Selenium + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr
Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr brand name: Vicks Formula 44M Cough, Cold & Flu Relief.
We found no known interaction between Selenium and Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.
Selenium and Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr
We checked these two against our interaction database. Here is what we found.
No Known Interaction Found
We did not find a documented interaction between Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr and Selenium in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.
If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.
Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.
Selenium safety at a glance
Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Why No Interaction Is Listed for Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr
Interactions in our licensed database are recorded against drug classes, not just single drug names. Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr is filed under 17 classifications — including cytochrome p450 2e1 (cyp2e1) substrates, glucuronidated drugs, cytochrome p450 2d6 (cyp2d6) inhibitors. Selenium has documented interactions with 6 drug classes — the most serious being anticoagulant/antiplatelet drugs (moderate), barbiturates (moderate) and immunosuppressants (moderate) — and none of Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr’s classifications are among them.
Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.
Selenium Does Interact With Other Medications
Selenium has 288 moderate, 33 minor known drug interactions in our database — Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr isn’t one of them. If you take anything else, check it against the full list below.
Check Another of Your Medications Against Selenium
We haven’t checked that one against Selenium yet — ask our pharmacists directly.
Covers the 2,830 medications we’ve checked against Selenium. Pick one to open its full report.
Selenium in Pregnancy & Breastfeeding
When used orally and appropriately. Selenium appears to be safe when used short-term in amounts that do not exceed the tolerable upper intake level (UL) of 400 mcg daily; however, there is concern that long-term use might not be safe.
When used orally in excessive doses. Doses above 400 mcg daily may cause significant toxicity.
When used orally and appropriately. Selenium appears to be safe when used short-term in amounts that do not exceed the tolerable upper intake level (UL) of 400 mcg daily when taken short-term; however, there is concern that long-term use might not be safe.
When used orally in excessive doses. Doses above 400 mcg daily may cause significant toxicity. ...when used orally in HIV-positive women. Selenium supplementation in HIV-positive women not taking highly active antiretroviral therapy may increase HIV-1 levels in breast milk.
DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center
Questions About Selenium or Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr
These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Selenium or Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:
Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.
See Every Supplement That Interacts With Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr
This page covers Selenium only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr page lists 275 supplements it has a documented interaction with, worst first, each one explained.
The most serious there right now: Activated Charcoal (major), Asarabacca (major), Beer (major), Grapefruit (major) and Henbane (major).
By severity: 10 major · 220 moderate · 45 minor.
From our pharmacist’s overview on the Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr page
“A three-drug cold formula like Vicks Formula 44M (acetaminophen, chlorpheniramine, and dextromethorphan) gives supplements three separate targets, so its interaction list warrants real vigilance, starting with the ten major-rated entries. The dominant patterns track each ingredient.”
Reviewed by 2 · Jul 18, 2026
Open the Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr interaction page
Taking Selenium as Part of a Dietary Supplement Product? Check It for Interactions
We hold 16,942 real supplement products containing Selenium, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Selenium. Even though Selenium itself has no known interaction with Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:
Where Selenium and Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr Sit Against Everything Else
Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.
#15 of 1,452 supplements looked up here in the last 7 days
#685 of 2,830 medications looked up here in the last 7 days
Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.
Where does our data come from?
- Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
- Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Selenium reference on this page ↓
- Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Selenium and Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr records this page draws on were last updated July 11, 2026.
- What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
About Selenium
What is Selenium?
- Thyroid health support
- Antioxidant support
- Immune support
- General nutrient supplementation
- Reproductive/fertility support
Selenium is an essential trace mineral your body needs in small amounts for thyroid function, antioxidant defense, and immune health. Most people who eat a varied diet get enough, and supplements are mainly useful for those who are deficient. Because too much selenium can be toxic, stick to recommended amounts and check with your pharmacist or doctor before supplementing.
Not applicable (selenium is a mineral, not a plant) · Tablets, capsules, softgels, multivitamin/mineral products; common forms include selenomethionine, sodium selenite, and selenium-enriched yeast
An interaction check asks whether these two react with each other — it does not ask whether Selenium is a good idea for someone in your situation. Here is what our Selenium record says about it on its own.
Selenium: dosing
Selenium needs are usually measured in micrograms (mcg) per day, and recommended amounts differ by age and life stage. Most adults need only a small daily amount, which many people already get from food. Health authorities also set an upper limit for safe daily intake that should not be exceeded.Because the right amount depends on your diet, health, and whether you are actually deficient, there is no single dose that fits everyone. Follow the product label and avoid stacking multiple products that all contain selenium.
From our Selenium monograph — the full record covers uses, side effects and every documented interaction.
About Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr
Most-Reported Side Effects for Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr
From FAERS, the FDA’s public side-effect reporting system (3,261 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.
Other Drugs & Selenium
Browse every other medication we’ve checked against Selenium — both the ones with a known interaction and the ones without. Select any drug for the full detail.
