Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

ALAmax CR Ingredients & Drug Interactions

by XYMOGEN

ALAmax CR label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking ALAmax CR against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

ALAmax CR is a dietary supplement by XYMOGEN with 2 active ingredients. Its ingredients are commonly taken for hair growth and thinning hair, brittle nails, skin health.Based on those ingredients, 263 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Alpha-Lipoic Acid. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against ALAmax CR by XYMOGEN

Ask about any prescription or over-the-counter medication and we check it for interactions with ALAmax CR by XYMOGEN — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of ALAmax CR by XYMOGEN

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

ALAmax CR has 2 active ingredients: biotin and alpha-lipoic acid. Biotin is a B vitamin that supports nail, hair, and skin health and is used to correct biotin deficiency.

Alpha-lipoic acid is an antioxidant compound that may help support blood sugar control and cholesterol levels in certain conditions. The product also contains several inactive ingredients (excipients) including cellulose compounds, dicalcium phosphate, magnesium stearate, silica, and medium chain triglyceride, which serve as binders, fillers, and flow agents in the tablet.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: restore metabolic edge and energy production.
  • We looked for evidence on: Chronic fatigue syndrome (CFS), Metabolic syndrome, Diabetes, Impaired glucose tolerance (prediabetes), Obesity, Hyperlipidemia — and 4 related terms.
  • The strongest evidence on file: Alpha-lipoic Acid is rated "Possibly Effective" for Hyperlipidemia (Natural Medicines).
  • Also on file: Alpha-lipoic Acid is rated "Possibly Effective" for Obesity.
  • Also on file: Alpha-lipoic Acid is rated "Possibly Ineffective" for Diabetes.

Biotin is likely effective for biotin deficiency. For other uses—multiple sclerosis and seborrheic dermatitis—the evidence suggests it's possibly ineffective.

For alopecia areata (hair loss), there isn't enough reliable evidence to say how well it works. Alpha-lipoic acid is possibly effective for diabetic neuropathy (nerve pain from diabetes), high cholesterol (hyperlipidemia), and obesity.

The evidence for these uses is suggestive but not definitive.

The evidence, ingredient by ingredient Biotin Alpha-lipoic Acid

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Biotin is generally well tolerated, even at fairly high doses, because your body excretes excess in your urine. High-dose biotin has rarely caused mild diarrhea.

One isolated case report linked a combination of high-dose biotin and pantothenic acid to a rare inflammation condition, but causation is unclear and no similar cases have been reported since. Biotin in normal dietary and supplement amounts is likely safe in pregnancy and while breastfeeding, though the facts advise checking with your doctor before taking high-dose supplements.

Alpha-lipoic acid is generally well tolerated orally, but it can lower blood sugar and is best used under medical guidance. Common side effects include headache, heartburn, nausea, and vomiting.

Rare serious adverse effects include a skin condition called insulin autoimmune syndrome. Alpha-lipoic acid is not recommended during pregnancy or while breastfeeding due to insufficient safety information.

Side effects, ingredient by ingredient Biotin Alpha-lipoic Acid

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Alpha-lipoic Acid.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; cancer treatments; diabetes medications.
  • For scale: 263 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking ALAmax CR, double-check with your pharmacist if you're on chemotherapy drugs (alkylating agents or antitumor antibiotics)—alpha-lipoic acid may reduce their effectiveness. Also check if you take blood thinners or antiplatelet drugs, thyroid hormone replacement, or diabetes medications.

Alpha-lipoic acid may increase bleeding risk with anticoagulants, lower thyroid drug effectiveness, or raise the risk of low blood sugar with diabetes medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

ALAmax CR may be worth considering if you have biotin deficiency or are looking to support blood sugar and cholesterol levels under the guidance of your healthcare provider. If you take blood thinners, chemotherapy, thyroid medication, or diabetes drugs, talk with your pharmacist or doctor before starting—alpha-lipoic acid can affect how these work.

