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Dietary supplement

5-Loxin 200 mg Ingredients & Drug Interactions

by SuperSmart

5-Loxin 200 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking 5-Loxin 200 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

5-Loxin 200 mg is a dietary supplement by SuperSmart with 1 active ingredient. Its ingredients are commonly taken for osteoarthritis joint pain, rheumatoid arthritis, inflammation.Based on those ingredients, 952 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are 5-Loxin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against 5-Loxin 200 mg by SuperSmart

Ask about any prescription or over-the-counter medication and we check it for interactions with 5-Loxin 200 mg by SuperSmart — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of 5-Loxin 200 mg by SuperSmart

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains a single active ingredient: 5-Loxin, a standardized extract of Boswellia serrata gum resin. The capsule is filled with inactive ingredients including hypromellose (a capsule coating), acacia gum, and white rice flour.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Joint pain and inflammation support.
  • We looked for evidence on: Osteoarthritis, Rheumatoid arthritis (RA), Knee pain.
  • The strongest evidence on file: Boswellia Serrata is rated "Possibly Effective" for Osteoarthritis (Natural Medicines).
  • Also on file: Boswellia Serrata is rated "Insufficient Reliable Evidence To Rate" for Rheumatoid arthritis (RA), Knee pain.

The evidence for 5-Loxin is strongest for osteoarthritis, where it's rated possibly effective — meaning there's some clinical support, though not yet conclusive. For allergic rhinitis (hay fever), Alzheimer disease, asthma, and cluster headache, the reliable evidence is insufficient to rate whether it works.

The data we hold doesn't establish its effectiveness for other uses.

The evidence, ingredient by ingredient Boswellia Serrata

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Boswellia serrata taken by mouth is generally well tolerated in the short term, though quality and dose vary widely between products — so consistency matters. The most common side effects are mild: abdominal pain, diarrhea, headache, heartburn, itching, and nausea.

In one clinical study, nearly 11% of people taking a specific Boswellia extract reported headache; dizziness and vertigo were also reported at lower rates. Rarely, very large amounts of the gum resin can cause a bezoar (a mass of plant material blocking the gut).

During pregnancy, there isn't enough safety data, so it's best avoided. While breastfeeding, safety is unknown, so it's best to avoid it as well.

Side effects, ingredient by ingredient Boswellia Serrata

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Boswellia Serrata.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs.
  • For scale: 953 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take 5-Loxin, check any medications that are metabolized by liver enzymes CYP2D6, CYP2C19, CYP1A2, CYP2C9, or CYP3A4 — this includes many common heart, psychiatric, and pain medications. Also check if you're on immunosuppressants or any immune-modulating drugs.

Use the interaction checker on this page with your exact medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

5-Loxin may be worth considering if you have osteoarthritis and want to try a botanical approach, but you'll need to check it against any medications you're on — it affects how your liver processes a large number of drugs. If you're on heart, blood pressure, or psychiatric medications, or anything that suppresses your immune system, talk with your pharmacist or doctor before starting.

Pregnant or breastfeeding? Skip it until you've had that conversation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about 5-Loxin 200 mg, straight from the product label.

Brand SuperSmart
Barcode (UPC) 5453003824749
Net contents 90 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Jun 25, 2025
DSLD ID 332595
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for 5-Loxin 200 mg by SuperSmart, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
45
UPC/BARCODE
5453003824749
IngredientAmount% DV
5-Loxin200 mg--

Other ingredients: Hypromellose, Acacia Gum, White Rice Flour

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

5-Loxin is a registered trademark of PL Thomas & Co. Inc.

FDA Statement of Identity

Dietary Supplement

Formula

5-Loxin 200 mg per day

Each capsule contains 100 mg of 5-Loxin.

Formulation

Guarantees: Vegan, non-GMO, gluten free, soy free, dairy free.

Guarantees: Vegan, non-GMO, gluten free, soy free, dairy free. No coloring, preservatives, or flavorings.

FDA registered lab, Good Manufacturing Practice, made in USA.

