Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Align Probiotic Ingredients & Drug Interactions

by Align

Align Probiotic label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Align Probiotic against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Align Probiotic is a dietary supplement by Align with 1 active ingredient. Its ingredients are commonly taken for digestive health and regularity, irritable bowel syndrome (ibs), diarrhea (including antibiotic-related).Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bifidobacterium longum longum 35624. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Align Probiotic by Align

Ask about any prescription or over-the-counter medication and we check it for interactions with Align Probiotic by Align — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Align Probiotic by Align

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Align contains one active ingredient: Bifidobacterium longum (specifically the longum 35624 strain), a live beneficial bacterium that's part of the normal gut microbiome. The capsule also contains several inactive ingredients — microcrystalline cellulose, hypromellose, sucrose, magnesium stearate, sodium caseinate, titanium dioxide, trisodium citrate dihydrate, propyl gallate, and gellan gum — which help deliver the probiotic and keep it stable.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Bifidobacterium Longum's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: digestive health and regularity.
  • We looked for evidence on: Abdominal pain, Antibiotic-associated diarrhea, Clostridioides difficile infection, Colic, Constipation, Diarrhea — and 4 related terms.
  • The closest evidence on file: Bifidobacterium Longum is rated "Insufficient Reliable Evidence To Rate" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Bifidobacterium Longum is rated "Insufficient Reliable Evidence To Rate" for Constipation, Diarrhea, Irritable bowel syndrome (IBS), Lactose intolerance, and more.

The evidence we hold doesn't establish that Bifidobacterium longum is reliably effective for age-related cognitive decline, hay fever (allergic rhinitis), antibiotic-associated diarrhea, generalized anxiety, asthma, or athletic performance — the data rated all of these as insufficient. If you're considering Align for a specific condition, talk with your doctor about whether the evidence supports its use for your situation.

The evidence, ingredient by ingredient Bifidobacterium Longum

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Bifidobacterium longum is generally well tolerated in healthy people, but caution is advised if you're seriously ill or have a weakened immune system. Rarely, people have reported mild abdominal discomfort, pain, bloating, flatulence, constipation, or a dry cough when taking it.

There are also rare case reports of the bacterium entering the bloodstream and causing serious infection in critically ill infants and adults, particularly those on life support or with recent surgery — this is very uncommon but underscores why immune-compromised patients need their doctor's guidance. For pregnancy and breastfeeding, the safety data rates Bifidobacterium longum as possibly safe, but limited information exists.

Talk with your doctor or pharmacist before using Align while pregnant or breastfeeding to make sure it's right for you.

Side effects, ingredient by ingredient Bifidobacterium Longum

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Bifidobacterium Longum.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antibiotic drugs, check with your doctor or pharmacist about timing — antibiotics can interfere with how well this probiotic works, so you may need to space them several hours apart. Use the medication checker below to verify any antibiotics you're on.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Align is a single-strain probiotic generally well tolerated by healthy people, though evidence for most health claims remains limited. If you take antibiotics, you'll need to separate them from your probiotic doses — ask your doctor or pharmacist about timing.

Anyone who is seriously ill, immune-compromised, pregnant, or breastfeeding should discuss Align with their own healthcare provider before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Align Probiotic, straight from the product label.

Brand Align
Barcode (UPC) 037000143437
Net contents 28 Capsule(s)
Market status On market
Date entered into DSLD Nov 22, 2022
DSLD ID 278084
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Align Probiotic by Align, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
28
UPC/BARCODE
037000143437
IngredientAmount% DV
Bifidobacterium longum longum 356244 mg--

Other ingredients: Microcrystalline Cellulose, Hypromellose, Sucrose, Magnesium Stearate, Sodium Caseinate, Titanium Dioxide, Trisodium Citrate Dihydrate, Propyl Gallate, Gellan Gum

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Gluten free Soy free

Vegetarian

Guaranteed potency

24/7 digestive support With continued daily use Naturally helps with occasional abdominal discomfort, gas, and bloating Helps promote and support a healthy digestive system

Why use Align? Helps with occasional abdominal discomfort, gas, and bloating

Fortifies the digestive system with healthy bacteria 24/7

Storage

No refrigeration required

For best results, we recommend you store Align below 86 degrees F (30 degrees C) in the original blister unit.

