Drug & supplement interaction

Zedoary + Anastrozole

Anastrozole brand name: Arimidex.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Zedoary and Anastrozole in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Zedoary and Anastrozole

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Anastrozole and Zedoary in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Zedoary safety at a glance

Zedoary overall Use caution Generally used in food amounts, but human safety data for supplement doses is limited.
Pregnancy Likely Unsafe When used orally. Zedoary is thought to have abortifacient effects; avoid using. Read the full pregnancy detail
Breastfeeding Avoid No reliable safety information during breastfeeding, so it is best avoided.

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Anastrozole and Zedoary? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Anastrozole

Interactions in our licensed database are recorded against drug classes, not just single drug names. Anastrozole is filed under 2 classifications — aromatase inhibitors, oral drugs. Zedoary has documented interactions with 1 drug class — the most serious being cytochrome p450 3a4 (cyp3a4) substrates (moderate) — and none of Anastrozole’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Zedoary Does Interact With Other Medications

Zedoary has 643 moderate known drug interactions in our database — Anastrozole isn’t one of them. If you take anything else, check it against the full list below.

Moderate 643 No known interaction 2,187 (incl. Anastrozole)
Taking anything else?

Check Another of Your Medications Against Zedoary

Covers the 2,830 medications we’ve checked against Zedoary. Pick one to open its full report.

What to actually watch for

What Anastrozole’s Own FDA Label Lists

This is not an interaction — none of it involves Zedoary. These are the most notable effects listed in the ADVERSE REACTIONS section of Anastrozole’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • A stroke or mini-stroke Worth acting on
  • Bone thinning Worth acting on
  • A heart attack Worth acting on
  • Blood clots Worth acting on
  • Yellowing of the skin or eyes Worth acting on
  • Confusion Worth acting on
  • A severe skin reaction Worth acting on
  • Chest pain Worth acting on
  • Low mood Worth acting on
  • Anemia Worth acting on

Showing the 10 most notable of 51 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Anastrozole. Read the label on DailyMed › Zedoary’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Zedoary side to compare — that is a limit of the record, not a statement that Zedoary has no side effects.

Special populations

Zedoary in Pregnancy & Breastfeeding

Pregnancy Likely Unsafe

When used orally. Zedoary is thought to have abortifacient effects; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Zedoary or Anastrozole

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Zedoary or Anastrozole, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Anastrozole

This page covers Zedoary only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Anastrozole page lists 22 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), 7-methoxyflavone (moderate), Arimistane (moderate), Atractylodes (moderate) and Chrysin (moderate).

By severity: 1 major · 12 moderate · 9 minor.

From our pharmacist’s overview on the Anastrozole page

“Activated charcoal carries the one major rating on the anastrozole (Arimidex) list, because it can soak up the drug in the gut and cut how much your body absorbs. For a medicine that treats hormone-sensitive breast cancer by keeping estrogen suppressed, anything that lowers its level deserves real concern, and I would act on this list…”

Reviewed by 2 · Jul 18, 2026

Open the Anastrozole interaction page

One more smart check

Taking Zedoary as Part of a Dietary Supplement Product? Check It for Interactions

We hold 83 real supplement products containing Zedoary, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Zedoary. Even though Zedoary itself has no known interaction with Anastrozole, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Zedoary and Anastrozole Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Zedoary
Top half

#687 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Anastrozole
Top half

#759 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Zedoary reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Zedoary and Anastrozole records this page draws on were last updated July 11, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Zedoary

What is Zedoary?

  • Digestive upset and bloating
  • Loss of appetite
  • Menstrual discomfort
  • Inflammation and pain
  • Traditional flavoring and tonic

Zedoary is a ginger-family root used in traditional Asian and Indian medicine, mostly for digestion and as a spice. Scientific evidence in humans is very limited, so its benefits are not well proven. Talk with your pharmacist or doctor before using it, and avoid it during pregnancy.

Curcuma zedoaria · Zingiberaceae · Rhizome (root) and essential oil · Dried powder, capsules, tinctures, essential oil, tea

An interaction check asks whether these two react with each other — it does not ask whether Zedoary is a good idea for someone in your situation. Here is what our Zedoary record says about it on its own.

Zedoary: dosing

There is no standardized, well-established dose for zedoary. The right amount depends on the form (powder, capsule, tincture, or oil) and the product's strength.The safest approach is to follow the directions on the product label and not exceed them.

From our Zedoary monograph — the full record covers uses, side effects and every documented interaction.

Read the full Zedoary monograph & all interactions
Medication

About Anastrozole

What Is Anastrozole Used For?

Brand name: Arimidex

Anastrozole (also sold as Arimidex) is used in postmenopausal women to treat hormone receptor-positive breast cancer at several stages. This includes early breast cancer after surgery (adjuvant therapy), locally advanced or metastatic breast cancer as a first treatment, and advanced breast cancer that has continued to grow after tamoxifen therapy.

For the second-line use in advanced breast cancer, women whose cancer did not respond to estrogen receptor (ER) testing or who did not respond to tamoxifen rarely benefited from anastrozole.

See full Anastrozole drug information
Keep checking

Other Drugs & Zedoary

Browse every other medication we’ve checked against Zedoary — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
643Moderate
0Minor
2,186No known interaction
643 Moderate 2,186 No interaction
Moderate

643 interactions

Showing 60 of 643 moderate interactions — see all 643 on the Zedoary page.

No interaction 2,186 drugs checked — show the list

We also checked Zedoary against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,186 medications checked with no known interaction — see the full Zedoary list.

See the full Zedoary interactions page
See every supplement checked against Anastrozole, ranked by severity
Evidence & sources

Zedoary References

The 5 references that drive our Zedoary monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  3. Tariq S, Imran M, Mushtaq Z, Asghar N. Phytopreventive antihypercholesterolemic and antilipidemic perspectives of zedoary (Curcuma Zedoaria Roscoe) herbal tea. Lipids Health Dis 2016;15:39. doi: 10.1186/s12944-016-0210-y.
  4. Rodseeda C, Yamanont P, Pinthong D, Korprasertthaworn P. Inhibitory effects of Thai herbal extracts on the cytochrome P450 3A-mediated the metabolism of gefitinib, lapatinib and sorafenib. Toxicol Rep 2022;9:1846-1852. PubMed
  5. Niu LQ, Xiao L, Cai QH, et al. Comparative effectiveness of Chinese herbal injections treating for rotavirus enteritis in children: A systematic review and Bayesian network meta-analysis. Integr Med Res 2023;12(2):100944. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Zedoary and Anastrozole Together: Common Questions

Is it safe to take Zedoary with Anastrozole?
We do not list a known interaction between Zedoary and Anastrozole. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Zedoary and Anastrozole combination checked?
Interactions in our licensed database are recorded against drug classes. Anastrozole is filed under 2 classifications, and Zedoary has documented interactions with 1 drug class — none of Anastrozole's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Zedoary interact with any other medications?
Yes. Zedoary has 643 documented drug interactions in our database — Anastrozole is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Anastrozole interact with any supplements?
Yes. Anastrozole has documented interactions with 22 supplements in our database — Zedoary is not one of them. The Anastrozole interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Zedoary monograph Uses, safety profile, and every drug interaction in one place Anastrozole drug information The full plain-English guide to this medication Anastrozole supplement interactions Every supplement checked against Anastrozole, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 5 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Anastrozole and Zedoary?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.