Pregnant or breastfeeding? The safety data for alpha-lipoic acid doesn't support it, so discuss with your doctor first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about ALAmax CR, straight from the product label.

Brand XYMOGEN
Barcode (UPC) 871149002169
Net contents 60 Packet(s); 60 Tablet(s)
Market status On market
Date entered into DSLD Oct 24, 2024
DSLD ID 303608
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for ALAmax CR by XYMOGEN, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
60
UPC/BARCODE
871149002169
IngredientAmount% DV
Biotin450 mcg1500%
Alpha-Lipoic Acid600 mg--

Other ingredients: Hydroxypropyl Methylcellulose, Microcrystalline Cellulose, Hydroxypropyl Cellulose, Dicalcium Phosphate, Magnesium Stearate, Silica, Hydroxypropyl Methylcellulose, Medium Chain Triglyceride

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Restore your metabolic edge

Uncomplicate your life with the Mitochondrial Renewal Kit. It contains ingredients that help restore your metabolic edge by activating the critical molecular "switches" that control mitochondrial biogenesis - the very same switches activated by caloric restriction and aerobic exercise. Embark on the restoration of your life. Restore your metabolic edge with the Mitochondrial Renewal Kit. Enjoy the look and feel of great metabolism.

Formulated to exclude: Wheat, gluten, yeast, soy, fish, shellfish, peanuts, tree nuts, egg, sesame, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, and artificial preservatives.

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

Metabolism is the wellspring of life. Mitochondria, representing a staggering 10% of body weight, are the cornerstone of energy production. Over time, mitochondria age. You lose your metabolic "edge." Your appearance, feeling of well-being, and physical capabilities progressively "dull."

This is how metabolism should look and feel Metabolism is the process by which your body's cells produce energy. Most of this energy is produced in mitochondria. These cellular "powerhouses" oxidize or "burn" calories, principally from glucose (blood sugar) and fat. Metabolically active cells, such as those of the brain, heart, and muscle, may contain 100s to 1,000s of mitochondria. The more mitochondria inside your cells, the more calories your body can burn. Thus, healthy mitochondria give your metabolism a calorie-burning, energy-generating edge. The process by which new mitochondria are produced inside your body's cells is known as mitochondrial biogenesis. In light of the many metabolic and protective roles played by mitochondria, it's no surprise that mitochondrial biogenesis is critical to delaying the effects of aging and age-associated declines in metabolisms (e.g., increased body fat and decreased lean muscle tissue.) Mitochondrial biogenesis is a complicated process involving more than 1,000 genes. Caloric restriction and aerobic exercise promote mitochondrial biogenesis. However, caloric restriction and consistent aerobic exercise regimens are difficult to maintain. Lopez-Lluch G, Irusta PM, Navas P, et al. Exp Gerontol. 2008 Sep;43(9):813-19. Lanza IR, Short DK, Short KR, et al. Diabetes. 2008 Nov;57(11):2933-42. Johnston AP, De Lisio M, Parise G. Appl Physiol Nutr Metab. 2008 Feb;33(1):191-99. Based on emerging experimental research.

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Xymogen supports the initiative Clean seas Turn the tide on plastic Xymogen is committed to reducing the amount of plastics used throughout our business, particularly in the packaging of out products. With our participation in the United Nations Environment Programme Clean Seas initiative, we strive to positively decrease our environmental footprint, providing results that can ultimately: Help free the ocean of litter, making it safer for millions of marine animals Reduce the use of non-renewable resources. Keep wild-caught seafood healthy and safe to eat. Protect maritime economies such as organic fishing, tourism, and recreation. We are doing our part to make a world of difference. How are you making an impact? #CleanSeas

Formula

Sharpen your metabolism back to a razor's edge with mitochondrial biogenesis. Three scientifically formulated, safe, and effective dietary supplements - ALAmax CR, N.O.max ER, and Reservatin Plus - seamlessly act as one entity to support the restoration of a lifetime.

