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Dietary supplement

Agaricus Blazei Ingredients & Drug Interactions

by Exploding Buds

Agaricus Blazei label
See full label image
Powder Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Agaricus Blazei against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Agaricus Blazei is a dietary supplement by Exploding Buds with 1 active ingredient. Its ingredients are commonly taken for immune support, general wellness and antioxidant, adjunct interest during cancer care.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Agaricus blazei . Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Agaricus Blazei by Exploding Buds

Ask about any prescription or over-the-counter medication and we check it for interactions with Agaricus Blazei by Exploding Buds — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Agaricus Blazei by Exploding Buds

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Agaricus blazei, a mushroom extract. It's sold as a powder, which means you're getting the whole ingredient without any other actives mixed in.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Agaricus Mushroom product and its label doesn't state a use — see Agaricus Mushroom's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for agaricus mushroom isn't established yet. The data we hold shows insufficient reliable evidence to rate it for hay fever, osteoporosis, cancer, heart disease, chemotherapy side effects, and Crohn disease.

That doesn't mean it doesn't work—it means the studies to prove it haven't been done or aren't strong enough yet.

The evidence, ingredient by ingredient Agaricus Mushroom

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Agaricus mushroom is generally well tolerated as a food, but supplement safety and long-term effects haven't been well studied. The most common side effects when taken by mouth are abdominal discomfort, diarrhea, and nausea.

Rare serious effects include allergic reactions, liver damage, and a lung condition called interstitial lung disease (ILD). Three cases of severe liver damage have been reported in women with ovarian or breast cancer taking chemotherapy who also used agaricus supplements—two of those cases were fatal.

There's not enough safety data to use this supplement during pregnancy or while breastfeeding; talk with your doctor or pharmacist for personalized advice.

Side effects, ingredient by ingredient Agaricus Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Agaricus Mushroom.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your antidiabetes medications (insulin, metformin, sulfonylureas, and others) before starting this product—low blood sugar is a documented Moderate-severity risk. If you have a history of liver disease or hepatitis B, talk with your doctor or pharmacist first.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you're curious about agaricus mushroom and don't take blood sugar medication, this product is generally well tolerated at typical doses. If you take any diabetes drug, you need to check with your pharmacist first—low blood sugar is a real concern.

Given the rare but serious risk of liver damage, especially in people with cancer or hepatitis B, be honest with your healthcare provider about what you're taking.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Agaricus Blazei, straight from the product label.

Brand Exploding Buds
Barcode (UPC) 810012470285
Net contents 120 Gram(s); 4.2 Ounce(s)
Market status On market
Date entered into DSLD Aug 23, 2022
DSLD ID 272599
Product type Botanical
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Organic, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Agaricus Blazei by Exploding Buds, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Gram(s)
Maximum serving Sizes:
2 Gram(s)
Servings per container
60
UPC/BARCODE
810012470285
IngredientAmount% DV
Calories8 Calorie(s)--
Agaricus blazei 2 Gram(s)--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Agaricus blazei is commonly referred to as 'Almond Mushroom,' given its almond-like taste and aroma. It is native to Sao Paolo, Brazil and typically thrives in an atmosphere with high temperatures and abundant moisture. It is also found growing in North America - particularly Canada and the United States - and Britain. The mushroom features a round cap with a gill-like structure under the cap. It typically forms single or clustered fruit bodies on fallen dead plant material.

Exploding Buds Full Spectrum Organic Mushrooms grown, dried, milled and packaged in a cGMP certified state-of-the-art indoor farm in California, USA naturally contain beta glucans, prebiotics, digestive enzymes, amino acids, proteins, peptides, polyphenols, flavonoids, selenium compounds, and an array of antioxidants including glutathione, ergothioneine, polyphenols, flavonoids, and SOD (superoxide dismutase).

Formulation

Certified Organic by A Bee Organics

Certified organic mushroom powder

Vegan

Non GMO Gluten free

Fermented

Warnings Aroma, color, consistency and taste may vary.

General Statements

Questions or Comments: [email protected]

28

Suggested/Recommended/Usage/Directions

Suggested Use Add one teaspoon (2 grams) to your favorite coffee, tea, juice, or smoothie or as directed by a qualified healthcare professional.

Storage

Double safety sealed, with outer shrink wrap film and inner bottle freshness seal. Best stored at room temperature 20 degrees C to 25 degrees C (68 degrees F to 77 degrees F). Improper storage conditions, such as extended exposure to direct sunlight, high heat & humidity can cause product degradation over time.

