Drug & supplement interaction

Vitamin E + Sofosbuvir

Sofosbuvir brand name: Sovaldi.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Vitamin E and Sofosbuvir in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Vitamin E and Sofosbuvir

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Sofosbuvir and Vitamin E in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Vitamin E safety at a glance

Vitamin E overall Use caution Usual dietary amounts are safe, but high-dose long-term supplements may raise the risk of bleeding and other harms.
Pregnancy Possibly Safe When used orally and appropriately. The tolerable upper intake level (UL) during pregnancy is 800 mg for those 14-18 years of age and 1000 mg for those 19 years... Read the full pregnancy detail
Breastfeeding Likely Safe When used orally in amounts that do not exceed the tolerable upper intake level (UL). The UL during lactation is 800 mg for those 14-18 years of age and 1000 mg... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Sofosbuvir and Vitamin E? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Sofosbuvir

Interactions in our licensed database are recorded against drug classes, not just single drug names. Sofosbuvir is filed under 4 classifications — including p-glycoprotein substrates, oral drugs. Vitamin E has documented interactions with 8 drug classes — the most serious being alkylating agents (moderate), anticoagulant/antiplatelet drugs (moderate) and antitumor antibiotics (moderate) — and none of Sofosbuvir’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Vitamin E Does Interact With Other Medications

Vitamin E has 763 moderate, 1 minor known drug interactions in our database — Sofosbuvir isn’t one of them. If you take anything else, check it against the full list below.

Moderate 763 Minor 1 No known interaction 2,066 (incl. Sofosbuvir)
Taking anything else?

Check Another of Your Medications Against Vitamin E

Covers the 2,830 medications we’ve checked against Vitamin E. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Vitamin E and Sofosbuvir May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Nausea reported in 7.5% of FDA reports for Sofosbuvir Additional detail

    Vitamin E

    “Orally, vitamin E supplementation has been associated with abdominal pain, nausea, diarrhea, or flu-like symptoms. Intravenously, large doses of vitamin E in premature infants are associated with an increased risk of necrotizing enterocolitis and sepsis.”

    Vitamin E · Natural Medicines adverse-effect record, reported in diarrhea.

    4 sources cited
    1. 85040. Soares, K. V. and McGrath, J. J. Vitamin E for neuroleptic-induced tardive dyskinesia. Cochrane.Database.Syst.Rev. 2001;(4):CD000209. DOI
    2. 85323. Barak, Y., Swartz, M., Shamir, E., Stein, D., and Weizman, A. Vitamin E (alpha-tocopherol) in the treatment of tardive dyskinesia: a statistical meta-analysis. Ann.Clin.Psychiatry 1998;10(3):101-105.
    3. 85083. Brion, L. P., Bell, E. F., Raghuveer, T. S., and Soghier, L. What is the appropriate intravenous dose of vitamin E for very-low-birth-weight infants? J.Perinatol. 2004;24(4):205-207. PubMed
    4. 85231. Bell, E. F. Upper limit of vitamin E in infant formulas. J.Nutr. 1989;119(12 Suppl):1829-1831. PubMed

    Sofosbuvir

    Listed in the ADVERSE REACTIONS section of the FDA label for Sofosbuvir, and in voluntary FDA adverse-event reports. Read the label on DailyMed ›

Reported for Vitamin E but not commonly for Sofosbuvir: a heart attack, a stroke or mini-stroke, stomach pain and heart failure.

Effects for Sofosbuvir come from the ADVERSE REACTIONS section of its FDA label; effects for Vitamin E come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 52,253 voluntary FDA FAERS reports for Sofosbuvir that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Vitamin E in Pregnancy & Breastfeeding

Pregnancy Possibly Safe

When used orally and appropriately. The tolerable upper intake level (UL) during pregnancy is 800 mg for those 14-18 years of age and 1000 mg for those 19 years and older. However, maternal supplementation is not generally recommended unless dietary vitamin E falls below the RDA. No serious adverse effects were reported with oral intake of 400 IU per day starting at weeks 9-22 of pregnancy in healthy patients or those at high risk for pre-eclampsia, or with 600-900 IU daily during the last two months of pregnancy. However, some preliminary evidence suggests that taking vitamin E supplements might be harmful when taken in early pregnancy. A case-control study found that taking a vitamin E supplement during the first 8 weeks of pregnancy is associated with a 1.7-9-fold increase in odds of congenital heart defects. However, the exact amount of vitamin E consumed during pregnancy in this study is unclear. Until more is known, advise patients to avoid taking a vitamin E supplement in early pregnancy unless needed for an appropriate medical indication.