ALAmax CR is a multifunctional antioxidant that helps to maintain healthy, well-functioning cells. ALA max CR is designed to neutralize free radicals. ALAmax CR has the ability to destroy free radicals in both the water-based and lipid-based portion of cells, making it the ideal whole-body antioxidant. In addition, ALAmax CR helps the body synthesize glutathione, the body's own master detoxifier. ALAmax CR also "recharges" other important antioxidants, such as Vitamins C and E and CoQ10, giving them the ability to continue fighting free radicals for extended periods of time. In addition, biotin support the function of alpha-lipoic acid in regulating glucose metabolism.

Each packet contains: 1 ALAmax CR tablets, 3 N.O.max ER tablets, 1 Reservatin Plus capsule.

Seals/Symbols

GMP Compliant Third-Party Verified

Storage: Keep closed in a cool, dry place out of reach of children.

ePV (ePedigree Verification)

Suggested/Recommended/Usage/Directions

Directions: Consume the contents of one packet with 8 oz. water, 30 minutes before breakfast and 30 minutes before lunch, or use as directed by your healthcare professional.

For optimal benefit, combine this product with a healthy diet and exercise regimen.

Precautions

Individuals with a medical condition (including diabetes or cold sores), that are taking prescription drugs, that are pregnant or lactating, or are under the age of 18 should consult their healthcare professional prior to use.

Individuals with a medical condition (including diabetes or cold sores), that are taking prescription drugs, that are pregnant or lactating, or are under the age of 18 should consult their healthcare professional prior to use.

Do not use if packet is damaged.

Brand IP Statement(s)

Copyright 2021 Xymogen

Exclusive Professional Formulas

Storage

Storage: Keep closed in a cool, dry place out of reach of children.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

ALAmax CR by XYMOGEN label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

ALAmax CR label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in ALAmax CR by XYMOGEN

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Biotin

No known
interactions
450 mcg per serving

Biotin (vitamin B7) is a water-soluble vitamin your body needs to turn food into energy and to support healthy hair, skin, and nails. Most people get...

Biotin monograph & interactions

Alpha-Lipoic Acid

Interacts with
263 drugs
600 mg per serving

Alpha-lipoic acid (ALA) is an antioxidant made naturally by the body and found in small amounts in foods. It is most studied for diabetic nerve pain,...

Alpha-Lipoic Acid monograph & interactions

Other (inactive) ingredients: Hydroxypropyl Methylcellulose, Microcrystalline Cellulose, Hydroxypropyl Cellulose, Dicalcium Phosphate, Magnesium Stearate, Silica, Hydroxypropyl Methylcellulose, Medium Chain Triglyceride. These complete the product’s ingredient list but are not active constituents.

Interaction report

ALAmax CR by XYMOGEN Drug Interactions

Want to check YOUR meds against ALAmax CR?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
263Drugs
177 Moderate 86 Minor

Ingredients driving the most interactions

Alpha-Lipoic Acid 263

Individual Drug Interactions

The ingredients in ALAmax CR interact with 263 drugs. Click any drug to see the details.

1 of the 2 ingredients in ALAmax CR interact with drugs. Each result below shows which ingredient is responsible. Alpha-Lipoic Acid

Each ingredient & the kinds of drugs it affects

For each ingredient in ALAmax CR with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Alpha-Lipoic Acid5 drug types · 263 drugs

Alkylating Agents

Theoretically, the antioxidant effects of alpha-lipoic acid might alter the effectiveness of alkylating agents.
The use of antioxidants like alpha-lipoic acid during chemotherapy is controversial. There are concerns that antioxidants could reduce the activity of chemotherapy drugs that generate free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as alpha-lipoic acid have on chemotherapy. Advise patients to consult their oncologist before using alpha-lipoic acid.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, alpha-lipoic acid may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro, alpha-lipoic acid inhibits platelet aggregation.

