Medication interaction hub

What Supplements Interact with Ethinyl Estradiol, Norethindrone, Ferrous Fumarate?

Ethinyl Estradiol, Norethindrone, Ferrous Fumarate brand names: Estrostep Fe, Loestrin Fe, Microgestin FE, Junel Fe 1.5/30, Loestrin Fe 1.5/30, and others. Every interaction below applies to the brands too.

240 Interactions 6 Major 196 Moderate 38 Minor
Curated & coded by · Clinical Pharmacist · Updated September 18, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Ethinyl Estradiol, Norethindrone, Ferrous Fumarate? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Ethinyl Estradiol, Norethindrone, Ferrous Fumarate against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

If you take a birth control pill that combines ethinyl estradiol, norethindrone, and iron (Loestrin Fe, Estrostep Fe, Microgestin Fe), a few supplements can genuinely undermine it, and I want you to know which ones first. Six of the 240 ingredients on file carry a major rating. St. John's wort tops that list because it speeds up hormone breakdown and can weaken the pill's protection; grapefruit does the reverse and raises hormone levels.

Activated charcoal, another major, can trap the dose in your gut before it absorbs, and bulky fiber supplements act similarly, so space those well apart from the pill. Heavy alcohol adds liver strain on top of the hormones. Most of the 196 moderate entries echo these same patterns, and only 38 rate minor. One quirk worth knowing is that estrogen slows caffeine clearance, so your usual coffee can hit harder and linger.

— , Clinical Pharmacist · July 18, 2026

Major 6 Moderate 196 Minor 38 No known interaction 1,212

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Ethinyl Estradiol, Norethindrone, Ferrous Fumarate: Top Interactions at a Glance

The Ethinyl Estradiol, Norethindrone, Ferrous Fumarate supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 240 interacting ingredients — plus 1,212 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Ethinyl Estradiol, Norethindrone, Ferrous Fumarate Combinations Today

The Ethinyl Estradiol, Norethindrone, Ferrous Fumarate + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Possible Milk Thistle + Ethinyl Estradiol, Norethindrone, Ferrous Fumaratei

Theoretically, milk thistle might interfere with estrogen therapy through competition for estrogen receptors.

Read the full interaction Minor Likelihood Possible Selenium + Ethinyl Estradiol, Norethindrone, Ferrous Fumaratei

Contraceptive drugs might increase levels of selenium, although the clinical significance of this effect is unclear.

Read the full interaction Moderate Likelihood Possible Panax Notoginseng + Ethinyl Estradiol, Norethindrone, Ferrous Fumaratei

Theoretically, taking Panax notoginseng might reduce the levels and clinical effects of CYP1A2 substrates.

Read the full interaction Minor Likelihood Possible Copper + Ethinyl Estradiol, Norethindrone, Ferrous Fumaratei

Theoretically, taking copper with contraceptive drugs might increase the levels and toxic effects of copper.

Read the full interaction Moderate Likelihood Possible Zizyphus + Ethinyl Estradiol, Norethindrone, Ferrous Fumaratei

Theoretically, zizyphus might decrease the levels and clinical effects of drugs metabolized by CYP1A2.

Read the full interaction Major Likelihood Likely Grapefruit + Ethinyl Estradiol, Norethindrone, Ferrous Fumaratei

Grapefruit juice can increase levels of drugs metabolized by CYP3A4.

Read the full interaction
The complete list

Every Supplement Checked Against Ethinyl Estradiol, Norethindrone, Ferrous Fumarate

All 1,452 ingredients in our database, ranked by severity — 240 with a Ethinyl Estradiol, Norethindrone, Ferrous Fumarate interaction on file and 1,212 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Ethinyl Estradiol, Norethindrone, Ferrous Fumarate?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Milk Thistle with Ethinyl Estradiol, Norethindrone, Ferrous Fumarate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, milk thistle might interfere with estrogen therapy through competition for estrogen receptors.

Full Milk Thistle + Ethinyl Estradiol, Norethindrone, Ferrous Fumarate answer

Can you take Selenium with Ethinyl Estradiol, Norethindrone, Ferrous Fumarate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Contraceptive drugs might increase levels of selenium, although the clinical significance of this effect is unclear.

Full Selenium + Ethinyl Estradiol, Norethindrone, Ferrous Fumarate answer

Can you take Panax Notoginseng with Ethinyl Estradiol, Norethindrone, Ferrous Fumarate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Panax notoginseng might reduce the levels and clinical effects of CYP1A2 substrates.

Full Panax Notoginseng + Ethinyl Estradiol, Norethindrone, Ferrous Fumarate answer

Can you take Copper with Ethinyl Estradiol, Norethindrone, Ferrous Fumarate?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking copper with contraceptive drugs might increase the levels and toxic effects of copper.

