Major interaction on record — check this product against your medications before combining. Based on 2 of 4 ingredients. Check your meds →
Dietary supplement

Advanced Therapeutics Ribose Rx-Energy Ingredients & Drug Interactions

by Nature's Plus

Advanced Therapeutics Ribose Rx-Energy label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Advanced Therapeutics Ribose Rx-Energy against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Advanced Therapeutics Ribose Rx-Energy is a dietary supplement by Nature's Plus with 4 active ingredients. Its ingredients are commonly taken for energy and fatigue, athletic performance and recovery, fibromyalgia symptoms.Based on those ingredients, 133 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are D-Ribose, AMP. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Advanced Therapeutics Ribose Rx-Energy by Nature's Plus

Ask about any prescription or over-the-counter medication and we check it for interactions with Advanced Therapeutics Ribose Rx-Energy by Nature's Plus — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Advanced Therapeutics Ribose Rx-Energy by Nature's Plus

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This supplement has two active ingredients. D-Ribose is a simple sugar your cells use for energy production.

AMP (also called adenosine) is a nucleotide — a building block that helps regulate energy and cellular signaling. The product also contains several inactive ingredients: microcrystalline cellulose, di-calcium phosphate, stearic acid, magnesium stearate, silica, and pharmaceutical glaze, which serve as fillers and binders to hold the tablet together.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: nutritional support for energy production and recovery.
  • We looked for evidence on: Athletic performance, Chronic fatigue syndrome (CFS), Fibromyalgia, Muscle soreness, Myocardial Infarction (MI), Congestive heart failure (CHF) — and 4 related terms.
  • The closest evidence on file: Ribose is rated "Possibly Ineffective" for Athletic performance (Natural Medicines).
  • Also on file: Adenosine is rated "Possibly Ineffective" for Myocardial Infarction (MI).
  • Also on file: Ribose is rated "Insufficient Reliable Evidence To Rate" for Coronary heart disease (CHD), Chronic fatigue syndrome (CFS), Congestive heart failure (CHF), Fibromyalgia, and more.

The evidence for D-Ribose is limited. It's rated possibly ineffective for athletic performance.

For restless legs syndrome, muscle soreness, heart failure, and recovery after heart bypass surgery, we don't have enough reliable evidence to rate it one way or the other. For the AMP ingredient, the research is strong but narrow — it's effective for treating a specific type of rapid heartbeat (paroxysmal supraventricular tachycardia) and for diagnostic heart imaging.

Those benefits come from the prescription injectable form given by a doctor, not from oral supplement use. The safety evidence for taking AMP as an oral supplement is very limited, so we can't reliably say how it works in that form.

The evidence, ingredient by ingredient Ribose Adenosine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

D-Ribose is generally well tolerated for short periods, but long-term safety hasn't been well studied. It can lower your blood sugar, so be cautious if you have diabetes or borderline blood sugar issues.

Common side effects include diarrhea, stomach discomfort, headache, nausea, and low blood sugar. A small number of people reported anxiety or lightheadedness, which sometimes improved when they lowered their dose.

For the AMP ingredient, oral and intramuscular safety data is very limited — the prescription injectable form can cause chest pain, dizziness, breathing problems, facial flushing, headache, low blood pressure, nausea, and in rare cases, serious heart rhythm problems. There isn't enough safety information to recommend either ingredient during pregnancy or while breastfeeding.

Side effects, ingredient by ingredient Ribose Adenosine

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Ribose, Adenosine.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 133 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, check with your pharmacist if you use dipyridamole (Persantine) — this is a Major interaction. Also double-check if you take diabetes medications, insulin, carbamazepine (Tegretol), or methylxanthines like caffeine, aminophylline, or theophylline.

These are Moderate or Minor concerns, but they matter.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.

This product is marketed for energy and may appeal to people interested in cellular energy support, but the evidence for its claimed uses is weak or absent. If you take diabetes medication, insulin, heart medications (especially dipyridamole), anti-seizure drugs, or caffeine-containing products, you need to check with us first.

