Medication interaction hub

What Supplements Interact with Methaqualone?

Methaqualone brand name: Quaalude. Every interaction below applies to the brands too.

95 Interactions 7 Major 73 Moderate 15 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Methaqualone? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Methaqualone against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Methaqualone (Quaalude) is a heavy sedative, and the people who take it for sleep are often the same ones drawn to calming supplements, which is exactly why this page deserves a wary read. Seventy-eight of its 95 listed ingredients add their own sedation, kava among the strongest, and the worst pairings can suppress breathing, not just deepen drowsiness. Even ordinary beer and wine carry a major rating here, since alcohol both stacks with the drug and can slow its breakdown.

A smaller cluster of 17 interferes with absorption instead; activated charcoal stands out because it can bind methaqualone in the gut and blunt its effect, so keep it well apart from your dose. Seven of the 95 are rated major, and I would read those first; most of the 73 moderate and 15 minor entries echo the sedation problem at lower strength.

— , Clinical Pharmacist · July 18, 2026

Major 7 Moderate 73 Minor 15 No known interaction 1,357

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Methaqualone: Top Interactions at a Glance

The most significant Methaqualone supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 95 interacting ingredients — plus 1,357 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Methaqualone + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Likely Beer + Methaqualonei

Concomitant use may increase sedative and other adverse effects.

Read the full interaction Major Likelihood Likely Wine + Methaqualonei

Concomitant use may increase sedative and other adverse effects.

Read the full interaction Major Likelihood Probable 1,4-butanediol + Methaqualonei

Theoretically, concomitant use of 1,4-butanediol with CNS depressants may potentiate respiratory and CNS depression.

Read the full interaction Major Likelihood Probable Activated Charcoal + Methaqualonei

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.

Read the full interaction Major Likelihood Probable Gamma-hydroxybutyrate (ghb) + Methaqualonei

GHB may increase the risk of serious CNS and respiratory depression.

Read the full interaction Major Likelihood Probable Kava + Methaqualonei

Combining kava with CNS depressants can have additive sedative effects.

Read the full interaction
The complete list

Every Supplement Checked Against Methaqualone

All 1,452 ingredients in our database, ranked by severity — 95 with a Methaqualone interaction on file and 1,357 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Methaqualone?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Black Seed with Methaqualone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with drugs that have sedative properties may cause additive effects.

Full Black Seed + Methaqualone answer

Can you take Kratom with Methaqualone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the risk for adverse CNS depressant effects.

Full Kratom + Methaqualone answer

Can you take Glucomannan with Methaqualone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, glucomannan may decrease absorption of drugs taken orally.

Full Glucomannan + Methaqualone answer

Can you take Yerba Mansa with Methaqualone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might cause additive or prolonged sedative effects.

Full Yerba Mansa + Methaqualone answer

Can you take 5-htp with Methaqualone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of 5-HTP with medications that cause sedation might have additive effects.

Full 5-htp + Methaqualone answer

Can you take Adrue with Methaqualone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research suggests that taking adrue in combination with sodium thiopental or diazepam increases total sleep time up to four-fold comp...

Full Adrue + Methaqualone answer

Can you take Albizia Julibrissin with Methaqualone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research suggests that certain constituents from Albizia julibrissin flowers can potentiate pentobarbital-induced sleeping time in mi...

Full Albizia Julibrissin + Methaqualone answer

Can you take Ashwagandha with Methaqualone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.

Full Ashwagandha + Methaqualone answer

Can you take Bay Leaf with Methaqualone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking bay leaf in large amounts may enhance the therapeutic and adverse effects of sedatives.

Full Bay Leaf + Methaqualone answer

Can you take Berberine with Methaqualone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, berberine might increase the sedative effects of CNS depressants.

Full Berberine + Methaqualone answer

Can you take Bitter Almond with Methaqualone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, bitter almond oil may have additive effects with other CNS depressants.

Full Bitter Almond + Methaqualone answer

Can you take Calamus with Methaqualone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concurrent use of CNS depressants and calamus might have an additive effect and increase the risk of sedative effects.

Full Calamus + Methaqualone answer

Can you take California Poppy with Methaqualone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking California poppy with drugs with sedative effects may increase the risk of sedative effects.

Full California Poppy + Methaqualone answer

Can you take Cannabichromene (cbc) with Methaqualone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Using cannabichromene with drugs that have sedative properties may cause additive therapeutic and adverse effects.

Full Cannabichromene (cbc) + Methaqualone answer

Can you take Cannabidiol (cbd) with Methaqualone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cannabidiol might have additive effects if used with other CNS depressants.

Full Cannabidiol (cbd) + Methaqualone answer

Can you take Cannabis with Methaqualone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cannabis might have additive effects if used with other CNS depressants.

Full Cannabis + Methaqualone answer

Can you take Caraway with Methaqualone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, caraway might increase the effects and adverse effects of CNS depressants.

Full Caraway + Methaqualone answer

Can you take Catnip with Methaqualone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with drugs with sedative properties may cause additive effects and side effects.

Full Catnip + Methaqualone answer

Can you take Cnidium with Methaqualone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In laboratory research, cnidium has been shown to have sedative and hypnotic effects, possibly related to constituent coumarins.

Full Cnidium + Methaqualone answer

Can you take Coriander with Methaqualone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, coriander might cause additive sedative effects when taken with CNS depressants.

Full Coriander + Methaqualone answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Methaqualone is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Methaqualone, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Methaqualone sits in 2 interaction categories. Open any one to see what the group means:

Cns Depressants 78 ingredients

Central-nervous-system depressants. Sedating supplements can intensify drowsiness and slowed reactions when combined.

78 of the supplement ingredients on this page reach Methaqualone through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Methaqualone through this category.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Methaqualone

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Methaqualone.

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Pharmacist Counseling Corner

Methaqualone & Supplements: Common Questions

What supplements interact with Methaqualone?
More than you might expect — 95 in total, though they are far from equal: 7 are rated major, 73 moderate, and 15 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Beer, Wine, 1,4-butanediol.
Which Methaqualone supplement interactions are the most serious?
Focus on the major group: Beer, Wine, 1,4-butanediol, Activated Charcoal and Gamma-hydroxybutyrate (ghb), among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Methaqualone?
Usually yes — most people on Methaqualone can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Quaalude have the same supplement interactions as Methaqualone?
Yes — Quaalude all contain Methaqualone, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Methaqualone and my other medications?
This page covers Methaqualone against supplements and herbal ingredients. Checking Methaqualone against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.