Zedoary + Naltrexone Hydrochloride, Oxycodone Hydrochloride
Naltrexone Hydrochloride, Oxycodone Hydrochloride brand name: Troxyca ER.
We found no known interaction between Zedoary and Naltrexone Hydrochloride, Oxycodone Hydrochloride in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Zedoary and Naltrexone Hydrochloride, Oxycodone Hydrochloride
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Naltrexone Hydrochloride, Oxycodone Hydrochloride and Zedoary in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Zedoary safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Naltrexone Hydrochloride, Oxycodone Hydrochloride
Interactions in our licensed database are recorded against drug classes, not just single drug names. Naltrexone Hydrochloride, Oxycodone Hydrochloride is filed under 7 classifications — including narcotic drugs, cytochrome p450 2d6 (cyp2d6) substrates, cns depressants. Zedoary has documented interactions with 1 drug class — the most serious being cytochrome p450 3a4 (cyp3a4) substrates (moderate) — and none of Naltrexone Hydrochloride, Oxycodone Hydrochloride’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Zedoary Does Interact With Other Medications
Zedoary has 643 moderate known drug interactions in our database — Naltrexone Hydrochloride, Oxycodone Hydrochloride isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Zedoary
We haven’t checked that one against Zedoary yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Zedoary. Pick one to open its full report.
Zedoary in Pregnancy & Breastfeeding
When used orally. Zedoary is thought to have abortifacient effects; avoid using.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
See Every Supplement That Interacts With Naltrexone Hydrochloride, Oxycodone Hydrochloride
This page covers Zedoary only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Naltrexone Hydrochloride, Oxycodone Hydrochloride page lists 145 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Kava (major).
By severity: 8 major · 114 moderate · 23 minor.
From our pharmacist’s overview on the Naltrexone Hydrochloride, Oxycodone Hydrochloride page
“Alcohol tops this list. Beer and wine both carry major, well-documented interactions with Troxyca ER (naltrexone and oxycodone hydrochloride), an extended-release opioid, because adding a second sedative to an opioid can slow breathing, not just deepen drowsiness.”
Reviewed by 2 · Jul 18, 2026
Open the Naltrexone Hydrochloride, Oxycodone Hydrochloride interaction page
Taking Zedoary as Part of a Dietary Supplement Product? Check It for Interactions
We hold 83 real supplement products containing Zedoary, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Zedoary. Even though Zedoary itself has no known interaction with Naltrexone Hydrochloride, Oxycodone Hydrochloride, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Zedoary and Naltrexone Hydrochloride, Oxycodone Hydrochloride Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#1,121 of 1,452 supplements looked up here in the last 7 days
#349 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Zedoary reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Zedoary and Naltrexone Hydrochloride, Oxycodone Hydrochloride records this page draws on were last updated July 11, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Zedoary
What is Zedoary?
- Digestive upset and bloating
- Loss of appetite
- Menstrual discomfort
- Inflammation and pain
- Traditional flavoring and tonic
Zedoary is a ginger-family root used in traditional Asian and Indian medicine, mostly for digestion and as a spice. Scientific evidence in humans is very limited, so its benefits are not well proven. Talk with your pharmacist or doctor before using it, and avoid it during pregnancy.
Curcuma zedoaria · Zingiberaceae · Rhizome (root) and essential oil · Dried powder, capsules, tinctures, essential oil, tea
An interaction check asks whether these two react with each other — it does not ask whether Zedoary is a good idea for someone in your situation. Here is what our Zedoary record says about it on its own.
Zedoary: dosing
There is no standardized, well-established dose for zedoary. The right amount depends on the form (powder, capsule, tincture, or oil) and the product's strength.The safest approach is to follow the directions on the product label and not exceed them.
From our Zedoary monograph — the full record covers uses, side effects and every documented interaction.