Talk to your pharmacist before starting, especially if you're pregnant, breastfeeding, or have heart or blood-sugar concerns.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 1, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Advanced Therapeutics Ribose Rx-Energy, straight from the product label.

Brand Nature's Plus
Barcode (UPC) 097467049918
Net contents 60 Tablet(s)
Market status On market
Date entered into DSLD Oct 1, 2012
DSLD ID 13579
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Advanced Therapeutics Ribose Rx-Energy by Nature's Plus, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
UPC/BARCODE
097467049918
IngredientAmount% DV
Calories5 {Calories}--
Sugar1 g--
D-Ribose1100 mg--
Carbohydrates1 g1%
AMP1000 mcg--

Other ingredients: Microcrystalline Cellulose, Di-Calcium Phosphate, Stearic Acid, Magnesium Stearate, Silica, Pharmaceutical Glaze

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

DIRECTIONS: As a dietary supplement, one tablet twice daily or as recommended by your health care professional.

Precautions

Do not use if you are pregnant or nursing without consulting a physician.

THIS IS NOT A PRESCRIPTION PRODUCT. It is a dietary supplement made with the highest possible quality standards.

KEEP OUT OF REACH OF CHILDREN.

General Statements

Advanced Therapeutics Ribose Rx-Energy is a precisely calibrated nutritional formulation born from leading-edge scientific studies and clinical evaluation. Each mega-potency tablet provides pure D-ribose, a naturally occurring pentose monosaccharide, and AMP, an essential adenine nucleotide. Ribose Rx-Energy is a unique specialty formula designed for any individual concerned with promoting optimal energy levels.

Nutritional Support for Energy Production and Recovery.*

FDA Statement of Identity

D-RIBOSE SUPPLEMENT

Formulation

Free from artificial colors and preservatives.

Storage

KEEP TIGHTLY CLOSED IN A COOL, DRY PLACE.

FDA Disclaimer Statement

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

RiboCell(R)

GLUTEN Free

Brand IP Statement(s)

Ribocell is a trademark of Nutratech, Inc.

The Energy Supplements(R)

(C)NATURAL ORGANICS(R)

General

PRODUCT NO. 4991 LBL. 1129971

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Advanced Therapeutics Ribose Rx-Energy by Nature's Plus label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Advanced Therapeutics Ribose Rx-Energy label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Advanced Therapeutics Ribose Rx-Energy by Nature's Plus

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sugar

1 g per serving

D-Ribose

Interacts with
86 drugs
1100 mg per serving

Ribose (D-ribose) is a simple sugar your body makes naturally and uses to build energy molecules like ATP. Some people take it for fatigue, fibromyalg...

D-Ribose monograph & interactions

Carbohydrates

1 g per serving

AMP

Interacts with
47 drugs
1000 mcg per serving

Adenosine is a natural building block your body uses for energy and cell signaling, and a prescription injectable version is used by doctors to treat...

AMP monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Di-Calcium Phosphate, Stearic Acid, Magnesium Stearate, Silica, Pharmaceutical Glaze. These complete the product’s ingredient list but are not active constituents.

Interaction report

Advanced Therapeutics Ribose Rx-Energy by Nature's Plus Drug Interactions

Want to check YOUR meds against Advanced Therapeutics Ribose Rx-Energy?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
133Drugs
2 Major 87 Moderate 44 Minor

Ingredients driving the most interactions

D-Ribose 86
AMP 47

Individual Drug Interactions

The ingredients in Advanced Therapeutics Ribose Rx-Energy interact with 133 drugs. Click any drug to see the details.

