Medication interaction hub

What Supplements Interact with Naltrexone Hydrochloride, Oxycodone Hydrochloride?

Naltrexone Hydrochloride, Oxycodone Hydrochloride brand name: Troxyca ER. Every interaction below applies to the brands too.

145 Interactions 8 Major 114 Moderate 23 Minor
Curated & coded by · Clinical Pharmacist · Updated September 18, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Naltrexone Hydrochloride, Oxycodone Hydrochloride? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Naltrexone Hydrochloride, Oxycodone Hydrochloride against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Alcohol tops this list. Beer and wine both carry major, well-documented interactions with Troxyca ER (naltrexone and oxycodone hydrochloride), an extended-release opioid, because adding a second sedative to an opioid can slow breathing, not just deepen drowsiness. That same danger runs through most of the page: 78 of the 145 ingredients on file, kava and GHB among them, pile onto the drug's sedating effects, and the eight rated major are the ones to understand before mixing anything with this medication.

A smaller group pulls the opposite way. St. John's wort speeds oxycodone's breakdown and can weaken pain relief; grapefruit does the reverse, raising its levels and side effects. About 60 entries touch CYP2D6, a liver enzyme that helps process oxycodone, at moderate strength. Charcoal and bulky fibers can blunt absorption and belong well apart from doses. The remaining 114 moderate and 23 minor entries matter, but sedation is where the real weight sits.

— , Clinical Pharmacist · July 18, 2026

Major 8 Moderate 114 Minor 23 No known interaction 1,307

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Naltrexone Hydrochloride, Oxycodone Hydrochloride: Top Interactions at a Glance

The most significant Naltrexone Hydrochloride, Oxycodone Hydrochloride supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 145 interacting ingredients — plus 1,307 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Naltrexone Hydrochloride, Oxycodone Hydrochloride + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Beer + Naltrexone Hydrochloride, Oxycodone Hydrochloridei

Concomitant use may increase sedative and other adverse effects.

Read the full interaction Major Likelihood Likely Wine + Naltrexone Hydrochloride, Oxycodone Hydrochloridei

Concomitant use may increase sedative and other adverse effects.

Read the full interaction Major Likelihood Probable 1,4-butanediol + Naltrexone Hydrochloride, Oxycodone Hydrochloridei

Theoretically, concomitant use of 1,4-butanediol with CNS depressants may potentiate respiratory and CNS depression.

Read the full interaction Major Likelihood Probable Activated Charcoal + Naltrexone Hydrochloride, Oxycodone Hydrochloridei

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable Gamma-hydroxybutyrate (ghb) + Naltrexone Hydrochloride, Oxycodone Hydrochloridei

GHB may increase the risk of serious CNS and respiratory depression.

Read the full interaction Major Likelihood Probable Kava + Naltrexone Hydrochloride, Oxycodone Hydrochloridei

Combining kava with CNS depressants can have additive sedative effects.

Read the full interaction
The complete list

Every Supplement Checked Against Naltrexone Hydrochloride, Oxycodone Hydrochloride

All 1,452 ingredients in our database, ranked by severity — 145 with a Naltrexone Hydrochloride, Oxycodone Hydrochloride interaction on file and 1,307 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Naltrexone Hydrochloride, Oxycodone Hydrochloride?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Eleuthero with Naltrexone Hydrochloride, Oxycodone Hydrochloride?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, eleuthero might increase levels of drugs metabolized by CYP2D6.

Full Eleuthero + Naltrexone Hydrochloride, Oxycodone Hydrochloride answer

Can you take Sassafras with Naltrexone Hydrochloride, Oxycodone Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of sassafras with drugs with sedative properties may cause additive sedative effects.

Full Sassafras + Naltrexone Hydrochloride, Oxycodone Hydrochloride answer

Can you take Slippery Elm with Naltrexone Hydrochloride, Oxycodone Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.

Full Slippery Elm + Naltrexone Hydrochloride, Oxycodone Hydrochloride answer

Can you take Spearmint with Naltrexone Hydrochloride, Oxycodone Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, spearmint might alter the sedative effects of CNS depressants.

Full Spearmint + Naltrexone Hydrochloride, Oxycodone Hydrochloride answer

Can you take Tarragon with Naltrexone Hydrochloride, Oxycodone Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from animal research suggests that tarragon essential oil can cause sedation and motor impairment when administered intraperitoneal...

Full Tarragon + Naltrexone Hydrochloride, Oxycodone Hydrochloride answer

Can you take Terminalia with Naltrexone Hydrochloride, Oxycodone Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP2D6 substrates.

Full Terminalia + Naltrexone Hydrochloride, Oxycodone Hydrochloride answer

Can you take Theacrine with Naltrexone Hydrochloride, Oxycodone Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, theacrine might alter the effects of CNS depressants.

Full Theacrine + Naltrexone Hydrochloride, Oxycodone Hydrochloride answer

Can you take Thuja with Naltrexone Hydrochloride, Oxycodone Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Thuja products can contains significant amounts of thujone, a neurotoxin.

Full Thuja + Naltrexone Hydrochloride, Oxycodone Hydrochloride answer

Can you take Tianeptine with Naltrexone Hydrochloride, Oxycodone Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Tianeptine has sedative effects; high doses may have additive effects with other CNS depressants.

Full Tianeptine + Naltrexone Hydrochloride, Oxycodone Hydrochloride answer

Can you take Tinospora Cordifolia with Naltrexone Hydrochloride, Oxycodone Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP2D6.

