Major interaction on record — check this product against your medications before combining. Based on 3 of 7 ingredients. Check your meds →
Dietary supplement

Amino2 Green Apple Ingredients & Drug Interactions

by MYOGENIX

Amino2 Green Apple label
See full label image
Powder Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Amino2 Green Apple against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Amino2 Green Apple is a dietary supplement by MYOGENIX with 7 active ingredients. Its ingredients are commonly taken for replacing fluids and electrolytes, preventing dehydration during exercise or illness, treating low blood sodium (under medical care).Based on those ingredients, 273 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Sodium, Potassium, Whey Protein hydrolysate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Amino2 Green Apple by MYOGENIX

Ask about any prescription or over-the-counter medication and we check it for interactions with Amino2 Green Apple by MYOGENIX — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Amino2 Green Apple by MYOGENIX

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 3 of its 6 active ingredients.
  • “INTRAVENOS(TM)” is listed as a grouped ingredient — the label gives one combined amount (6,600 mg) without saying how much of each component you get.

Amino2 Green Apple has 6 active ingredients. Sodium and potassium are electrolytes that help with muscle function and hydration.

Leucine is an amino acid that supports muscle protein synthesis. Whey protein hydrolysate is a rapidly absorbed form of milk protein, broken down into smaller peptides for faster uptake.

The product also contains other carbohydrates for energy. Beyond these active ingredients, the powder includes maltodextrin, citric acid, natural and artificial flavors, potassium citrate, sodium chloride, sucralose, acesulfame potassium, and sodium copper chlorophyllin as inactive ingredients.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: amino acids for muscle recovery and athletic performance.
  • We looked for evidence on: Athletic performance, Exercise-induced muscle damage, Sarcopenia, HIV/AIDS-related wasting, muscle protein synthesis, exercise recovery — and 1 related terms.
  • The strongest evidence on file: Whey Protein is rated "Possibly Effective" for Athletic performance (Natural Medicines).
  • Also on file: Whey Protein is rated "Insufficient Reliable Evidence To Rate" for HIV/AIDS-related wasting, Sarcopenia, Exercise-induced muscle damage.

For whey protein — the main active protein in this product — evidence supports it as possibly effective for athletic performance. It's listed as possibly ineffective for osteoporosis, COPD, and there isn't enough reliable evidence yet to rate it for age-related cognitive decline or HIV/AIDS-related wasting.

The sodium in this product is likely effective for cystic fibrosis and possibly effective for reducing kidney toxicity from amphotericin B (a fungal medication), though for most athletic or general wellness purposes, the evidence isn't established in our data. Potassium and leucine effectiveness ratings aren't available in our records.

The evidence, ingredient by ingredient Sodium Potassium Whey Protein

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Whey protein is generally well tolerated by most healthy adults at typical doses. Common side effects include bloating, cramps, diarrhea, nausea, headache, acne, and reduced appetite — most dose-dependent.

A few case reports link whey protein to acne development in teens and young adults, usually reversing after discontinuation. One rare case report associated large amounts of whey with coronary artery clots, though this is extremely uncommon.

Sodium is essential in small amounts but too much raises blood pressure and stresses the heart. Normal dietary sodium is fine, but avoid sodium supplements or very high intake without checking with your doctor first.

Potassium from food is safe, but supplements can cause dangerously high blood levels in people with kidney disease or those taking certain medications — talk to your doctor before supplementing, especially if you're pregnant or breastfeeding. Pregnancy and lactation safety data is limited for the concentrated supplement form of whey protein.

Side effects, ingredient by ingredient Sodium Potassium Whey Protein

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Whey Protein, Potassium, Sodium.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: lithium; Parkinson's medications.
  • For scale: 273 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take levodopa, whey protein in this product may reduce how well it works and worsen Parkinson symptoms — this is a Major interaction. Check with your doctor before using Amino2.