Likelihood Possible Evidence D
Antitumor Antibiotics

Theoretically, the antioxidant effects of alpha-lipoic acid might alter the effectiveness of antitumor antibiotics.
The use of antioxidants like alpha-lipoic acid during chemotherapy is controversial. There are concerns that antioxidants could reduce the activity of antitumor antibiotic drugs, which work by generating free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as alpha-lipoic acid have on chemotherapy involving antitumor antibiotics. Advise patients to consult their oncologist before using alpha-lipoic acid.

Likelihood Possible Evidence D
Thyroid Hormone

Theoretically, alpha-lipoic acid might decrease the effects of thyroid hormone drugs.
Animal research suggests that co-administration of thyroxine with alpha-lipoic acid reduces conversion into the active T3 form.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking alpha-lipoic acid with antidiabetes drugs might increase the risk of hypoglycemia.
Although some small clinical studies have suggested that alpha-lipoic acid can lower blood glucose levels, larger clinical studies in patients with diabetes have shown no clinically meaningful effect. Additionally, co-administration of single doses of alpha-lipoic acid and glyburide or acarbose did not cause detectable drug interactions in healthy volunteers.

Likelihood Unlikely Evidence B
Alpha-Lipoic Acid full monograph & interactions
The maker

Brand information

Manufacturer and brand details for ALAmax CR, from the product label.

XYMOGEN

See all XYMOGEN products
Name
XYMOGEN Exclusive Professional Formulas
Street Address
6900 Kingspointe Pkwy.
City
Orlando
State
FL
ZipCode
32819
Phone Number
800-647-6100
Web Address
www.xymogen.com
Pharmacist Counseling Corner

ALAmax CR by XYMOGEN: Common Questions

Does ALAmax CR by XYMOGEN interact with any medications?
Yes. Based on its ingredients, ALAmax CR has a known interaction with 263 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
ALAmax CR contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take ALAmax CR if I'm pregnant or breastfeeding?
Biotin is likely safe in pregnancy and while breastfeeding at normal dietary amounts. However, alpha-lipoic acid does not have enough safety data, and the facts advise against it during pregnancy and breastfeeding. Talk with your doctor or pharmacist to decide what's right for you.
What are the most common side effects of ALAmax CR?
Alpha-lipoic acid most commonly causes headache, heartburn, nausea, and vomiting. High-dose biotin has rarely caused mild diarrhea. Most people tolerate the product well, but if you notice persistent nausea or headache, mention it to your pharmacist.
Is ALAmax CR safe to take with diabetes medication?
Alpha-lipoic acid in this product has a Minor interaction with diabetes drugs—there's a theoretical risk it could raise the chance of low blood sugar (hypoglycemia), though larger clinical trials haven't shown a strong effect. If you take diabetes medication, check with your pharmacist before starting and monitor your blood sugar closely.
Will ALAmax CR help my hair loss or nerve pain?
Biotin has not been shown to work for alopecia areata (hair loss) based on the evidence we have. Alpha-lipoic acid is possibly effective for diabetic neuropathy (nerve pain from diabetes), meaning the evidence suggests it may help, but it's not certain.
Can I take ALAmax CR with blood thinners like warfarin?
Alpha-lipoic acid in this product may increase the risk of bleeding if you're on blood thinners or antiplatelet drugs, a Moderate interaction. Check with your pharmacist or doctor before starting, and they may want to monitor you more closely.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if ALAmax CR is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

ALAmax CR label
Go deeper

The Full Monographs Behind ALAmax CR’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Biotin

Biotin (vitamin B7) is a water-soluble vitamin your body needs to turn food into energy and to support healthy hair, skin, and nails. Most people get plenty from a normal diet, and true defi...

Read the full Biotin monograph → Herb & supplement monograph

Alpha-lipoic Acid

Interacts with 263 drugs

Alpha-lipoic acid (ALA) is an antioxidant made naturally by the body and found in small amounts in foods. It is most studied for diabetic nerve pain, where some evidence suggests it may help...