No drugs match “”.
288 interactions
- Diclofenac Sodium ›
- Ibuprofen ›
- Aspirin ›
- Hydrocortisone ›
- Naproxen ›
- Minocycline ›
- Prednisone ›
- Cyclosporine ›
- Dexamethasone ›
- Prednisolone ›
- Tacrolimus ›
- Triamcinolone ›
- Diclofenac Potassium ›
- Dipyridamole ›
- Ketoprofen ›
- Betamethasone ›
- Bivalirudin ›
- Ciclesonide ›
- Phenobarbital ›
- Warfarin Sodium ›
- Azathioprine ›
- Beclomethasone ›
- Beclomethasone Dipropionate ›
- Bromfenac Sodium ›
- Butabarbital Sodium ›
- Cladribine ›
- Cortisone Acetate ›
- Cyclophosphamide ›
- Dabigatran ›
- Daclizumab ›
- Denosumab ›
- Diclofenac Epolamine ›
- Fingolimod ›
- Hexobarbital ›
- Hexobarbitone ›
- Iloprost ›
- Methylprednisolone ›
- Piroxicam ›
- Streptokinase ›
- Ticlopidine ›
- Tofacitinib ›
- Treprostinil (oral) ›
- Triamcinolone Acetonide ›
- 6-mercaptopurine ›
- Abatacept ›
- Abciximab ›
- Abrocitinib ›
- Acenocoumarol ›
- Acetylsalicylic Acid ›
- Adalimumab ›
- Adalimumab-adaz ›
- Adalimumab-adbm ›
- Adalimumab-afzb ›
- Adalimumab-atto ›
- Adalimumab-bwwd ›
- Adalimumab-fkjp ›
- Alefacept ›
- Alemtuzumab ›
- Amobarbital ›
- Anacaulase-bcdb ›
Showing 60 of 288 moderate interactions — see all 288 on the Selenium page.
33 interactions
- Levonorgestrel ›
- Niacin (prescription Drug) ›
- Norgestrel ›
- Birth Control Pills ›
- Drospirenone ›
- Etonogestrel ›
- Gestodene ›
- Ulipristal Acetate ›
- Ethinyl Estradiol, Norethindrone ›
- Ethinyl Estradiol, Levonorgestrel ›
- Ethinyl Estradiol, Norgestimate ›
- Ethinyl Estradiol, Desogestrel ›
- Ethinyl Estradiol, Norethindrone, Ferrous Fumarate ›
- Desogestrel, Ethinyl Estradiol ›
- Mestranol, Norethindrone ›
- Ethinyl Estradiol, Ethynodiol Diacetate ›
- Levonorgestrel, Ethinyl Estradiol ›
- Ethinyl Estradiol, Norgestrel ›
- Drospirenone, Ethinyl Estradiol ›
- Ethiny Estradiol, Levonorgestrel ›
- Norelgestromin, Ethinyl Estradiol ›
- Norethindrone Acetate, Ethinyl Estradiol, Ferrous Fumarate ›
- Drospirenone, Estetrol ›
- Drospirenone, Ethinyl Estradiol, Levomefolate ›
- Ethinyl Estradiol, Drospirenone ›
- Ethinyl Estradiol, Levonogestrel ›
- Ethynodiol Diacetate, Mestranol ›
- Etonogestrel, Ethinyl Estradiol ›
- Lactic Acid, Citric Acid, Potassium Bitartrate ›
- Mestranol, Norethynodrel ›
- Niacin, Lovastatin ›
- Niacin, Simvastatin ›
- Segesterone Acetate, Ethinyl Estradiol ›
No interaction 2,508 drugs checked — show the list
We also checked Selenium against these medications and found no known interaction in our sources. Open any page to confirm.
- Levothyroxine ›
- Amlodipine ›
- Methylphenidate ›
- Sertraline ›
- Testosterone ›
- Losartan Potassium ›
- Metoprolol ›
- Ivermectin ›
- Rosuvastatin ›
- Escitalopram ›
- Tadalafil ›
- Acetaminophen ›
- Valacyclovir ›
- Atorvastatin ›
- Docusate ›
- Hydroxyurea ›
- Abemaciclib ›
- Methamphetamine ›
- Sumatriptan ›
- Semaglutide ›
- Tirzepatide ›
- Propranolol ›
- Lisdexamfetamine ›
- Acyclovir ›
- Bupropion ›
- Metformin ›
- Amoxicillin ›
- Lisinopril ›
- Bendamustine ›
- Amitriptyline ›
- Doxycycline ›
- Lamotrigine ›
- Fluoxetine ›
- Methotrexate ›
- Acetaminophen, Codeine ›
- Gabapentin ›
- Amphetamine ›
- Pregabalin ›
- Isotretinoin ›
- Dextroamphetamine ›
- Azithromycin ›
- Clonazepam ›
- Quetiapine ›
- Omeprazole ›
- Amlodipine Besylate ›
- Methylene Blue ›
- Duloxetine ›
- Letrozole ›
- Buspirone ›
- Citalopram ›
- Ciprofloxacin ›
- Bisoprolol ›
- Levothyroxine, Liothyronine ›
- Acetaminophen, Oxycodone ›
- Dapsone ›
- Diazepam ›
- Cyclopentolate ›
- Candesartan Cilexetil ›
- Mannitol ›
- Cephalexin ›
Showing the 60 most looked-up of 2,508 medications checked with no known interaction — see the full Selenium list.