Lactation Likely Safe

When used orally in amounts that do not exceed the tolerable upper intake level (UL). The UL during lactation is 800 mg for those 14-18 years of age and 1000 mg for those 19 years and older.

Lactation Possibly Unsafe

When used orally in amounts that exceed the UL due to increased risk of adverse effects.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

Overlapping uses

What Sofosbuvir Is Prescribed For, and What Vitamin E Has Been Studied For

These two come up together because they touch the same health topic — not because they do the same job. Sofosbuvir is a prescription medicine with approved uses on its FDA label. Vitamin E is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.

Sofosbuvir is prescribed for: Sovaldi (sofosbuvir) is used to treat chronic hepatitis C virus (HCV) infection. In adults, it treats genotype 1, 2, 3, or 4 HCV — with or without compensated cirrhosis (mild liver scarring that the liver is still managing). It is always used as part of a combination regimen with other antiviral medicines. In children 3 years and older, Sovaldi is approved for genotype 2 or 3 HCV, with or without compensated cirrhosis, in combination with ribavirin.

Read the rest of what Sofosbuvir is prescribed for

Sovaldi is also used with ribavirin in adults with HCV-related liver cancer (hepatocellular carcinoma) who are waiting for a liver transplant, to help prevent HCV from returning after transplant.

Vitamin E has been studied for:

  • Scarring studied, not established Vitamin E has been studied for this. Natural Medicines rates the evidence: Possibly Ineffective Read what the research shows

    Vitamin E for scarring

    Topical vitamin E does not seem to improve scar appearance.

Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Sofosbuvir on your own; if you are taking Vitamin E for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.

Everything else you take

See Every Supplement That Interacts With Sofosbuvir

This page covers Vitamin E only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Sofosbuvir page lists 55 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), St. John's Wort (major), Bitter Melon (moderate), Black Pepper (moderate) and Bulbine Natalensis (moderate).

By severity: 2 major · 37 moderate · 16 minor.

From our pharmacist’s overview on the Sofosbuvir page

“Sofosbuvir (Sovaldi) cures hepatitis C over a fixed course, so a supplement that lowers its blood level risks more than a side effect; it can let the virus survive treatment. The two major-rated interactions among the 55 ingredients here do exactly that: St.”

Reviewed by 2 · Jul 18, 2026

Open the Sofosbuvir interaction page

One more smart check

Taking Vitamin E as Part of a Dietary Supplement Product? Check It for Interactions

We hold 22,182 real supplement products containing Vitamin E, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Vitamin E. Even though Vitamin E itself has no known interaction with Sofosbuvir, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Vitamin E and Sofosbuvir Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Vitamin E
Top 10

#9 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Sofosbuvir
Steady interest

#1,498 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Vitamin E reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Vitamin E and Sofosbuvir records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Vitamin E

What is Vitamin E?

Vitamin E
  • General antioxidant support
  • Skin and hair care
  • Heart health
  • Eye health (age-related conditions)
  • Immune support

Vitamin E is an essential fat-soluble vitamin and antioxidant that most people get in adequate amounts from a normal diet. Supplements can help correct a true deficiency, but high-dose vitamin E has not been clearly proven to prevent heart disease or cancer and may carry risks. Talk to your pharmacist or doctor before taking high doses.

Vitamin E is a nutrient, not a plant part; it is found in plant oils, nuts, seeds, and leafy greens · Softgels, capsules, oral liquid, chewable tablets, topical oils and creams

An interaction check asks whether these two react with each other — it does not ask whether Vitamin E is a good idea for someone in your situation. Here is what our Vitamin E record says about it on its own.

Vitamin E: dosing

Vitamin E needs are usually met through a normal diet. There is a recommended daily intake set by health authorities, and there is also an upper limit for supplements that should not be exceeded without medical guidance, because higher amounts raise the risk of side effects.Because the right amount depends on your age, health, and diet, it is best to follow the product label and avoid high-dose products unless a healthcare provider recommends them.

From our Vitamin E monograph — the full record covers uses, side effects and every documented interaction.

Read the full Vitamin E monograph & all interactions
Medication

About Sofosbuvir

What Is Sofosbuvir Used For?

Brand name: Sovaldi

Sovaldi (sofosbuvir) is used to treat chronic hepatitis C virus (HCV) infection. In adults, it treats genotype 1, 2, 3, or 4 HCV — with or without compensated cirrhosis (mild liver scarring that the liver is still managing). It is always used as part of a combination regimen with other antiviral medicines.

In children 3 years and older, Sovaldi is approved for genotype 2 or 3 HCV, with or without compensated cirrhosis, in combination with ribavirin. Sovaldi is also used with ribavirin in adults with HCV-related liver cancer (hepatocellular carcinoma) who are waiting for a liver transplant, to help prevent HCV from returning after transplant.

