Herb & supplement monograph

Albizia Julibrissin Drug Interactions, Uses, Safety & More

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS ·Updated June 2026

What is this page for?

First and foremost: how Albizia Julibrissin interacts with medications. The heart of this page is the interaction list — every drug Albizia Julibrissin is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Albizia Julibrissin is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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Albizia Julibrissin Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the overall risk of a clinically significant Albizia Julibrissin drug interaction appears low for most people, though caution makes sense with sedating medicines. No interactions are rated major, and the long list of moderate ratings all traces back to a single concern that so far rests on animal research rather than human studies.

Interactions deserving the most attention

The one interaction worth attention involves CNS depressants, meaning medicines that slow brain activity and cause drowsiness. This group includes benzodiazepines such as lorazepam and clonazepam, along with barbiturates like phenobarbital and sleep medicines like zolpidem. In animal studies, parts of the Albizia julibrissin flower made a sedative work longer, so in theory the supplement could add to the drowsiness these medicines cause. Anyone taking a sedating medicine should watch for extra sleepiness or slowed thinking with this combination.

What the rest of the list means

Although hundreds of medications appear on the list, they all reflect this same single theoretical concern rather than hundreds of separate problems. Every listed medicine simply belongs to the sedating-drug group, and the added-drowsiness effect has been seen only in animals so far. Whether it happens in people, and how much it would matter, has not been established.

Check your medications against Albizia Julibrissin

Based on HelloPharmacist’s Albizia Julibrissin interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Albizia Julibrissin

248 medications have a known interaction with Albizia Julibrissin, graded by severity. Select any drug for the full evidence-based detail.

Don’t want to scroll the list? Just ask.

Tell us the medications you take and we’ll check each one against Albizia Julibrissin using our pharmacist-reviewed interaction data.

AI summaries are generated from our Albizia Julibrissin interaction data for education only — always confirm with your pharmacist. How we use AI

2,830 drugs

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
Each drug listed above links to the full report for that exact Albizia Julibrissin combination — clinical detail, likelihood, evidence level, and citations.
Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

The big picture

The kinds of drugs Albizia Julibrissin affects

Every type of medication (drug category) Albizia Julibrissin is known to interact with. Open any category for the detail — or search your exact drug in the checker above.

All 1 drug category Albizia Julibrissin interacts with

Cns Depressants

Animal research suggests that certain constituents from Albizia julibrissin flowers can potentiate pentobarbital-induced sleeping time in mice. Theoretically, Albizia julibrissin might enhance the therapeutic and adverse effects of CNS depressants.
Some CNS depressants include pentobarbital (Nembutal), phenobarbital (Luminal), secobarbital (Seconal), clonazepam (Klonopin), lorazepam (Ativan), zolpidem (Ambien), and others.

Likelihood Possible Evidence D

Monograph

Albizia Julibrissin: Uses, Safety & Side Effects

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Reviewed June 2026 ·

The bottom line

Albizia julibrissin (Persian silk tree, He Huan) is a plant used in traditional Chinese medicine, mainly the flower and bark, for calming the mind, lifting mood, and easing sleep problems. Human evidence is very limited, so its benefits are not well proven. Talk with your pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.

Scientific name: Albizia julibrissin
Family: Fabaceae
Part used: Flower (He Huan Hua) and stem bark (He Huan Pi)
Common forms: Dried flowers or bark, teas, decoctions, tinctures, capsules, and powders

People commonly use it for

Anxiety and stress
Low mood or mild depression
Sleep trouble (insomnia)
Irritability
Traditional support for swelling or injuries

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance

OverallUse caution

Limited human safety data, so use carefully and under professional guidance.

PregnancyInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full pregnancy detail

BreastfeedingInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

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Overview

Albizia julibrissin is a flowering tree often called the Persian silk tree, pink silk tree, or mimosa tree. It belongs to the pea family and is known for its feathery leaves and fluffy pink flowers. It grows in parts of Asia, including China, Korea, and Iran, and has spread to other warm regions.

In traditional Chinese medicine, the dried flower is known as He Huan Hua and the stem bark as He Huan Pi. These parts have long been used in teas and herbal mixtures meant to calm the mind, support a steady mood, and help with restless sleep. Today it is sold as dried herb, tinctures, and capsules, sometimes blended with other calming herbs.

Uses & effectiveness

People most commonly use Albizia for emotional and sleep-related concerns, such as anxiety, stress, low mood, irritability, and trouble sleeping. It is also used in traditional practice for swelling, bruises, and other complaints.

It is important to be honest about the evidence: most of what we know comes from traditional use and from laboratory or animal studies. High-quality human studies are lacking. This means we cannot say with confidence that Albizia works for anxiety, depression, insomnia, or any other condition. If you are dealing with significant mood or sleep problems, it should not replace proven treatments or a proper medical evaluation.

How it works

Albizia contains a mix of natural compounds, including saponins (such as julibrosides), flavonoids, and other plant chemicals. Researchers have studied these mostly in test tubes and animals.

Some animal research suggests the plant's extracts may affect brain chemicals and pathways involved in mood and stress, which is why it is sometimes called a calming or "mood-lifting" herb in traditional use. Other lab studies have looked at possible antioxidant and anti-inflammatory effects. These findings are early and do not prove the same effects happen in people at the amounts found in supplements or teas.

