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Dietary supplement

Full Spectrum Agaricus 500 mg Ingredients & Drug Interactions

by Planetary Herbals

Full Spectrum Agaricus 500 mg label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Full Spectrum Agaricus 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Full Spectrum Agaricus 500 mg is a dietary supplement by Planetary Herbals with 2 active ingredients. Its ingredients are commonly taken for immune support, general wellness and antioxidant, adjunct interest during cancer care.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Agaricus blazei extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Full Spectrum Agaricus 500 mg by Planetary Herbals

Ask about any prescription or over-the-counter medication and we check it for interactions with Full Spectrum Agaricus 500 mg by Planetary Herbals — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Full Spectrum Agaricus 500 mg by Planetary Herbals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 30, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This capsule contains 2 active ingredients, both forms of agaricus mushroom: an agaricus blazei extract and agaricus blazei whole mushroom, totaling 500 mg. The product also includes inactive ingredients (gelatin capsule, dibasic calcium phosphate, silica, and magnesium stearate) that help hold and deliver the active content.

Agaricus mushroom, also known as the Brazilian or sun mushroom, is a fungus used in traditional medicine. This product delivers it in a full-spectrum form, meaning it aims to capture multiple compounds from the mushroom rather than isolating a single one.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Agaricus Mushroom's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Immune and natural killer cell activation.
  • We looked for evidence on: Cancer, Chemotherapy-induced adverse effects, Multiple myeloma, Immune function, NK cell activity, Immunomodulation.
  • The closest evidence on file: Agaricus Mushroom is rated "Insufficient Reliable Evidence To Rate" for Cancer (Natural Medicines).
  • Also on file: Agaricus Mushroom is rated "Insufficient Reliable Evidence To Rate" for Chemotherapy-induced adverse effects, Multiple myeloma.

The evidence for agaricus mushroom in the conditions studied isn't established in our data. We hold insufficient reliable evidence to rate its use for hay fever, osteoporosis, cancer, heart disease, chemotherapy side effects, or Crohn disease.

If you're considering this product for a specific health goal, talk with your doctor or pharmacist about what the research actually supports for your situation.

The evidence, ingredient by ingredient Agaricus Mushroom

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Agaricus mushroom is generally well tolerated when taken by mouth. The most common side effects are abdominal discomfort, diarrhea, and nausea — a small number of people may experience these.

Rare but serious effects have been reported: allergic reactions (including rashes and lip swelling), liver damage (hepatotoxicity), and a lung condition called interstitial lung disease (ILD). Three cases of severe liver damage occurred in women taking agaricus supplements while undergoing chemotherapy; two progressed to life-threatening hepatitis.

Do not take this supplement during pregnancy — there isn't enough safety data. The same applies if you're breastfeeding.

Long-term safety and effects are not well established. If you have liver disease, a history of hepatitis, or are undergoing chemotherapy, discuss agaricus with your doctor or pharmacist before starting.

Side effects, ingredient by ingredient Agaricus Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Agaricus Mushroom.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take any antidiabetes drugs (insulin, metformin, sulfonylureas, or others), check with your doctor or pharmacist before starting this product — there's a Moderate interaction risk of low blood sugar. No other medication interactions are documented for the ingredients we checked.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This agaricus mushroom supplement is most relevant if you're interested in mushroom-based nutrition, but evidence for its health claims is not yet established. The main caution is if you take diabetes medications — you'll need to check with your doctor or pharmacist first because of a moderate risk of low blood sugar.

Avoid it in pregnancy and while breastfeeding, and be aware that rare serious effects on the liver have been reported, especially in people with cancer undergoing chemotherapy.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 20, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Full Spectrum Agaricus 500 mg, straight from the product label.

Brand Planetary Herbals
Barcode (UPC) 021078107019
Net contents 30 Capsule(s)
Market status On market
Date entered into DSLD Nov 20, 2017
DSLD ID 80397
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Full Spectrum Agaricus 500 mg by Planetary Herbals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
UPC/BARCODE
021078107019
IngredientAmount% DV
Agaricus blazei extract200 mg--
Agaricus blazei300 mg--

Other ingredients: Gelatin, Dibasic Calcium Phosphate, Silica, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Immune & natural killer cell activator

Approved by Michael Tierra L.Ac, O.M.D

Agaricus blazei is native to Brazil and is popular in Japan, where it is eaten as a food and widely used for its health-promoting benefits.

FDA Statement of Identity

Herbal Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: 1 capsule three times daily.

Precautions

Note: If you are pregnant, may become pregnant, or breastfeeding, consult your health care professional before using this product.

Do not use if either tamper-evident seal is broken or missing.

Keep out of the reach of children.

Storage

Store in a cool, dry place.

Formula

Planetary Herbals Full Spectrum Agaricus, also known as the "sun mushroom", contains polysaccharides known to fortify the body's natural immune response by increasing macrophage, natural killer cell, and T-cell activity.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Brand IP Statement(s)

Planetary Herbals, LLC

General

PF0701 REV D151

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Full Spectrum Agaricus 500 mg by Planetary Herbals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Full Spectrum Agaricus 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Full Spectrum Agaricus 500 mg by Planetary Herbals

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Agaricus blazei extract

Interacts with
86 drugs
200 mg per serving

Agaricus mushroom (often Agaricus blazei/subrufescens) is a culinary and medicinal mushroom studied mostly for possible immune and antioxidant effects...