Suggested/Recommended/Usage/Directions

Directions: Adults. As a supplement, take 1 capsule two times daily or as directed by the practitioner.

Precautions

Cautions: Keep out of reach of children.

Consult a healthcare provider before using this product if pregnant, breastfeeding, or having health concerns.

Tamper evident: Do not use if seal under cap is broken or missing.

Storage

Store in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

5-Loxin 200 mg by SuperSmart label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

5-Loxin 200 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in 5-Loxin 200 mg by SuperSmart

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container45 Amounts shown are per serving.

5-Loxin

Interacts with
952 drugs
200 mg per serving Form: Boswellia serrata Resin Extract

Boswellia serrata is a tree resin used in traditional medicine, mainly for joint pain and inflammation. Some studies suggest it may help with osteoart...

5-Loxin monograph & interactions

Other (inactive) ingredients: Hypromellose, Acacia Gum, White Rice Flour. These complete the product’s ingredient list but are not active constituents.

Interaction report

5-Loxin 200 mg by SuperSmart Drug Interactions

Want to check YOUR meds against 5-Loxin 200 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
952Drugs
952 Moderate

Ingredients driving the most interactions

5-Loxin 952

Individual Drug Interactions

The ingredients in 5-Loxin 200 mg interact with 952 drugs. Click any drug to see the details.

1 of the 1 ingredient in 5-Loxin 200 mg interact with drugs. Each result below shows which ingredient is responsible. 5-Loxin

Each ingredient & the kinds of drugs it affects

For each ingredient in 5-Loxin 200 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

5-Loxin6 drug types · 952 drugs

Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP1A2 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, Boswellia serrata might increase the levels of CYP2C19 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP2C19 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, Boswellia serrata might increase the levels of CYP2C9 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP2C9 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, Boswellia serrata might increase the levels of CYP2D6 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP2D6 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, Boswellia serrata might increase or decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP3A4 enzymes. Other in vitro research shows that Boswellia serrata extract inhibits CYP3A4 enzymes at most concentrations, although it may modestly induce enzyme activity at low concentrations.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, Boswellia serrata might alter the effects of immunosuppressive drugs.
Some in vitro research suggests that Boswellia serrata extracts might inhibit mediators of autoimmune disorders such as leukotrienes and reduce production of antibodies and cell-mediated immunity. However, other in vitro research suggests that, when coupled with calcium ions, boswellic acids containing the keto group have immunostimulant properties within specific cell signaling pathways.

Likelihood Possible Evidence D
5-Loxin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for 5-Loxin 200 mg, from the product label.

SuperSmart

See all SuperSmart products
Name
SuperSmart USA LLC
City
Miami
State
FL
ZipCode
33130
Phone Number
1 (786) 522-3907
Web Address
us.SuperSmart.com
Pharmacist Counseling Corner

5-Loxin 200 mg by SuperSmart: Common Questions

Does 5-Loxin 200 mg by SuperSmart interact with any medications?
Yes. Based on its ingredients, 5-Loxin 200 mg has a known interaction with 952 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
5-Loxin 200 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does 5-Loxin actually work for arthritis?
For osteoarthritis specifically, it's rated possibly effective — there's clinical evidence to support it, but the research isn't yet definitive. For other types of arthritis or joint conditions, the evidence hasn't been established in our data.
What are the most common side effects?
The mild ones you're most likely to notice are stomach upset — abdominal pain, diarrhea, nausea, heartburn — plus headache, itching, or dizziness. Most people tolerate it without trouble, but stomach symptoms are the ones to watch for.
Can I take this while pregnant or breastfeeding?
During pregnancy, there isn't enough safety data, so it's best avoided. While breastfeeding, safety is also unknown, so avoid it too. Talk with your doctor or pharmacist about safer options.
Why does this interact with so many medications?
5-Loxin affects multiple liver enzyme systems that break down many different drugs — think of it like jamming the processing centers your body uses to clear medications. That's why you need to check your specific prescriptions before starting.
How long can I safely take 5-Loxin?
The safety data we hold supports short-term use — it's generally well tolerated for that window. For long-term use, quality and dosing vary widely between products, so chat with your pharmacist about which brand and how long is right for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if 5-Loxin 200 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

5-Loxin 200 mg label
Go deeper

The Full Monographs Behind 5-Loxin 200 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Boswellia Serrata

Interacts with 952 drugs

Boswellia serrata is a tree resin used in traditional medicine, mainly for joint pain and inflammation. Some studies suggest it may help with osteoarthritis symptoms, but the overall evidenc...

