Major interaction on record — check this product against your medications before combining. Based on 10 of 18 ingredients. Check your meds →
Dietary supplement

Amplified Creatine XXX Fruit Punch Ingredients & Drug Interactions

by GNC Pro Performance AMP

Amplified Creatine XXX Fruit Punch label
See full label image
Powder Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Amplified Creatine XXX Fruit Punch against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Amplified Creatine XXX Fruit Punch is a dietary supplement by GNC Pro Performance AMP with 18 active ingredients. Its ingredients are commonly taken for bone health and osteoporosis prevention, dietary calcium deficiency, heartburn relief (calcium carbonate antacids).Based on those ingredients, 1,005 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are resVida Trans-Resveratrol, Calcium, L-Glutamine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Amplified Creatine XXX Fruit Punch by GNC Pro Performance AMP

Ask about any prescription or over-the-counter medication and we check it for interactions with Amplified Creatine XXX Fruit Punch by GNC Pro Performance AMP — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Amplified Creatine XXX Fruit Punch by GNC Pro Performance AMP

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 2 of its 17 active ingredients.
  • “Micronized Creatine Matrix Blend” is a proprietary blend — the label gives one combined amount (10 Gram(s)) without saying how much of each component you get.
  • “Proprietary Amino Acid Complex” is a proprietary blend — the label gives one combined amount (7 Gram(s)) without saying how much of each component you get.

Amplified Creatine XXX Fruit Punch contains 17 ingredients, including several active amino acids and creatine compounds. The amino acids include L-glutamine, L-leucine, L-isoleucine, L-methionine, L-phenylalanine, L-valine, L-histidine, L-threonine, L-lysine, and L-arginine (in micronized form), along with glycine and a proprietary amino acid complex.

The product also features micronized creatine monohydrate, alpha-ketoglutarate, and resveratrol (branded as resVida Trans-Resveratrol), plus calcium and guanidinoacetate. The remaining ingredients are inactive: dextrose, natural and artificial flavors, citric acid, silicon dioxide, calcium silicate, lecithin, malic acid, sucralose, and FD&C Red #40 (colorant).

These inactive items are fillers, binders, thickeners, and flavorings typical in powder supplements.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: muscle strength, power, and athletic performance.
  • We looked for evidence on: Athletic performance, Exercise-induced muscle damage, Bench press strength, Vertical jump power, Muscle endurance.
  • The strongest evidence on file: Creatine is rated "Possibly Effective" for Athletic performance (Natural Medicines).
  • Also on file: Glutamine is rated "Possibly Ineffective" for Athletic performance.
  • Also on file: Lysine is rated "Insufficient Reliable Evidence To Rate" for Athletic performance.

Evidence for this product's effectiveness is mixed and limited. Creatine monohydrate itself shows possibly effective evidence for building muscle strength and athletic performance, as well as possibly effective for sarcopenia (age-related muscle loss) and cerebral creatine deficiency syndromes.

L-lysine is possibly effective for cold sores (herpes labialis). L-glutamine shows possibly effective evidence for sickle cell disease and possibly effective for HIV/AIDS-related wasting and recovery after surgery or critical illness, though the last two have weaker evidence.

Most of the other amino acids either lack established evidence in our data or show insufficient reliable evidence—meaning the research so far cannot support a claim. Phenylalanine is possibly ineffective for ADHD, and threonine is possibly ineffective for ALS.

Resveratrol shows possibly effective evidence for obesity and allergic rhinitis (hay fever), but possibly ineffective for cardiovascular disease and high cholesterol. If you're considering this product for a specific purpose, talk with your pharmacist about whether the evidence supports that use.

The evidence, ingredient by ingredient Calcium Methionine Glycine Creatine Glutamine Phenylalanine Histidine Threonine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 9 of the 10 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 10 of 10.
  • General safety write-ups exist for 10 of 10.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most of the amino acids and creatine in this product are generally well tolerated at typical doses in healthy adults. Common mild side effects from amino acids include gastrointestinal upset—bloating, constipation, diarrhea, nausea—and headache.

Creatine commonly causes water retention and muscle cramps. Phenylalanine may cause anxiety, insomnia, or heartburn.

Glycine rarely causes mild sedation. Methionine in high doses may increase homocysteine levels, a risk factor for vascular disease.

