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Dietary supplement

Agaricus Bisporus SAP Ingredients & Drug Interactions

by NFH

Agaricus Bisporus SAP label
See full label image
Powder Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Agaricus Bisporus SAP against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Agaricus Bisporus SAP is a dietary supplement by NFH with 1 active ingredient. Its ingredients are commonly taken for immune support, general wellness and antioxidant, adjunct interest during cancer care.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Agaricus bisporus Mycelium Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Agaricus Bisporus SAP by NFH

Ask about any prescription or over-the-counter medication and we check it for interactions with Agaricus Bisporus SAP by NFH — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Agaricus Bisporus SAP by NFH

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Agaricus Bisporus SAP is a single-ingredient supplement: agaricus mushroom mycelium extract, a concentrate derived from the common white button mushroom (Agaricus bisporus). The product contains no inactive ingredients or fillers.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Agaricus Mushroom's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: supports prostate health.
  • We looked for evidence on: Benign prostatic hyperplasia, Prostate cancer, Prostatitis, Urinary health.
  • The closest evidence on file: Agaricus Mushroom is rated "Insufficient Reliable Evidence To Rate" for Cancer (Natural Medicines).

The evidence we hold for agaricus mushroom doesn't yet support its use for any condition listed in our data. Researchers have looked at it for allergic rhinitis (hay fever), osteoporosis, cancer, cardiovascular disease, chemotherapy side effects, and Crohn disease, but the evidence is insufficient to rate whether it actually works for these purposes.

If you're considering this supplement for a specific health goal, talk with your pharmacist about what the current research actually shows.

The evidence, ingredient by ingredient Agaricus Mushroom

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Agaricus mushroom is generally well tolerated when taken by mouth. The most common side effects are abdominal discomfort, diarrhea, and nausea—mild issues that many people don't experience.

Rare but serious adverse effects have been reported: allergic reactions (including rashes and swelling of the lips), liver damage (hepatotoxicity), and a lung condition called interstitial lung disease. Three cases of severe liver damage, including two that were fatal, occurred in women with cancer who took agaricus mushroom during chemotherapy.

Because long-term safety data are limited, the supplement is not recommended during pregnancy or breastfeeding—there isn't enough information to know whether it's safe for you or your baby.

Side effects, ingredient by ingredient Agaricus Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Agaricus Mushroom.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check this product with your pharmacist if you take any antidiabetes medication—blood sugar-lowering drugs carry a Moderate risk of increased low blood sugar when combined with agaricus mushroom.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Agaricus mushroom supplement is generally tolerated, but it's not proven to work for the conditions it's often used for, and it does interact with diabetes medications. If you take blood sugar-lowering drugs, check with your pharmacist first.

Pregnant or nursing? Skip it until you've talked to your doctor, because we don't have enough safety data.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Agaricus Bisporus SAP, straight from the product label.

Brand NFH
Barcode (UPC) 856711111364
Net contents 2.1 Ounce(s); 60 Gram(s)
Market status On market
Date entered into DSLD Jan 23, 2023
DSLD ID 273440
Product type Botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Agaricus Bisporus SAP by NFH, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Gram(s)
Maximum serving Sizes:
2 Gram(s)
Servings per container
30
UPC/BARCODE
856711111364
IngredientAmount% DV
Agaricus bisporus Mycelium Extract2 Gram(s)--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Agaricus Bisporus SAP is a source of fungal polysaccharides with immunomodulation properties. Agaricus Bisporus SAP is a source of antioxidants.

(White Button Mushroom) Hot-water extract

Formulation

Agaricus Bisporus SAP supports prostate health.

All ingredients listed for this product lot number have been tested by a third-party laboratory for identity, potency, and purity.

Contains no: Gluten, soy, wheat, corn, eggs, dairy, yeast, citrus, preservatives, artificial flavor or color, starch, or sugar.

This product is non-GMO and vegan friendly.

This product is non-GMO and vegan friendly.

It is normal for this product to clump / solidify.

Color and smell may vary from one lot to another.

Made in Canada

Suggested/Recommended/Usage/Directions

Directions for use: Adults: Take 1 scoop (approx. 2 g) daily or as directed by your healthcare practitioner. May be mixed in hot or cold water, or as directed by your healthcare practitioner.

Stir well before each use.

Precautions

Cautions and warnings: Consult a healthcare practitioner prior to use if you are pregnant or breast-feeding, or if you have diabetes.

Do not use if seal is broken.

Keep out of reach of children.

Storage

Keep refrigerated once opened.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

General Statements

NPN 80080634

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Agaricus Bisporus SAP by NFH label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Agaricus Bisporus SAP label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Agaricus Bisporus SAP by NFH

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Gram(s) Dosage formPowder Servings per container30 Amounts shown are per serving.

