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Dietary supplement

Artichoke Leaf Extract Ingredients & Drug Interactions

by SuperiorLabs

Artichoke Leaf Extract label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Artichoke Leaf Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Artichoke Leaf Extract is a dietary supplement by SuperiorLabs with 1 active ingredient. Its ingredients are commonly taken for high cholesterol, indigestion and heartburn, constipation and bloating.Based on those ingredients, 363 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Artichoke (Cynara scolymus L.) leaf 4:1 extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Artichoke Leaf Extract by SuperiorLabs

Ask about any prescription or over-the-counter medication and we check it for interactions with Artichoke Leaf Extract by SuperiorLabs — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Artichoke Leaf Extract by SuperiorLabs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Artichoke (Cynara scolymus L.) leaf extract in a 4:1 concentration, which means the extract is four times more potent than the raw leaf. The capsule also holds two inactive ingredients — plant cellulose and organic rice hull concentrate — which are fillers and capsule material.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: digestive function and cardiovascular health support.
  • We looked for evidence on: Dyspepsia, Hyperlipidemia, Biliary disorders, gallbladder function, bile metabolism.
  • The strongest evidence on file: Artichoke is rated "Possibly Effective" for Dyspepsia (Natural Medicines).
  • Also on file: Artichoke is rated "Possibly Effective" for Hyperlipidemia.
  • Also on file: Artichoke is rated "Insufficient Reliable Evidence To Rate" for Biliary disorders.

Artichoke leaf extract is rated possibly effective for two uses: lowering cholesterol (hyperlipidemia) and easing indigestion (dyspepsia). The evidence supporting these benefits comes from small clinical studies, so the picture isn't as clear as we'd like.

For nonalcoholic fatty liver disease, we don't have enough reliable evidence to say whether it works.

The evidence, ingredient by ingredient Artichoke

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Artichoke extract is generally well tolerated when used short-term, though quality and dosing vary between products. The most common side effects are mild — abdominal pain, diarrhea, gas, and nausea.

A small number of people may have an allergic reaction, especially if they're sensitive to plants in the ragweed family (like daisies and marigolds); in rare cases, severe allergic shock (anaphylaxis) has been reported in people with inulin sensitivity. Topical contact with artichoke can cause skin redness in sensitive individuals.

During pregnancy, there isn't enough safety information, so it's best avoided. The same goes for breastfeeding — safety hasn't been established, so talk with your doctor or pharmacist about whether it's right for you.

Side effects, ingredient by ingredient Artichoke

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Artichoke.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 363 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, double-check with your doctor or pharmacist if you're on blood pressure medication (antihypertensive drugs) or diabetes medication (antidiabetes drugs) — both carry Moderate-severity risks. Also flag any drugs your liver breaks down using the CYP2C19 or CYP2B6 pathways, which artichoke may inhibit.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Artichoke leaf extract may help with cholesterol and indigestion, but it does interact with blood pressure and diabetes medications. If you take either of those, or any drug metabolized by CYP2C19 or CYP2B6 enzymes, check with your doctor or pharmacist before starting this supplement.

It's generally well tolerated, though allergies are possible if you're sensitive to ragweed-family plants.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Artichoke Leaf Extract, straight from the product label.

Brand SuperiorLabs
Barcode (UPC) 850569006124
Net contents 180 Vegetable Capsule(s)
Market status On market
Date entered into DSLD Oct 22, 2021
DSLD ID 255992
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Artichoke Leaf Extract by SuperiorLabs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetarian Capsule(s)
Maximum serving Sizes:
1 Vegetarian Capsule(s)
Servings per container
180
UPC/BARCODE
850569006124
IngredientAmount% DV
Artichoke (Cynara scolymus L.) leaf 4:1 extract600 mg--

Other ingredients: Plant Cellulose, organic Rice hull concentrate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Artichoke leaf extract maintains healthy digestive function through its ability to support normal bile flow, which aids in fat digestion and metabolism. In addition, Artichoke extract contains antioxidants that support healthy cardiovascular function. Superior Labs Artichoke leaf extract capsules contain 600 mg pure Artichoke leaf extract with absolutely no magnesium stearate, dioxides, preservatives or other potentially harmful artificial ingredients of any kind.

5% Caffeoylquinic Acids

Formulation

This product is formulated, developed and manufactured in an FDA registered and GMP certified facility, 3rd party inspected by a leading compliance authority for superior quality assurance.