Safety & precautions

There is not much solid safety information on Albizia in humans, so a cautious approach is best. Use only well-labeled products from trustworthy sources, since herbal products can be mislabeled or contaminated.

Pregnancy and breastfeeding: Because reliable safety data is missing and the herb is traditionally avoided during pregnancy, you should not use Albizia if you are pregnant, trying to become pregnant, or breastfeeding.

People with liver problems, those taking sedatives or mood medicines, older adults, and anyone with a chronic health condition should check with a pharmacist or doctor first. Stop using it and seek care if you have an allergic reaction or any unusual symptoms. Keep it away from children unless a healthcare provider advises otherwise.

Side effects

Because Albizia has not been carefully studied in people, its full side-effect profile is unknown. Reported or possible effects include stomach upset, drowsiness, and allergic reactions in sensitive people.

Since it is used traditionally as a calming herb, it could add to feelings of sleepiness, especially if combined with other things that cause drowsiness. Stop using it and contact a healthcare provider if you notice rash, swelling, trouble breathing, severe drowsiness, or any other concerning symptoms.

Dosing

There is no well-established or standardized dose for Albizia julibrissin. Traditional preparations use the dried flower or bark in teas and decoctions, but the strength of commercial products varies widely.

If you choose to try it, follow the directions on the product label and do not exceed the suggested amount. A pharmacist can help you review the product and decide whether it is appropriate for you. Starting low and watching how you feel is a sensible approach with any new supplement.

Pregnancy & Breastfeeding

Albizia Julibrissin & Pregnancy

Insufficient reliable information

Insufficient reliable information available; avoid using.

Albizia Julibrissin & Breastfeeding

Insufficient reliable information

Insufficient reliable information available; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 1 references that drive our Albizia Julibrissin monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Kang, T. H., Jeong, S. J., Kim, N. Y., Higuchi, R., and Kim, Y. C. Sedative activity of two flavonol glycosides isolated from the flowers of Albizzia julibrissin Durazz. J Ethnopharmacol 2000;71(1-2):321-323. PubMed

Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

Brand directory

Brands that make products with Albizia Julibrissin

29 brands in our database make a supplement containing Albizia Julibrissin.

Allergy Research Group 1,595 products BiOptimizers 50 products Bioray Kids 27 products Biotics Research Corporation 250 products Clinical Synergy Professional Formulas 33 products ecoNugenics 102 products Five Flavors Herbs 23 products Gaia Herbs 700 products Gaia Herbs Adapt & Balance 5 products Gaia Herbs Adrenal Health 12 products Gaia Herbs Professional Solutions 145 products Guang Ci Tang 121 products Hawaii Pharm 4,726 products Herb Pharm 3,320 products Herb Pharm Professional 28 products Herbal Terra 3,138 products Herbalist & Alchemist 613 products HoltraCeuticals 143 products Min Shan 86 products Moon Juice 31 products moonbrew 1 product Nature's Sunshine 1,360 products NutriCology 678 products Planetary Herbals 558 products

Product directory

Supplement products with Albizia Julibrissin

124 products in our database contain Albizia Julibrissin. Open any to see its full ingredient list and every drug interaction we check.

Pharmacist Counseling Corner

Albizia Julibrissin: Common Questions

Does Albizia Julibrissin interact with prescription medications?

Yes. We list 248 medications with a known interaction with Albizia Julibrissin. Use the checker above to see how Albizia Julibrissin interacts with a specific drug.

How are Albizia Julibrissin interactions rated?

Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.

Is it safe to take Albizia Julibrissin with my medications?

It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.

Where does this Albizia Julibrissin interaction information come from?

Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.

What is Albizia Julibrissin used for?

It is used in traditional Chinese medicine, mainly as the flower and bark, to calm the mind, support mood, and help with restless sleep, anxiety, and irritability. These uses are based on tradition, not on strong human studies.

Does Albizia really work for anxiety or sleep?

We don't have good human studies to confirm this. Most evidence comes from traditional use and animal or lab research, so its benefits remain unproven.

Is Albizia safe to take?

Safety data in people is limited, so use it cautiously and only under the guidance of a pharmacist or doctor, especially if you have a health condition or take other medicines.

Can I use Albizia while pregnant or breastfeeding?

No. Because there is not enough safety information and it is traditionally avoided in pregnancy, you should not use it while pregnant or breastfeeding.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Keep exploring

Products that contain Albizia Julibrissin

A rotating sample of real supplements in our database that list Albizia Julibrissin — open any to see its full ingredients and every drug interaction we check.

See all 124 products with Albizia Julibrissin →

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Albizia Julibrissin Drug Interactions, Uses, Safety & More

Your Choice:

Albizia Julibrissin Drug Interactions: The Bottom Line

Drugs that interact with Albizia Julibrissin

Don’t want to scroll the list? Just ask.

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

Likelihood — How Well It’s Documented

Where This Data Comes From

The kinds of drugs Albizia Julibrissin affects

Albizia Julibrissin: Uses, Safety & Side Effects

Overview

Uses & effectiveness

How it works

Safety & precautions

Side effects

Dosing

Albizia Julibrissin & Pregnancy

Albizia Julibrissin & Breastfeeding

References & further reading

Brands that make products with Albizia Julibrissin

Supplement products with Albizia Julibrissin

Albizia Julibrissin: Common Questions

Related supplements & herbs

Products that contain Albizia Julibrissin

Have a question about Albizia Julibrissin?