Resveratrol may cause diarrhea or gastrointestinal discomfort. Pregnancy and breastfeeding: Calcium is likely safe at recommended amounts in pregnancy and while breastfeeding.

L-methionine and L-histidine are likely safe in pregnancy and lactation. L-glutamine safety data advise against it during pregnancy and breastfeeding unless your doctor recommends it.

L-phenylalanine is rated unsafe during pregnancy and unsafe during breastfeeding—avoid it if you are pregnant or nursing. Creatine, resveratrol, threonine, and L-lysine lack sufficient safety data for pregnancy or breastfeeding, so check with your doctor or pharmacist before use.

People with kidney disease should use caution with glutamine and creatine and only under medical supervision.

Side effects, ingredient by ingredient Calcium Methionine Glycine Creatine Glutamine Phenylalanine Histidine Threonine

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 7 of the 10 matched ingredients can interact with medications — Lysine, Resveratrol, Phenylalanine, Calcium, Glutamine, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; seizure medications; heart-rhythm medications; lithium; Parkinson's medications.
  • For scale: 1,006 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take HIV medications like dolutegravir, elvitegravir, or raltegravir, or the antibiotic ceftriaxone, do not use this product without talking to your pharmacist or doctor first—the calcium can significantly lower drug levels or cause serious complications. If you take levodopa for Parkinson disease, the phenylalanine in this product may worsen your symptoms.

Blood thinners or antiplatelet drugs (like warfarin, aspirin, or clopidogrel) may have increased bleeding risk. Seizure medications and monoamine oxidase inhibitors (older antidepressants) also carry documented concerns.

Check your exact medications with the tool on this page before starting.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This is a multifaceted amino acid and creatine blend aimed at athletes and people seeking muscle support. If you take medications—especially HIV drugs, seizure medication, Parkinson disease treatment, blood thinners, thyroid medication, or any drugs metabolized by your liver—you need to check each of your specific medications before using this product.

Pregnant or breastfeeding women should avoid it or talk with their doctor first. Run your medication list through the checker below.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 11 of 17 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Amplified Creatine XXX Fruit Punch, straight from the product label.

Brand GNC Pro Performance AMP
Barcode (UPC) 048107096168
Net contents 44.37 Oz(s); 2.77 lb; 1260 Gram(s)
Market status On market
Date entered into DSLD Aug 22, 2017
DSLD ID 74753
Product type Other Combinations
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Amplified Creatine XXX Fruit Punch by GNC Pro Performance AMP, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
31.5 Gram(s)
Maximum serving Sizes:
63 Gram(s)
Servings per container
20
UPC/BARCODE
048107096168
IngredientAmount% DV
Calories140 Calorie(s), 70 Calorie(s)--
Total Carbohydrates35 Gram(s), 18 Gram(s)12%, 6%
L-Glutamine0 NP, 0 NP--
Sugar33 Gram(s), 17 Gram(s)--
Calcium48 mg, 24 mg5%, 2%
L-Leucine0 NP, 0 NP--
L-Isoleucine0 NP, 0 NP--
L-Methionine0 NP, 0 NP--
L-Phenylalanine0 NP, 0 NP--
L-Valine0 NP, 0 NP--
L-Histidine0 NP, 0 NP--
L-Threonine0 NP, 0 NP--
L-Lysine0 NP, 0 NP--
L-Arginine, Micronized0 NP, 0 NP--
L-Methionine, Micronized0 NP, 0 NP--
Glycine, Micronized0 NP, 0 NP--
Micronized Creatine Matrix Blend10 Gram(s), 5 Gram(s)--
micronized Creatine Monohydrate0 NP, 0 NP--
micronized Guanidinoacetate0 NP, 0 NP--
micronized Alpha-Ketoglutarate0 NP, 0 NP--
Proprietary Amino Acid Complex7 Gram(s), 3.5 Gram(s)--
resVida Trans-Resveratrol30 mg, 15 mg--

Other ingredients: Dextrose, Natural and Artificial flavors, Citric Acid, Silicon Dioxide, Calcium Silicate, Lecithin, Malic Acid, Sucralose, FD&C Red #40

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Daily Post-workout

Directions: As a dietary supplement, mix one to two scoops with 4-8 fl. oz. water, immediately after your workout. On non-training days, take immediately upon waking up in the morning. Consume ample amounts of water while taking this product.

