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Dietary supplement

Artichoke Standardized Extract Ingredients & Drug Interactions

by Nature's Way

Artichoke Standardized Extract label
See full label image
Tablet Or Pill Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Artichoke Standardized Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Artichoke Standardized Extract is a dietary supplement by Nature's Way with 1 active ingredient. Its ingredients are commonly taken for high cholesterol, indigestion and heartburn, constipation and bloating.Based on those ingredients, 363 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Artichoke (leaf) extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Artichoke Standardized Extract by Nature's Way

Ask about any prescription or over-the-counter medication and we check it for interactions with Artichoke Standardized Extract by Nature's Way — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Artichoke Standardized Extract by Nature's Way

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: artichoke leaf extract. The rest of the tablet is made up of inactive ingredients — cellulose, sodium croscarmellose, silica, magnesium stearate, hypromellose, and glycerin — which are fillers, binders, and capsule materials.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: promotes healthy liver and gallbladder function.
  • We looked for evidence on: Biliary disorders, Hyperlipidemia, Nonalcoholic fatty liver disease (NAFLD), gallstone disease, cholestasis.
  • The strongest evidence on file: Artichoke is rated "Possibly Effective" for Hyperlipidemia (Natural Medicines).
  • Also on file: Artichoke is rated "Insufficient Reliable Evidence To Rate" for Biliary disorders, Nonalcoholic fatty liver disease (NAFLD).

Artichoke extract is possibly effective for high cholesterol (hyperlipidemia) and indigestion (dyspepsia). The evidence for these uses comes from small clinical studies.

For nonalcoholic fatty liver disease (NAFLD), the evidence isn't established enough for us to rate it one way or the other.

The evidence, ingredient by ingredient Artichoke

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Artichoke extract is generally well tolerated when taken by mouth, though side effects do happen. The most common ones are abdominal pain, diarrhea, gas, increased hunger, and nausea.

If you're allergic to ragweed, chrysanthemums, daisies, marigolds, or other plants in the Asteraceae family, you're at higher risk of an allergic reaction to artichoke. Rarely, people sensitive to artichoke inulin have had severe allergic reactions (anaphylaxis).

During pregnancy, there isn't enough safety information, so it's best avoided in supplement form. The same goes for breastfeeding — safety hasn't been established.

Talk with your doctor or pharmacist if you're pregnant or nursing and wondering whether this is right for you.

Side effects, ingredient by ingredient Artichoke

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Artichoke.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 363 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this, double-check with your doctor or pharmacist if you're on blood pressure medications, blood sugar medications, or any drugs processed through your liver's CYP2C19 or CYP2B6 pathways. All four are Moderate-severity interactions.

No other interactions are documented for the ingredient we checked.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Artichoke extract may help with high cholesterol and indigestion, but it can lower blood pressure and blood sugar. If you take medications for either of those conditions, or if you take drugs metabolized by your liver's CYP2C19 or CYP2B6 enzymes, you'll want to check your exact medications with your doctor or pharmacist before starting.

People allergic to ragweed or similar plants should avoid it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 25, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Artichoke Standardized Extract, straight from the product label.

Brand Nature's Way
Barcode (UPC) 763948088096
Net contents 45 Tablet(s)
Market status On market
Date entered into DSLD Apr 25, 2019
DSLD ID 200887
Product type Botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Artichoke Standardized Extract by Nature's Way, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
UPC/BARCODE
763948088096
IngredientAmount% DV
Total Carbohydrates1 Gram(s)1%
Artichoke (leaf) extract320 mg--

Other ingredients: Cellulose, Sodium Croscarmellose, Silica, Magnesium Stearate, Hypromellose, Glycerin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

13-18% Caffeoylquinic acids

General Statements

Promotes healthy liver and gallbladder function

Since 1969

Liver/Gallbladder

Precautions

Keep out of reach of children.

Safety sealed with printed inner seal. Do not use if seal is broken or missing.

Warning: Do not use if you are allergic to plants of the Asteraceae (Compositae) family, including ragweed, or if you have bile duct obstruction.

If pregnant, nursing, or taking any medications, consult a healthcare professional before use.

Formulation

Gluten free. No sugar, wheat, yeast, corn, dairy products, artificial colors, flavors, or preservatives.