See full Sofosbuvir drug information
Keep checking

Other Drugs & Vitamin E

Browse every other medication we’ve checked against Vitamin E — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
763Moderate
1Minor
2,065No known interaction
763 Moderate 1 Minor 2,065 No interaction
Moderate

763 interactions

Showing 60 of 763 moderate interactions — see all 763 on the Vitamin E page.

Minor

1 interaction

No interaction 2,065 drugs checked — show the list

We also checked Vitamin E against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,065 medications checked with no known interaction — see the full Vitamin E list.

See the full Vitamin E interactions page
See every supplement checked against Sofosbuvir, ranked by severity
Evidence & sources

Vitamin E References

The 64 references that drive our Vitamin E monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Kim JM, White RH. Effect of vitamin E on the anticoagulant response to warfarin. Am J Cardiol 1996;77:545-6. PubMed
  2. Corrigan JJ Jr. The effect of vitamin E on warfarin-induced vitamin K deficiency. Ann N Y Acad Sci 1982;393:361-8. PubMed
  3. Corrigan JJ Jr. Coagulation problems relating to vitamin E. Am J Pediatr Hematol Oncol 1979;1:169-73.
  4. Corrigan JJ Jr, Marcus FI. Coagulopathy associated with vitamin E ingestion. JAMA 1974;230:1300-1. DOI
  5. Labriola D, Livingston R. Possible interactions between dietary antioxidants and chemotherapy. Oncology 1999;13:1003-8.
  6. Chang T, Benet LZ, Hebert MF. The effect of water-soluble vitamin E on cyclosporine pharmacokinetics in healthy volunteers. Clin Pharmacol Ther 1996;59:297-303. PubMed
  7. Pan SH, Lopez RR Jr, Sher LS, et al. Enhanced oral cyclosporine absorption with water-soluble vitamin E early after liver transplantation. Pharmacother 1996;16:59-65. DOI
  8. Anon. Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Soprawivenza nell'Infarto miocardico. Lancet 1999;354:447-55. DOI
  9. Chappell LC, Seed PT, Briley AL, et al. Effect of antioxidants on the occurrence of pre-eclampsia in women at increased risk: a randomised trial. Lancet 1999;354:810-6. DOI
  10. Yusuf S, Dagenais G, Pogue J, et al. Vitamin E supplementation and cardiovascular events in high-risk patients. The heart outcomes prevention evaluation study investigators. N Engl J Med 2000;342:154-60. PubMed
  11. Stephens NG, Parsons A, Schofield PM, et al. Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study. Lancet 1996;347:781-6.
  12. The Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group. The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J Med 1994;330:1029-35. PubMed
  13. Takahashi O. Haemorrhagic toxicity of a large dose of alpha-, beta-, gamma- and delta-tocopherols, ubiquinone, beta-carotene, retinol acetate and L-ascorbic acid in the rat. Food Chem Toxicol 1995;33:121-8.
  14. Briggs GB, Freeman RK, Yaffe SJ. Drugs in Pregnancy and Lactation. 5th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 1998.
  15. Sano M, Ernesto C, Thomas RG, et al. A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study. N Engl J Med 1997;336:1216-22. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Vitamin E and Sofosbuvir Together: Common Questions

Is it safe to take Vitamin E with Sofosbuvir?
We do not list a known interaction between Vitamin E and Sofosbuvir. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Vitamin E and Sofosbuvir have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Are Vitamin E and Sofosbuvir used for the same thing?
They overlap in purpose, which usually means the real question is whether you need both rather than whether they are safe together. This page lists the shared uses and how strong the evidence is for Vitamin E in each. That is a conversation for your prescriber, especially if Sofosbuvir is being adjusted to a target.
How was the Vitamin E and Sofosbuvir combination checked?
Interactions in our licensed database are recorded against drug classes. Sofosbuvir is filed under 4 classifications, and Vitamin E has documented interactions with 8 drug classes — none of Sofosbuvir's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Vitamin E interact with any other medications?
Yes. Vitamin E has 764 documented drug interactions in our database — Sofosbuvir is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Sofosbuvir interact with any supplements?
Yes. Sofosbuvir has documented interactions with 55 supplements in our database — Vitamin E is not one of them. The Sofosbuvir interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Vitamin E monograph Uses, safety profile, and every drug interaction in one place Sofosbuvir drug information The full plain-English guide to this medication Sofosbuvir supplement interactions Every supplement checked against Sofosbuvir, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 64 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Sofosbuvir and Vitamin E?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.