2 of the 4 ingredients in Advanced Therapeutics Ribose Rx-Energy interact with drugs. Each result below shows which ingredient is responsible. D-Ribose AMP

Each ingredient & the kinds of drugs it affects

For each ingredient in Advanced Therapeutics Ribose Rx-Energy with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

D-Ribose2 drug types · 86 drugs

Antidiabetes Drugs

Theoretically, taking ribose in combination with antidiabetes drugs might increase the risk of hypoglycemia.
In clinical research, ribose decreases serum glucose levels in a dose-dependent manner.

Likelihood Probable Evidence B
Insulin

Theoretically, taking ribose with insulin could increase the hypoglycemic effect of insulin.
In clinical pharmacokinetic studies, oral administration of ribose modestly increased serum insulin levels.

Likelihood Possible Evidence B
D-Ribose full monograph & interactions

AMP3 drug types · 47 drugs

Dipyridamole (Persantine)

Dipyridamole can increase the therapeutic and toxic effects of adenosine.
Dipyridamole decreases the metabolism of adenosine. Intravenous infusion of adenosine in patients who are taking dipyridamole can cause dizziness, bradycardia, and syncope. Dipyridamole should be discontinued for several days prior to a cardiac stress test using adenosine.

Likelihood Likely Evidence D
Carbamazepine (Tegretol)

Carbamazepine might increase the risk of heart block when used concomitantly with adenosine.
Carbamazepine and adenosine can both cause heart block. Giving them concurrently might produce an additive effect.

Likelihood Possible Evidence D
Methylxanthines

Methylxanthines are competitive antagonists of adenosine and can block its pharmacologic effects.
The methylxanthines, aminophylline, caffeine, and theophylline, can block the effects of adenosine by acting as competitive antagonists at adenosine cell surface receptors. It is recommended that methylxanthines be avoided for 24 hours prior to cardiac stress tests.

Likelihood Possible Evidence D
AMP full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Advanced Therapeutics Ribose Rx-Energy, from the product label.

Nature's Plus

See all Nature's Plus products
Name
Natural Organics Laboratories, Inc. makers of Nature's Plus
Street Address
9500 New Horizons Blvd.
City
Amityville
State
New York
ZipCode
11701
Web Address
www.naturesplus.com
Pharmacist Counseling Corner

Advanced Therapeutics Ribose Rx-Energy by Nature's Plus: Common Questions

Does Advanced Therapeutics Ribose Rx-Energy by Nature's Plus interact with any medications?
Yes. Based on its ingredients, Advanced Therapeutics Ribose Rx-Energy has a known interaction with 133 medications, including 2 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Advanced Therapeutics Ribose Rx-Energy contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this lower my blood sugar?
D-Ribose can lower blood glucose levels, especially at higher doses. If you have diabetes or prediabetes, that's a real concern — you should talk with your doctor or pharmacist before starting.
What are the most common side effects?
Diarrhea, stomach discomfort, headache, and nausea are the most frequent. A few people have reported lightheadedness or an anxious feeling, and lowering the dose resolved those issues in some cases.
Is this safe during pregnancy?
There isn't enough safety information for either ingredient during pregnancy. You should avoid this product and talk with your doctor about whether it's right for you.
Can I use this while breastfeeding?
No, there isn't enough safety data. Both ingredients should be avoided while you're breastfeeding — check with your pharmacist or doctor about safer alternatives.
Does this actually improve athletic performance?
D-Ribose is rated possibly ineffective for athletic performance based on the evidence we have. If boosting endurance or recovery is your goal, the data doesn't support that claim.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Advanced Therapeutics Ribose Rx-Energy is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Advanced Therapeutics Ribose Rx-Energy label
Go deeper

The Full Monographs Behind Advanced Therapeutics Ribose Rx-Energy’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Ribose

Interacts with 86 drugs

Ribose (D-ribose) is a simple sugar your body makes naturally and uses to build energy molecules like ATP. Some people take it for fatigue, fibromyalgia, exercise recovery, or heart conditio...