Vegetarian

Seals/Symbols

Vegetarian

General

LE08809.B01 BLK880B

FDA Disclaimer Statement

These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Recommendation: Take 1 tablet three times daily.

Brand IP Statement(s)

2018 Nature's Way Brands, LLC

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Artichoke Standardized Extract by Nature's Way label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Artichoke Standardized Extract label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Artichoke Standardized Extract by Nature's Way

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

Artichoke (leaf) extract

Interacts with
363 drugs
320 mg per serving Form: Caffeoylquinic Acids

Artichoke leaf extract is a generally well-tolerated supplement that may have a mild cholesterol-lowering effect and is often used for indigestion, th...

Artichoke (leaf) extract monograph & interactions

Other (inactive) ingredients: Cellulose, Sodium Croscarmellose, Silica, Magnesium Stearate, Hypromellose, Glycerin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Artichoke Standardized Extract by Nature's Way Drug Interactions

Want to check YOUR meds against Artichoke Standardized Extract?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
363Drugs
363 Moderate

Ingredients driving the most interactions

Artichoke (leaf) extract 363

Individual Drug Interactions

The ingredients in Artichoke Standardized Extract interact with 363 drugs. Click any drug to see the details.

1 of the 1 ingredient in Artichoke Standardized Extract interact with drugs. Each result below shows which ingredient is responsible. Artichoke (leaf) extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Artichoke Standardized Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Artichoke (leaf) extract4 drug types · 363 drugs

Antidiabetes Drugs

Theoretically, artichoke leaf extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
A meta-analysis of small clinical studies shows that taking artichoke leaf extract for 8-12 weeks can modestly reduce fasting plasma glucose when compared with placebo.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, artichoke leaf extract may increase the risk of hypotension when taken with antihypertensive drugs.
A meta-analysis of small clinical studies in patients with hypertension shows that taking artichoke can reduce systolic blood pressure by around 3 mmHg and diastolic blood pressure by around 2 mmHg when compared with placebo.

Likelihood Possible Evidence D
Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2B6.
In vitro research shows that artichoke leaf extract inhibits CYP2B6 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, artichoke might increase serum levels of drugs metabolized by CYP2C19.
In vitro research shows that artichoke leaf extract inhibits CYP2C19 activity. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Artichoke (leaf) extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Artichoke Standardized Extract, from the product label.

Nature's Way

See all Nature's Way products
Name
Nature's Way Brands, LLC (previously branded Enzymatic Therapy, LLC)
City
Green Bay
State
WI
ZipCode
54311
Phone Number
1-800-962-8873
Web Address
naturesway.com
Pharmacist Counseling Corner

Artichoke Standardized Extract by Nature's Way: Common Questions

Does Artichoke Standardized Extract by Nature's Way interact with any medications?
Yes. Based on its ingredients, Artichoke Standardized Extract has a known interaction with 363 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Artichoke Standardized Extract contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will artichoke extract lower my blood pressure too much?
It may. Artichoke can add to the blood-pressure-lowering effect of your medications, raising the risk of blood pressure dropping too low. Clinical studies show it lowers systolic pressure by a few points, which is small on its own — but combined with your medication, it could matter. Check with your doctor or pharmacist before adding it if you take blood pressure meds.
Can I take this if I'm allergic to ragweed?
You should be careful. Artichoke belongs to the same plant family as ragweed, chrysanthemums, daisies, and marigolds. If you're allergic to those plants, you're at higher risk of reacting to artichoke. Talk with your doctor before using it.
What side effects might I notice?
Most common are stomach pain, diarrhea, gas, nausea, and increased hunger. These are usually mild. Rarely, people sensitive to artichoke inulin have had severe allergic reactions. Stop taking it and seek medical care if you have trouble breathing, chest tightness, or other signs of an allergic reaction.
Can I take this while pregnant or breastfeeding?
No — there isn't enough safety information. It's best avoided in supplement form during pregnancy and breastfeeding. Talk with your doctor or pharmacist if you're thinking about using it while pregnant or nursing.
Does artichoke extract actually work for cholesterol and digestion?
For cholesterol and indigestion, the evidence says it's possibly effective — meaning small studies support it, but more research would help us be more confident. For liver health (NAFLD), we don't have enough reliable evidence yet to know.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Artichoke Standardized Extract is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Artichoke Standardized Extract label
Go deeper

The Full Monographs Behind Artichoke Standardized Extract’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Artichoke

Interacts with 363 drugs

Artichoke leaf extract is a generally well-tolerated supplement that may have a mild cholesterol-lowering effect and is often used for indigestion, though the evidence is modest. It is not a...