100% Pure Pure and Potent Aid digestion Support metabolism Cholesterol support Healthy cardiovascular function

Does Not Contain: Magnesium stearate, dioxides, preservatives, or artificial ingredients of any kind.

Superior Labs Artichoke leaf extract capsules contain 600 mg pure Artichoke leaf extract with absolutely no magnesium stearate, dioxides, preservatives or other potentially harmful artificial ingredients of any kind.

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, adults take 1 capsule twice per day or as directed by your health care practitioner. Best when taken with a meal.

Precautions

Caution: Do not exceed recommended dosage.

Please consult a physician before consuming this product if you are pregnant or nursing, taking medication or have a medical condition.

Not intended for use by individuals under the age of 18.

Do not use if safety seal is damaged or missing.

Keep out of reach of children.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Metal Safe Heavy Metal Tested Certified GMP Facility Made In USA

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Artichoke Leaf Extract by SuperiorLabs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Artichoke Leaf Extract label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Artichoke Leaf Extract by SuperiorLabs

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Vegetarian Capsule(s) Dosage formCapsule Servings per container180 Amounts shown are per serving.

Artichoke (Cynara scolymus L.) leaf 4:1 extract

Interacts with
363 drugs
600 mg per serving Form: Caffeoylquinic Acid

Artichoke leaf extract is a generally well-tolerated supplement that may have a mild cholesterol-lowering effect and is often used for indigestion, th...

Artichoke (Cynara scolymus L.) leaf 4:1 extract monograph & interactions

Other (inactive) ingredients: Plant Cellulose, Organic Rice hull concentrate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Artichoke Leaf Extract by SuperiorLabs Drug Interactions

Want to check YOUR meds against Artichoke Leaf Extract?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
363Drugs
363 Moderate

Ingredients driving the most interactions

Artichoke (Cynara scolymus L.) leaf 4:1 extract 363

Individual Drug Interactions

The ingredients in Artichoke Leaf Extract interact with 363 drugs. Click any drug to see the details.

1 of the 1 ingredient in Artichoke Leaf Extract interact with drugs. Each result below shows which ingredient is responsible. Artichoke (Cynara scolymus L.) leaf 4:1 extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Artichoke Leaf Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Artichoke (Cynara scolymus L.) leaf 4:1 extract4 drug types · 363 drugs

Antidiabetes Drugs

Theoretically, artichoke leaf extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
A meta-analysis of small clinical studies shows that taking artichoke leaf extract for 8-12 weeks can modestly reduce fasting plasma glucose when compared with placebo.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, artichoke leaf extract may increase the risk of hypotension when taken with antihypertensive drugs.
A meta-analysis of small clinical studies in patients with hypertension shows that taking artichoke can reduce systolic blood pressure by around 3 mmHg and diastolic blood pressure by around 2 mmHg when compared with placebo.

Likelihood Possible Evidence D
Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2B6.
In vitro research shows that artichoke leaf extract inhibits CYP2B6 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2C19.
In vitro research shows that artichoke leaf extract inhibits CYP2C19 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Artichoke (Cynara scolymus L.) leaf 4:1 extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Artichoke Leaf Extract, from the product label.

SuperiorLabs

See all SuperiorLabs products
Name
Superior Labs, LLC.
City
Park City
State
UT
ZipCode
84098
Phone Number
(888) 708-5227
Web Address
www.superiorlabs.com
Pharmacist Counseling Corner

Artichoke Leaf Extract by SuperiorLabs: Common Questions

Does Artichoke Leaf Extract by SuperiorLabs interact with any medications?
Yes. Based on its ingredients, Artichoke Leaf Extract has a known interaction with 363 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Artichoke Leaf Extract contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this with my blood pressure medication?
Not without checking first — artichoke lowers blood pressure on its own, and combining it with a blood pressure drug could push your pressure too low. Talk with your doctor or pharmacist before you start.
Can I take this with my diabetes medication?
You'll want to check with your doctor or pharmacist. Artichoke can lower blood sugar, so taking it with a diabetes drug increases the risk of low blood sugar.
What are the most common side effects?
Most people tolerate it well, but some experience abdominal pain, diarrhea, gas, or nausea. If you're allergic to ragweed or related plants, you're at higher risk for an allergic reaction.
Is this safe to use during pregnancy or while breastfeeding?
There isn't enough safety information for either, so it's best to avoid the supplement form during pregnancy and breastfeeding. Talk with your doctor or pharmacist about what's right for you.
Does artichoke really lower cholesterol and help with indigestion?
It's rated possibly effective for both — meaning small clinical studies suggest a benefit, but the evidence isn't ironclad. Results vary by person.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Artichoke Leaf Extract label
Go deeper

The Full Monographs Behind Artichoke Leaf Extract’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Artichoke

Interacts with 363 drugs

Artichoke leaf extract is a generally well-tolerated supplement that may have a mild cholesterol-lowering effect and is often used for indigestion, though the evidence is modest. It is not a...