Selenium References
The 36 references that drive our Selenium monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington, DC: National Academy Press, 2000. Available at: http://www.nap.edu/books/0309069351/html/.
- Brown BG, Zhao XQ, Chait A, et al. Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. N Engl J Med 2001;345:1583-93. DOI
- Trafikowska U, Zachara BA, Wiacek M, et al. Selenium supply and glutathione peroxidase activity in breastfed Polish infants. Acta Paediatr 1996;85:1143-5. PubMed
- Duffield-Lillico AJ, Slate EH, Reid ME, et al. Selenium supplementation and secondary prevention of nonmelanoma skin cancer in a randomized trial. J Natl Cancer Inst 2003;95:1477-81.. PubMed
- Cheung MC, Zhao XQ, Chait A, et al. Antioxidant supplements block the response of HDL to simvastatin-niacin therapy in patients with coronary artery disease and low HDL. Arterioscler Thromb Vasc Biol 2001;21:1320-6. PubMed
- Schiavon R, Freeman GE, Guidi GC, et al. Selenium enhances prostacyclin production by cultured endothelial cells: possible explanation for increased bleeding times in volunteers taking selenium as a dietary supplement. Thromb Res 1984;34:389-96. PubMed
- Davila JC, Edds GT, Osuna O, Simpson CF. Modification of the effects of aflatoxin B1 and warfarin in young pigs given selenium. Am J Vet Res 1983;44:1877-83. DOI
- Heese HD, Lawrence MA, Dempster WS, Pocock F. Reference concentrations of serum selenium and manganese in healthy nulliparas. S Afr Med J 1988;73:163-5.
- Lloyd B, Lloyd RS, Clayton BE. Effect of smoking, alcohol and other factors on the selenium status of a healthy population. J Epidemiol Commun Health 1983;37:213-7. PubMed
- Capel ID, Jenner M, Williams DC, et al. The effect of prolonged oral contraceptive steroid use on erythrocyte glutathione peroxidase activity. J Steroid Biochem 1981;14:729-32. PubMed
- Contempre B, Dumont JE, Ngo B, et al. Effect of selenium supplementation in hypothyroid subjects of an iodine and selenium deficient area: the possible danger of indiscriminate supplementation of iodine-deficient subjects with selenium. J Clin Endocrinol PubMed
- Hofbauer LC, Spitzweg C, Magerstadt RA, Heufelder AE. Selenium-induced thyroid dysfunction. Postgrad Med J 1997;73:103-4. PubMed
- Debski B, Milner JA. Dietary selenium supplementation prolongs pentobarbital induced hypnosis. J Nutr Biochem 2004;15:548-53. PubMed
- Ishikawa M, Sasaki M, Koiwai K, et al. Inhibition of hepatic mixed-function oxidase enzymes in mice by acute and chronic treatment with selenium. J Pharmacobiodyn 1992;15:377-85. PubMed
- Lippmann SM, Klein EA, Goodman PJ, et al. Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the selenium and vitamin E cancer prevention trial (SELECT). JAMA 2009;301:39-51. DOI
- Reid SM, Middleton P, Cossich MC, Crowther CA. Interventions for clinical and subclinical hypothyroidism in pregnancy. Cochrane Database Syst Rev 2010;(7):CD007752. PubMed
- Vinceti, M., Wei, E. T., Malagoli, C., Bergomi, M., and Vivoli, G. Adverse health effects of selenium in humans. Rev.Environ.Health 2001;16(4):233-251. PubMed
- Abrams, C. K., Siram, S. M., Galsim, C., Johnson-Hamilton, H., Munford, F. L., and Mezghebe, H. Selenium deficiency in long-term total parenteral nutrition. Nutr Clin Pract 1992;7(4):175-178. PubMed
- Spiller, H. A. and Pfiefer, E. Two fatal cases of selenium toxicity. Forensic Sci Int 8-24-2007;171(1):67-72. PubMed
- Negro, R., Greco, G., Mangieri, T., Pezzarossa, A., Dazzi, D., and Hassan, H. The influence of selenium supplementation on postpartum thyroid status in pregnant women with thyroid peroxidase autoantibodies. J Clin Endocrinol.Metab 2007;92(4):1263-1268. PubMed
- Alexander, J. Selenium. Novartis.Found.Symp 2007;282:143-149.
