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Dietary supplement

Agaricus Blazei 500 mg Ingredients & Drug Interactions

by Aloha Medicinals

Agaricus Blazei 500 mg label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Agaricus Blazei 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Agaricus Blazei 500 mg is a dietary supplement by Aloha Medicinals with 1 active ingredient. Its ingredients are commonly taken for immune support, general wellness and antioxidant, adjunct interest during cancer care.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are organic Agaricus blazei. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Agaricus Blazei 500 mg by Aloha Medicinals

Ask about any prescription or over-the-counter medication and we check it for interactions with Agaricus Blazei 500 mg by Aloha Medicinals — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Agaricus Blazei 500 mg by Aloha Medicinals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: organic Agaricus blazei mushroom at 500 mg per capsule. Agaricus blazei is a medicinal mushroom used in traditional herbal medicine.

The capsule itself is vegetarian, and the product also contains organic white milo as an inactive ingredient.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Agaricus Mushroom's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: immune function and cell support.
  • We looked for evidence on: Cancer, Chemotherapy-induced adverse effects, Hepatitis B, Crohn Disease, Ulcerative colitis, immune function — and 2 related terms.
  • The closest evidence on file: Agaricus Mushroom is rated "Insufficient Reliable Evidence To Rate" for Cancer (Natural Medicines).
  • Also on file: Agaricus Mushroom is rated "Insufficient Reliable Evidence To Rate" for Chemotherapy-induced adverse effects, Crohn Disease, Hepatitis B, Ulcerative colitis.

The evidence for Agaricus blazei is not established in the data we hold. The supplement has been studied for allergic rhinitis (hay fever), osteoporosis, cancer, cardiovascular disease, chemotherapy side effects, and Crohn disease, but the evidence for each of these uses is insufficient to rate.

If you're considering this for a specific health goal, talk with your pharmacist or doctor about what the research actually supports.

The evidence, ingredient by ingredient Agaricus Mushroom

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Agaricus blazei is generally well tolerated when taken by mouth as a food. The most common side effects reported are abdominal discomfort, diarrhea, and nausea.

Rare but serious effects have been reported, including allergic reactions, liver injury (hepatotoxicity), and a type of lung inflammation called interstitial lung disease (ILD). Three cases of severe liver injury have been documented in women with cancer who were also taking chemotherapy and agaricus mushroom supplements; two were fatal.

Due to insufficient safety data, the supplement is not recommended during pregnancy or while breastfeeding. Long-term safety and effects are not well established.

Side effects, ingredient by ingredient Agaricus Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Agaricus Mushroom.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your exact medications against our interaction search tool if you take antidiabetes drugs (blood sugar medications). This is the Moderate severity interaction documented for this product.

No other medication interactions are documented in our data for the ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Agaricus blazei may be worth considering if you're interested in medicinal mushrooms and your doctor approves — but the evidence for its effectiveness on any specific condition is not yet established. If you take blood sugar medication, check with your pharmacist before starting this, as it may lower your blood sugar further.

Anyone with liver disease, lung conditions, or a hepatitis B history should talk to their doctor first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 19, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Agaricus Blazei 500 mg, straight from the product label.

Brand Aloha Medicinals
Barcode (UPC) 835186008034
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD May 19, 2022
DSLD ID 264673
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Organic, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Agaricus Blazei 500 mg by Aloha Medicinals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
Servings per container
90
UPC/BARCODE
835186008034
IngredientAmount% DV
organic Agaricus blazei500 mg--

Other ingredients: Vegetarian Capsule, organic White Milo

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Gluten free No GMO

DNA verified Full Spectrum MycoProduct

Made in USA All natural Supports immune function

100% organic Certified organic by QAI Quality Assurance International Certified Organic

Formula

Royal sun agaricus - known in its native Brazil as "mushroom of the gods". This amazing mushroom has long been revered for its immune and cell supporting properties. Agaricus blazei is the best 100% Full Spectrum MycoProduct available today. Guaranteed to contain more than 300 mg of polysaccharides (60%) in every capsule and made by the world's largest producer of (Full Spectrum) medicinal mushrooms - 100% satisfaction guaranteed!

Made with organic Agaricus blazei

Suggested/Recommended/Usage/Directions

Suggested use: Take 1-3 capsules twice daily with meals.

Brand IP Statement(s)

Aloha Medicinals Natural products

FDA Statement of Identity

Dietary Supplement

Precautions

Do not use if tamper evident seal is broken.

As with any supplement, if you are pregnant, nursing, or taking any medication, consult your healthcare provider before use.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

Quality Assurance International Certified Organic

General Statements

Toll free 877-835-6091 Please recycle bottle after use.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Agaricus Blazei 500 mg by Aloha Medicinals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Agaricus Blazei 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Agaricus Blazei 500 mg by Aloha Medicinals

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Organic Agaricus blazei

Interacts with
86 drugs
500 mg per serving

Agaricus mushroom (often Agaricus blazei/subrufescens) is a culinary and medicinal mushroom studied mostly for possible immune and antioxidant effects...