Read the full Artichoke monograph →
Sources

Sources & How We Checked

Artichoke Leaf Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 16 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Artichoke 16 references
  1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  2. Walker AF, Middleton RW, Petrowicz O. Artichoke leaf extract reduces symptoms of irritable bowel syndrome in a post-marketing surveillance study. Phytother Res 2001;15:58-61. PubMed
  3. Pittler MH, White AR, Stevinson C, Ernst E. Effectiveness of artichoke extract in preventing alcohol-induced hangovers: a randomized controlled trial. CMAJ 2003;169:1269-73.
  4. Romano, C., Ferrara, A., and Falagiani, P. A case of allergy to globe artichoke and other clinical cases of rare food allergy. J Investig.Allergol.Clin Immunol. 2000;10(2):102-104.
  5. Miralles, J. C., Garcia-Sells, J., Bartolome, B., and Negro, J. M. Occupational rhinitis and bronchial asthma due to artichoke (Cynara scolymus). Ann Allergy Asthma Immunol. 2003;91(1):92-95. PubMed
  6. Franck, P., Moneret-Vautrin, D. A., Morisset, M., Kanny, G., Megret-Gabeaux, M. L., and Olivier, J. L. Anaphylactic reaction to inulin: first identification of specific IgEs to an inulin protein compound. Int Arch Allergy Immunol 2005;136(2):155-158. PubMed
  7. Meding, B. Allergic contact dermatitis from artichoke, Cynara scolymus. Contact Dermatitis 1983;9(4):314.
  8. Quirce, S., Tabar, A. I., Olaguibel, J. M., and Cuevas, M. Occupational contact urticaria syndrome caused by globe artichoke (Cynara scolymus). J Allergy Clin Immunol. 1996;97(2):710-711. PubMed
  9. Held C. Von der 1. Deutsche-Ungarischen Phytopharmakon-Konferenz, Budapest, 20. November 1991. Z Klin Med 1992;47:92-93.
  10. Barrat E, Zaïr Y, Ogier N, et al. A combined natural supplement lowers LDL cholesterol in subjects with moderate untreated hypercholesterolemia: a randomized placebo-controlled trial. Int J Food Sci Nutr. 2013;64(7):882-9. PubMed
  11. Huber R, Müller M, Naumann J, Schenk T, Lüdtke R. Artichoke leave extract for chronic hepatitis C - a pilot study. Phytomedicine. 2009 Sep;16(9):801-4. PubMed
  12. Caputo F, Barranco R, Bonsignore A, Fraternali Orcioni G, Ventura F. A rare case of fatal bowel obstruction secondary to a colonic bezoar. Am J Forensic Med Pathol. 2018;39(1):38-40. PubMed
  13. Elsebai MF, Abass K, Hakkola J, Atawia AR, Farag MA. The wild Egyptian artichoke as a promising functional food for the treatment of hepatitis C virus as revealed via UPLC-MS and clinical trials. Food Funct. 2016;7(7):3006-16. PubMed
  14. Moradi M, Sohrabi G, Golbidi M, et al. Effects of artichoke on blood pressure: a systematic review and meta-analysis. Complement Ther Med 2021;57:102668. PubMed
  15. Jalili C, Moradi S, Babaei A, et al. Effects of Cynara scolymus L. on glycemic indices: a systematic review and meta-analysis of randomized clinical trials. Complement Ther Med 2020;52:102496. PubMed
  16. Gallo R, Oddenino G, Trave I, Gasparini G, Guadagno A, Parodi A. Contact sensitivity to sesquiterpene lactone mix and artichoke in a patient with severe recurrent dermatitis: A puzzling case. Contact Dermatitis 2023;88(2):156-158. PubMed

See these in context on the Artichoke monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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