Full Copper + Ethinyl Estradiol, Norethindrone, Ferrous Fumarate answer

Can you take Zizyphus with Ethinyl Estradiol, Norethindrone, Ferrous Fumarate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, zizyphus might decrease the levels and clinical effects of drugs metabolized by CYP1A2.

Full Zizyphus + Ethinyl Estradiol, Norethindrone, Ferrous Fumarate answer

Can you take Limonene with Ethinyl Estradiol, Norethindrone, Ferrous Fumarate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. There's preliminary evidence that limonene might be a substrate for cytochrome P450 2C19 (CYP2C19).

Full Limonene + Ethinyl Estradiol, Norethindrone, Ferrous Fumarate answer

Can you take Mace with Ethinyl Estradiol, Norethindrone, Ferrous Fumarate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research suggests that intraperitoneal injections of myristicin, a constituent of mace, can induce cytochrome P450 1A2 (CYP1A2) enzym...

Full Mace + Ethinyl Estradiol, Norethindrone, Ferrous Fumarate answer

Can you take Manchurian Thorn with Ethinyl Estradiol, Norethindrone, Ferrous Fumarate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research suggests that high doses of Manchurian thorn can induce liver damage.

Full Manchurian Thorn + Ethinyl Estradiol, Norethindrone, Ferrous Fumarate answer

Can you take Methoxylated Flavones with Ethinyl Estradiol, Norethindrone, Ferrous Fumarate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Some in vitro evidence suggests that methoxylated flavones might induce CYP1A2, possibly by increasing gene transcription.

Full Methoxylated Flavones + Ethinyl Estradiol, Norethindrone, Ferrous Fumarate answer

Can you take Moringa with Ethinyl Estradiol, Norethindrone, Ferrous Fumarate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, moringa might increase or decrease levels of CYP3A4 substrates.

Full Moringa + Ethinyl Estradiol, Norethindrone, Ferrous Fumarate answer

Can you take Neem with Ethinyl Estradiol, Norethindrone, Ferrous Fumarate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, neem leaf extract might increase the levels and clinical effects of CYP1A2 substrates.

Full Neem + Ethinyl Estradiol, Norethindrone, Ferrous Fumarate answer

Can you take Niacin with Ethinyl Estradiol, Norethindrone, Ferrous Fumarate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.

Full Niacin + Ethinyl Estradiol, Norethindrone, Ferrous Fumarate answer

Can you take Noni with Ethinyl Estradiol, Norethindrone, Ferrous Fumarate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking noni with hepatotoxic drugs might increase the risk of liver damage.

Full Noni + Ethinyl Estradiol, Norethindrone, Ferrous Fumarate answer

Can you take Nutmeg with Ethinyl Estradiol, Norethindrone, Ferrous Fumarate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, nutmeg might decrease levels of drugs metabolized by CYP1A2.

Full Nutmeg + Ethinyl Estradiol, Norethindrone, Ferrous Fumarate answer

Can you take Oregon Grape with Ethinyl Estradiol, Norethindrone, Ferrous Fumarate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Oregon grape might increase serum levels of drugs metabolized by CYP3A4.

Full Oregon Grape + Ethinyl Estradiol, Norethindrone, Ferrous Fumarate answer

Can you take Ostarine with Ethinyl Estradiol, Norethindrone, Ferrous Fumarate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with hepatotoxic drugs might increase the risk of adverse hepatotoxic effects.

Full Ostarine + Ethinyl Estradiol, Norethindrone, Ferrous Fumarate answer

Can you take Padang Cassia with Ethinyl Estradiol, Norethindrone, Ferrous Fumarate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. There is some concern that ingesting large amounts of Padang cassia might cause hepatotoxicity in some people.

Full Padang Cassia + Ethinyl Estradiol, Norethindrone, Ferrous Fumarate answer

Can you take Panax Ginseng with Ethinyl Estradiol, Norethindrone, Ferrous Fumarate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of large amounts of Panax ginseng might interfere with hormone replacement therapy.

Full Panax Ginseng + Ethinyl Estradiol, Norethindrone, Ferrous Fumarate answer

Can you take Parsley with Ethinyl Estradiol, Norethindrone, Ferrous Fumarate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, parsley might increase serum levels of CYP1A2 substrates.

Full Parsley + Ethinyl Estradiol, Norethindrone, Ferrous Fumarate answer

Can you take Peony with Ethinyl Estradiol, Norethindrone, Ferrous Fumarate?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, use of peony may increase the levels and clinical effects of drugs metabolized by CYP1A2.