Organic Agaricus blazei monograph & interactions

Other (inactive) ingredients: Vegetarian Capsule, Organic White Milo. These complete the product’s ingredient list but are not active constituents.

Interaction report

Agaricus Blazei 500 mg by Aloha Medicinals Drug Interactions

Want to check YOUR meds against Agaricus Blazei 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

organic Agaricus blazei 86

Individual Drug Interactions

The ingredients in Agaricus Blazei 500 mg interact with 86 drugs. Click any drug to see the details.

1 of the 1 ingredient in Agaricus Blazei 500 mg interact with drugs. Each result below shows which ingredient is responsible. organic Agaricus blazei

Each ingredient & the kinds of drugs it affects

For each ingredient in Agaricus Blazei 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

organic Agaricus blazei1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking agaricus mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
In one clinical study in patients with type 2 diabetes who are stabilized on conventional oral hypoglycemic agents, 3 of 29 patients taking an agaricus mushroom extract 500 mg three times daily for 12 weeks reported hypoglycemia, compared to one of 29 patients in the placebo group.

Likelihood Possible Evidence D
organic Agaricus blazei full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Agaricus Blazei 500 mg, from the product label.

Aloha Medicinals

See all Aloha Medicinals products
Name
Aloha Medicinals
Street Address
2300 Arrowhead Dr
City
Carson City
State
NV
ZipCode
89706
Phone Number
877-835-6091
Web Address
www.alohamedicinals.com
Pharmacist Counseling Corner

Agaricus Blazei 500 mg by Aloha Medicinals: Common Questions

Does Agaricus Blazei 500 mg by Aloha Medicinals interact with any medications?
Yes. Based on its ingredients, Agaricus Blazei 500 mg has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Agaricus Blazei 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on metformin or another diabetes medication?
Not without talking to your pharmacist or doctor first. Agaricus blazei may increase the risk of low blood sugar when combined with antidiabetes drugs. In one study, a small number of patients reported low blood sugar episodes at this same dose. Your doctor might decide it's okay with closer monitoring, or might recommend skipping it. Check your exact medication with our tool before you start.
What side effects should I watch for?
The most common ones are stomach discomfort, diarrhea, and nausea. Those are usually mild. Rarely, allergic reactions, liver injury, or lung inflammation have been reported. If you develop a rash, yellowing skin, dark urine, or shortness of breath, stop taking it and contact your doctor right away.
Is this safe to take during pregnancy or breastfeeding?
No — there isn't enough safety data, so it's best to avoid supplement doses during pregnancy and while breastfeeding. Talk with your doctor if you're planning to conceive or are nursing and want to discuss your options.
What is Agaricus blazei actually for?
It's been studied for hay fever, osteoporosis, cancer, heart disease, chemotherapy side effects, and Crohn disease. But the evidence for any of these uses is currently insufficient to rate. We don't have solid data that it works for a specific condition yet.
Does this product have any fillers or other inactive ingredients?
Yes — the capsule is vegetarian, and there's organic white milo included. The only active ingredient is the agaricus mushroom itself at 500 mg.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Agaricus Blazei 500 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Agaricus Blazei 500 mg label
Go deeper

The Full Monographs Behind Agaricus Blazei 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Agaricus Mushroom

Interacts with 86 drugs

Agaricus mushroom (often Agaricus blazei/subrufescens) is a culinary and medicinal mushroom studied mostly for possible immune and antioxidant effects. The human evidence is limited and not...

Read the full Agaricus Mushroom monograph →
Sources

Sources & How We Checked

Agaricus Blazei 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Agaricus Mushroom 5 references
  1. Hsu CH, Liao YL, Lin SC, et al. The mushroom Agaricus Blazei Murill in combination with metformin and gliclazide improves insulin resistance in type 2 diabetes: a randomized, double-blinded, and placebo-controlled clinical trial. J Altern Complement Med 2
  2. Mukai H, Watanabe T, Ando M, Katsumata N. An alternative medicine, Agaricus blazei, may have induced severe hepatic dysfunction in cancer patients. Jpn J Clin Oncol 2006;36:808-10. PubMed
  3. Ohno S, Sumiyoshi Y, Hashine K, et al. Phase I clinical study of the dietary supplement, Agaricus blazei Murill, in cancer patients in remission. Evid Based Complement Alternat Med 2011, doi 10.1155/2011/192381.
  4. Suehiro M, Katoh N, Kishimoto S. Chelitis due to Agaricus blazei Murill mushroom extract. Contact Dermatitis 2007;56(5):293-4.
  5. Iwai N, Okuda T, Sawada R, et al. Interstitial lung disease associated with Agaricus blazei Murill in a patient with pancreatic ductal adenocarcinoma receiving gemcitabine-based therapy. Case Rep Gastroenterol 2022;16(1):229-234.

See these in context on the Agaricus Mushroom monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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