Medication interaction hub

What Supplements Interact with Prasterone (prescription drug)?

Prasterone (prescription drug) brand name: Intrarosa. Every interaction below applies to the brands too.

63 Interactions 1 Major 56 Moderate 6 Minor
Curated & coded by · Clinical Pharmacist · Updated October 7, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Prasterone (prescription drug)? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Prasterone (prescription drug) against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Grapefruit is the single major-rated interaction on prasterone's (Intrarosa) list, and it earns that spot. It blocks the enzyme that clears estrogens, so estrogen levels can climb, and side effects with them. Because prasterone is a vaginal insert the body converts to estrogen (prescribed for painful intercourse after menopause), 60 of the 63 supplements here connect through estrogen in some way, and this is a list that calls for real caution rather than a quick skim.

The other 56 moderate entries and six minors mostly follow two patterns. Everyday caffeine matters because estrogen slows its breakdown, so a normal cup of coffee can hit harder and linger. Plant estrogens like red clover may compete at the same receptors and weaken the therapy, and a few ingredients can nudge estrogen levels higher still. Three entries involve other topical products. If grapefruit juice is part of your morning, raise that pairing with your pharmacist first.

— , Clinical Pharmacist · July 18, 2026

Major 1 Moderate 56 Minor 6 No known interaction 1,389

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Top Ingredient Interactions

Prasterone (prescription drug): Top Interactions at a Glance

The most significant Prasterone (prescription drug) supplement & herbal interactions, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 63 interacting ingredients — plus 1,389 more checked with no known interaction. See the complete ranked list.

Start here

The Major Interactions to Know About

The most clinically significant Prasterone (prescription drug) + supplement combinations in our database, best-documented first. Open any card for the full report.

Major Likelihood Probable Grapefruit + Prasterone (prescription drug)i

Grapefruit juice can increase blood levels of estrogens, potentially increasing the effects and adverse effects of estrogens.

Read the full interaction
The complete list

Every Supplement Checked Against Prasterone (prescription drug)

All 1,452 ingredients in our database, ranked by severity — 63 with a Prasterone (prescription drug) interaction on file and 1,389 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Prasterone (prescription drug)?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Hemp with Prasterone (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.

Full Hemp + Prasterone (prescription drug) answer

Can you take Hops with Prasterone (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of large amounts of hops might interfere with hormone replacement therapy due to competition for estrogen rec...

Full Hops + Prasterone (prescription drug) answer

Can you take Horny Goat Weed with Prasterone (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of horny goat weed with estrogens might increase their therapeutic and adverse effects.

Full Horny Goat Weed + Prasterone (prescription drug) answer

Can you take Hu Zhang with Prasterone (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, hu zhang might competitively inhibit the effects of estrogen replacement therapy.

Full Hu Zhang + Prasterone (prescription drug) answer

Can you take Indole-3-carbinol with Prasterone (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Indole-3-carbinol might interfere with the effects of estrogen therapy.

Full Indole-3-carbinol + Prasterone (prescription drug) answer

Can you take Kudzu with Prasterone (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, kudzu might alter the effects of estrogen therapy.

Full Kudzu + Prasterone (prescription drug) answer

Can you take Licorice with Prasterone (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, licorice might increase or decrease the effects of estrogen therapy.

Full Licorice + Prasterone (prescription drug) answer

Can you take Panax Ginseng with Prasterone (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of large amounts of Panax ginseng might interfere with hormone replacement therapy.

Full Panax Ginseng + Prasterone (prescription drug) answer

Can you take Peony with Prasterone (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of large amounts of peony might interfere with hormone replacement therapy and/or increase the risk for estro...

Full Peony + Prasterone (prescription drug) answer

Can you take Pleurisy Root with Prasterone (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, excessive amounts of pleurisy root might interfere with hormone drug therapy.

Full Pleurisy Root + Prasterone (prescription drug) answer

Can you take Pregnenolone with Prasterone (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking pregnenolone might enhance the effects of estrogens.

Full Pregnenolone + Prasterone (prescription drug) answer

Can you take Progesterone with Prasterone (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, using estrogen along with progesterone supplements or non-prescription bioidentical progesterone products might alter the eff...

Full Progesterone + Prasterone (prescription drug) answer

Can you take Rose Hip with Prasterone (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, rose hip might increase blood levels of estrogens.

Full Rose Hip + Prasterone (prescription drug) answer

Can you take Sage with Prasterone (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, sage might interfere with hormone therapy.

Full Sage + Prasterone (prescription drug) answer

Can you take Saw Palmetto with Prasterone (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Saw palmetto might reduce the effectiveness of estrogens.

Full Saw Palmetto + Prasterone (prescription drug) answer

Can you take Senna with Prasterone (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking senna may interfere with the absorption of exogenous estrogens.

Full Senna + Prasterone (prescription drug) answer

Can you take Soy with Prasterone (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, soy might competitively inhibit the effects of estrogen replacement therapy.

Full Soy + Prasterone (prescription drug) answer

Can you take Strontium with Prasterone (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, estrogens might reduce the excretion of strontium, potentially increasing its effects and adverse effects.

Full Strontium + Prasterone (prescription drug) answer

Can you take Thyme with Prasterone (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, thyme might competitively inhibit the effects of estrogen replacement therapy.

Full Thyme + Prasterone (prescription drug) answer

Can you take Turpentine Oil with Prasterone (prescription drug)?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Some in vitro research shows that alpha-pinene, the major constituent of turpentine oil, does not increase the absorption of chlorpromazine...

Full Turpentine Oil + Prasterone (prescription drug) answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Prasterone (prescription drug) is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Prasterone (prescription drug), and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Prasterone (prescription drug) sits in 2 interaction categories. Open any one to see what the group means:

Estrogens 60 ingredients

Hormone-related medications. Supplements with hormone-like activity can add to or interfere with them.

60 of the supplement ingredients on this page reach Prasterone (prescription drug) through this category.

Topical Drugs 3 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

3 of the supplement ingredients on this page reach Prasterone (prescription drug) through this category.

About Prasterone (prescription drug)

Prasterone vaginal is a steroid used to treat moderate to severe painful intercourse caused by vaginal and vulvar tissue changes due to menopause.

Generic name: Prasterone (prescription drug)  ·  Brand name: Intrarosa.

See the full Prasterone Vaginal drug information

Related: does Prasterone (prescription drug) deplete any nutrients?

Prasterone (prescription drug) has 5 reported nutrient associations in the research literature — see the Prasterone (prescription drug) nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Prasterone (prescription drug)

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Prasterone (prescription drug).

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Pharmacist Counseling Corner

Prasterone (prescription drug) & Supplements: Common Questions

What supplements interact with Prasterone (prescription drug)?
More than you might expect — 63 in total, though they are far from equal: 1 are rated major, 56 moderate, and 6 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Grapefruit, Black Tea, Caffeine.
Which Prasterone (prescription drug) supplement interactions are the most serious?
The 1 major-rated combination — led by Grapefruit — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Prasterone (prescription drug)?
Usually yes — most people on Prasterone (prescription drug) can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Intrarosa have the same supplement interactions as Prasterone (prescription drug)?
Yes — Intrarosa all contain Prasterone (prescription drug), so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Prasterone (prescription drug) deplete any vitamins or nutrients?
It might — Prasterone (prescription drug) has 5 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Prasterone (prescription drug) nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Prasterone (prescription drug) and my other medications?
This page covers Prasterone (prescription drug) against supplements and herbal ingredients. Checking Prasterone (prescription drug) against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Prasterone Vaginal drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of October 7, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.