Drug & supplement interaction

Wheatgrass + Sodium valproate

Sodium valproate brand name: Epilim.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Wheatgrass and Sodium valproate in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Sodium valproate states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Wheatgrass and Sodium valproate

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Sodium valproate and Wheatgrass in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Wheatgrass safety at a glance

Wheatgrass overall Use caution Generally well tolerated as a food, but quality and contamination concerns mean caution is wise.
Pregnancy Avoid Safety is not established, and raw products may carry contamination risk, so avoid unless cleared by your doctor.
Breastfeeding Avoid There is not enough safety information, so avoid unless your doctor approves.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Sodium valproate and Wheatgrass? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Sodium valproate

Interactions in our licensed database are recorded against drug classes, not just single drug names. Sodium valproate is filed under 8 classifications — including valproate, anticonvulsants, serotonergic drugs. Wheatgrass has documented interactions with 2 drug classes — the most serious being antidiabetes drugs (moderate) and cytochrome p450 1a2 (cyp1a2) substrates (moderate) — and none of Sodium valproate’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Wheatgrass Does Interact With Other Medications

Wheatgrass has 272 moderate known drug interactions in our database — Sodium valproate isn’t one of them. If you take anything else, check it against the full list below.

Moderate 272 No known interaction 2,558 (incl. Sodium valproate)
Taking anything else?

Check Another of Your Medications Against Wheatgrass

Covers the 2,830 medications we’ve checked against Wheatgrass. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Wheatgrass and Sodium valproate May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • An allergic reaction Worth acting on Additional detail

    Wheatgrass

    “Wheat can cause allergic reactions in sensitive individuals. Due to the prevalence of this allergy in the general population, wheat and wheat products, such as wheatgrass, are classified as major food allergens in the United States.”

    Wheatgrass · Natural Medicines adverse-effect record, reported in allergic rhinitis (hay fever).

    1 source cited
    1. 105410. Food and Drug Administration. Food Allergen Labeling and Consumer Protection Act of 2004 (FALCPA); Public Law 108-282, Title II. Accessed on May 19, 2021. Available at: https://www.fda.gov/food/food-allergensgluten-free-guidance-documents-regulatory-infor

    Sodium valproate

    Listed in the ADVERSE REACTIONS section of the FDA label for Sodium valproate. Read the label on DailyMed ›

  • Reduced appetite / Constipation / Nausea Additional detail

    Wheatgrass

    “Orally, wheatgrass may cause nausea, anorexia, and constipation.”

    Wheatgrass · Natural Medicines adverse-effect record, reported in anorexia.

    1 source cited
    1. 11165. Ben-Arye E, Golden E, Wengrower D, et al. Wheat grass juice in the treatment of active distal ulcerative colitis a randomized double-blind placebo-controlled trial. Scand J Gastroenterol 2002;4:444-9.. PubMed

    Sodium valproate

    Listed in the ADVERSE REACTIONS section of the FDA label for Sodium valproate. Read the label on DailyMed ›

Effects for Sodium valproate come from the ADVERSE REACTIONS section of its FDA label; effects for Wheatgrass come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

How to take them

Some Sodium valproate Products Have a Food Rule — Wheatgrass Should Not Break It

At least one FDA label for a product containing Sodium valproate says to take it with food. If you take Wheatgrass on an empty stomach out of habit, keep them separate — and take Sodium valproate with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Sodium valproate products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

irritation may benefit from administration of the drug with food or by slowly building up the dose from an initial low level.

From the Dosage and Administration section of the FDA label we read for Sodium valproate — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Sodium valproate

This page covers Wheatgrass only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Sodium valproate page lists 173 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Kava (major).

By severity: 9 major · 147 moderate · 17 minor.

From our pharmacist’s overview on the Sodium valproate page

“Sodium valproate (Epilim) controls seizures and stabilizes mood, and the supplement list on this page warrants genuine care rather than a quick skim. Nine of the 173 ingredients on file carry a major rating, and most of the danger follows two patterns.”

Reviewed by 2 · Jul 18, 2026

Open the Sodium valproate interaction page

One more smart check

Taking Wheatgrass as Part of a Dietary Supplement Product? Check It for Interactions

We hold 104 real supplement products containing Wheatgrass, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Wheatgrass. Even though Wheatgrass itself has no known interaction with Sodium valproate, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Wheatgrass and Sodium valproate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Wheatgrass
Top half

#457 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Sodium valproate
Steady interest

#1,743 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Wheatgrass reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Wheatgrass and Sodium valproate records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Wheatgrass

What is Wheatgrass?