Read the full Ribose monograph → Herb & supplement monograph

Adenosine

Interacts with 47 drugs

Adenosine is a natural building block your body uses for energy and cell signaling, and a prescription injectable version is used by doctors to treat certain fast heart rhythms. As an over-t...

Read the full Adenosine monograph →
Sources

Sources & How We Checked

Advanced Therapeutics Ribose Rx-Energy's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 18 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Ribose 8 references
  1. Segal S, Foley J. The metabolism of D-ribose in man. J Clin Invest 1958;37:719-35. PubMed
  2. Perlmutter NS, Wilson RA, Angello DA, et al. Ribose facilitates thallium-201 redistribution in patients with coronary artery disease. J Nucl Med 1991;32:193-200.
  3. Hegewald MG, Palac RT, Angello DA, et al. Ribose infusion accelerates thallium redistribution with early imaging compared with late 24-hour imaging without ribose. J Am Coll Cardiol 1991;18:1671-81. PubMed
  4. Pliml W, von Arnim T, Stalein A, et al. Effects of ribose on excercise-induced ischaemia in stable coronary artery disease. Lancet 1992;340:507-10.
  5. Burke ER. D-Ribose What You Need To Know. Garden City Park, NY: Avery Publishing Group 1999;1-43.
  6. Gross M, Reiter S, Zollner N. Metabolism of D-ribose administered continuously to healthy persons and to patients with myoadenylate deaminase deficiency. Klin Wochenschr 1989;67:1205-13. PubMed
  7. Teitelbaum JE, Johnson C, St Cyr J. The use of D-ribose in chronic fatigue syndrome and fibromyalgia: a pilot study. J Altern Complement Med 2006;12:857-62. PubMed
  8. Thompson J, Neutel J, Homer K, Tempero K, Shah A, Khankari R. Evaluation of D-ribose pharmacokinetics, dose proportionality, food effect, and pharmacodynamics after oral solution administration in healthy male and female subjects. J Clin Pharmacol 2014;54 PubMed

See these in context on the Ribose monograph →

Adenosine 10 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Agteresch HJ, Dagnelie PC, van den Berg JW, Wilson JH. Adenosine triphosphate: established and potential clinical applications. Drugs 1999;58:211-32.. PubMed
  3. Agteresch HJ, Dagnelie PC, van der Gaast A, et al. Randomized clinical trial of adenosine 5'-triphosphate in patients with advanced non-small-cell lung cancer. J Natl Cancer Inst 2000;92:321-8.. PubMed
  4. Haskell CM, Wong M, Williams A, Lee LY. Phase I trial of extracellular adenosine 5'-triphosphate in patients with advanced cancer. Med Pediatr Oncol 1996;27:165-73.. DOI
  5. Haskell CM, Mendoza E, Pisters KM, et al. Phase II study of intravenous adenosine 5'-triphosphate in patients with previously untreated stage IIIB and stage IV non-small cell lung cancer. Invest New Drugs 1998;16:81-5.. PubMed
  6. Eisenach JC, Curry R, Hood DD. Dose response of intrathecal adenosine in experimental pain and allodynia. Anesthesiology 2002;97:938-42.. PubMed
  7. Agteresch HJ, Dagnelie PC, Rietveld T, et al. Pharmacokinetics of intravenous ATP in cancer patients. Eur J Clin Pharmacol 2000;56:49-55.. PubMed
  8. Underwood DA. Which medications should be held before a pharmacologic or exercise stress test? Cleve Clin J Med 2002;69:449-50. PubMed
  9. Litmann L, Anderson JD, Monroe MH. Adenosine and Aggrenox: A hazardous combination. Ann Intern Med 2002;137:E-76. PubMed
  10. Faghihi G, Iraji F, Rajaee Harandi M, et al. Comparison of the efficacy of topical minoxidil 5% and adenosine 0.75% solutions on male androgenic alopecia and measuring patient satisfaction rate. Acta Dermatovenerol Croat 2013;21(3):155-9.

See these in context on the Adenosine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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