Suggested/Recommended/Usage/Directions

Directions: Take one capsule per day.

Brand IP Statement(s)

Patents: www.pg.com/patents

General Statements

Developed by Gastroenterologists #1 doctor recommended brand

Why use probiotics? Common issues such as diet, changes in routine, travel and stress may disrupt your natural balance of good bacteria.

#1 Doctor and #1 gastroenterologist recommended probiotic brand

Money Back Guarantee Procter & Gamble stands behind our product. If you are not satisfied with Align, simply return the UPC code from this package and your original sales receipt within 60 days of purchase for a full refund in the form of a prepaid card. Visit AlignProbioitics.com/refund for details. Among gastroenterologists who recommend a brand of probiotic in ProVoice 2008-2018 surveys. Among doctors who recommend a brand of probiotic in ProVoice 2018 survey.

Questions? 1-800-208-0112 or AlignProbiotics.com

FDA Statement of Identity

Probiotic Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Contains: Milk

Warnings: Parental supervision is recommended for the use of this product. Keep out of reach of children.

Tamper evident: Carton sealed for your protection. Do not use if blister unit is open or torn.

Formula

Align Probiotic is the product of more than 10 years of scientific research and contains the pure-strain probiotic, Bifidobacterium 35624

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Align Probiotic by Align label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Align Probiotic label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Align Probiotic by Align

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container28 Amounts shown are per serving.

Bifidobacterium longum longum 35624

Interacts with
182 drugs
4 mg per serving

Bifidobacterium longum is a 'friendly' bacterium found naturally in the human gut and used as a probiotic. It is generally well tolerated and is most...

Bifidobacterium longum longum 35624 monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Hypromellose, Sucrose, Magnesium Stearate, Sodium Caseinate, Titanium Dioxide, Trisodium Citrate Dihydrate, Propyl Gallate, Gellan Gum. These complete the product’s ingredient list but are not active constituents.

Interaction report

Align Probiotic by Align Drug Interactions

Want to check YOUR meds against Align Probiotic?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Bifidobacterium longum longum 35624 182

Individual Drug Interactions

The ingredients in Align Probiotic interact with 182 drugs. Click any drug to see the details.

1 of the 1 ingredient in Align Probiotic interact with drugs. Each result below shows which ingredient is responsible. Bifidobacterium longum longum 35624

Each ingredient & the kinds of drugs it affects

For each ingredient in Align Probiotic with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Bifidobacterium longum longum 356241 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B. longum.
Since B. longum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. longum preparations by at least 2 hours.

Likelihood Probable Evidence D
Bifidobacterium longum longum 35624 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Align Probiotic, from the product label.

Align

See all Align products
Name
Procter & Gamble
City
Cincinnati
State
OH
ZipCode
45202
Phone Number
1-800-208-0112
Web Address
www.pg.com
Pharmacist Counseling Corner

Align Probiotic by Align: Common Questions

Does Align Probiotic by Align interact with any medications?
Yes. Based on its ingredients, Align Probiotic has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Align Probiotic contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What exactly is in Align?
Align contains live Bifidobacterium longum bacteria — a beneficial microorganism that naturally lives in your gut. It's meant to support your digestive microbiome.
Can I take Align while I'm on antibiotics?
You can, but timing matters. Since antibiotics can kill the live bacteria in Align, you'll want to separate them — typically by a few hours. Your doctor or pharmacist can recommend the best spacing for your specific antibiotic.
Is Align safe if I'm pregnant or breastfeeding?
The data rates Bifidobacterium longum as possibly safe in pregnancy and lactation, but information is limited. Talk with your doctor or pharmacist before using it while pregnant or breastfeeding to decide what's best for you.
What side effects might I notice?
Most people tolerate Align well. Rarely, some report mild bloating, gas, abdominal discomfort, constipation, or a dry cough. If you have a weakened immune system or are seriously ill, talk with your doctor first — there are very rare case reports of serious infection.
Does Align actually work for digestive problems?
The evidence we hold doesn't establish reliable effectiveness for specific digestive or other health claims. If you're taking it for a particular condition, check with your doctor about whether it's supported for your situation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Align Probiotic is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Align Probiotic label
Go deeper

The Full Monographs Behind Align Probiotic’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bifidobacterium Longum

Interacts with 182 drugs

Bifidobacterium longum is a 'friendly' bacterium found naturally in the human gut and used as a probiotic. It is generally well tolerated and is most studied for digestive issues, though evi...