General Statements

Power Stamina Endurance

Performance improvement Perfect improvement Bench Press Amplified Creatine XXX Carbohydrate only Vertical jump 100 yard dash

In one study, eight weeks of supplementation with this product's creatine and carbohydrate blend in male collegiate athletes during off-season training produced a 12.9% increase in bench press, 8.4% increase in vertical jump and a 2.6% improvement in 100 yard dash performance compared to those taking only carbohydrates who experienced a 4.5%, 1.1% and 0.4% improvement, respectively. Another randomized controlled cross-over clinical study including healthy adults that examined the benefits of consuming the specific blend of amino acids and carbohydrates in this formula before exercise resulted in dramatic increase in amino acid delivery to the leg muscles.

Per 2 scoop serving.

The full muscle-building potential of a GNC product is based on its total nitrogen content - so the more nitrogen a product has, the stronger it will perform.

Clinically shown to increase upper body strength by 12.9% Maximizes post-workout replenishment and performance

Clinically researched

Natural + artificial flavors

Notice: Significant product settling may occur.

Products bearing this logo have been tested for banned substances by LGC Science, Inc., a world-class anti-doping lab. Product was tested for over 145 banned substances on the 2015 World Anti-Doping Agency (WADA) Prohibited List via LDG skip lot testing protocol #ICP0307. See gnc.com for more information.

The ultimate performance supplement breakthrough.

This powerful formula includes a clinically studied strength enhancer for superior muscular creatine absorption, amino acid delivery and glycogen re-loading.

In the body, creatine is converted to creatine phosphate which helps fuel skeletal muscles and provides support for immediate energy production during high-intensity workouts, while amino acids are involved in protein synthesis for the muscle growth and repairing process.

Where's the proof? Numerous studies have shown the benefits of creatine and amino acids for training. The supplementation of creatine may help improve athletic performance and promote cellular hydration, while amino acids promote the growth and repair of tissues, including muscles. Our research and development experts have taken the science and developed a powerful creatine formulation...

Brand IP Statement(s)

Nitro-factor-maximize muscle building

Nitro-factor 25g

resVida is a trademark of DSM.

Pro Performance AMP Amplified Creatine XXX has taken creatine supplementation to a whole new level.

Amplified Creatine XXX gives you the most powerful creatine and amino acid system available today.

Amplified Creatine XXX, loaded with a blend of ingredients that significantly maximize the effects of creatine and amino acids.

Who should be taking Amplified Creatine XXX?

If you are ready to take your workout to the next level and want to increase athletic performance through effective creatine and amino acid delivery with just one product, take Amplified Creatine XXX!

Formula

Pro Performance AMP Amplified Creatine XXX with a Nitro-Factor of 25 grams helps fuel performance and anabolism.

Powerful 10g Micronized Creatine Matrix strength & power enhancer + Glycogen-loading carb blend Features 3g micronized Arginine and 7g Amino Acid Complex

Contains: Soybeans.

It’s created with a 10g Micronized Creatine Matrix Blend to deliver fast fuel for powerful performance. This innovation keeps on delivering with an amino muscle surge providing a clinically studies blend of amino acids, including branched chain amino acids (BCAA), and carbohydrates to help reduce the breakdown of muscle during intense training. This advanced formula supplies three of the most critical components to training, creatine, amino acids, and carbohydrates, designed for serious and hardcore athletes striving to go beyond their maximum potential.

Carbohydrates are the body's main source of post-workout recovery and energy, and this formula is infused with a 33-gram supply of dextrose, a fast-acting carbohydrate, to help spike insulin and drive creatine and amino acids into the muscles more efficiently. It also includes micronized creatine precursors designed to help fuel your body's natural creatine production process. This clinically researched creatine and carbohydrate blend has been shown to dramatically increase bench press, vertical jump and 100 yard dash performance. Making it more extreme, additional research shows the amino acid and carbohydrate blend delivers the power of 40 grams of amino acids, providing benefits to your muscle and energy levels to help enhance performance.

It's not for everyone-it's for the select hardcore. The serious athlete. The dedicated, highly competitive fitness athlete, and weekend warrior who wants the edge. You're serious about sports nutrition and we know what you're looking for in an advanced creatine formula.

Precautions

Keep out of reach of children.

Contains: Soybeans.

