — the most serious being anticoagulant/antiplatelet drugs (moderate) — and none of Pimavanserin Tartrate’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Swallowroot Does Interact With Other Medications

Swallowroot has 122 moderate known drug interactions in our database — Pimavanserin Tartrate isn’t one of them. If you take anything else, check it against the full list below.

Moderate 122 No known interaction 2,708 (incl. Pimavanserin Tartrate)
Taking anything else?

Check Another of Your Medications Against Swallowroot

Covers the 2,830 medications we’ve checked against Swallowroot. Pick one to open its full report.

What to actually watch for

What Pimavanserin Tartrate’s Own FDA Label Lists

This is not an interaction — none of it involves Swallowroot. These are the most notable effects listed in the ADVERSE REACTIONS section of Pimavanserin Tartrate’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 3 of them are worth acting on rather than waiting out — marked below.

  • Hallucinations Worth acting on mentioned in 27.3% of FDA reports for Pimavanserin Tartrate
  • Confusion Worth acting on mentioned in 7.9% of FDA reports for Pimavanserin Tartrate
  • Unsteadiness Worth acting on
  • Constipation
  • Swelling
  • Nausea

From the ADVERSE REACTIONS section of the FDA label for Pimavanserin Tartrate. Read the label on DailyMed › Where a percentage is shown, it is the share of 52,308 voluntary FDA FAERS reports for Pimavanserin Tartrate that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Swallowroot’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Swallowroot side to compare — that is a limit of the record, not a statement that Swallowroot has no side effects.

Everything else you take

See Every Supplement That Interacts With Pimavanserin Tartrate

This page covers Swallowroot only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Pimavanserin Tartrate page lists 153 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), American Hellebore (major), Arsenic (major), Cesium (major) and Ephedra (major).

By severity: 10 major · 103 moderate · 40 minor.

From our pharmacist’s overview on the Pimavanserin Tartrate page

“Pimavanserin (Nuplazid) eases the hallucinations and delusions of Parkinson's disease psychosis, and its supplement list deserves genuine care, since 10 of the 153 ingredients on file carry a major rating. The dominant pattern runs through CYP3A4, the liver enzyme that clears pimavanserin: grapefruit can push its blood level up, while St.”

Reviewed by 2 · Jul 18, 2026

Open the Pimavanserin Tartrate interaction page

How much people look this up

Where Swallowroot and Pimavanserin Tartrate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Swallowroot
Top half

#505 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Pimavanserin Tartrate
Top half

#717 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Swallowroot reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Swallowroot and Pimavanserin Tartrate records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Swallowroot

What is Swallowroot?

  • Digestive complaints
  • General tonic and appetite stimulant
  • Blood purifier in folk medicine
  • Antimicrobial and food preservative
  • Cooling drink in hot weather

Swallowroot (Decalepis hamiltonii) is a root used in South Indian folk medicine and as a food flavoring, often pickled or made into a cooling drink. Modern scientific evidence for its health benefits in people is very limited, resting mostly on laboratory and animal studies, so its effectiveness is not proven. If you are considering it, talk with your pharmacist or doctor first, especially during pregnancy or breastfeeding.

Decalepis hamiltonii · Apocynaceae · Roots and root tubers · Dried root, root powder, pickles, syrups, and traditional decoctions

An interaction check asks whether these two react with each other — it does not ask whether Swallowroot is a good idea for someone in your situation. Here is what our Swallowroot record says about it on its own.

Swallowroot: dosing

There is no established standardized dose for Swallowroot. Traditional use varies widely depending on whether it is taken as a pickle, a drink, or a powder.If you choose to use a commercial product, follow the directions on the label and do not exceed them.

From our Swallowroot monograph — the full record covers uses, side effects and every documented interaction.

Read the full Swallowroot monograph & all interactions
Medication

About Pimavanserin

What Is Pimavanserin Used For?

Brand name: Nuplazid

Pimavanserin — sold as Nuplazid and also available as a generic capsule — is approved to treat hallucinations and delusions in adults with Parkinson's disease psychosis. These are the unsettling false perceptions and beliefs that can occur as part of Parkinson's disease.

It is not approved for psychosis caused by other forms of dementia. Using it in elderly patients with non-Parkinson's dementia-related psychosis carries serious safety risks.

Most-Reported Side Effects for Pimavanserin Tartrate

From FAERS, the FDA’s public side-effect reporting system (54,981 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Hallucination 12,702 reports
Confusional state 4,287 reports
Fall 4,005 reports
Delusion 2,770 reports
Hallucination, visual 2,322 reports
See full Pimavanserin drug information
Keep checking

Other Drugs & Swallowroot

Browse every other medication we’ve checked against Swallowroot — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
122Moderate
0Minor
2,707No known interaction
122 Moderate 2,707 No interaction
Moderate

122 interactions

Showing 60 of 122 moderate interactions — see all 122 on the Swallowroot page.

No interaction 2,707 drugs checked — show the list

We also checked Swallowroot against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,707 medications checked with no known interaction — see the full Swallowroot list.

See the full Swallowroot interactions page
See every supplement checked against Pimavanserin Tartrate, ranked by severity
Evidence & sources

Swallowroot References

The 1 references that drive our Swallowroot monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Suneetha WJ, Krishnakantha TP. Effect of swallowroot extract on functions of platelets in vitro. J Thromb Thrombolysis 2005;19:133-4. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Swallowroot and Pimavanserin Tartrate Together: Common Questions

Is it safe to take Swallowroot with Pimavanserin Tartrate?
We do not list a known interaction between Swallowroot and Pimavanserin Tartrate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Swallowroot and Pimavanserin Tartrate combination checked?
Interactions in our licensed database are recorded against drug classes. Pimavanserin Tartrate is filed under 4 classifications, and Swallowroot has documented interactions with 1 drug class — none of Pimavanserin Tartrate's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Swallowroot interact with any other medications?
Yes. Swallowroot has 122 documented drug interactions in our database — Pimavanserin Tartrate is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Pimavanserin Tartrate interact with any supplements?
Yes. Pimavanserin Tartrate has documented interactions with 153 supplements in our database — Swallowroot is not one of them. The Pimavanserin Tartrate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Swallowroot monograph Uses, safety profile, and every drug interaction in one place Pimavanserin drug information The full plain-English guide to this medication Pimavanserin Tartrate supplement interactions Every supplement checked against Pimavanserin Tartrate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Pimavanserin Tartrate and Swallowroot?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.