Wheatgrass
  • General nutrition support
  • Digestive health
  • Antioxidant support
  • Energy and wellness
  • Arthritis symptoms
  • Detox or cleansing routines

Wheatgrass is the young grass of the wheat plant, taken as a juice or powder, and is mainly used as a concentrated source of vitamins and plant nutrients. Solid scientific evidence for most health claims is limited, and it is best viewed as a nutritional add-on rather than a treatment. It is generally well tolerated, but people with celiac disease, wheat allergy, or who are pregnant should be cautious and check with a healthcare provider.

Triticum aestivum · Poaceae · Young grass (leaves/shoots) of the wheat plant · Fresh juice, powder, tablets, capsules, and added to smoothies or health drinks

An interaction check asks whether these two react with each other — it does not ask whether Wheatgrass is a good idea for someone in your situation. Here is what our Wheatgrass record says about it on its own.

Wheatgrass: dosing

There is no official or standardized dose for wheatgrass. Amounts vary widely between fresh juice, powder, and tablets, so the right amount depends on the specific product.The safest approach is to follow the directions on the product label and start with a small amount to see how your body responds.

From our Wheatgrass monograph — the full record covers uses, side effects and every documented interaction.

Read the full Wheatgrass monograph & all interactions
Keep checking

Other Drugs & Wheatgrass

Browse every other medication we’ve checked against Wheatgrass — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
272Moderate
0Minor
2,557No known interaction
272 Moderate 2,557 No interaction
Moderate

272 interactions

Showing 60 of 272 moderate interactions — see all 272 on the Wheatgrass page.

No interaction 2,557 drugs checked — show the list

We also checked Wheatgrass against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,557 medications checked with no known interaction — see the full Wheatgrass list.

See the full Wheatgrass interactions page
See every supplement checked against Sodium valproate, ranked by severity
Evidence & sources

Wheatgrass References

The 5 references that drive our Wheatgrass monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Ben-Arye E, Golden E, Wengrower D, et al. Wheat grass juice in the treatment of active distal ulcerative colitis a randomized double-blind placebo-controlled trial. Scand J Gastroenterol 2002;4:444-9.. PubMed
  2. Mohan Y, Jesuthankaraj GN1, Ramasamy Thangavelu N. Antidiabetic and antioxidant properties of Triticum aestivum in streptozotocin-induced diabetic rats. Adv Pharmacol Sci 2013;2013:716073.
  3. Shakya G, Randhi PK, Pajaniradje S, Mohankumar K, Rajagopalan R. Hypoglycaemic role of wheatgrass and its effect on carbohydrate metabolic enzymes in type II diabetic rats. Toxicol Ind Health 2016;32(6):1026-32. PubMed
  4. Food and Drug Administration. Food Allergen Labeling and Consumer Protection Act of 2004 (FALCPA); Public Law 108-282, Title II. Accessed on May 19, 2021. Available at: https://www.fda.gov/food/food-allergensgluten-free-guidance-documents-regulatory-infor
  5. Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Wheatgrass and Sodium valproate Together: Common Questions

Is it safe to take Wheatgrass with Sodium valproate?
We do not list a known interaction between Wheatgrass and Sodium valproate. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Wheatgrass and Sodium valproate have any of the same side effects?
Yes — our sources link each of them separately to 4 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Wheatgrass and Sodium valproate at the same time of day?
At least one FDA label for a product containing Sodium valproate says to take it with food. If you take Wheatgrass on an empty stomach out of habit, keep them separate and take Sodium valproate with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Sodium valproate products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Wheatgrass and Sodium valproate combination checked?
Interactions in our licensed database are recorded against drug classes. Sodium valproate is filed under 8 classifications, and Wheatgrass has documented interactions with 2 drug classes — none of Sodium valproate's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Wheatgrass interact with any other medications?
Yes. Wheatgrass has 272 documented drug interactions in our database — Sodium valproate is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Sodium valproate interact with any supplements?
Yes. Sodium valproate has documented interactions with 173 supplements in our database — Wheatgrass is not one of them. The Sodium valproate interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Wheatgrass monograph Uses, safety profile, and every drug interaction in one place Sodium valproate supplement interactions Every supplement checked against Sodium valproate, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 5 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Sodium valproate and Wheatgrass?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.