Read the full Alpha-lipoic Acid monograph →
Sources

Sources & How We Checked

ALAmax CR's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 52 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Biotin 4 references
  1. Debourdeau PM, Djezzar S, Estival JL, et al. Life-threatening eosinophilic pleuropericardial effusion related to vitamins B5 and H. Ann Pharmacother 2001;35:424-6. DOI
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. Mock DM, Quirk JG, Mock NI. Marginal biotin deficiency during normal pregnancy. Am J Clin Nutr 2002;75:295-9. PubMed
  4. Sedel F, Papeix C, Bellanger A, Touitou V, Lebrun-Frenay C, Galanaud D, et al. High doses of biotin in chronic progressive multiple sclerosis: a pilot study.Mult Scler Relat Disord. 2015;4(2):159-69. doi: 10.1016/j.msard.2015.01.005. PubMed

See these in context on the Biotin monograph →

Alpha-lipoic Acid 48 references
  1. Labriola D, Livingston R. Possible interactions between dietary antioxidants and chemotherapy. Oncology 1999;13:1003-8.
  2. Anon. Alpha-lipoic acid. Altern Med Rev 1998;3:308-10.
  3. Konrad T, Vicini P, Kusterer K, et al. Alpha-lipoic acid treatment decreases serum lactate and pyruvate concentrations and improves glucose effectiveness in lean and obese patients with Type 2 diabetes. Diabetes Care 1999;22:280-7. PubMed
  4. Ziegler D, Hanefeld M, Ruhnau KJ, et al. Treatment of symptomatic diabetic peripheral neuropathy with the antioxidant alpha-lipoic acid: A 3-week, multicentre randomized controlled trial (ALADIN Study). Diabetologia 1995;38:1425-33.
  5. Gleiter CH, Schreeb KH, Freudenthaler S, et al. Lack of interaction between thioctic acid, glibenclamide and acarbose. Br J Clin Pharmacol 1999;48:819-25. PubMed
  6. Jacob S, Henriksen EJ, Tritschler HJ, et al. Improvement of insulin-stimulated glucose-disposal in type 2 diabetes after repeated parenteral administration of thioctic acid. Exp Clin Endocrinol Diabet 1996;104:284-8. PubMed
  7. Jacob S, Henriksen EJ, Schiemann AL, et al. Enhancement of glucose disposal in patients with type 2 diabetes by alpha-lipoic acid. Arzneimittelforschung 1995;45:872-4.
  8. Jacob S, Ruus P, Hermann R, et al. Oral administration of RAC-alpha-lipoic acid modulates insulin sensitivity in patients with type-2 diabetes mellitus: a placebo-controlled, pilot trial. Free Rad Biol Med 1999;27:309-14.
  9. Segermann J, Hotze A, Ulrich H, Rao GS. Effect of alpha-lipoic acid on the peripheral conversion of thyroxine to triiodothyronine and on serum lipid-, protein- and glucose levels. Arzneimittelforschung 1991;41:1294-8.
  10. Beitner H. Randomized, placebo controlled, double-blind study on the clinical efficacy of a cream containing 5% alpha-lipoic acid related to photoaging of facial skin. Br J Dermatol 2003;149:841-9.
  11. Ziegler D, Nowak H, Kempler P, et al. Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: A meta-analysis. Diabet Med 2004;21:114-21.
  12. Prasad KN. Rationale for using high-dose multiple dietary antioxidants as an adjunct to radiation therapy and chemotherapy. J Nutr 2004;134:3182S-3S. PubMed
  13. Conklin KA. Cancer chemotherapy and antioxidants. J Nutr 2004;134:3201S-3204S. PubMed
  14. Vincent HK, Bourguignon CM, Vincent KR, Taylor AG. Effects of alpha-lipoic acid supplementation in peripheral arterial disease: a pilot study. J Alt Complement Med 2007;13:577-84. PubMed
