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Dietary supplement

Tribulus Terrestris Ingredients & Drug Interactions

by GNC Pro Performance AMP

Tribulus Terrestris label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Tribulus Terrestris against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Tribulus Terrestris is a dietary supplement by GNC Pro Performance AMP with 1 active ingredient. Its ingredients are commonly taken for low libido and sexual function, athletic performance and muscle building, testosterone support.Based on those ingredients, 259 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Tribulus terrestris extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Tribulus Terrestris by GNC Pro Performance AMP

Ask about any prescription or over-the-counter medication and we check it for interactions with Tribulus Terrestris by GNC Pro Performance AMP — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Tribulus Terrestris by GNC Pro Performance AMP

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 17, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: tribulus terrestris extract. Tribulus is a plant traditionally used for sexual function and athletic performance, and the supplement form here is made into capsules with gelatin and cellulose as inactive ingredients.

Does it work?

Leans against
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Leans against

The strongest graded evidence we hold for the stated purpose leans against a benefit.

Why this rating?
  • The label markets this product for: advanced muscle performance and strength training.
  • We looked for evidence on: Athletic performance, Exercise-induced muscle damage, muscle hypertrophy, strength gains, resistance training adaptation.
  • The closest evidence on file: Tribulus is rated "Possibly Ineffective" for Athletic performance (Natural Medicines).
  • Also on file: Tribulus is rated "Insufficient Reliable Evidence To Rate" for Exercise-induced muscle damage.

The evidence shows tribulus is possibly effective for sexual dysfunction — that's the main claim backed by clinical research. For athletic performance, the data suggests it's possibly ineffective.

For benign prostatic hyperplasia (enlarged prostate), we don't have enough reliable evidence to rate it one way or the other.

The evidence, ingredient by ingredient Tribulus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Short-term, tribulus is generally well tolerated in healthy adults, but long-term safety data and product quality information are limited. The safety data advises against use during pregnancy because it may affect hormones and safety isn't established.

You should also avoid it while breastfeeding due to lack of reliable safety information. Serious side effects are rare but have been reported, including liver and kidney injury, seizures, and chronic painful erection.

More commonly, some people experience stomach upset — abdominal pain, cramping, nausea, vomiting, diarrhea, or constipation — though in one study these rates matched placebo. One case of severe toxicity involved drinking 2 liters of tribulus water daily and required hospitalization.

Side effects, ingredient by ingredient Tribulus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Tribulus.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications; lithium.
  • For scale: 259 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you take blood pressure medication, diabetes medication, or lithium — all three carry Moderate interaction risk with tribulus.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with graded evidence leaning against its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Tribulus terrestris may help with sexual dysfunction if that's a concern for you. If you take blood pressure medicine, diabetes medication, or lithium, this product isn't something to add without checking first — talk with your doctor or pharmacist about whether it's safe for your situation.

Avoid it entirely if you're pregnant or breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Tribulus Terrestris, straight from the product label.

Brand GNC Pro Performance AMP
Net contents 30 Pak(s)
Market status On market
Date entered into DSLD Feb 25, 2015
DSLD ID 42328
Product type Botanical
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult Male (18-50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Tribulus Terrestris by GNC Pro Performance AMP, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Brown Capsule(s)
Maximum serving Sizes:
1 Brown Capsule(s)
IngredientAmount% DV
Tribulus terrestris extract300 mg--

Other ingredients: Gelatin, Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

In a randomized, double-blind, placebo-controlled study of 112 healthy volunteers, subjects taking the GNC vitamin and mineral blend in this product for six weeks experienced statistically significant improvements in markers of B vitamins and antioxidant status, as well as improvements in SF-36 Vitality and Mental health scores compared to those taking a placebo. In a clinical study of 17 healthy young adults, muscle biopsy results revealed that GNC Pro Performance(R) AMP Amplified Creatine 189(TM) resulted in 189% greater muscle creatine uptake relative to benchmark amounts of ordinary creatine monohydrate powder. When used in conjunction with regular resistance training. In a randomized, double-blind clinicial study of 57 healthy young adult males, subjects who took, GNC Pro Performance(R) AMP Amplified Creatine 189(TM) containing only 1.25 grams creatine significantly improved leg press 1-RM performance by 54 lbs, while subjects on 5 grams of creatine monohydrate improved by 52 lbs, and the placebo group demonstrated no significant improvement when used in conjunction with regular resistance training.

ADVANCED MUSCLE PERFORMANCE

ADVANCED SPORTS VITAMIN SYSTEM TO ENHANCE STRENGTH TRAINING WITH OVER 50 POWERFUL INGREDIENTS

- Features GNC’s Highest-Potency Sports Multivitamin to Fuel Maximum Strength Training - Scientifically Formulated to Improve Upper and Lower Body Strength and Help Pack on Mass

Daily Strength Size Power

Clinically Researched

Each pak contains:

{Capsule} Actual Size

{QRC} SCAN & LEARN MORE

GNC QUALITY COMMITMENT For more than 75 years, GNC has been the leader in the development and manufacture of dietary supplements, is committed to producing the most superior products. We use only the highest quality ingredients manufactured under the strictest quality controls. Every raw material used is tested to ensure its purity and potency. Each product is dated and then shipped immediately to our stores to ensure that you are purchasing the freshest supplements available.