Seals/Symbols

USDA Organic

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Agaricus Blazei by Exploding Buds label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Agaricus Blazei label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Agaricus Blazei by Exploding Buds

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Gram(s) Dosage formPowder Servings per container60 Amounts shown are per serving.

Agaricus blazei

Interacts with
86 drugs
2 Gram(s) per serving Form: Agaricus blazei, Agaricus blazei, Oats

Agaricus mushroom (often Agaricus blazei/subrufescens) is a culinary and medicinal mushroom studied mostly for possible immune and antioxidant effects...

Agaricus blazei monograph & interactions
Interaction report

Agaricus Blazei by Exploding Buds Drug Interactions

Want to check YOUR meds against Agaricus Blazei?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Agaricus blazei 86

Individual Drug Interactions

The ingredients in Agaricus Blazei interact with 86 drugs. Click any drug to see the details.

1 of the 1 ingredient in Agaricus Blazei interact with drugs. Each result below shows which ingredient is responsible. Agaricus blazei

Each ingredient & the kinds of drugs it affects

For each ingredient in Agaricus Blazei with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Agaricus blazei 1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking agaricus mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
In one clinical study in patients with type 2 diabetes who are stabilized on conventional oral hypoglycemic agents, 3 of 29 patients taking an agaricus mushroom extract 500 mg three times daily for 12 weeks reported hypoglycemia, compared to one of 29 patients in the placebo group.

Likelihood Possible Evidence D
Agaricus blazei full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Agaricus Blazei, from the product label.

Exploding Buds

See all Exploding Buds products
Name
Simple Brands Group, LLC
Pharmacist Counseling Corner

Agaricus Blazei by Exploding Buds: Common Questions

Does Agaricus Blazei by Exploding Buds interact with any medications?
Yes. Based on its ingredients, Agaricus Blazei has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Agaricus Blazei contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
There's not enough safety data to know either way. The facts advise against supplement doses during pregnancy and breastfeeding. Talk with your doctor or pharmacist to decide what's right for you.
What are the most common side effects?
Abdominal discomfort, diarrhea, and nausea are the most common. Most people tolerate it well when taken by mouth.
Are there any serious side effects I should know about?
Serious effects are rare but have been reported: allergic reactions, liver damage, and a lung condition called interstitial lung disease. Liver damage is especially concerning in people taking chemotherapy or living with hepatitis B.
Does agaricus mushroom actually work for anything?
The evidence isn't established yet for the conditions we checked—hay fever, osteoporosis, cancer, heart disease, chemotherapy side effects, and Crohn disease. That means we don't have strong enough studies to say yes or no.
Why do I need to check my diabetes medicine?
Agaricus mushroom can lower blood sugar, so taking it with diabetes drugs might drop your blood sugar too much. A small number of patients in one study experienced low blood sugar when they added this mushroom to their medication.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Agaricus Blazei is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Agaricus Blazei label
Go deeper

The Full Monographs Behind Agaricus Blazei’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Agaricus Mushroom

Interacts with 86 drugs

Agaricus mushroom (often Agaricus blazei/subrufescens) is a culinary and medicinal mushroom studied mostly for possible immune and antioxidant effects. The human evidence is limited and not...

Read the full Agaricus Mushroom monograph →
Sources

Sources & How We Checked

Agaricus Blazei's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Agaricus Mushroom 5 references
  1. Hsu CH, Liao YL, Lin SC, et al. The mushroom Agaricus Blazei Murill in combination with metformin and gliclazide improves insulin resistance in type 2 diabetes: a randomized, double-blinded, and placebo-controlled clinical trial. J Altern Complement Med 2
  2. Mukai H, Watanabe T, Ando M, Katsumata N. An alternative medicine, Agaricus blazei, may have induced severe hepatic dysfunction in cancer patients. Jpn J Clin Oncol 2006;36:808-10. PubMed
  3. Ohno S, Sumiyoshi Y, Hashine K, et al. Phase I clinical study of the dietary supplement, Agaricus blazei Murill, in cancer patients in remission. Evid Based Complement Alternat Med 2011, doi 10.1155/2011/192381.
  4. Suehiro M, Katoh N, Kishimoto S. Chelitis due to Agaricus blazei Murill mushroom extract. Contact Dermatitis 2007;56(5):293-4.
  5. Iwai N, Okuda T, Sawada R, et al. Interstitial lung disease associated with Agaricus blazei Murill in a patient with pancreatic ductal adenocarcinoma receiving gemcitabine-based therapy. Case Rep Gastroenterol 2022;16(1):229-234.

See these in context on the Agaricus Mushroom monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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