Medication interaction hub

What Supplements Interact with Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr?

Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr brand name: Vicks Formula 44M Cough, Cold & Flu Relief. Every interaction below applies to the brands too.

275 Interactions 10 Major 220 Moderate 45 Minor
Curated & coded by · Clinical Pharmacist · Updated September 24, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

A three-drug cold formula like Vicks Formula 44M (acetaminophen, chlorpheniramine, and dextromethorphan) gives supplements three separate targets, so its interaction list warrants real vigilance, starting with the ten major-rated entries. The dominant patterns track each ingredient. Alcohol adds to the liver strain acetaminophen can already cause. Herbs with anticholinergic activity pile extra drowsiness, dry mouth, and blurred vision onto the antihistamine. Serotonin-active supplements can nudge dextromethorphan toward serotonin syndrome, a dangerous overload of that brain chemical.

The largest share of entries simply change how the liver processes these drugs, with grapefruit raising levels and St. John's wort lowering them. Since this is short-term cold and flu relief, the simplest answer is often pausing the supplement, or the drink, until you finish the medicine. The full tally runs to 275 ingredients, 220 of them moderate and 45 minor, alongside those ten major.

— , Clinical Pharmacist · July 18, 2026

Major 10 Moderate 220 Minor 45 No known interaction 1,177

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr: Top Interactions at a Glance

The Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 275 interacting ingredients — plus 1,177 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr Combinations Today

The Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Probable Vitamin C + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBri

High-dose vitamin C might slightly prolong the clearance of acetaminophen.

Read the full interaction Moderate Likelihood Possible Beet + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBri

Theoretically, beet might increase the levels of CYP3A4 substrates.

Read the full interaction Minor Likelihood Possible Vitamin D + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBri

Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.

Read the full interaction Moderate Likelihood Possible Cranberry + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBri

Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.

Read the full interaction Minor Likelihood Possible Aloe + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBri

Theoretically, aloe might decrease the levels and clinical effects of CYP1A2 substrates.

Read the full interaction Moderate Likelihood Possible Alfalfa + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBri

Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.

Read the full interaction
The complete list

Every Supplement Checked Against Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr

All 1,452 ingredients in our database, ranked by severity — 275 with a Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr interaction on file and 1,177 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Vitamin C with Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. High-dose vitamin C might slightly prolong the clearance of acetaminophen.

Full Vitamin C + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr answer

Can you take Beet with Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, beet might increase the levels of CYP3A4 substrates.

Full Beet + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr answer

Can you take Vitamin D with Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.

Full Vitamin D + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr answer

Can you take Cranberry with Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.

Full Cranberry + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr answer

Can you take Aloe with Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, aloe might decrease the levels and clinical effects of CYP1A2 substrates.

Full Aloe + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr answer

Can you take Thunder God Vine with Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, thunder god vine might increase the levels and clinical effects of CYP1A2 substrates.

Full Thunder God Vine + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr answer

Can you take Thyme with Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use of anticholinergic drugs and thyme essential oil might reduce the effects of anticholinergic drugs.

Full Thyme + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr answer

Can you take Tinospora Cordifolia with Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP2D6.

Full Tinospora Cordifolia + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr answer

Can you take Toothed Clubmoss with Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In animal models, toothed clubmoss and huperzine A, an active constituent of toothed clubmoss, reversed cognitive deficits induced by scopol...

Full Toothed Clubmoss + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr answer

Can you take Tragacanth with Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tragacanth might alter absorption of oral drugs.

Full Tragacanth + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr answer

Can you take Turmeric with Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, turmeric might increase the risk of liver damage when taken with hepatotoxic drugs.

Full Turmeric + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr answer

Can you take Uva Ursi with Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, uva ursi may decrease the metabolism of CYP3A4 substrates.

Full Uva Ursi + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr answer

Can you take Valerian with Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.

Full Valerian + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr answer

Can you take Vitamin A with Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking high doses of vitamin A in combination with other potentially hepatotoxic drugs might increase the risk of liver disea...

