Medication interaction hub

What Supplements Interact with Human Chorionic Gonadotropin (HCG)?

Human Chorionic Gonadotropin (HCG) brand name: Pregnyl. Every interaction below applies to the brands too.

21 Interactions 1 Major 19 Moderate 1 Minor
Curated & coded by · Clinical Pharmacist · Updated September 15, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Human Chorionic Gonadotropin (HCG)? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Human Chorionic Gonadotropin (HCG) against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Tiratricol is the entry to understand first. It is a thyroid hormone in its own right, and it carries the only major rating among the 21 supplements known to interact with human chorionic gonadotropin (HCG, sold as Pregnyl). Everything on this page acts through thyroid hormone activity in one direction or another, and with a hormone therapy like HCG, used to trigger ovulation or support testosterone production, that calls for real care rather than a casual glance.

The 19 moderate entries pull in opposite directions. Some, ashwagandha among them, may amplify thyroid hormone effects and their side effects, while others appear to blunt them, and iodine-rich seaweeds such as sea moss can push thyroid function up or down depending on the person. Only one entry rates minor. Since trouble here can mean too much hormone effect or too little, check each of these against the full list below before pairing it with HCG.

— , Clinical Pharmacist · July 18, 2026

Major 1 Moderate 19 Minor 1 No known interaction 1,431

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Human Chorionic Gonadotropin (HCG): Top Interactions at a Glance

The most significant Human Chorionic Gonadotropin (HCG) supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 21 interacting ingredients — plus 1,431 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Human Chorionic Gonadotropin (HCG) + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Probable Tiratricol + Human Chorionic Gonadotropin (HCG)i

Concomitant use of tiratricol with thyroid hormones may have additive effects.

Read the full interaction
The complete list

Every Supplement Checked Against Human Chorionic Gonadotropin (HCG)

All 1,452 ingredients in our database, ranked by severity — 21 with a Human Chorionic Gonadotropin (HCG) interaction on file and 1,431 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Human Chorionic Gonadotropin (HCG)?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take L-carnitine with Human Chorionic Gonadotropin (HCG)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, L-carnitine might decrease the effectiveness of thyroid hormone replacement.

Full L-carnitine + Human Chorionic Gonadotropin (HCG) answer

Can you take Bugleweed with Human Chorionic Gonadotropin (HCG)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, bugleweed may alter thyroid function.

Full Bugleweed + Human Chorionic Gonadotropin (HCG) answer

Can you take Guggul with Human Chorionic Gonadotropin (HCG)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, guggul might increase the risk for adverse effects when taken with thyroid hormone therapy.

Full Guggul + Human Chorionic Gonadotropin (HCG) answer

Can you take Niacin with Human Chorionic Gonadotropin (HCG)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, niacin might antagonize the therapeutic effects of thyroid hormones.

Full Niacin + Human Chorionic Gonadotropin (HCG) answer

Can you take Tyrosine with Human Chorionic Gonadotropin (HCG)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tyrosine might have additive effects with thyroid hormone medications.

Full Tyrosine + Human Chorionic Gonadotropin (HCG) answer

Can you take Alpha-lipoic Acid with Human Chorionic Gonadotropin (HCG)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, alpha-lipoic acid might decrease the effects of thyroid hormone drugs.

Full Alpha-lipoic Acid + Human Chorionic Gonadotropin (HCG) answer

Can you take Ascophyllum Nodosum with Human Chorionic Gonadotropin (HCG)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Due to its iodine content, Ascophyllum nodosum might alter the effects of thyroid hormone.

Full Ascophyllum Nodosum + Human Chorionic Gonadotropin (HCG) answer

Can you take Cassava with Human Chorionic Gonadotropin (HCG)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from human and animal research suggests that cassava root has marked antithyroid effects, particularly if poorly processed or if co...

Full Cassava + Human Chorionic Gonadotropin (HCG) answer

Can you take Dulse with Human Chorionic Gonadotropin (HCG)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, due to its iodine content, dulse might alter the effects of thyroid hormone.

Full Dulse + Human Chorionic Gonadotropin (HCG) answer

Can you take Fucus Vesiculosus with Human Chorionic Gonadotropin (HCG)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Due to its iodine content, Fucus vesiculosus might alter the effects of thyroid hormone.