Warning: Consult your physician prior to using this product if you are pregnant, nursing, taking medication, under 18 years of age or have a medical condition.

Warning: Consult your physician prior to using this product if you are pregnant, nursing, taking medication, under 18 years of age or have a medical condition.

Discontinue use two weeks prior to surgery.

Storage

Store in a cool, dry place.

Seals/Symbols

Banned substance free

Informed-Choice.org Trusted by sport

FDA Statement of Identity

Dietary Supplement

General

Code 351220 IPG

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Amplified Creatine XXX Fruit Punch by GNC Pro Performance AMP label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Amplified Creatine XXX Fruit Punch label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Amplified Creatine XXX Fruit Punch by GNC Pro Performance AMP

These are the 18 active ingredients this product is made of. Select any to open its full monograph.

Serving size31.5 Gram(s) Dosage formPowder Servings per container20 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sugar

33 Gram(s) per serving

Calcium

Interacts with
168 drugs
48 mg per serving

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet f...

Calcium monograph & interactions

Micronized Creatine Matrix Blend

10 Gram(s) per serving

Proprietary Amino Acid Complex

7 Gram(s) per serving

ResVida Trans-Resveratrol

Interacts with
822 drugs
30 mg per serving

Resveratrol is a plant compound found in red grapes, berries, and peanuts that is popular for heart health, anti-aging, and antioxidant support. While...

ResVida Trans-Resveratrol monograph & interactions

Other (inactive) ingredients: Dextrose, Natural and Artificial flavors, Citric Acid, Silicon Dioxide, Calcium Silicate, Lecithin, Malic Acid, Sucralose, FD&C Red #40. These complete the product’s ingredient list but are not active constituents.

Interaction report

Amplified Creatine XXX Fruit Punch by GNC Pro Performance AMP Drug Interactions

Want to check YOUR meds against Amplified Creatine XXX Fruit Punch?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,005Drugs
15 Major 989 Moderate 1 Minor

Ingredients driving the most interactions

resVida Trans-Resveratrol 822
Calcium 168
L-Glutamine 50
L-Phenylalanine 16
L-Threonine 3

Individual Drug Interactions

The ingredients in Amplified Creatine XXX Fruit Punch interact with 1,005 drugs. Click any drug to see the details.

7 of the 18 ingredients in Amplified Creatine XXX Fruit Punch interact with drugs. Each result below shows which ingredient is responsible. resVida Trans-Resveratrol Calcium L-Glutamine L-Phenylalanine L-Threonine Glycine, Micronized L-Lysine

Each ingredient & the kinds of drugs it affects

For each ingredient in Amplified Creatine XXX Fruit Punch with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

resVida Trans-Resveratrol5 drug types · 822 drugs

Anticoagulant/Antiplatelet Drugs

Resveratrol may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Resveratrol seems to have antiplatelet effects.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, resveratrol might increase levels of drugs metabolized by CYP1A2.
In vitro research shows that resveratrol can inhibit CYP1A2 enzymes. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, resveratrol might increase levels of drugs metabolized by CYP2C19.
In vitro research shows that resveratrol can inhibit CYP2C19 enzymes. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Resveratrol might increase levels of drugs metabolized by CYP2E1.
In vitro research suggests that resveratrol inhibits CYP2E1 isoenzyme. Also, a pharmacokinetic study shows that taking resveratrol 500 mg daily for 10 days prior to taking a single dose of chlorzoxazone 250 mg increases the maximum concentration of chlorzoxazone by about 54%, the area under the curve of chlorzoxazone by about 72%, and the half-life of chlorzoxazone by about 35%. Chlorzoxazone is used as a probe drug for CYP2E1.

Likelihood Probable Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, resveratrol might increase levels of drugs metabolized by CYP3A4.
In vitro research shows that resveratrol can inhibit the CYP3A4 enzyme. However, clinical research shows that taking resveratrol 3000 mg daily for 8 weeks does not necessitate dose adjustments to medications metabolized by CYP3A4.

Likelihood Possible Evidence D
resVida Trans-Resveratrol full monograph & interactions

Calcium18 drug types · 168 drugs

Ceftriaxone (Rocephin)

Co-administration of intravenous calcium and ceftriaxone can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys.
Avoid administering intravenous calcium in any form, such as parenteral nutrition or Lactated Ringers, within 48 hours of intravenous ceftriaxone. Case reports in neonates show that administering intravenous ceftriaxone and calcium can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys. In several cases, neonates have died as a result of this interaction. So far there are no reports in adults; however, there is still concern that this interaction might occur in adults.

