Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Apigenin 50 mg with L-Theanine Ingredients & Drug Interactions

by aSquared Nutrition

Apigenin 50 mg with L-Theanine label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Apigenin 50 mg with L-Theanine against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Apigenin 50 mg with L-Theanine is a dietary supplement by aSquared Nutrition with 2 active ingredients. Its ingredients are commonly taken for anxiety and stress, relaxation and calm, sleep support.Based on those ingredients, 565 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Theanine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Apigenin 50 mg with L-Theanine by aSquared Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with Apigenin 50 mg with L-Theanine by aSquared Nutrition — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Apigenin 50 mg with L-Theanine by aSquared Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains two active ingredients: apigenin (50 mg) and L-theanine. L-theanine is an amino acid found naturally in tea that may support cognitive function.

The inactive ingredients are methylcellulose capsule and microcrystalline cellulose, which are the capsule material and a filler.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Theanine's overall clinical evidence instead.

Moderate

Some clinical evidence supports Theanine for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Cognitive function — rated "Possibly Effective" (Natural Medicines).

L-theanine is possibly effective for cognitive function. For other uses listed — age-related cognitive decline, Alzheimer disease, and anxiety disorders like GAD and OCD — the evidence isn't strong enough to rate.

We hold no effectiveness data for apigenin in our system.

The evidence, ingredient by ingredient Theanine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-theanine is generally well tolerated in healthy adults for short-term use, though long-term safety hasn't been well studied. Some people report headaches, drowsiness, increased sleep duration, or more vivid dreams.

There isn't enough safety data during pregnancy or breastfeeding, so it's best to avoid it if you're pregnant or nursing. Talk with your doctor or pharmacist for personalized advice if you're in either situation.

Side effects, ingredient by ingredient Theanine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Theanine.
  • The most serious interaction on file is rated Moderate.
  • For scale: 565 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this, check your medications against these types: blood pressure drugs (antihypertensives) — theanine can lower your pressure further — and sedating or brain-depressant drugs (CNS depressants). Serotonergic drugs (like certain antidepressants) show mixed research, but no cases of harm have been reported.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

This product might be worth considering if you're looking for cognitive support and don't take blood pressure medications or sedating drugs. If you're on any prescription, especially for blood pressure or sleep, check with your pharmacist first — the interaction with blood pressure drugs is real.

Pregnant or breastfeeding? Skip it until you've talked to your doctor.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Apigenin 50 mg with L-Theanine, straight from the product label.

Brand aSquared Nutrition
Barcode (UPC) X0035GFHTV
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Aug 23, 2023
DSLD ID 295344
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Apigenin 50 mg with L-Theanine by aSquared Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
120
UPC/BARCODE
X0035GFHTV
IngredientAmount% DV
L-Theanine200 mg--
Apigenin50 mg--

Other ingredients: Methylcellulose Capsule, Microcrystalline Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: Take 1 capsule per day with a meal, or as directed by your qualified healthcare professional.

Precautions

Caution: Do not exceed the recommended dose.

Not for use by children under 18 years of age.

Pregnant or nursing mothers, individuals taking any medications, individuals with a known medical condition, and individuals planning a medical procedure should consult a physician before using this or any dietary supplement.

Keep out of the reach of children.

Do not use if safety seal is damaged or missing.

Seals/Symbols

Good Manufacturing Practice Sourced from a GMP Certified Facility Quality Assured

USA Formulated

General Statements

Please recycle.

120 day supply

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This produce is not intended to diagnose, treat, cure, or prevent any disease.

Formulation

Ultra strength

Natural formulation Third-party tested Supports normal sleep

No preservatives

Formula

Enhanced with L-Theanine

aSquared Nutrition is proud to offer an ultra strength apigenin with L-Theanine supplement. Our formula contains 50 mg of apigenin and 200 mg of L-Theanine per capsule.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Apigenin 50 mg with L-Theanine by aSquared Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Apigenin 50 mg with L-Theanine label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Apigenin 50 mg with L-Theanine by aSquared Nutrition

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container120 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

L-Theanine

Interacts with
565 drugs
200 mg per serving

Theanine (usually L-theanine) is an amino acid found naturally in tea leaves that many people take to feel calmer and less stressed without strong dro...

L-Theanine monograph & interactions

Apigenin

50 mg per serving

Other (inactive) ingredients: Methylcellulose Capsule, Microcrystalline Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Apigenin 50 mg with L-Theanine by aSquared Nutrition Drug Interactions

Want to check YOUR meds against Apigenin 50 mg with L-Theanine?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
565Drugs
172 Moderate 393 Minor

Ingredients driving the most interactions

L-Theanine 565

Individual Drug Interactions

The ingredients in Apigenin 50 mg with L-Theanine interact with 565 drugs. Click any drug to see the details.