Read the full Bifidobacterium Longum monograph →
Sources

Sources & How We Checked

Align Probiotic's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 21 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bifidobacterium Longum 21 references
  1. Ha GY, Yang CH, Kim H, Chong Y. Case of sepsis caused by Bifidobacterium longum. J Clin Microbiol 1999;37:1227-8.
  2. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  3. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  4. Rautava S, Kainonen E, Salminen S, Isolauri E. Maternal probiotic supplementation during pregnancy and breast-feeding reduces the risk of eczema in the infant. J Allergy Clin Immunol. 2012;130(6):1355-60. PubMed
  5. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  6. Pellonperä O, Vahlberg T, Mokkala K, et al. Weight gain and body composition during pregnancy: a randomised pilot trial with probiotics and/or fish oil. Br J Nutr. 2020 Nov 4:1-11. PubMed
  7. Pellonperä O, Mokkala K, Houttu N, et al. Efficacy of fish oil and/or probiotic intervention on the incidence of gestational diabetes mellitus in an at-risk group of overweight and obese women: A randomized, placebo-controlled, double-blind clinical trial PubMed
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed
  10. Enomoto T, Sowa M, Nishimori K, et al. Effects of bifidobacterial supplementation to pregnant women and infants in the prevention of allergy development in infants and on fecal microbiota. Allergol Int 2014;63(4):575-85. PubMed
  11. US Food and Drug Administration (FDA). Dear Healthcare Provider Letter: Warning Regarding Use of Probiotics in Preterm Infants. September 2023. Available at: https://www.fda.gov/media/172606/download?attachment. Accessed November 1, 2023.
  12. Pillai A, Tan J, Paquette V, Panczuk J. Does probiotic bacteremia in premature infants impact clinically relevant outcomes? A case report and updated review of literature. Clin Nutr ESPEN. 2020;39:255-259. PubMed
  13. Sabaté JM, Iglicki F. Effect of Bifidobacterium longum 35624 on disease severity and quality of life in patients with irritable bowel syndrome. World J Gastroenterol 2022;28(7):732-744.
  14. Malaguarnera M, Greco F, Barone G, Gargante MP, Malaguarnera M, Toscano MA. Bifidobacterium longum with fructo-oligosaccharide (FOS) treatment in minimal hepatic encephalopathy: a randomized, double-blind, placebo-controlled study. Dig Dis Sci 2007;52(11) PubMed
  15. Zbinden A, Zbinden R, Berger C, Arlettaz R. Case series of Bifidobacterium longum bacteremia in three preterm infants on probiotic therapy. Neonatology 2015;107(1):56-9.
  16. Tamaki H, Nakase H, Inoue S, et al. Efficacy of probiotic treatment with Bifidobacterium longum 536 for induction of remission in active ulcerative colitis: A randomized, double-blinded, placebo-controlled multicenter trial. Dig Endosc 2016;28(1):67-74.
  17. Bertelli C, Pillonel T, Torregrossa A, et al. Bifidobacterium longum bacteremia in preterm infants receiving probiotics. Clin Infect Dis 2015;60(6):924-7. PubMed
  18. Esaiassen E, Cavanagh P, Hjerde E, Simonsen GS, Støen R, Klingenberg C. Bifidobacterium longum subspecies infantis bacteremia in 3 extremely preterm infants receiving probiotics. Emerg Infect Dis 2016;22(9):1664-6.
  19. Tena D, Losa C, Medina MJ, Sáez-Nieto JA. Peritonitis caused by Bifidobacterium longum: case report and literature review. Anaerobe 2014;27:27-30. PubMed
  20. Sangkanjanavanich S, Pradubpongsa P, Mitthamsiri W, Sangasapaviliya A, Boonpiyathad T. Bifidobacterium infantis 35624 efficacy in patients with uncontrolled asthma: A randomized placebo-controlled trial. Ann Allergy Asthma Immunol 2022;129(6):790-792. PubMed
  21. Wilson HL, Ong CW. Bifidobacterium longum vertebrodiscitis in a patient with cirrhosis and prostate cancer. Anaerobe 2017;47:47-50. PubMed

See these in context on the Bifidobacterium Longum monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team