Likelihood Probable Evidence D
Dolutegravir (Tivicay)

Calcium seems to reduce levels of dolutegravir.
Advise patients to take dolutegravir either 2 hours before or 6 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium carbonate 1200 mg concomitantly with dolutegravir 50 mg reduces plasma levels of dolutegravir by almost 40%. Calcium appears to decrease levels of dolutegravir through chelation.

Likelihood Probable Evidence B
Elvitegravir (Vitekta)

Calcium seems to reduce levels of elvitegravir.
Advise patients to take elvitegravir either 2 hours before or 2 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium along with elvitegravir can reduce blood levels of elvitegravir through chelation.

Likelihood Probable Evidence B
Aluminum

Calcium citrate might increase aluminum absorption and toxicity. Other types of calcium do not increase aluminum absorption.
Calcium citrate can increase the absorption of aluminum when taken with aluminum hydroxide. The increase in aluminum levels may become toxic, particularly in individuals with kidney disease. However, the effect of calcium citrate on aluminum absorption is due to the citrate anion rather than calcium cation. Calcium acetate does not appear to increase aluminum absorption.

Likelihood Possible Evidence B
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Calcium might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide and calcium can be taken together if taken with food. However, if taken on an empty stomach, bictegravir/emtricitabine/tenofovir alafenamide should not be taken with, or 2 hours after, calcium containing products.

Likelihood Probable Evidence D
Bisphosphonates

Calcium reduces the absorption of bisphosphonates.
Advise patients to take bisphosphonates at least 30 minutes before calcium, but preferably at a different time of day. Calcium supplements decrease absorption of bisphosphonates.

Likelihood Probable Evidence C
Calcipotriene (Dovonex)

Taking calcipotriene with calcium might increase the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with calcium supplements might increase the risk of hypercalcemia.

Likelihood Possible Evidence B
Digoxin (Lanoxin)

Using intravenous calcium with digoxin might increase the risk of fatal cardiac arrhythmias.
Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. However, one retrospective analysis of clinical data suggests that intravenous calcium does not increase the risk of dysrhythmias or mortality in patients receiving digoxin.

Likelihood Possible Evidence B
Diltiazem (Cardizem, Others)

Theoretically, calcium may reduce the therapeutic effects of diltiazem.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, calcium might increase this risk of hypercalcemia and reduce the effectiveness of diltiazem.

Likelihood Probable Evidence D
Levothyroxine (Synthroid, Others)

Calcium seems to reduce the absorption and effectiveness of levothyroxine.
Advise patients to take levothyroxine and calcium supplements at least 4 hours apart. Calcium reduces levothyroxine absorption, probably by forming insoluble complexes. Calcium carbonate supplements reduce effectiveness of levothyroxine in patients with hypothyroidism.

Likelihood Probable Evidence B
Lithium

Theoretically, concomitant use of calcium and lithium may increase this risk of hypercalcemia.
Clinical research suggests that long-term use of lithium may cause hypercalcemia in 10% to 60% of patients. Theoretically, concomitant use of lithium and calcium supplements may further increase this risk.

Likelihood Possible Evidence B
Quinolone Antibiotics

Calcium seems to reduce the absorption of quinolone antibiotics.
Advise patients to take oral quinolones at least 2 hours before or 4-6 hours after calcium supplements or calcium-fortified foods. Taking calcium at the same time as oral quinolones can reduce quinolone absorption. Calcium binds to quinolones in the gut.

Likelihood Probable Evidence B
Raltegravir (Isentress)

Calcium may reduce levels of raltegravir.
Pharmacokinetic research shows that taking a single dose of calcium carbonate 3000 mg along with raltegravir 400 mg twice daily modestly decreases the mean area under the curve of raltegravir, but the decrease does not necessitate a dose adjustment of raltegravir. However, a case of elevated HIV-1 RNA levels and documented resistance to raltegravir has been reported for a patient taking calcium carbonate 1 gram three times daily plus vitamin D3 (cholecalciferol) 400 IU three times daily in combination with raltegravir 400 mg twice daily for 11 months. It is thought that calcium reduced raltegravir levels by chelation, leading to treatment failure.