1 of the 2 ingredients in Apigenin 50 mg with L-Theanine interact with drugs. Each result below shows which ingredient is responsible. L-Theanine

Each ingredient & the kinds of drugs it affects

For each ingredient in Apigenin 50 mg with L-Theanine with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

L-Theanine3 drug types · 565 drugs

Antihypertensive Drugs

Theanine might lower blood pressure, potentiating the effects of antihypertensive drugs.
Animal research shows that theanine can lower blood pressure in spontaneously hypertensive animals. Theoretically, concomitant use of theanine and antihypertensive drugs might potentiate the antihypertensive activity.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, theanine might have additive sedative effects when used in conjunction with CNS depressants. However, it is unclear if this concern is clinically relevant.
Theoretically, theanine may compete with glutamate and/or increase plasma gamma-aminobutyric acid (GABA) levels, which could cause CNS depression. In one clinical study, some subjects taking oral theanine reported drowsiness.

Likelihood Unlikely Evidence D
Serotonergic Drugs

Clinical studies regarding the effects of L-theanine on serotonin levels are conflicting. Some studies suggest it can increase serotonin levels in the brain while others report that it may decrease them. Nevertheless, there have been no reports of l-theanine being a causative agent in serotonergic-related side effects or serotonin syndrome.

Likelihood Unlikely Evidence C
L-Theanine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Apigenin 50 mg with L-Theanine, from the product label.

aSquared Nutrition

See all aSquared Nutrition products
Name
aSquared Brands LLC
Street Address
382 NE 191st Street, #98406
City
Miami
State
Florida
ZipCode
33179
Phone Number
1-800-557-4120
Pharmacist Counseling Corner

Apigenin 50 mg with L-Theanine by aSquared Nutrition: Common Questions

Does Apigenin 50 mg with L-Theanine by aSquared Nutrition interact with any medications?
Yes. Based on its ingredients, Apigenin 50 mg with L-Theanine has a known interaction with 565 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Apigenin 50 mg with L-Theanine contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is L-theanine and what does it do?
L-theanine is an amino acid from tea that may help support cognitive function — how your brain thinks and focuses. It's possibly effective for that, though the research is still developing.
Can I take this if I'm on blood pressure medication?
Not without checking with your pharmacist first. L-theanine can lower blood pressure on its own, so adding it to your blood pressure drug might make your pressure drop too much. Your pharmacist can tell you whether it's safe for your specific medications and dose.
Will this make me drowsy?
Some people report drowsiness or increased sleep after taking L-theanine, though it's not the main effect. If you're also on sedating medications, the risk is higher, so mention that to your pharmacist.
Is it safe to take during pregnancy or breastfeeding?
There isn't enough safety data, so it's best to avoid it while pregnant or nursing. Talk with your doctor or pharmacist about what's right for your situation.
How much safety data is there on long-term use?
L-theanine is generally well tolerated for short-term use in healthy adults, but long-term safety hasn't been well studied. If you plan to take it regularly over months, that's worth discussing with your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Apigenin 50 mg with L-Theanine is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Apigenin 50 mg with L-Theanine label
Go deeper

The Full Monographs Behind Apigenin 50 mg with L-Theanine’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Theanine

Interacts with 565 drugs

Theanine (usually L-theanine) is an amino acid found naturally in tea leaves that many people take to feel calmer and less stressed without strong drowsiness. Early research suggests it may...

Read the full Theanine monograph →
Sources

Sources & How We Checked

Apigenin 50 mg with L-Theanine's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Theanine 6 references
  1. Yokogoshi H, Kobayashi M. Hypotensive effect of gamma-glutamylethylamide in spontaneously hypertensive rats. Life Sci 1998;62:1065-8.
  2. Haskell, C. F., Kennedy, D. O., Milne, A. L., Wesnes, K. A., and Scholey, A. B. The effects of L-theanine, caffeine and their combination on cognition and mood. Biol.Psychol. 2008;77(2):113-122. PubMed
  3. Yokogoshi, H., Kato, Y., Sagesaka, Y. M., Takihara-Matsuura, T., Kakuda, T., and Takeuchi, N. Reduction effect of theanine on blood pressure and brain 5-hydroxyindoles in spontaneously hypertensive rats. Biosci.Biotechnol.Biochem. 1995;59(4):615-618. PubMed
  4. Lyon MR, Kapoor MP, Juneja LR. The effects of L-theanine (Suntheanine®) on objective sleep quality in boys with attention deficit hyperactivity disorder (ADHD): a randomized, double-blind, placebo-controlled clinical trial. Altern Med Rev. 2011;16(4):348-
  5. Hidese S, Ota M, Wakabayashi C, et al. Effects of chronic l-theanine administration in patients with major depressive disorder: an open-label study. Acta Neuropsychiatr 2017;29(2):72-9.
  6. Tsuchiya T, Honda H, Oikawa M, et al. Oral administration of the amino acids cystine and theanine attenuates the adverse events of S-1 adjuvant chemotherapy in gastrointestinal cancer patients. Int J Clin Oncol 2016;21(6):1085-90. PubMed

See these in context on the Theanine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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