Full Fucus Vesiculosus + Human Chorionic Gonadotropin (HCG) answer

Can you take Fulvic Acid with Human Chorionic Gonadotropin (HCG)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking fulvic acid with thyroid hormone therapy might interfere with the ability to normalize thyroid function.

Full Fulvic Acid + Human Chorionic Gonadotropin (HCG) answer

Can you take Horseradish with Human Chorionic Gonadotropin (HCG)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, horseradish might interfere with the effects of thyroid hormone.

Full Horseradish + Human Chorionic Gonadotropin (HCG) answer

Can you take Laminaria with Human Chorionic Gonadotropin (HCG)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Due to its iodine content, laminaria might alter the effects of thyroid hormone.

Full Laminaria + Human Chorionic Gonadotropin (HCG) answer

Can you take Lemon Balm with Human Chorionic Gonadotropin (HCG)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, lemon balm might interfere with thyroid hormone replacement therapy.

Full Lemon Balm + Human Chorionic Gonadotropin (HCG) answer

Can you take Propionyl-l-carnitine with Human Chorionic Gonadotropin (HCG)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, acetyl-L-carnitine might decrease the effectiveness of thyroid hormone replacement.

Full Propionyl-l-carnitine + Human Chorionic Gonadotropin (HCG) answer

Can you take Sea Moss with Human Chorionic Gonadotropin (HCG)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Due to its iodine content, sea moss might alter the effects of thyroid hormone.

Full Sea Moss + Human Chorionic Gonadotropin (HCG) answer

Can you take Shepherd's Purse with Human Chorionic Gonadotropin (HCG)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use may interfere with thyroid dysfunction therapy.

Full Shepherd's Purse + Human Chorionic Gonadotropin (HCG) answer

Can you take Bacopa with Human Chorionic Gonadotropin (HCG)?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, bacopa might have additive effects when used with thyroid hormone.

Full Bacopa + Human Chorionic Gonadotropin (HCG) answer

Can you take Tiratricol with Human Chorionic Gonadotropin (HCG)?

Major Use real caution — this is a major-rated interaction, generally best avoided or used only under close supervision. Concomitant use of tiratricol with thyroid hormones may have additive effects.

Full Tiratricol + Human Chorionic Gonadotropin (HCG) answer

Can you take Acetyl-l-carnitine with Human Chorionic Gonadotropin (HCG)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, acetyl-L-carnitine might decrease the effectiveness of thyroid hormone replacement.

Full Acetyl-l-carnitine + Human Chorionic Gonadotropin (HCG) answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Human Chorionic Gonadotropin (HCG) is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Human Chorionic Gonadotropin (HCG), and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Human Chorionic Gonadotropin (HCG) sits in 1 interaction category. Open any one to see what the group means:

Thyroid Hormone 21 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

21 of the supplement ingredients on this page reach Human Chorionic Gonadotropin (HCG) through this category.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Human Chorionic Gonadotropin (HCG)

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Human Chorionic Gonadotropin (HCG).

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Pharmacist Counseling Corner

Human Chorionic Gonadotropin (HCG) & Supplements: Common Questions

What supplements interact with Human Chorionic Gonadotropin (HCG)?
More than you might expect — 21 in total, though they are far from equal: 1 are rated major, 19 moderate, and 1 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Tiratricol, Acetyl-l-carnitine, Ashwagandha.
Which Human Chorionic Gonadotropin (HCG) supplement interactions are the most serious?
The 1 major-rated combination — led by Tiratricol — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Human Chorionic Gonadotropin (HCG)?
Usually yes — most people on Human Chorionic Gonadotropin (HCG) can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Pregnyl have the same supplement interactions as Human Chorionic Gonadotropin (HCG)?
Yes — Pregnyl all contain Human Chorionic Gonadotropin (HCG), so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Human Chorionic Gonadotropin (HCG) and my other medications?
This page covers Human Chorionic Gonadotropin (HCG) against supplements and herbal ingredients. Checking Human Chorionic Gonadotropin (HCG) against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 15, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.