Yogurt + Tipiracil Hydrochloride, Trifluridine
Tipiracil Hydrochloride, Trifluridine brand name: Lonsurf.
We found no known interaction between Yogurt and Tipiracil Hydrochloride, Trifluridine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Tipiracil Hydrochloride, Trifluridine states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.
Yogurt and Tipiracil Hydrochloride, Trifluridine
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Tipiracil Hydrochloride, Trifluridine and Yogurt in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Yogurt safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Tipiracil Hydrochloride, Trifluridine
Interactions in our licensed database are recorded against drug classes, not just single drug names. Tipiracil Hydrochloride, Trifluridine is filed under a single classification — oral drugs. Yogurt has documented interactions with 3 drug classes — the most serious being ciprofloxacin (cipro) (moderate), tetracycline antibiotics (moderate) and nilotinib (tasigna) (minor) — and none of Tipiracil Hydrochloride, Trifluridine’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Yogurt Does Interact With Other Medications
Yogurt has 21 moderate, 1 minor known drug interactions in our database — Tipiracil Hydrochloride, Trifluridine isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Yogurt
We haven’t checked that one against Yogurt yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Yogurt. Pick one to open its full report.
Yogurt in Pregnancy & Breastfeeding
When consumed in amounts commonly found in foods.
When used intravaginally. A small clinical study in pregnancy reported no adverse reactions.
When used in amounts commonly found in foods. There is insufficient reliable information available about the safety of the intravaginal use of yogurt during breast-feeding.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
Some Tipiracil Hydrochloride, Trifluridine Products Have a Food Rule — Yogurt Should Not Break It
At least one FDA label for a product containing Tipiracil Hydrochloride, Trifluridine says to take it with food. If you take Yogurt on an empty stomach out of habit, keep them separate — and take Tipiracil Hydrochloride, Trifluridine with a meal where the label says to.
This may not be true of your version. Food instructions belong to the product, not the ingredient: two Tipiracil Hydrochloride, Trifluridine products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.
2 DOSAGE AND ADMINISTRATION Recommended Dosage : 35 mg/m 2 /dose orally twice daily with food on Days 1 through 5 and Days 8 through 12 of each 28-day cycle.
From the Dosage and Administration section of the FDA label we read for Tipiracil Hydrochloride, Trifluridine — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›
A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.
What Tipiracil Hydrochloride, Trifluridine Is Prescribed For, and What Yogurt Has Been Studied For
These two come up together because they touch the same health topic — not because they do the same job. Tipiracil Hydrochloride, Trifluridine is a prescription medicine with approved uses on its FDA label. Yogurt is a supplement: what follows is what researchers have looked at it for, and how strong that evidence is.
Tipiracil Hydrochloride, Trifluridine is prescribed for: Lonsurf (trifluridine and tipiracil) is used to treat adults with metastatic colorectal cancer — either alone or combined with bevacizumab — after prior treatment with several other chemotherapy regimens and targeted therapies. Lonsurf is also used for adults with metastatic gastric or gastroesophageal junction adenocarcinoma (cancer of the stomach or where the stomach meets the esophagus) who have already received at least two prior chemotherapy regimens.
Yogurt has been studied for:
-
Colorectal cancer studied, not established Yogurt has been studied for this. Natural Medicines rates the evidence: Insufficient Reliable Evidence To Rate Read what the research shows
Yogurt for colorectal cancer
It is unclear if eating yogurt is beneficial for preventing colorectal cancer.
Effectiveness ratings and the research summaries above are the verbatim record from the Natural Medicines database, which grades evidence from “Effective” down to “Insufficient Reliable Evidence To Rate”. A rating below the top of that scale means researchers have looked at it — not that it works, and never that it can stand in for a prescribed medicine. Do not stop or replace Tipiracil Hydrochloride, Trifluridine on your own; if you are taking Yogurt for the same health topic, tell your prescriber, especially if the medicine is being adjusted to a target.