- Salonen, J. T., Salonen, R., Seppanen, K., Rinta-Kiikka, S., Kuukka, M., Korpela, H., Alfthan, G., Kantola, M., and Schalch, W. Effects of antioxidant supplementation on platelet function: a randomized pair-matched, placebo-controlled, double-blind trial
- Kupka, R., Mugusi, F., Aboud, S., Msamanga, G. I., Finkelstein, J. L., Spiegelman, D., and Fawzi, W. W. Randomized, double-blind, placebo-controlled trial of selenium supplements among HIV-infected pregnant women in Tanzania: effects on maternal and chil
- Kamble, P., Mohsin, N., Jha, A., Date, A., Upadhaya, A., Mohammad, E., Khalil, M., Pakkyara, A., and Budruddin, M. Selenium intoxication with selenite broth resulting in acute renal failure and severe gastritis. Saudi.J Kidney Dis.Transpl. 2009;20(1):106
- Peretz, A., Neve, J., Desmedt, J., Duchateau, J., Dramaix, M., and Famaey, J. P. Lymphocyte response is enhanced by supplementation of elderly subjects with selenium-enriched yeast. Am.J Clin.Nutr. 1991;53(5):1323-1328. PubMed
- Kumpulainen, J., Salmenpera, L., Siimes, M. A., Koivistoinen, P., and Perheentupa, J. Selenium status of exclusively breast-fed infants as influenced by maternal organic or inorganic selenium supplementation. Am.J Clin.Nutr. 1985;42(5):829-835. PubMed
- Han, L. and Zhou, S. M. Selenium supplement in the prevention of pregnancy induced hypertension. Chin Med J (Engl) 1994;107(11):870-871.
- Kiremidjian-Schumacher, L., Roy, M., Wishe, H. I., Cohen, M. W., and Stotzky, G. Supplementation with selenium and human immune cell functions. II. Effect on cytotoxic lymphocytes and natural killer cells. Biol.Trace Elem.Res. 1994;41(1-2):115-127. PubMed
- Srivastava, A. K., Gupta, B. N., Bihari, V., and Gaur, J. S. Generalized hair loss and selenium exposure. Vet.Hum.Toxicol. 1995;37(5):468-469.
- Sudfeld CR, Aboud S, Kupka R, et al. Effect of selenium supplementation on HIV-1 RNA detection in breast milk of Tanzanian women. Nutrition 2014;30(9):1081-4. PubMed
- Rees K, Hartley L, Day C, et al. Selenium supplementation for the primary prevention of cardiovascular disease. Cochrane Database Syst Rev 2013;1:CD009671. PubMed
- Thompson PA, Ashbeck EL, Roe DJ, et al. Selenium Supplementation for Prevention of Colorectal Adenomas and Risk of Associated Type 2 Diabetes. J Natl Cancer Inst. 2016;108(12). PubMed
- Wichman J, Winther KH, Bonnema SJ, Hegedüs L. Selenium supplementation significantly reduces thyroid autoantibody levels in patients with chronic autoimmune thyroiditis: a systematic review and meta-analysis. Thyroid 2016;26(12):1681-92. PubMed
- Vinceti M, Filippini T, Rothman KJ. Selenium exposure and the risk of type 2 diabetes: a systematic review and meta-analysis. Eur J Epidemiol. 2018 Sep;33(9):789-810. Epub 2018 Jul 5. Review. PubMed
- Fallah S, Sani FV, Firoozrai M. Effect of contraceptive pill on the selenium and zinc status of healthy subjects. Contraception. 2009;80(1):40-3. PubMed
- Malpas CB, Vivash L, Genc S, et al. A Phase IIa Randomized Control Trial of VEL015 (Sodium Selenate) in Mild-Moderate Alzheimer's Disease. J Alzheimers Dis. 2016;54(1):223-232. PubMed
Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr Is Linked to Lower Levels of One Nutrient
Natural Medicines records Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr as a medicine that can lower these. This is not an interaction with Selenium — it is a separate effect of the medicine, and it is a reason some people are advised to supplement rather than to avoid one:
Selenium is itself a nutrient we track — see which medications may deplete SELENIUM.
Depletion records come from the licensed Natural Medicines database. Do not start a supplement on the strength of this page — ask your pharmacist or doctor whether it applies to you.
Taking Selenium and Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr Together: Common Questions
Is it safe to take Selenium with Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr?
How was the Selenium and Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr combination checked?
Does Selenium interact with any other medications?
Does Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr interact with any supplements?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Keep Exploring
Still Have a Question About Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan HBr and Selenium?
Our pharmacists answer your medication & supplement questions — free.
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.