You should also double-check if you're on blood pressure pills, lithium, water pills (especially potassium-sparing types), ACE inhibitors, ARBs, corticosteroids, or quinolone/tetracycline antibiotics or bisphosphonates — the sodium, potassium, and whey protein all carry Moderate interactions with these drug types. Discuss your full medication list with your pharmacist or doctor before starting.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This is an amino acid and electrolyte powder marketed for athletic performance and muscle support. If you take levodopa for Parkinson disease, blood pressure medication, lithium, water pills, ACE inhibitors, ARBs, or certain antibiotics (quinolones or tetracyclines) or bone medications (bisphosphonates), you'll need to check with your doctor or pharmacist before using it — the sodium and potassium content and whey protein could affect how those medications work or raise the risk of dangerously high electrolyte levels.

Talk it over with your own healthcare provider to see if this product is right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 1, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Amino2 Green Apple, straight from the product label.

Brand MYOGENIX
Barcode (UPC) 68026933910
Net contents 420 g
Market status On market
Date entered into DSLD Oct 1, 2012
DSLD ID 12590
Product type Other Combinations
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Amino2 Green Apple by MYOGENIX, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
12 Gram(s)
Maximum serving Sizes:
12 Gram(s)
Servings per container
35
UPC/BARCODE
68026933910
IngredientAmount% DV
Calories40 {Calories}--
Total Carbohydrates3 g1%
Protein6 g--
Sodium100 mg4%
Potassium140 mg4%
Cholesterol0 mg--
Total Fat0 g--
Leucine0 NP--
Other Carbohydrates3 g--
Whey Protein hydrolysate0 NP--
INTRAVENOS(TM)6600 mg--
NOS(TM)0 NP--

Other ingredients: Maltodextrin, Citric Acid, Natural & Artificial flavors, Potassium Citrate, Sodium Chloride, Sucralose, Acesulfame Potassium, Sodium Copper Chlorophyllin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

PRE-INTRA-POST

250% SUPERIOR LEUCINE ABSORPTION BCAA RATIO 5:1:1

NITRIC OXIDE UPREGULATE NO2 LEVELS UP TO 950%

Manufactured In A Facility That Processes Milk, Soy, Eggs, Tree Nuts, Wheat.

(flag) Made in the USA.

AMINO2(R) with INTRAVENOS(TM) Cutting Edge BCAA, Amino Acid & NO2 Symbiote AMINO2(R) Utilizes Advanced Peptide Bonding Technology to Deliver: -250% Better Leucine Absorption, and faster delivery of nutrients, compared to regular l-leucine. - An Ideal 5:1:1 BCAA Ratio of Leucine : Isoleucine : Valine. - All 9 Essential Amino Acids, which are absolutely critical for muscle synthesis & recovery. - Enriched Bioactive Peptides, shown to increase NO2 levels as much as 950%.

AMINO ACIDS Alanine Arginine Aspartic acid Cysteine Glutamic acid Glycine Histidine Isoleucine Leucine Lysine Methionine Phenylalanine Proline Serine Threonine Tryptophan Tyrosine Valine

Formula

AMINO ACIDS + NITRIC OXIDE

BCAA + ESSENTIAL AMINO ACIDS

CONTAINS ALL 9 ESSENTIAL AMINO ACIDS

Suggested/Recommended/Usage/Directions

Directions for use: Add 1 level scoop (12g) of AMINO2(R) to 8oz-10oz of water and stir/shake powder into solution. LET STAND FOR 30-60 SECONDS. Stir again until mixture has dissolved. For best results, take AMINO2(R) immediately before and after exercising. On strenuous training days, AMINO2(R) can also be consumed during your workout. On non-training days, take 1 serving upon waking.

Formulation

SUGAR FREE

FDA Statement of Identity

DIETARY SUPPLEMENT

Precautions

Allergen Statement: This Product Contains Ingredients Derived From Soy and Milk.

FDA Disclaimer Statement

This statement has not been evaluated by the FDA. This product is not intended to diagnose, cure, treat or prevent any disease.

Brand IP Statement(s)

Demand More From Your Amino Acids & Expect Better Results with AMINO2(R)

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Amino2 Green Apple by MYOGENIX label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Amino2 Green Apple label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Amino2 Green Apple by MYOGENIX

These are the 7 active ingredients this product is made of. Select any to open its full monograph.

Serving size12 Gram(s) Dosage formPowder Servings per container35 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Protein

6 g per serving

Sodium

Interacts with
205 drugs
100 mg per serving

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

Potassium

Interacts with
62 drugs
140 mg per serving

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanc...

