Tragacanth - Vosevi (Sofosbuvir, Velpatasvir, Voxilaprevir) Interaction
Herbal: Tragacanth
Also Known As: Adragante, Astragale Adragant, Astragale de Marseille, Coussin-de-Belle-Mère, Goat's Thorn, Gomme Adragante, Gomme de Dragon, Green Dragon, Gum Dragon, Gum Tragacanth, Gummi Tragacanthae, Hog Gum, Syrian Tragacanth, Tragacanth Gum, Tragacanthe, Tragacanto, Astragalus gum
Drug: Sofosbuvir, Velpatasvir, Voxilaprevir
Brand names:
Vosevi
Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 11, 2025
Interaction Details
Sofosbuvir, Velpatasvir, Voxilaprevir is classified as belonging to the following category: Oral Drugs
Theoretically, tragacanth might alter absorption of oral drugs.
Tragacanth contains hydrocolloidal fiber which can decrease, increase, or not affect oral drug absorption. To avoid changes in absorption, take tragacanth 30-60 minutes after oral medications.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
References
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
Tragacanth Overview
Tragacanth is a natural gum that is derived from the sap of several species of Middle Eastern and Mediterranean plants, including Astragalus gummifer and Astragalus tragacanthus. In traditional medicine, this gum tragacanth has been used to treat a variety of conditions, including gastrointestinal disorders and sore throat. It is believed to work by forming a protective barrier on the mucous membranes of the digestive and respiratory tracts, which can help to soothe irritation and reduce inflammation.
Sofosbuvir, Velpatasvir, Voxilaprevir Overview
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The combination of sofosbuvir, velpatasvir, and voxilaprevir is used to treat chronic (long-term) hepatitis C infection (swelling of the liver caused by a virus) in adults who have already received other HCV treatments. Sofosbuvir is a non-nucleoside NS5B polymerase inhibitor. It works by decreasing the amount of hepatitis C virus in the body. Velpatasvir is a hepatitis C virus (HCV) NS5A inhibitor. It works by stopping the virus that causes hepatitis C from spreading inside the body. Voxilaprevir is in a class of medications called HCV NS3/4A protease inhibitors. It works by decreasing the amount of HCV in the body.
Tragacanth - More Interactions
Tragacanth interacts with 1987 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
| Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
| Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
| Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
| Unknown | No interactions have been reported or no interaction data is currently available. |
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.
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Dr. Brian Staiger, PharmD
In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!
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