Full Peony + Ethinyl Estradiol, Norethindrone, Ferrous Fumarate answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Ethinyl Estradiol, Norethindrone, Ferrous Fumarate is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Ethinyl Estradiol, Norethindrone, Ferrous Fumarate, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Ethinyl Estradiol, Norethindrone, Ferrous Fumarate sits in 13 interaction categories. Open any one to see what the group means:

Cytochrome P450 3A4 (Cyp3A4) Substrates 121 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

121 of the supplement ingredients on this page reach Ethinyl Estradiol, Norethindrone, Ferrous Fumarate through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 79 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

79 of the supplement ingredients on this page reach Ethinyl Estradiol, Norethindrone, Ferrous Fumarate through this category.

Estrogens 60 ingredients

Hormone-related medications. Supplements with hormone-like activity can add to or interfere with them.

60 of the supplement ingredients on this page reach Ethinyl Estradiol, Norethindrone, Ferrous Fumarate through this category.

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Ethinyl Estradiol, Norethindrone, Ferrous Fumarate through this category.

P-Glycoprotein Substrates 37 ingredients

A drug-transport group: these medications are moved in and out of cells by the P-glycoprotein pump. Supplements that affect the pump can change how much of the drug is absorbed or kept in the body.

37 of the supplement ingredients on this page reach Ethinyl Estradiol, Norethindrone, Ferrous Fumarate through this category.

Contraceptive Drugs 30 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

30 of the supplement ingredients on this page reach Ethinyl Estradiol, Norethindrone, Ferrous Fumarate through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Ethinyl Estradiol, Norethindrone, Ferrous Fumarate through this category.

Cytochrome P450 3A4 (Cyp3A4) Inhibitors 13 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

13 of the supplement ingredients on this page reach Ethinyl Estradiol, Norethindrone, Ferrous Fumarate through this category.

Cytochrome P450 1A2 (Cyp1A2) Inhibitors 10 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

10 of the supplement ingredients on this page reach Ethinyl Estradiol, Norethindrone, Ferrous Fumarate through this category.

Ethinyl Estradiol 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Ethinyl Estradiol, Norethindrone, Ferrous Fumarate through this category.

Cytochrome P450 2C19 (Cyp2C19) Inducers 2 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

2 of the supplement ingredients on this page reach Ethinyl Estradiol, Norethindrone, Ferrous Fumarate through this category.

Cytochrome P450 1A2 (Cyp1A2) Substrates 1 ingredient

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

1 of the supplement ingredient on this page reaches Ethinyl Estradiol, Norethindrone, Ferrous Fumarate through this category.

Progestin 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Ethinyl Estradiol, Norethindrone, Ferrous Fumarate through this category.

Related: does Ethinyl Estradiol, Norethindrone, Ferrous Fumarate deplete any nutrients?

Ethinyl Estradiol, Norethindrone, Ferrous Fumarate has 63 reported nutrient associations in the research literature — see the Ethinyl Estradiol, Norethindrone, Ferrous Fumarate nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Ethinyl Estradiol, Norethindrone, Ferrous Fumarate

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Ethinyl Estradiol, Norethindrone, Ferrous Fumarate.

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Pharmacist Counseling Corner

Ethinyl Estradiol, Norethindrone, Ferrous Fumarate & Supplements: Common Questions

What supplements interact with Ethinyl Estradiol, Norethindrone, Ferrous Fumarate?
More than you might expect — 240 in total, though they are far from equal: 6 are rated major, 196 moderate, and 38 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Grapefruit, Siberian Cocklebur, Activated Charcoal.
Which Ethinyl Estradiol, Norethindrone, Ferrous Fumarate supplement interactions are the most serious?
The 6 major-rated combinations — led by Grapefruit, Siberian Cocklebur, Activated Charcoal, Beer and St. John's Wort — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Ethinyl Estradiol, Norethindrone, Ferrous Fumarate?
Usually yes — most people on Ethinyl Estradiol, Norethindrone, Ferrous Fumarate can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Estrostep Fe have the same supplement interactions as Ethinyl Estradiol, Norethindrone, Ferrous Fumarate?
Yes — Estrostep Fe, Loestrin Fe, Microgestin FE, Junel Fe 1.5/30, Loestrin Fe 1.5/30 and other brands all contain Ethinyl Estradiol, Norethindrone, Ferrous Fumarate, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Ethinyl Estradiol, Norethindrone, Ferrous Fumarate deplete any vitamins or nutrients?
It might — Ethinyl Estradiol, Norethindrone, Ferrous Fumarate has 63 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Ethinyl Estradiol, Norethindrone, Ferrous Fumarate nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Ethinyl Estradiol, Norethindrone, Ferrous Fumarate and my other medications?
This page covers Ethinyl Estradiol, Norethindrone, Ferrous Fumarate against supplements and herbal ingredients. Checking Ethinyl Estradiol, Norethindrone, Ferrous Fumarate against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 18, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.