Full Vitamin A + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr answer

Can you take Vitamin E with Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.

Full Vitamin E + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr answer

Can you take Wheatgrass with Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, wheatgrass might decrease the levels and clinical effects of CYP1A2 substrates.

Full Wheatgrass + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr answer

Can you take White Pepper with Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro evidence suggests that some constituents of white pepper inhibit cytochrome P450 2D6 (CYP2D6).

Full White Pepper + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr answer

Can you take Wild Cherry with Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research suggests that wild cherry can inhibit cytochrome P450 3A4 (CYP3A4) enzymes.

Full Wild Cherry + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr answer

Can you take Wild Lettuce with Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Studies report varying evidence on whether or not wild lettuce contains hyoscyamine, an anticholinergic drug.

Full Wild Lettuce + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr answer

Can you take Winter Cherry with Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro, winter cherry extract inhibited levels of cytochrome P450 2E1 (CYP2E1).

Full Winter Cherry + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr sits in 17 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 79 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

79 of the supplement ingredients on this page reach Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr through this category.

Cytochrome P450 2D6 (Cyp2D6) Substrates 60 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

60 of the supplement ingredients on this page reach Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr through this category.

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr through this category.

Anticholinergic Drugs 30 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

30 of the supplement ingredients on this page reach Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr through this category.

Cytochrome P450 2E1 (Cyp2E1) Substrates 24 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

24 of the supplement ingredients on this page reach Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr through this category.

Serotonergic Drugs 20 ingredients

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

20 of the supplement ingredients on this page reach Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr through this category.

Glucuronidated Drugs 12 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

12 of the supplement ingredients on this page reach Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr through this category.

Dextromethorphan (Robitussin Dm, Others) 9 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

9 of the supplement ingredients on this page reach Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr through this category.

Acetaminophen (Tylenol, Others) 8 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

8 of the supplement ingredients on this page reach Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr through this category.

Nephrotoxic Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr through this category.

Cytochrome P450 2D6 (Cyp2D6) Inhibitors 3 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

3 of the supplement ingredients on this page reach Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr through this category.

Serotonergic Drugs 1 ingredient

Medications that raise serotonin activity. Combining them with serotonin-active supplements can, in rare cases, push serotonin too high.

1 of the supplement ingredient on this page reaches Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr through this category.

Related: does Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr deplete any nutrients?

Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr has 1 reported nutrient association in the research literature — see the Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr.

Search a supplement product

Type a product name, brand, or UPC — smart search across our full catalog.

Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

Or scan the bottle

Photograph any Supplement Facts panel — we read the ingredients and check each one against your medications. Free, in seconds.

Open the label scanner

Prefer typing? The interaction checker looks up products by name too.

Pharmacist Counseling Corner

Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr & Supplements: Common Questions

What supplements interact with Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr?
In our interaction database, 275 supplement and herbal ingredients have an interaction with Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr on file — 10 rated major, 220 moderate, and 45 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Grapefruit, Siberian Cocklebur, Activated Charcoal.
Which Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr supplement interactions are the most serious?
The 10 major-rated combinations — led by Grapefruit, Siberian Cocklebur, Activated Charcoal, Beer and Henbane — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr?
That depends entirely on which supplement. The honest answer for Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Vicks Formula 44M Cough, Cold & Flu Relief have the same supplement interactions as Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr?
Yes — Vicks Formula 44M Cough, Cold & Flu Relief all contain Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr deplete any vitamins or nutrients?
It might — Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr has 1 reported nutrient-depletion association in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr and my other medications?
This page covers Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr against supplements and herbal ingredients. Checking Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

More Free Pharmacist Tools

Supplement interaction checker Check any supplement or product against your medications Supplement label scanner Photograph a Supplement Facts panel; we check every ingredient Browse medications A–Z Every drug we’ve checked against herbs & supplements Ingredient directory Every vitamin, herb & mineral we track, with interaction data Product directory Look up any bottle by name, brand, or barcode Ask a pharmacist Free, personal answer from our licensed team
Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 24, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.