Potassium monograph & interactions

Other Carbohydrates

3 g per serving

INTRAVENOS(TM)

6600 mg per serving

Other (inactive) ingredients: Maltodextrin, Citric Acid, Natural & Artificial flavors, Potassium Citrate, Sodium Chloride, Sucralose, Acesulfame Potassium, Sodium Copper Chlorophyllin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Amino2 Green Apple by MYOGENIX Drug Interactions

Want to check YOUR meds against Amino2 Green Apple?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
273Drugs
5 Major 268 Moderate

Ingredients driving the most interactions

Sodium 205
Potassium 62
Whey Protein hydrolysate 53

Individual Drug Interactions

The ingredients in Amino2 Green Apple interact with 273 drugs. Click any drug to see the details.

3 of the 7 ingredients in Amino2 Green Apple interact with drugs. Each result below shows which ingredient is responsible. Sodium Potassium Whey Protein hydrolysate

Each ingredient & the kinds of drugs it affects

For each ingredient in Amino2 Green Apple with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Sodium7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium full monograph & interactions

Potassium3 drug types · 62 drugs

Ace Inhibitors (Aceis)

Using ACEIs with high doses of potassium increases the risk of hyperkalemia.
ACEIs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Angiotensin Receptor Blockers (Arbs)

Using ARBs with high doses of potassium increases the risk of hyperkalemia.
ARBs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Potassium-Sparing Diuretics

Concomitant use increases the risk of hyperkalemia.
Using potassium-sparing diuretics with potassium supplements increases the risk of hyperkalemia.

Likelihood Likely Evidence C
Potassium full monograph & interactions

Whey Protein hydrolysate4 drug types · 53 drugs

Levodopa

Theoretically, whey protein might decrease levodopa absorption.
Small clinical studies show that concomitant ingestion of protein or high doses of leucine or isoleucine (100 mg/kg) and levodopa can exacerbate tremor, rigidity, and the "on-off" syndrome in patients with Parkinson disease.

Likelihood Probable Evidence D
Bisphosphonates

Theoretically, whey protein might reduce the absorption of bisphosphonates.
Whey protein contains minerals such as calcium that bind bisphosphonates in the gut. Advise patients to take bisphosphonates at least 30 minutes before whey protein, but preferably at a different time of day.

Likelihood Probable Evidence D
Quinolone Antibiotics

Theoretically, whey protein might decrease quinolone absorption.
Whey protein contains minerals, such as calcium, that can bind to quinolones in the gut. To avoid this interaction, advise patients to take oral quinolones at least 2 hours before or 4-6 hours after whey protein.

Likelihood Probable Evidence D
Tetracycline Antibiotics

Theoretically, whey protein might decrease tetracycline absorption.
Whey protein contains minerals, such as calcium, that bind to tetracyclines in the gut. To avoid this interaction, advise patients to take oral tetracyclines at least 2 hours before or 4-6 hours after whey protein.

Likelihood Probable Evidence D
Whey Protein hydrolysate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Amino2 Green Apple, from the product label.

MYOGENIX

See all MYOGENIX products
Name
MYOGENIX Inc., 2011
Street Address
2309 A Street
City
Santa Maria
State
CA
ZipCode
93455
Phone Number
(800) 950-0348
Web Address
www.myogenix.com
Pharmacist Counseling Corner