Likelihood Possible Evidence B
Sotalol (Betapace)

Calcium seems to reduce the absorption of sotalol.
Advise patients to separate doses by at least 2 hours before or 4-6 hours after calcium. Calcium appears to reduce the absorption of sotalol, probably by forming insoluble complexes.

Likelihood Possible Evidence B
Tetracycline Antibiotics

Calcium seems to reduce the absorption of tetracycline antibiotics.
Advise patients to take oral tetracyclines at least 2 hours before, or 4-6 hours after calcium supplements. Taking calcium at the same time as oral tetracyclines can reduce tetracycline absorption. Calcium binds to tetracyclines in the gut.

Likelihood Probable Evidence C
Thiazide Diuretics

Taking calcium along with thiazides might increase the risk of hypercalcemia and renal failure.
Thiazides reduce calcium excretion by the kidneys. Using thiazides along with moderately large amounts of calcium carbonate increases the risk of milk-alkali syndrome (hypercalcemia, metabolic alkalosis, renal failure). Patients may need to have their serum calcium levels and/or parathyroid function monitored regularly.

Likelihood Probable Evidence C
Verapamil (Calan, Others)

Theoretically, calcium may reduce the therapeutic effects of verapamil.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, use of calcium supplements may increase this risk of hypercalcemia and reduce the effectiveness of verapamil.

Likelihood Probable Evidence D
Calcium Channel Blockers

Intravenous calcium may decrease the effects of calcium channel blockers; oral calcium is unlikely to have this effect.
Intravenous calcium is used to decrease the effects of calcium channel blockers in the management of overdose. Intravenous calcium gluconate has been used before intravenous verapamil (Isoptin) to prevent or reduce the hypotensive effects without affecting the antiarrhythmic effects. But there is no evidence that dietary or supplemental calcium when taken orally interacts with calcium channel blockers.

Likelihood Unlikely Evidence D
Calcium full monograph & interactions

L-Glutamine1 drug type · 50 drugs

Anticonvulsants

Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Glutamine is metabolized to the excitatory neurotransmitter glutamate. Glutamate might have antagonistic effects with anticonvulsant drugs. However, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D
L-Glutamine full monograph & interactions

L-Phenylalanine3 drug types · 16 drugs

Levodopa

Phenylalanine, especially in high doses, can reduce the effectiveness of levodopa.
Phenylalanine competes with levodopa for carrier-mediated transport into the brain. The resulting reduction in levels of levodopa in the brain can exacerbate tremor, rigidity, and the "on-off" phenomenon in patients with Parkinson disease.

Likelihood Probable Evidence B
Baclofen

Concomitant intake of phenylalanine may reduce the intestinal absorption of baclofen.
Phenylalanine and baclofen share the same intestinal carrier for absorption; phenylalanine competitively inhibits the absorption of baclofen, reducing its plasma levels.

Likelihood Possible Evidence D
Monoamine Oxidase Inhibitors (Maois)

Theoretically, concomitant use of L-phenylalanine and non-selective MAOIs might increase the risk of hypertensive crisis.
L-phenylalanine is metabolized to tyrosine. Some evidence suggests that L-phenylalanine, given with the non-selective MAOI pargyline, might prevent the elimination of tyramine, increasing the risk of hypertensive crisis. However, this was not reported in a small number of patients when using L-phenylalanine with the partially selective MAO-B inhibitor, selegiline.

Likelihood Possible Evidence D
L-Phenylalanine full monograph & interactions

L-Threonine1 drug type · 3 drugs

Nmda Antagonists

Theoretically, threonine might decrease the effects of NMDA antagonists.
Threonine increases central nervous system (CNS) glycine levels. Glycine seems to bind a site on NMDA receptors and enhance the activity of the receptors.

Likelihood Likely Evidence B
L-Threonine full monograph & interactions

Glycine, Micronized1 drug type · 1 drug

Clozapine (Clozaril)

Theoretically, glycine might decrease the effectiveness of clozapine.
One small clinical study in patients with schizophrenia shows that adding glycine to clozapine therapy worsens symptoms of schizophrenia when compared with clozapine alone. The mechanism of this interaction is unclear.

