Drug & supplement interaction

Flaxseed + Prasterone (prescription drug)

Prasterone (prescription drug) brand name: Intrarosa.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Flaxseed has a moderate interaction with Prasterone (prescription drug). Theoretically, taking flaxseed might decrease the effects of estrogens.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Flaxseed and Prasterone (prescription drug)

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ESTROGENS

Why this applies to Prasterone (prescription drug)

Prasterone (prescription drug) falls under ESTROGENS — the group Flaxseed interacts with.

Theoretically, taking flaxseed might decrease the effects of estrogens.
Flaxseed contains lignans with mild estrogenic and possible antiestrogenic effects. The lignans seem to compete with circulating endogenous estrogen and might reduce estrogen binding to estrogen receptors, resulting in an anti-estrogen effect. It is unclear if this effect transfers to exogenously administered estrogens.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist with Intrarosa (prasterone): it's a vaginal insert your body turns into estrogen and testosterone right in the vaginal tissue to ease dryness and painful intercourse after menopause. Flaxseed contains plant compounds called lignans that act weakly on estrogen receptors, so in theory they could nudge against estrogen's effect.

The honest truth is this concern is theoretical and based only on how these compounds behave in the lab, not on real-world cases with prasterone. Since Intrarosa works mostly right where it's placed, a flaxseed effect on it is unlikely to be meaningful. At worst, you might notice less relief from dryness or discomfort. Eating flaxseed as a food is very unlikely to matter. If you use concentrated supplements, just mention it to your pharmacist or doctor.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Mousavi Y, Adlercreutz H. Enterolactone and estradiol inhibit each other's proliferative effect on MCF-7 breast cancer cells in culture. J Steroid Biochem Mol Biol 1992;41:615-9.. PubMed
  2. Rose DP. Dietary fiber and breast cancer. Nutr Cancer 1990;13:1-8.. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Flaxseed Also Interacts With Other Medications

Flaxseed has 596 moderate known drug interactions in our database — the Prasterone (prescription drug) one above is one of them. If you take anything else, check it against the full list below.

Moderate 596 No known interaction 2,234 (incl. Prasterone (prescription drug))
Taking anything else?

Check Another of Your Medications Against Flaxseed

Covers the 2,830 medications we’ve checked against Flaxseed. Pick one to open its full report.

From our Q&A

Questions About Flaxseed or Prasterone (prescription drug)

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Flaxseed or Prasterone (prescription drug), not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Prasterone (prescription drug)

This page covers Flaxseed only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Prasterone (prescription drug) page lists 63 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Grapefruit (major), Aletris (moderate), Alfalfa (moderate), Androstenediol (moderate) and Androstenedione (moderate).

By severity: 1 major · 56 moderate · 6 minor.

From our pharmacist’s overview on the Prasterone (prescription drug) page

“Grapefruit is the single major-rated interaction on prasterone's (Intrarosa) list, and it earns that spot. It blocks the enzyme that clears estrogens, so estrogen levels can climb, and side effects with them.”

Reviewed by 2 · Jul 18, 2026

Open the Prasterone (prescription drug) interaction page

One more smart check

Taking Flaxseed as Part of a Dietary Supplement Product? Check It for Interactions

We hold 236 real supplement products containing Flaxseed, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Flaxseed. Your product may carry other ingredients that interact with Prasterone (prescription drug) too, on top of Flaxseed — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Flaxseed and Prasterone (prescription drug) Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Flaxseed
Top half

#403 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Prasterone (prescription drug)
Top 10%

#200 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Flaxseed

What is Flaxseed?

Flaxseed
  • Constipation and digestive health
  • High cholesterol
  • Heart health
  • Menopausal symptoms
  • Blood sugar support

Flaxseed is a nutritious food rich in fiber, omega-3 fats (ALA), and plant compounds called lignans. It is most reliably helpful for constipation and may modestly lower cholesterol, but evidence for many other uses is mixed or limited. It is generally safe as a food, but talk to your pharmacist or doctor before using it as a supplement, especially if you are pregnant or breastfeeding.

Read the full Flaxseed monograph & all interactions
Medication

About Prasterone Vaginal

What Is Prasterone Vaginal Used For?

Brand name: Intrarosa

Intrarosa (prasterone) vaginal insert is used to treat moderate to severe dyspareunia — that is, pain during sex — which is a symptom of vulvar and vaginal atrophy (thinning and drying of vaginal tissues) caused by menopause.

See full Prasterone Vaginal drug information
Keep checking

Other Drugs & Flaxseed

Browse every other medication we’ve checked against Flaxseed — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
596Moderate
0Minor
2,233No known interaction
596 Moderate 2,233 No interaction
Moderate

596 interactions

Showing 60 of 596 moderate interactions — see all 596 on the Flaxseed page.

No interaction 2,233 drugs checked — show the list

We also checked Flaxseed against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,233 medications checked with no known interaction — see the full Flaxseed list.

See the full Flaxseed interactions page
See every supplement checked against Prasterone (prescription drug), ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Flaxseed monograph › Uses, safety, and every drug interaction in one place Prasterone (prescription drug) supplement interactions › Every supplement checked against Prasterone (prescription drug), ranked by severity Prasterone Vaginal drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Flaxseed and Prasterone (prescription drug) Together: Common Questions

Can you take Flaxseed with Prasterone (prescription drug)?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Flaxseed and Prasterone (prescription drug) interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Prasterone (prescription drug) and Flaxseed?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.