Amino2 Green Apple by MYOGENIX: Common Questions

Does Amino2 Green Apple by MYOGENIX interact with any medications?
Yes. Based on its ingredients, Amino2 Green Apple has a known interaction with 273 medications, including 5 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Amino2 Green Apple contains 7 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does whey protein in this product cause acne?
Whey protein can trigger or worsen acne in some people, especially teens and young adults. Case reports show that stopping whey protein usually clears up the acne. If you're prone to acne, mention this to your doctor or pharmacist before using this product.
Is this safe for someone with high blood pressure?
This product contains sodium, which can raise blood pressure and may reduce how well your blood pressure medications work. If you have high blood pressure, talk with your doctor or pharmacist before using it — they can tell you if it's okay given your specific situation.
Can I use this if I take a potassium-sparing water pill?
No — combining this product's potassium with potassium-sparing diuretics raises the risk of dangerously high potassium levels in your blood. Check with your doctor or pharmacist before using Amino2.
What does the whey protein do in this product?
Whey protein is rapidly absorbed and supports muscle protein synthesis — it's possibly effective for athletic performance. The research doesn't support it for bone health or lung disease, though.
Can I take this while breastfeeding?
Dietary potassium is fine while breastfeeding, but we don't have enough data on concentrated whey protein supplements during lactation. Talk with your doctor or pharmacist before using this product if you're nursing.
What's leucine and what does it do?
Leucine is an amino acid that helps trigger muscle protein synthesis. We don't have effectiveness data on file for it, but it's one of the three branched-chain amino acids commonly used in athletic supplements.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Amino2 Green Apple is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Amino2 Green Apple label
Go deeper

The Full Monographs Behind Amino2 Green Apple’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph → Herb & supplement monograph

Potassium

Interacts with 62 drugs

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanced diet rich in fruits and vegetables. P...

Read the full Potassium monograph → Herb & supplement monograph

Whey Protein

Interacts with 53 drugs

Whey protein is a high-quality, complete protein made from cow's milk that can help people meet protein needs and support muscle growth when combined with exercise. It is generally safe for...