Read the full Artichoke monograph →
Sources

Sources & How We Checked

Artichoke Standardized Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 16 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Artichoke 16 references
  1. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  2. Walker AF, Middleton RW, Petrowicz O. Artichoke leaf extract reduces symptoms of irritable bowel syndrome in a post-marketing surveillance study. Phytother Res 2001;15:58-61. PubMed
  3. Pittler MH, White AR, Stevinson C, Ernst E. Effectiveness of artichoke extract in preventing alcohol-induced hangovers: a randomized controlled trial. CMAJ 2003;169:1269-73.
  4. Romano, C., Ferrara, A., and Falagiani, P. A case of allergy to globe artichoke and other clinical cases of rare food allergy. J Investig.Allergol.Clin Immunol. 2000;10(2):102-104.
  5. Miralles, J. C., Garcia-Sells, J., Bartolome, B., and Negro, J. M. Occupational rhinitis and bronchial asthma due to artichoke (Cynara scolymus). Ann Allergy Asthma Immunol. 2003;91(1):92-95. PubMed
  6. Franck, P., Moneret-Vautrin, D. A., Morisset, M., Kanny, G., Megret-Gabeaux, M. L., and Olivier, J. L. Anaphylactic reaction to inulin: first identification of specific IgEs to an inulin protein compound. Int Arch Allergy Immunol 2005;136(2):155-158. PubMed
  7. Meding, B. Allergic contact dermatitis from artichoke, Cynara scolymus. Contact Dermatitis 1983;9(4):314.
  8. Quirce, S., Tabar, A. I., Olaguibel, J. M., and Cuevas, M. Occupational contact urticaria syndrome caused by globe artichoke (Cynara scolymus). J Allergy Clin Immunol. 1996;97(2):710-711. PubMed
  9. Held C. Von der 1. Deutsche-Ungarischen Phytopharmakon-Konferenz, Budapest, 20. November 1991. Z Klin Med 1992;47:92-93.
  10. Barrat E, Zaïr Y, Ogier N, et al. A combined natural supplement lowers LDL cholesterol in subjects with moderate untreated hypercholesterolemia: a randomized placebo-controlled trial. Int J Food Sci Nutr. 2013;64(7):882-9. PubMed
  11. Huber R, Müller M, Naumann J, Schenk T, Lüdtke R. Artichoke leave extract for chronic hepatitis C - a pilot study. Phytomedicine. 2009 Sep;16(9):801-4. PubMed
  12. Caputo F, Barranco R, Bonsignore A, Fraternali Orcioni G, Ventura F. A rare case of fatal bowel obstruction secondary to a colonic bezoar. Am J Forensic Med Pathol. 2018;39(1):38-40. PubMed
  13. Elsebai MF, Abass K, Hakkola J, Atawia AR, Farag MA. The wild Egyptian artichoke as a promising functional food for the treatment of hepatitis C virus as revealed via UPLC-MS and clinical trials. Food Funct. 2016;7(7):3006-16. PubMed
  14. Moradi M, Sohrabi G, Golbidi M, et al. Effects of artichoke on blood pressure: a systematic review and meta-analysis. Complement Ther Med 2021;57:102668. PubMed
  15. Jalili C, Moradi S, Babaei A, et al. Effects of Cynara scolymus L. on glycemic indices: a systematic review and meta-analysis of randomized clinical trials. Complement Ther Med 2020;52:102496. PubMed
  16. Gallo R, Oddenino G, Trave I, Gasparini G, Guadagno A, Parodi A. Contact sensitivity to sesquiterpene lactone mix and artichoke in a patient with severe recurrent dermatitis: A puzzling case. Contact Dermatitis 2023;88(2):156-158. PubMed

See these in context on the Artichoke monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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