Read the full Boswellia Serrata monograph →
Sources

Sources & How We Checked

5-Loxin 200 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 16 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Boswellia Serrata 16 references
  1. Gupta I, Gupta V, Parihar A, et al. Effects of Boswellia serrata gum resin in patients with bronchial asthma: results of a double-blind, placebo-controlled, 6-week clinical study. Eur J Med Res 1998;3:511-4.
  2. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  3. Kimmatkar N, Thawani V, Hingorani L, et al. Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee--a randomized double blind placebo controlled trial. Phytomedicine 2003;10:3-7. PubMed
  4. Liu JJ, Nilsson A, Oredsson S, et al. Boswellic acids trigger apoptosis via a pathway dependent on caspase-8 activation but independent on Fas/Fas ligand interaction in colon cancer HT-29 cells. Carcinogenesis 2002;23:2087-93. PubMed
  5. Wildfeuer A, Neu IS, Safayhi H, et al. Effects of boswellic acids extracted from a herbal medicine on the biosynthesis of leukotrienes and the course of experimental autoimmune encephalomyelitis. Arzneimittelforschung 1998;48:668-74.
  6. Gupta I, Parihar A, Malhotra P, et al. Effects of gum resin of Boswellia serrata in patients with chronic colitis. Planta Med 2001;67:391-5. PubMed
  7. Sengupta K, Alluri KV, Satish AR, et al. A double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin. Arthritis Res Ther 2008;10:R85.
  8. Sengupta K, Krishnaraju AV, Vishal AA, et al. Comparative efficacy and tolerability of 5-Loxin and Aflapin against osteoarthritis of the knee: a double blind, randomized, placebo controlled clinical study. Int J Med Sci 2010;7:366-77.
  9. Ernst E. Frankincense: systematic review. BMJ 2008;337:a2813. PubMed
  10. Kirste S, Treier M, Wehrle SJ, et al. Boswellia serratea extract acts on cerebral edema in patients irradiated for brain tumors: a prospective, randomized, placebo-controlled, double-blind pilot trial. Cancer 2011;117:3788-95.
  11. Frank A, Unger M. Analysis of frankincense from various Boswellia species with inhibitory activity on human drug metabolising cytochrome P450 enzymes using liquid chromatography mass spectrometry after automated on-line extraction. J Chromatogr A 2006;111 PubMed
  12. Altmann A, Poeckel D, Fischer L, et al. Coupling of boswellic acid-incuded Ca2+ mobilisation and MAPK activation to lipid metabolism and peroxide formation in human leucocytes. Br J Pharmacol 2004;141:223-32.
  13. El Fortia, M., Badi, H., Elalem, Kh, Kadiki, O., and Topov, Y. Olibanum bezoar: complication of a traditional popular medicine. East Mediterr.Health J 2006;12(6):927-929.
  14. Meshkat S, Mahmoodi Baram S, Rajaei S, et al. Boswellia serrata extract shows cognitive benefits in a double-blind, randomized, placebo-controlled pilot clinical trial in individuals who suffered traumatic brain injury. Brain Inj 2022;36(4):553-559. PubMed
  15. Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed
  16. Valente IVB, Garcia D, Abbott A, et al. The anti-proliferative effects of a frankincense extract in a window of opportunity phase ia clinical trial for patients with breast cancer. Breast Cancer Res Treat 2024;204(3):521-530. PubMed

See these in context on the Boswellia Serrata monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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