Likelihood Probable Evidence B
Glycine, Micronized full monograph & interactions

L-Lysine1 drug type · 1 drug

5-Ht4 Agonists

Theoretically, lysine may reduce the effects of 5-HT4 agonists.
Animal research suggests that L-lysine is a partial serotonin receptor 4 (5-HT4) antagonist and inhibits diarrhea induced by the 5-HT4 agonist, 5-hydroxytryptophane.

Likelihood Unlikely Evidence D
L-Lysine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Amplified Creatine XXX Fruit Punch, from the product label.

GNC Pro Performance AMP

See all GNC Pro Performance AMP products
Name
General Nutrition Corporation
City
Pittsburgh
State
PA
ZipCode
15222
Phone Number
1-888-462-2548
Web Address
gnc.com
Pharmacist Counseling Corner

Amplified Creatine XXX Fruit Punch by GNC Pro Performance AMP: Common Questions

Does Amplified Creatine XXX Fruit Punch by GNC Pro Performance AMP interact with any medications?
Yes. Based on its ingredients, Amplified Creatine XXX Fruit Punch has a known interaction with 1,005 medications, including 15 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Amplified Creatine XXX Fruit Punch contains 18 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
L-phenylalanine is unsafe in pregnancy and while breastfeeding—avoid this product if you are. Creatine, resveratrol, threonine, and L-lysine lack enough safety data, so talk with your doctor or pharmacist before using. Some amino acids like L-methionine are likely safe at food amounts but not as high-dose supplements without medical guidance.
Does this product have creatine in it?
Yes. The product contains micronized creatine monohydrate and a micronized creatine matrix blend as active ingredients. Creatine may help build muscle strength and athletic performance in some people, though evidence is stronger for athletes doing resistance training.
What are the most common side effects I might notice?
Gastrointestinal upset—bloating, diarrhea, constipation, nausea—is most common, along with water retention and muscle cramps from the creatine. Some people report headache or mild sedation. These are usually mild and often resolve if you reduce the dose or take the product with food.
Why should I be careful about this product if I take seizure medication?
L-glutamine is theoretically metabolized to glutamate, which may antagonize (work against) how seizure medications work. This interaction hasn't been reported in humans, but it's important enough that you should check with your pharmacist or doctor before using this product if you take anticonvulsants.
Is this product safe to use with HIV medications?
The calcium in this product can significantly reduce blood levels of HIV drugs like dolutegravir and elvitegravir, potentially making them less effective. If you take any HIV medication, talk with your pharmacist or doctor before starting this—do not use without medical clearance.
Will this help me build muscle?
Creatine, which is in this product, is possibly effective for muscle strength and athletic performance, especially when combined with resistance training. Most of the amino acids lack strong evidence in our data for muscle building, though some amino acids support protein synthesis when part of an overall program with proper nutrition and exercise.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Amplified Creatine XXX Fruit Punch is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Amplified Creatine XXX Fruit Punch label
Go deeper

The Full Monographs Behind Amplified Creatine XXX Fruit Punch’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Calcium

Interacts with 168 drugs

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet falls short. Most people do best getting...

Read the full Calcium monograph → Herb & supplement monograph

Methionine

Methionine is an essential amino acid that your body needs for protein building and many basic chemical reactions. Most people get enough from a normal diet, and supplements are generally no...

Read the full Methionine monograph → Herb & supplement monograph

Glycine

Interacts with 1 drug

Glycine is a non-essential amino acid your body makes on its own and that also appears in protein-rich foods. It is most studied for improving sleep quality, where early research is promisin...

Read the full Glycine monograph → Herb & supplement monograph

Creatine

Creatine is one of the most studied sports supplements, with solid evidence that it can boost strength and performance during short, high-intensity activities like weightlifting and sprintin...

Read the full Creatine monograph → Herb & supplement monograph

Glutamine

Interacts with 50 drugs

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle cell disease complications, but for most...

Read the full Glutamine monograph → Herb & supplement monograph

Phenylalanine

Interacts with 16 drugs

Phenylalanine is an essential amino acid the body uses to make brain chemicals like dopamine and norepinephrine. Some people take it for mood, vitiligo, or pain, but the evidence is mostly l...

Read the full Phenylalanine monograph → Herb & supplement monograph

Histidine

Histidine is an essential amino acid your body needs to build proteins and to make compounds like histamine and carnosine. Most people get enough from a normal diet, and good-quality researc...