  15. Furukawa N, Miyamura N, Nishida K, et al. Possible relevance of alpha lipoic acid contained in a health supplement in a case of insulin autoimmune syndrome. Diabetes Res Clin Pract 2007;75:366-7. PubMed
  16. Ziegler D., Ametov A., Barinov A., Dyck P. J., Gurieva I., Low P. A., Munzel U., Yakhno N., Raz I., Novosadova M., Maus J., Samigullin, R. Oral treatment with alpha-lipoic acid improves symptomatic diabetic polyneuropathy: the SYDNEY 2 trial. Diabetes Car
  17. Gu X. M., Zhang S. S., Wu J. C., Tang Z. Y., Lu Z. Q., Li H., Liu C., Chen L., Ning, G. [Efficacy and safety of high-dose a-lipoic acid in the treatment of diabetic polyneuropathy]. Zhonghua Yi Xue Za Zhi 2010;90(35):2473-2476.
  18. Porasuphatana S., Suddee S., Nartnampong A., Konsil J., Harnwong B., Santaweesuk A. Glycemic and oxidative status of patients with type 2 diabetes mellitus following oral administration of alpha-lipoic acid: a randomized double-blinded placebo-controlled
  19. Ansar H., Mazloom Z., Kazemi F., Hejazi N. Effect of alpha-lipoic acid on blood glucose, insulin resistance and glutathione peroxidase of type 2 diabetic patients. Saudi Med J 2011;32(6):584-588. DOI
  20. de Oliveira A. M., Rondó P. H., Luzia L. A., D'Abronzo F. H., Illison V. K. The effects of lipoic acid and a-tocopherol supplementation on the lipid profile and insulin sensitivity of patients with type 2 diabetes mellitus: a randomized, double-blind, pla
  21. Mazloom Z., Ansar H. The Effect of Alpha-Lipoic Acid on Blood Pressure in Type 2 Diabetics. Iranian Journal of Endocrinology and Metabolism 2009;11(3):245-250.
  22. Volchegorskii I. A., Rassokhina L. M., Koliadich M. I., Alekseev M. I. [Comparative study of alpha-lipoic acid and mexidol effects on affective status, cognitive functions and quality of life in diabetes mellitus patients]. Eksp Klin Farmakol 2011;74(11):
  23. Cavalcanti D. R., da Silveira F. R. Alpha lipoic acid in burning mouth syndrome--a randomized double-blind placebo-controlled trial. J Oral Pathol Med 2009;38(3):254-261. PubMed
  24. Koh E. H., Lee W. J., Lee S. A., Kim E. H., Cho E. H., Jeong E., Kim D. W., Kim M. S., Park J. Y., Park K. G., Lee H. J., Lee I. K., Lim S., Jang H. C., Lee K. H., Lee K. U. Effects of alpha-lipoic Acid on body weight in obese subjects. Am J Med 2011;124( PubMed
  25. Bergqvist-Karlsson, A., Thelin, I., and Bergendorff, O. Contact dermatitis to alpha-lipoic acid in an anti-wrinkle cream. Contact Dermatitis 2006;55(1):56-57.
  26. Tang, J., Wingerchuk, D. M., Crum, B. A., Rubin, D. I., and Demaerschalk, B. M. Alpha-lipoic acid may improve symptomatic diabetic polyneuropathy. Neurologist. 2007;13(3):164-167. PubMed
  27. Hegazy SK, Tolba OA, Mostafa TM, Eid MA, El-Afify DR. Alpha-lipoic acid improves subclinical left ventricular dysfunction in asymptomatic patients with type 1 diabetes. Rev Diabet Stud 2013;10(1):58-67. PubMed
  28. Huang Z, Wan X, Liu J, et al. Short-term continuous subcutaneous insulin infusion combined with insulin sensitizers rosiglitazone, metformin, or antioxidant a-lipoic acid in patients with newly diagnosed type 2 diabetes mellitus. Diabetes Technol Ther 201
  29. Sarezky D, Raquib AR, Dunaief JL, Kim BJ. Tolerability in the elderly population of high-dose alpha lipoic acid: a potential antioxidant therapy for the eye. Clin Ophthalmol. 2016 Sep 29;10:1899-1903. PubMed
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See these in context on the Alpha-lipoic Acid monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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