Read the full Whey Protein monograph →
Sources

Sources & How We Checked

Amino2 Green Apple's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 75 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Sodium 38 references
  1. Garabedian-Ruffalo SM, Ruffalo RL. Drug and nutrient interactions. Am Fam Physician 1986;33:165-74.
  2. Food and Drug Administration Science Background: Safety of Sodium Phosphates Oral Solution. September 17, 2001. Available at: http://www.fda.gov/cder/drug/safety/sodiumphospate.htm
  3. Coton T, Mallaret C, Coilliot C, Carre D, Guisset M. Severe acute ulcerated gastritis induced by salt. Presse Med 2009;38(3):499-500. PubMed
  4. Frings-Meuthen P, Buehlmeier J, Baecker N, et al. High sodium chloride intake exacerbates immobilization-induced bone resorption and protein losses. J Appl Physiol 2011;111(2):537-542. PubMed
  5. Frings-Meuthen P, Baecker N, Heer M. Low-grade metabolic acidosis may be the cause of sodium chloride-induced exaggerated bone resorption. J Bone Miner Res 2008;23(4):517-524. PubMed
  6. Alam S, Johnson AG. A meta-analysis of randomised controlled trials (RCT) among healthy normotensive and essential hypertensive elderly patients to determine the effect of high salt (NaCl) diet of blood pressure. J Hum Hypertens 1999;13(6):367-74.
  7. Boudville N, Ward S, Benaroia M, House AA. Increased sodium intake correlates with greater use of antihypertensive agents by subjects with chronic kidney disease. Am J Hypertens 2005;18(10):1300-5. PubMed
  8. Bennett WM. Drug interactions and consequences of sodium restriction. Am J Clin Nutr 1997;65(2 Suppl):678S-681S. PubMed
  9. Okusa MD, Crystal LJ. Clinical manifestations and management of acute lithium intoxication. Am J Med 1994;97(4):383-9. PubMed
  10. Food and Nutrition Board, Institute of Medicine. Dietary reference intakes for water, potassium, sodium, chloride, and sulfate. Washington, DC: National Academy Press, 2005. Available at: http://www.nap.edu/openbook.php?record_id=10925. DOI
  11. D'Elia L, Rossi G, Ippolito R, Cappuccio FP, Strazzullo P. Habitual salt intake and risk of gastric cancer: a meta-analysis of prospective studies. Clin Nutr 2012;31(4):489-98. PubMed
  12. Goldsmith SR. Hyponatremia in heart failure: time for a trial. J Card Fail 2013;19(6):398-400. PubMed
  13. Willocks L, Brettle R, Keen J, Valentine C, Pinching AJ. Formulations of didanosine (ddI) and salt overload. Lancet 1992;339(8786):190.
  14. Chen L, Zhang Z, Chen W, Whelton PK, Appel LJ. Lower Sodium Intake and Risk of Headaches: Results From the Trial of Nonpharmacologic Interventions in the Elderly. Am J Public Health. 2016;106(7):1270-5. PubMed
  15. Cook NR, Appel LJ, Whelton PK. Lower levels of sodium intake and reduced cardiovascular risk. Circulation. 2014;129(9):981-9. PubMed
  16. Cook NR, Appel LJ, Whelton PK. Sodium Intake and All-Cause Mortality Over 20 Years in the Trials of Hypertension Prevention. J Am Coll Cardiol. 2016;68(15):1609-1617. PubMed
  17. Mente A, O'Donnell M, Rangarajan S, et al. Associations of urinary sodium excretion with cardiovascular events in individuals with and without hypertension: a pooled analysis of data from four studies. Lancet. 2016;388(10043):465-75. PubMed
  18. Moosavian SP, Haghighatdoost F, Surkan PJ, Azadbakht L. Salt and obesity: a systematic review and meta-analysis of observational studies. Int J Food Sci Nutr. 2017;68(3):265-277. PubMed
  19. O'Donnell M, Mente A, Rangarajan S, et al. Urinary sodium and potassium excretion, mortality, and cardiovascular events. N Engl J Med. 2014;371(7):612-23. DOI
  20. Poggio R, Gutierrez L, Matta MG, Elorriaga N, Irazola V, Rubinstein A. Daily sodium consumption and CVD mortality in the general population: systematic review and meta-analysis of prospective studies. Public Health Nutr. 2015;18(4):695-704. PubMed
  21. Stallings VA, Harrison M, Oria M; Committee to Review the Dietary Reference Intakes for Sodium and Potassium, Food and Nutrition Board, Health and Medicine Division, National Academies of Sciences, Engineering, and Medicine. Washington (DC): National Acad
  22. Mahtani KR, Heneghan C, Onakpoya I, et al. Reduced Salt Intake for Heart Failure: A Systematic Review. JAMA Intern Med. 2018 Dec 1;178(12):1693-1700. PubMed
  23. Yancy CW. Sodium Restriction in Heart Failure: Too Much Uncertainty-Do the Trials. JAMA Intern Med. 2018 Dec 1;178(12):1700-1701. PubMed
  24. He FJ, Campbell NRC, Ma Y, MacGregor GA, Cogswell ME, Cook NR. Errors in estimating usual sodium intake by the Kawasaki formula alter its relationship with mortality: implications for public health. Int J Epidemiol. 2018;47(6):1784-1795. PubMed
  25. Murthy K, Ondrey GJ, Malkani N, et al. THE EFFECTS OF HYPONATREMIA ON BONE DENSITY AND FRACTURES: A SYSTEMATIC REVIEW AND META-ANALYSIS. Endocr Pract. 2019;25(4):366-378. PubMed
  26. Messerli FH, Hofstetter L, Syrogiannouli L, et al. Sodium intake, life expectancy, and all-cause mortality. Eur Heart J 2021;42(21):2103-2112. PubMed
  27. Graudal NA, Hubeck-Graudal T, Jurgens G. Effects of low sodium diet versus high sodium diet on blood pressure, renin, aldosterone, catecholamines, cholesterol, and triglyceride. Cochrane Database Syst Rev 2020;12(12):CD004022. PubMed
  28. Giatti S, Santos RB, Aielo AN, et al. Association of sodium with obstructive sleep apnea. The ELSA-Brasil study. Ann Am Thorac Soc 2021;18(3):502-510. PubMed
  29. Nan X, Lu H, Wu J, et al. The interactive association between sodium intake, alcohol consumption and hypertension among elderly in northern China: a cross-sectional study. BMC Geriatr 2021;21(1):135. PubMed
  30. Kyozuka H, Fukusda T, Murata T, et al. Impact of preconception sodium intake on hypertensive disorders of pregnancy: The Japan Environment and Children's study. Pregnancy Hypertens 2021;23:66-72. PubMed
  31. Zhao L, Ogden CL, Yang Q, et al. Association of usual sodium intake with obesity among US children and adolescents, NHANES 2009-2016. Obesity (Silver Spring) 2021;29(3):587-594. PubMed
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Whey Protein 25 references
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See these in context on the Whey Protein monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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