Agaricus bisporus Mycelium Extract

Interacts with
86 drugs
2 Gram(s) per serving Form: Polysaccharides

Agaricus mushroom (often Agaricus blazei/subrufescens) is a culinary and medicinal mushroom studied mostly for possible immune and antioxidant effects...

Agaricus bisporus Mycelium Extract monograph & interactions
Interaction report

Agaricus Bisporus SAP by NFH Drug Interactions

Want to check YOUR meds against Agaricus Bisporus SAP?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Agaricus bisporus Mycelium Extract 86

Individual Drug Interactions

The ingredients in Agaricus Bisporus SAP interact with 86 drugs. Click any drug to see the details.

1 of the 1 ingredient in Agaricus Bisporus SAP interact with drugs. Each result below shows which ingredient is responsible. Agaricus bisporus Mycelium Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Agaricus Bisporus SAP with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Agaricus bisporus Mycelium Extract1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking agaricus mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
In one clinical study in patients with type 2 diabetes who are stabilized on conventional oral hypoglycemic agents, 3 of 29 patients taking an agaricus mushroom extract 500 mg three times daily for 12 weeks reported hypoglycemia, compared to one of 29 patients in the placebo group.

Likelihood Possible Evidence D
Agaricus bisporus Mycelium Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Agaricus Bisporus SAP, from the product label.

NFH

See all NFH products
Name
NFH - Nutritional Fundamentals for Health, Inc.
Street Address
351 Rue Joseph-Carrier
City
Vaudreuil
State
QC
ZipCode
J7V 5V5
Phone Number
1 866 510-3123
Web Address
nfh.ca
Pharmacist Counseling Corner

Agaricus Bisporus SAP by NFH: Common Questions

Does Agaricus Bisporus SAP by NFH interact with any medications?
Yes. Based on its ingredients, Agaricus Bisporus SAP has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Agaricus Bisporus SAP contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is agaricus mushroom?
It's an extract from the mycelium (the root structure) of the common white button mushroom. This supplement delivers a concentrated form of compounds from that mushroom.
Does this actually work for anything?
We don't have reliable evidence yet that it works for any of the conditions it's marketed for—hay fever, bone health, cancer, heart disease, or others. That doesn't mean it doesn't; it means the research isn't there yet.
What are the most common side effects?
Most people tolerate it well. Some experience stomach discomfort, diarrhea, or nausea—usually mild. Serious allergic reactions, liver damage, and lung problems are rare but have been reported.
Is it safe during pregnancy or breastfeeding?
No—there isn't enough safety data to know either way. The recommendation is to avoid it during pregnancy and while breastfeeding. Talk with your doctor if you're considering it and pregnant or nursing.
Can I take this if I'm on diabetes medication?
You need to check with your pharmacist or doctor first. This supplement may increase the risk of low blood sugar when combined with diabetes drugs, so your prescriber needs to know you're taking it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Agaricus Bisporus SAP is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Agaricus Bisporus SAP label
Go deeper

The Full Monographs Behind Agaricus Bisporus SAP’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Agaricus Mushroom

Interacts with 86 drugs

Agaricus mushroom (often Agaricus blazei/subrufescens) is a culinary and medicinal mushroom studied mostly for possible immune and antioxidant effects. The human evidence is limited and not...

Read the full Agaricus Mushroom monograph →
Sources

Sources & How We Checked

Agaricus Bisporus SAP's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Agaricus Mushroom 5 references
  1. Hsu CH, Liao YL, Lin SC, et al. The mushroom Agaricus Blazei Murill in combination with metformin and gliclazide improves insulin resistance in type 2 diabetes: a randomized, double-blinded, and placebo-controlled clinical trial. J Altern Complement Med 2
  2. Mukai H, Watanabe T, Ando M, Katsumata N. An alternative medicine, Agaricus blazei, may have induced severe hepatic dysfunction in cancer patients. Jpn J Clin Oncol 2006;36:808-10. PubMed
  3. Ohno S, Sumiyoshi Y, Hashine K, et al. Phase I clinical study of the dietary supplement, Agaricus blazei Murill, in cancer patients in remission. Evid Based Complement Alternat Med 2011, doi 10.1155/2011/192381.
  4. Suehiro M, Katoh N, Kishimoto S. Chelitis due to Agaricus blazei Murill mushroom extract. Contact Dermatitis 2007;56(5):293-4.
  5. Iwai N, Okuda T, Sawada R, et al. Interstitial lung disease associated with Agaricus blazei Murill in a patient with pancreatic ductal adenocarcinoma receiving gemcitabine-based therapy. Case Rep Gastroenterol 2022;16(1):229-234.

See these in context on the Agaricus Mushroom monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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