GNC GUARANTEE If you are not 100% completely satisfied, return the unused portion of the product with your receipt to a GNC store within 30 days. Our trained sales staff will either refund your purchase price or, if you prefer, assist you in finding a replacement product to help you LIVE WELL.

Each performance boosting pak delivers GNC’s most optimal and precise combination of a premium daily multivitamin and sports nutrients. With over 50 powerful ingredients to support your total exercise strength training program, we’ve taken athletic performance nutrition to a whole new level. This scientifically mastered formula features a daily premium multivitamin and support nutrients combined with strength supporting mechanisms.

When activating the strength-building potential of this exclusive system, you amplify total strength results, increase muscular power and prepare your muscles to utilize the nutrients necessary to build mass with this complete training stack.* Most athletes today are not combining the proper combinations and ratios of critical sports nutrition.

Creatine promotes cellular hydration and helps fuel muscles to improve and enhance athletic performance. This form increases strength with only 25% of the dose of ordinary creatine. In a clinical study, this form of creatine yielded 189% muscle creatine uptake relative to ordinary creatine monohydrate. This allows you to take less and get more into the muscle.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Formula

- The Power of 5g of Creatine in 2 Tablets Delivers 189% Improved Muscle Creatine Absorption - Triggers Anabolic Factors with High-Quality Tribulus & Fenugreek

Tribulus Terrestris

Mega Men(R) Sport contains B-vitamins that are important for energy production and carbohydrate metabolism. It provides amino acids, including BCAA, and a joint cushioning blend for healthy joint cartilage. Also features a broad spectrum of cell-protecting antioxidants and nutrients that aid in boosting immunity.*

Amplified Creatine 189(TM) - This advanced, cutting edge formula has been clinically proven to get in your muscles better than ordinary creatine.

Tribulus Terrestris & Anabolic Primer – Features high-quality Tribulus Terrestris and Fenugreek extract clinically studied to support anabolic muscle factors in the body.

General

CODE 331811 ANG

Suggested/Recommended/Usage/Directions

DIRECTIONS: As a dietary supplement, take the contents of one pak 30-60 minutes per-workout. On non-training days, take the contents of one pak first thing in the morning with food.

To take muscular strength gains to new levels, stack with: - Amplified Muscle Igniter 4X – to improve physical and mental intensity - Amplified Mass XXX(TM) - provides a ratio of nutrients proven to accelerate increases in lean mass and exercise performance.

Precautions

WARNING: Consult your physician prior to using this product if you are pregnant, nursing, taking medication, under 18 years of age or have a medical condition.

Discontinue use two weeks prior to surgery.

KEEP OUT OF REACH OF CHILDREN.

Formulation

No Wheat, No Gluten, No Dairy, Yeast Free.

Storage

Store in a cool, dry place.

Brand IP Statement(s)

The Pro Performance(R) AMP Strength Vitapak(R) Program Evolution

This advanced multivitamin platform delivered by Mega Men(R) Sport allows well-trained muscles to develop, build and recover. If attaining every possible ounce of strength is your goal to improve your competitive edge, then the Pro Performance(R) AMP Strength Vitapak(R) Program is your new weapon in training. Mega Men(R) Sport – This high-potency clinically studied sports multivitamin formula includes critical components to fill important nutrient gaps in regular supplementation programs.

What is Pro Performance(R) AMP Strength Vitapak(R) Program? Strength. Power. Mass. You train and prepare in the gym and on the field to reach your fullest physical potential. Now, with the Pro Performance(R) AMP Strength Vitapak(R) Program powered by Mega Men(R) Sport, ensure you leave nothing under-utilized by maximizing the results of your supplement and training regimen.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Tribulus Terrestris by GNC Pro Performance AMP label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Tribulus Terrestris label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Tribulus Terrestris by GNC Pro Performance AMP

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Brown Capsule(s) Dosage formCapsule Amounts shown are per serving.

Tribulus terrestris extract

Interacts with
259 drugs
300 mg per serving

Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims...

Tribulus terrestris extract monograph & interactions

Other (inactive) ingredients: Gelatin, Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Tribulus Terrestris by GNC Pro Performance AMP Drug Interactions

Want to check YOUR meds against Tribulus Terrestris?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
259Drugs
259 Moderate

Ingredients driving the most interactions

Tribulus terrestris extract 259

Individual Drug Interactions

The ingredients in Tribulus Terrestris interact with 259 drugs. Click any drug to see the details.