Agaricus blazei extract monograph & interactions

Agaricus blazei

Interacts with
86 drugs
300 mg per serving

Agaricus mushroom (often Agaricus blazei/subrufescens) is a culinary and medicinal mushroom studied mostly for possible immune and antioxidant effects...

Agaricus blazei monograph & interactions

Other (inactive) ingredients: Gelatin, Dibasic Calcium Phosphate, Silica, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Full Spectrum Agaricus 500 mg by Planetary Herbals Drug Interactions

Want to check YOUR meds against Full Spectrum Agaricus 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Agaricus blazei extract 86

Individual Drug Interactions

The ingredients in Full Spectrum Agaricus 500 mg interact with 86 drugs. Click any drug to see the details.

1 of the 2 ingredients in Full Spectrum Agaricus 500 mg interact with drugs. Each result below shows which ingredient is responsible. Agaricus blazei extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Full Spectrum Agaricus 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Agaricus blazei extract1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking agaricus mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
In one clinical study in patients with type 2 diabetes who are stabilized on conventional oral hypoglycemic agents, 3 of 29 patients taking an agaricus mushroom extract 500 mg three times daily for 12 weeks reported hypoglycemia, compared to one of 29 patients in the placebo group.

Likelihood Possible Evidence D
Agaricus blazei extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Full Spectrum Agaricus 500 mg, from the product label.

Planetary Herbals

See all Planetary Herbals products
Name
Planetary Herbals, LLC
Street Address
P.O. Box 1760
City
Soquel
State
CA
ZipCode
95073
Web Address
www.planetaryherbals.com
Pharmacist Counseling Corner

Full Spectrum Agaricus 500 mg by Planetary Herbals: Common Questions

Does Full Spectrum Agaricus 500 mg by Planetary Herbals interact with any medications?
Yes. Based on its ingredients, Full Spectrum Agaricus 500 mg has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Full Spectrum Agaricus 500 mg contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is agaricus mushroom, and why is it in this product?
Agaricus blazei is a mushroom also called the Brazilian or sun mushroom, used traditionally in herbal medicine. This product delivers it as a full-spectrum extract, meaning it captures multiple compounds from the mushroom rather than just one isolated ingredient.
Can I take this if I'm pregnant or breastfeeding?
No. There isn't enough safety data to recommend agaricus mushroom supplement doses during pregnancy or while breastfeeding. Talk with your doctor or pharmacist for personalized advice if you're in either situation.
What side effects might I notice?
Most people tolerate it well. Some may experience abdominal discomfort, diarrhea, or nausea. Rare serious reactions include allergic rashes and, very rarely, liver or lung problems. Stop taking it and contact your doctor if you develop a rash, yellowing of skin or eyes, or shortness of breath.
Does this actually work for the conditions listed on the label?
The evidence isn't established in our data for hay fever, osteoporosis, cancer, heart disease, chemotherapy side effects, or Crohn disease. If you're considering it for a specific health goal, ask your doctor what research actually supports.
I take diabetes medication — can I use this?
You'll need to check with your doctor or pharmacist first. Agaricus mushroom may increase the risk of low blood sugar when combined with diabetes drugs, and monitoring may need to change.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Full Spectrum Agaricus 500 mg is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Full Spectrum Agaricus 500 mg label
Go deeper

The Full Monographs Behind Full Spectrum Agaricus 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Agaricus Mushroom

Interacts with 86 drugs

Agaricus mushroom (often Agaricus blazei/subrufescens) is a culinary and medicinal mushroom studied mostly for possible immune and antioxidant effects. The human evidence is limited and not...

Read the full Agaricus Mushroom monograph →
Sources

Sources & How We Checked

Full Spectrum Agaricus 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Agaricus Mushroom 5 references
  1. Hsu CH, Liao YL, Lin SC, et al. The mushroom Agaricus Blazei Murill in combination with metformin and gliclazide improves insulin resistance in type 2 diabetes: a randomized, double-blinded, and placebo-controlled clinical trial. J Altern Complement Med 2
  2. Mukai H, Watanabe T, Ando M, Katsumata N. An alternative medicine, Agaricus blazei, may have induced severe hepatic dysfunction in cancer patients. Jpn J Clin Oncol 2006;36:808-10. PubMed
  3. Ohno S, Sumiyoshi Y, Hashine K, et al. Phase I clinical study of the dietary supplement, Agaricus blazei Murill, in cancer patients in remission. Evid Based Complement Alternat Med 2011, doi 10.1155/2011/192381.
  4. Suehiro M, Katoh N, Kishimoto S. Chelitis due to Agaricus blazei Murill mushroom extract. Contact Dermatitis 2007;56(5):293-4.
  5. Iwai N, Okuda T, Sawada R, et al. Interstitial lung disease associated with Agaricus blazei Murill in a patient with pancreatic ductal adenocarcinoma receiving gemcitabine-based therapy. Case Rep Gastroenterol 2022;16(1):229-234.

See these in context on the Agaricus Mushroom monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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