Full Tinospora Cordifolia + Naltrexone Hydrochloride, Oxycodone Hydrochloride answer

Can you take Tragacanth with Naltrexone Hydrochloride, Oxycodone Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tragacanth might alter absorption of oral drugs.

Full Tragacanth + Naltrexone Hydrochloride, Oxycodone Hydrochloride answer

Can you take Tree Turmeric with Naltrexone Hydrochloride, Oxycodone Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, use of tree turmeric along with CNS depressants might increase the risk of additive therapeutic and adverse effects.

Full Tree Turmeric + Naltrexone Hydrochloride, Oxycodone Hydrochloride answer

Can you take Valerian with Naltrexone Hydrochloride, Oxycodone Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.

Full Valerian + Naltrexone Hydrochloride, Oxycodone Hydrochloride answer

Can you take White Pepper with Naltrexone Hydrochloride, Oxycodone Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro evidence suggests that some constituents of white pepper inhibit cytochrome P450 2D6 (CYP2D6).

Full White Pepper + Naltrexone Hydrochloride, Oxycodone Hydrochloride answer

Can you take Wild Lettuce with Naltrexone Hydrochloride, Oxycodone Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with drugs with sedative effects might cause additive therapeutic effects and adverse effects.

Full Wild Lettuce + Naltrexone Hydrochloride, Oxycodone Hydrochloride answer

Can you take Yin Chen with Naltrexone Hydrochloride, Oxycodone Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, yin chen might enhance the therapeutic and adverse effects of other CNS depressants.

Full Yin Chen + Naltrexone Hydrochloride, Oxycodone Hydrochloride answer

Can you take Yohimbe with Naltrexone Hydrochloride, Oxycodone Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, yohimbe might increase the levels and adverse effects of CYP2D6 substrates.

Full Yohimbe + Naltrexone Hydrochloride, Oxycodone Hydrochloride answer

Can you take Zizyphus with Naltrexone Hydrochloride, Oxycodone Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, zizyphus might cause additive sedative effects when taken with CNS depressants.

Full Zizyphus + Naltrexone Hydrochloride, Oxycodone Hydrochloride answer

Can you take Lavender with Naltrexone Hydrochloride, Oxycodone Hydrochloride?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, lavender might potentiate the therapeutic effects and adverse effects of CNS depressants.

Full Lavender + Naltrexone Hydrochloride, Oxycodone Hydrochloride answer

Can you take Thyroid Extract with Naltrexone Hydrochloride, Oxycodone Hydrochloride?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Food and medications can interfere with thyroid hormone absorption.

Full Thyroid Extract + Naltrexone Hydrochloride, Oxycodone Hydrochloride answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Naltrexone Hydrochloride, Oxycodone Hydrochloride is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Naltrexone Hydrochloride, Oxycodone Hydrochloride, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Naltrexone Hydrochloride, Oxycodone Hydrochloride sits in 7 interaction categories. Open any one to see what the group means:

Cns Depressants 78 ingredients

Central-nervous-system depressants. Sedating supplements can intensify drowsiness and slowed reactions when combined.

78 of the supplement ingredients on this page reach Naltrexone Hydrochloride, Oxycodone Hydrochloride through this category.

Cytochrome P450 2D6 (Cyp2D6) Substrates 60 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

60 of the supplement ingredients on this page reach Naltrexone Hydrochloride, Oxycodone Hydrochloride through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Naltrexone Hydrochloride, Oxycodone Hydrochloride through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Naltrexone Hydrochloride, Oxycodone Hydrochloride through this category.

Narcotic Drugs 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Naltrexone Hydrochloride, Oxycodone Hydrochloride through this category.

Oxycodone (Oxycontin) 2 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

2 of the supplement ingredients on this page reach Naltrexone Hydrochloride, Oxycodone Hydrochloride through this category.

Naltrexone (Vivitrol) 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Naltrexone Hydrochloride, Oxycodone Hydrochloride through this category.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Naltrexone Hydrochloride, Oxycodone Hydrochloride

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Naltrexone Hydrochloride, Oxycodone Hydrochloride.

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Pharmacist Counseling Corner

Naltrexone Hydrochloride, Oxycodone Hydrochloride & Supplements: Common Questions

What supplements interact with Naltrexone Hydrochloride, Oxycodone Hydrochloride?
In our interaction database, 145 supplement and herbal ingredients have an interaction with Naltrexone Hydrochloride, Oxycodone Hydrochloride on file — 8 rated major, 114 moderate, and 23 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Beer, Wine, 1,4-butanediol.
Which Naltrexone Hydrochloride, Oxycodone Hydrochloride supplement interactions are the most serious?
Focus on the major group: Beer, Wine, 1,4-butanediol, Activated Charcoal and Gamma-hydroxybutyrate (ghb), among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Naltrexone Hydrochloride, Oxycodone Hydrochloride?
That depends entirely on which supplement. The honest answer for Naltrexone Hydrochloride, Oxycodone Hydrochloride is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Troxyca ER have the same supplement interactions as Naltrexone Hydrochloride, Oxycodone Hydrochloride?
Yes — Troxyca ER all contain Naltrexone Hydrochloride, Oxycodone Hydrochloride, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Naltrexone Hydrochloride, Oxycodone Hydrochloride and my other medications?
This page covers Naltrexone Hydrochloride, Oxycodone Hydrochloride against supplements and herbal ingredients. Checking Naltrexone Hydrochloride, Oxycodone Hydrochloride against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 18, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.