Other Drugs & Zedoary
Browse every other medication we’ve checked against Zedoary — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
643 interactions
- Diltiazem ›
- Nifedipine ›
- Hydrocortisone ›
- Erythromycin ›
- Estradiol ›
- Lidocaine ›
- Norethindrone ›
- Testosterone ›
- Verapamil ›
- Levonorgestrel ›
- Prednisone ›
- Quinidine ›
- Cyclosporine ›
- Dexamethasone ›
- Triazolam ›
- Zopiclone ›
- Colchicine ›
- Fentanyl ›
- Oxybutynin ›
- Prednisolone ›
- Tacrolimus ›
- Temazepam ›
- Budesonide ›
- Carbamazepine ›
- Clindamycin ›
- Dextromethorphan ›
- Doxorubicin ›
- Fluticasone ›
- Miconazole ›
- Buprenorphine ›
- Conjugated Estrogens ›
- Diazepam ›
- Everolimus ›
- Ivabradine ›
- Medroxyprogesterone ›
- Medroxyprogesterone Acetate ›
- Rifampin ›
- Testosterone Undecanoate ›
- Aripiprazole ›
- Caffeine (otc Drug) ›
- Ciclesonide ›
- Clonazepam ›
- Cyclobenzaprine ›
- Dapsone ›
- Erythromycin Ethylsuccinate ›
- Erythromycin Stearate ›
- Etoposide ›
- Fluticasone Propionate ›
- Hydroxyzine ›
- Itraconazole ›
- Midazolam ›
- Modafinil ›
- Nicardipine ›
- Omeprazole ›
- Pantoprazole ›
- Progesterone (prescription Drug) ›
- Tramadol ›
- Warfarin Sodium ›
- Zolpidem ›
- Abiraterone Acetate ›
Showing 60 of 643 moderate interactions — see all 643 on the Zedoary page.
No interaction 2,186 drugs checked — show the list
We also checked Zedoary against these medications and found no known interaction in our sources. Open any page to confirm.
- Levothyroxine ›
- Methylphenidate ›
- Ivermectin ›
- Metoprolol ›
- Aspirin ›
- Acetaminophen ›
- Rosuvastatin ›
- Escitalopram ›
- Docusate ›
- Valacyclovir ›
- Ibuprofen ›
- Tirzepatide ›
- Methamphetamine ›
- Hydroxyurea ›
- Semaglutide ›
- Sumatriptan ›
- Propranolol ›
- Lisdexamfetamine ›
- Metformin ›
- Lisinopril ›
- Amoxicillin ›
- Bupropion ›
- Methotrexate ›
- Bendamustine ›
- Acyclovir ›
- Doxycycline ›
- Fluoxetine ›
- Amphetamine ›
- Pregabalin ›
- Lamotrigine ›
- Azithromycin ›
- Acetaminophen, Codeine ›
- Isotretinoin ›
- Gabapentin ›
- Dextroamphetamine ›
- Methylene Blue ›
- Duloxetine ›
- Naproxen ›
- Ciprofloxacin ›
- Bisoprolol ›
- Levothyroxine, Liothyronine ›
- Acetaminophen, Oxycodone ›
- Candesartan Cilexetil ›
- Cephalexin ›
- Cyclopentolate ›
- Acetaminophen, Dextromethorphan, Doxylamine ›
- Mannitol ›
- Roxithromycin ›
- Levetiracetam ›
- Pegunigalsidase Alfa-iwxj ›
- Ezetimibe ›
- Amoxicillin, Clavulanate Potassium ›
- Levothyroxine Sodium ›
- Dexmethylphenidate ›
- Daptomycin ›
- Spironolactone ›
- Phentermine, Topiramate ›
- Valsartan ›
- Mitomycin ›
- Thyroid Hormone ›
Showing the 60 most looked-up of 2,186 medications checked with no known interaction — see the full Zedoary list.
Zedoary References
The 5 references that drive our Zedoary monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Tariq S, Imran M, Mushtaq Z, Asghar N. Phytopreventive antihypercholesterolemic and antilipidemic perspectives of zedoary (Curcuma Zedoaria Roscoe) herbal tea. Lipids Health Dis 2016;15:39. doi: 10.1186/s12944-016-0210-y.
- Rodseeda C, Yamanont P, Pinthong D, Korprasertthaworn P. Inhibitory effects of Thai herbal extracts on the cytochrome P450 3A-mediated the metabolism of gefitinib, lapatinib and sorafenib. Toxicol Rep 2022;9:1846-1852. PubMed
- Niu LQ, Xiao L, Cai QH, et al. Comparative effectiveness of Chinese herbal injections treating for rotavirus enteritis in children: A systematic review and Bayesian network meta-analysis. Integr Med Res 2023;12(2):100944. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Taking Zedoary and Naltrexone Hydrochloride, Oxycodone Hydrochloride Together: Common Questions
Is it safe to take Zedoary with Naltrexone Hydrochloride, Oxycodone Hydrochloride?
How was the Zedoary and Naltrexone Hydrochloride, Oxycodone Hydrochloride combination checked?
Does Zedoary interact with any other medications?
Does Naltrexone Hydrochloride, Oxycodone Hydrochloride interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.