1 of the 1 ingredient in Tribulus Terrestris interact with drugs. Each result below shows which ingredient is responsible. Tribulus terrestris extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Tribulus Terrestris with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Tribulus terrestris extract3 drug types · 259 drugs

Antidiabetes Drugs

Taking tribulus with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that Tribulus can lower blood glucose levels in adults with type 2 diabetes who are taking antidiabetes medications.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that tribulus can lower blood pressure by inhibiting angiotensin-converting enzyme (ACE). Tribulus has also demonstrated hypotensive effects in pre-hypertensive adults.

Likelihood Possible Evidence D
Lithium

Theoretically, tribulus might increase the levels and clinical effects of lithium.
Tribulus is thought to have diuretic properties. Due to these potential diuretic effects, tribulus might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Tribulus terrestris extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Tribulus Terrestris, from the product label.

GNC Pro Performance AMP

See all GNC Pro Performance AMP products
Phone Number
1-888-462-2548
Pharmacist Counseling Corner

Tribulus Terrestris by GNC Pro Performance AMP: Common Questions

Does Tribulus Terrestris by GNC Pro Performance AMP interact with any medications?
Yes. Based on its ingredients, Tribulus Terrestris has a known interaction with 259 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Tribulus Terrestris contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
No. The safety data advises against it during pregnancy because tribulus may affect hormones and safety isn't established. You should also avoid it while breastfeeding due to lack of reliable safety information. Talk with your doctor or pharmacist about what's safe for you.
Does tribulus actually work for sexual dysfunction?
The evidence shows it's possibly effective — meaning there's clinical support, but it's not definitive. Results vary from person to person, and you may want to discuss realistic expectations with your doctor.
Does this help with athletic performance?
No, the data suggests tribulus is possibly ineffective for that purpose.
What are the most common side effects?
Tribulus is generally well tolerated, though some people report stomach complaints like nausea, cramping, diarrhea, or constipation. In one study, these rates were similar to placebo.
Is this safe to take long-term?
Short-term use in healthy adults appears well tolerated, but long-term safety data are limited. If you're thinking about taking it regularly, discuss that with your doctor or pharmacist.
Why does this interact with so many blood pressure and diabetes drugs?
Tribulus can lower blood pressure and blood glucose on its own. When you combine it with medications that do the same thing, those levels can drop too far — potentially causing weakness, dizziness, or other problems. That's why your doctor or pharmacist needs to know you're taking it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Tribulus Terrestris is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Tribulus Terrestris label
Go deeper

The Full Monographs Behind Tribulus Terrestris’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Tribulus

Interacts with 259 drugs

Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims is weak and inconsistent. It is general...

Read the full Tribulus monograph →
Sources

Sources & How We Checked

Tribulus Terrestris's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 10 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Tribulus 10 references
  1. Sharifi AM, Darabi R, Akbarloo N. Study of antihypertensive mechanism of Tribulus terrestris in 2K1C hypertensive rats: role of tissue ACE activity. Life Sci 2003;73:2963-71. PubMed
  2. Walker D, Bird A, Flora T, O'Sullivan B. Some effects of feeding Tribulus terrestris, Ipomoea lonchophylla and the seed of Abelmoschus ficulneus on fetal development and the outcome of pregnancy in sheep. Reprod Fertil Dev 1992;4:135-44. PubMed
  3. Al-Ali M, Wahbi S, Twaij H, Al-Badr A. Tribulus terrestris: preliminary study of its diuretic and contractile effects and comparison with Zea mays. J Ethnopharmacol 2003;85:257-60. PubMed
  4. Tabakova, P., Dimitrov, M., Ognyanov, K., and et al. Clinical study of Tribestan in females with endocrine sterility. Documentation for Registration (unpublished) 1999.
  5. Akhtari E, Raisi F, Keshavarz M, et al. Tribulus terrestris for treatment of sexual dysfunction in women: randomized double-blind placebo-controlled study. Daru 2014;22:40. PubMed
  6. Ryan M, Lazar I, Nadasdy GM, et al. Acute kidney injury and hyperbilirubinemia in a young male after ingestion of Tribulus terrestris. Clin Nephrol 2015;83(3):177-83. PubMed
  7. Postigo S, Lima SM, Yamada SS, et al. Assessment of the effects of Tribulus terrestris on sexual function of menopausal women. Rev Bras Ginecol Obstet 2016;38(3):140-6. PubMed
  8. Talasaz AH, Abbasi MR, Abkhiz S, Dashti-Khavidaki S. Tribulus terrestris-induced severe nephrotoxicity in a young healthy male. Nephrol Dial Tranplant 2010;25(11):3792-3. PubMed
  9. Samani NB, Jokar A, Soveid M, Heydari M, Mosavat SH. Efficacy of the hydroalcoholic extract of Tribulus terrestris on the serum glucose and lipid profile of women with diabetes mellitus: a double-blind randomized placebo-controlled clinical trial. J Evid
  10. Siddiqui MA, Itrat M, Mobeen A, Khan MI. Efficacy of khar-i-khasak (Tribulus terrestris Linn.) in prehypertension: a randomized, double-blind, placebo-controlled trial. J Complement Integr Med. 2021.

See these in context on the Tribulus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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