See Every Supplement That Interacts With Tipiracil Hydrochloride, Trifluridine
This page covers Yogurt only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Tipiracil Hydrochloride, Trifluridine page lists 17 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Coffee Charcoal (moderate), European Mandrake (moderate), Glucomannan (moderate) and Guar Gum (moderate).
By severity: 1 major · 7 moderate · 9 minor.
Open the Tipiracil Hydrochloride, Trifluridine interaction page
Taking Yogurt as Part of a Dietary Supplement Product? Check It for Interactions
We hold 45 real supplement products containing Yogurt, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Yogurt. Even though Yogurt itself has no known interaction with Tipiracil Hydrochloride, Trifluridine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Yogurt and Tipiracil Hydrochloride, Trifluridine Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,061 of 1,452 supplements looked up here in the last 7 days
#1,059 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Yogurt reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Yogurt and Tipiracil Hydrochloride, Trifluridine records this page draws on were last updated July 11, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Yogurt
What is Yogurt?
- Digestive health
- Restoring gut bacteria after antibiotics
- Vaginal yeast or bacterial balance
- Source of protein and calcium
- General immune and gut support
Yogurt is a fermented dairy food that often contains live bacteria (probiotics) and provides protein, calcium, and other nutrients. For most healthy people it is a safe, nutritious food, and some yogurts with live cultures may help with digestion and gut balance, though evidence varies by strain and condition. If you are lactose intolerant, have a milk allergy, or have a weakened immune system, talk to your pharmacist or doctor first.
Fermented milk product (made with live bacterial cultures) · Plain yogurt, Greek yogurt, drinkable yogurt (kefir-style), probiotic yogurt, dairy-free yogurt alternatives
An interaction check asks whether these two react with each other — it does not ask whether Yogurt is a good idea for someone in your situation. Here is what our Yogurt record says about it on its own.
Yogurt: dosing
There is no official "dose" for yogurt because it is a food, not a standardized medicine. The amount and type of live bacteria can vary widely from product to product, and many people simply eat one or more servings a day as part of a healthy diet.If you are using yogurt specifically for its probiotic content, look for a label that says "live and active cultures" and check whether the strains are listed. There is no proven "best" amount for any health condition. If you want a specific probiotic strain or dose, a standardized probiotic supplement may be more reliable.
From our Yogurt monograph — the full record covers uses, side effects and every documented interaction.
About Trifluridine and Tipiracil
What Is Trifluridine and Tipiracil Used For?
Brand name: Lonsurf
Lonsurf (trifluridine and tipiracil) is used to treat adults with metastatic colorectal cancer — either alone or combined with bevacizumab — after prior treatment with several other chemotherapy regimens and targeted therapies.
Lonsurf is also used for adults with metastatic gastric or gastroesophageal junction adenocarcinoma (cancer of the stomach or where the stomach meets the esophagus) who have already received at least two prior chemotherapy regimens.
Other Drugs & Yogurt
Browse every other medication we’ve checked against Yogurt — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
21 interactions
- Doxycycline ›
- Minocycline ›
- Tetracycline ›
- Ciprofloxacin ›
- Doxycycline Hyclate ›
- Minocycline Hydrochloride ›
- Retapamulin ›
- Chlortetracycline ›
- Demeclocycline ›
- Doripenem ›
- Doxycycline Monohydrate ›
- Doxycyline ›
- Eravacycline ›
- Omadacycline (iv) ›
- Omadacycline (oral) ›
- Oxytetracycline ›
- Tigecycline ›
- Amphotericin, Tetracycline ›
- Bismuth Subsalicylate, Metronidazole, Tetracycline ›
- Metronidazole, Tetracyline, Bismuth Subcitrate Potassium ›
- Oxytetracycline, Phenazopyridine, Sulfamethizole ›
1 interaction
No interaction 2,807 drugs checked — show the list
We also checked Yogurt against these medications and found no known interaction in our sources. Open any page to confirm.