Read the full Histidine monograph → Herb & supplement monograph

Threonine

Interacts with 3 drugs

Threonine is an essential amino acid your body needs but cannot make, so you must get it from food or supplements. Most people get plenty from a normal diet, and high-quality evidence for ta...

Read the full Threonine monograph → Herb & supplement monograph

Lysine

Interacts with 1 drug

Lysine is an essential amino acid your body cannot make on its own, so it must come from food or supplements. People most often take extra lysine to try to prevent or shorten cold sores, but...

Read the full Lysine monograph → Herb & supplement monograph

Resveratrol

Interacts with 822 drugs

Resveratrol is a plant compound found in red grapes, berries, and peanuts that is popular for heart health, anti-aging, and antioxidant support. While lab and animal studies are promising, s...

Read the full Resveratrol monograph →
Sources

Sources & How We Checked

Amplified Creatine XXX Fruit Punch's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 237 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glutamine 11 references
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  11. Ogden HB, Child RB, Fallowfield JL, et al. Gastrointestinal Tolerance of Low, Medium and High Dose Acute Oral l-Glutamine Supplementation in Healthy Adults: A Pilot Study. Nutrients. 2020;12(10):2953. PubMed

See these in context on the Glutamine monograph →

Calcium 62 references
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  30. Rocephin (ceftriaxone) and calcium interaction. Pharmacist's Letter / Prescriber's Letter 2007;23(10):231005.
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  38. Neuhofel, A. L., Wilton, J. H., Victory, J. M., Hejmanowsk, L. G., and Amsden, G. W. Lack of bioequivalence of ciprofloxacin when administered with calcium-fortified orange juice: a new twist on an old interaction. J Clin Pharmacol. 2002;42(4):461-466. DOI
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See these in context on the Calcium monograph →

Methionine 12 references
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  7. Hanratty, C. G., McGrath, L. T., McAuley, D. F., Young, I. S., and Johnston, G. D. The effects of oral methionine and homocysteine on endothelial function. Heart 2001;85(3):326-330. PubMed
  8. Ward, M., McNulty, H., McPartlin, J., Strain, J. J., Weir, D. G., and Scott, J. M. Effect of supplemental methionine on plasma homocysteine concentrations in healthy men: a preliminary study. Int.J.Vitam.Nutr.Res. 2001;71(1):82-86. PubMed
  9. Yaghmai, R., Kashani, A. H., Geraghty, M. T., Okoh, J., Pomper, M., Tangerman, A., Wagner, C., Stabler, S. P., Allen, R. H., Mudd, S. H., and Braverman, N. Progressive cerebral edema associated with high methionine levels and betaine therapy in a patient
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See these in context on the Methionine monograph →

Phenylalanine 23 references
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  21. Kravitz, H. M., Sabelli, H. C., and Fawcett, J. Dietary supplements of phenylalanine and other amino acid precursors of brain neuroamines in the treatment of depressive disorders. J Am Osteopath.Assoc 1984;84(1 Suppl):119-123. DOI
  22. Mann, J., Peselow, E. D., Snyderman, S., and Gershon, S. D-phenylalanine in endogenous depression. Am.J.Psychiatry 1980;137(12):1611-1612. PubMed
  23. Katoulis AC, Alevizou A, Bozi E, et al. A randomized, double-blind, vehicle-controlled study of a preparation containing undecylenoyl phenylalanine 2% in the treatment of solar lentigines. Clin Exp Dermatol 2010;35(5):473-6. PubMed

See these in context on the Phenylalanine monograph →

Histidine 3 references
  1. Histidine — MedlinePlus (U.S. National Library of Medicine) Source
  2. Amino Acids — MedlinePlus (U.S. National Library of Medicine) Source
  3. Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source

See these in context on the Histidine monograph →

Threonine 4 references
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Lysine 7 references
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Glycine 5 references
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  5. Woods SW, Walsh BC, Hawkins KA, Miller TJ, Saksa JR, D'Souza DC, Pearlson GD, Javitt DC, McGlashan TH, Krystal JH. Glycine treatment of the risk syndrome for psychosis: report of two pilot studies. Eur Neuropsychopharmacol. 2013 Aug;23(8):931-40. PubMed

See these in context on the Glycine monograph →

Creatine 86 references
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Resveratrol 24 references
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