- Apixaban ›
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Warfarin ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Ivermectin ›
- Metoprolol ›
- Rivaroxaban ›
- Aspirin ›
- Rosuvastatin ›
- Acetaminophen ›
- Escitalopram ›
- Abemaciclib ›
- Clopidogrel ›
- Tadalafil ›
- Atorvastatin ›
- Docusate ›
- Tirzepatide ›
- Valacyclovir ›
- Ibuprofen ›
- Methamphetamine ›
- Hydroxyurea ›
- Warfarin Sodium ›
- Semaglutide ›
- Sumatriptan ›
- Prednisone ›
- Propranolol ›
- Lisdexamfetamine ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Bupropion ›
- Amitriptyline ›
- Methotrexate ›
- Bendamustine ›
- Acyclovir ›
- Amphetamine ›
- Fluoxetine ›
- Isotretinoin ›
- Lamotrigine ›
- Pregabalin ›
- Azithromycin ›
- Acetaminophen, Codeine ›
- Gabapentin ›
- Amlodipine Besylate ›
- Dextroamphetamine ›
- Clonazepam ›
- Methylene Blue ›
- Omeprazole ›
- Quetiapine ›
- Letrozole ›
- Duloxetine ›
- Naproxen ›
- Buspirone ›
- Citalopram ›
- Bisoprolol ›
- Levothyroxine, Liothyronine ›
Showing the 60 most looked-up of 2,807 medications checked with no known interaction — see the full Yogurt list.
Yogurt References
The 9 references that drive our Yogurt monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
- Neri A, Sabah G, Samra Z. Bacterial vaginosis in pregnancy treated with yogurt. Acta Obstet Gynecol Scand 1993;72:17-9.
- Neuvonen PJ, Kivisto KT, Lehto P. Interference of dairy products with the absorption of ciprofloxacin. Clin Pharmacol Ther 1991;50:498-502. PubMed
- MacGregor G, Smith AJ, Thakker B, Kinsella J. Yoghurt biotherapy: contraindicated in immunosuppressed patients? Postgrad Med J 2002;78:366-7. PubMed
- Liu J, Tang W, Sang L, Dai X, Wei D, Luo Y, Zhang J. Milk, yogurt, and lactose intake and ovarian cancer risk: a meta-analysis. Nutr Cancer. 2015;67(1):68-72. PubMed
- Merenstein DJ, Smith KH, Scriven M, Roberts RF, Sanders ME, Petterson S. The study to investigate the potential benefits of probiotics in yogurt, a patient-oriented, double-blind, cluster-randomised, placebo-controlled, clinical trial. Eur J Clin Nutr. 20 PubMed
- Yin OQ, Rudoltz M, Galetic I, Filian J, Krishna A, Zhou W, Custodio J, Golor G, Schran H. Effects of yogurt and applesauce on the oral bioavailability of nilotinib in healthy volunteers. J Clin Pharmacol. 2011 Nov;51(11):1580-6. PubMed
- Küçükosmanoglu E, Özen E, Eltan SB, Özkars MY, Keskin Ö. Most children who are allergic to cow's milk tolerate yogurt. J Int Med Res. 2018;46(12):5099-5106. PubMed
- Zhang K, Dai H, Liang W, Zhang L, Deng Z. Fermented dairy foods intake and risk of cancer. Int J Cancer. 2019;144(9):2099-2108. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Yogurt and Tipiracil Hydrochloride, Trifluridine Together: Common Questions
Is it safe to take Yogurt with Tipiracil Hydrochloride, Trifluridine?
Do Yogurt and Tipiracil Hydrochloride, Trifluridine have any of the same side effects?
Should I take Yogurt and Tipiracil Hydrochloride, Trifluridine at the same time of day?
Are Yogurt and Tipiracil Hydrochloride, Trifluridine used for the same thing?
How was the Yogurt and Tipiracil Hydrochloride, Trifluridine combination checked?
Does Yogurt interact with any other medications?
Does Tipiracil Hydrochloride, Trifluridine interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.