Interactions on record — worth a quick check against your medications. Based on 3 of 10 ingredients. Check your meds →
Dietary supplement

BIG BLEND Proteosynthetic Vanilla Cappuccino Ingredients & Drug Interactions

by Betancourt Nutrition

BIG BLEND Proteosynthetic Vanilla Cappuccino label
See full label image
Powder Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Oct 7, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking BIG BLEND Proteosynthetic Vanilla Cappuccino against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

BIG BLEND Proteosynthetic Vanilla Cappuccino is a dietary supplement by Betancourt Nutrition with 10 active ingredients. Its ingredients are commonly taken for constipation, diarrhea, high cholesterol.Based on those ingredients, 2,038 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Dietary Fiber, Sodium, Glutamine Analogues Blend. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against BIG BLEND Proteosynthetic Vanilla Cappuccino by Betancourt Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with BIG BLEND Proteosynthetic Vanilla Cappuccino by Betancourt Nutrition — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of BIG BLEND Proteosynthetic Vanilla Cappuccino by Betancourt Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 2 of its 8 active ingredients.

This 7-ingredient powder contains sodium and glutamine as active components, supported by a Big Multi-Source Blend, Refined Protein Blend, Amino Acid Derivatives Blend, Nitrated BCAA Blend, and Big Digestive Enzyme Blend—the exact composition of these blends isn't specified on the label. Inactive ingredients include caramel, sucralose, and natural flavoring to deliver a vanilla cappuccino taste.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Muscle recovery and sports performance.
  • We looked for evidence on: Athletic performance, Exercise-induced muscle damage, Postoperative recovery, Strength and endurance, Lean muscle mass, Training recovery.
  • The strongest evidence on file: Glutamine is rated "Possibly Effective" for Postoperative recovery (Natural Medicines).
  • Also on file: Glutamine is rated "Possibly Ineffective" for Athletic performance.
  • Also on file: Glutamine is rated "Insufficient Reliable Evidence To Rate" for Exercise-induced muscle damage.

The sodium in this product is likely effective for cystic fibrosis and possibly effective for preventing kidney damage from the antibiotic amphotericin B. For other uses like bipolar disorder or congestive heart failure, the evidence we hold isn't reliable enough to rate it.

Glutamine is effective for sickle cell disease and possibly effective for HIV/AIDS-related wasting, postoperative recovery, and critical illness from trauma.

The evidence, ingredient by ingredient Black Psyllium Sodium Glutamine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Sodium is well tolerated at normal dietary levels, but this product is not a sodium supplement in the clinical sense—it's a protein powder that happens to contain sodium. Too much sodium is linked to high blood pressure, heart strain, and kidney disease.

The safety data for this product's full formulation isn't on file, so if you have heart disease, high blood pressure, or kidney issues, talk with your doctor or pharmacist before using it. Glutamine is generally well tolerated in healthy adults but should be used only under medical supervision if you have kidney or liver disease.

Common side effects from glutamine in trials include belching, bloating, constipation, diarrhea, nausea, vomiting, and headache. Two people with bipolar disorder reported mania or hypomania on glutamine supplements, so caution is warranted if you have a mood disorder.

Side effects, ingredient by ingredient Black Psyllium Sodium Glutamine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Black Psyllium, Glutamine, Sodium.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: seizure medications; heart-rhythm medications; lithium.
  • For scale: 2,039 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Blood pressure medications (antihypertensives)—sodium can reduce how well they work. Lithium, corticosteroids, didanosine, sodium phosphate products, tolvaptan, and other sodium-containing drugs—sodium in this blend could raise your blood sodium to unsafe levels.

Seizure medications (anticonvulsants)—glutamine may theoretically interfere, though this hasn't been seen in people yet. Check your specific medications with the search tool on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This is a protein and amino acid blend, not a sodium supplement, so routine use at normal portions is generally fine for most healthy people. If you take blood pressure medication, lithium, seizure medication, corticosteroids, or any sodium-containing drug, check your exact medications with the tool on this page before starting.

Anyone with heart disease, high blood pressure, kidney disease, or a mood disorder should talk with their pharmacist first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 25, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about BIG BLEND Proteosynthetic Vanilla Cappuccino, straight from the product label.

Brand Betancourt Nutrition
Barcode (UPC) 857487000678
Net contents 2.47 lbs; 1120 Gram(s)
Market status On market
Date entered into DSLD Oct 25, 2012
DSLD ID 12870
Product type Other Combinations
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for BIG BLEND Proteosynthetic Vanilla Cappuccino by Betancourt Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
32 Gram(s)
Maximum serving Sizes:
32 Gram(s)
Servings per container
35
UPC/BARCODE
857487000678
IngredientAmount% DV
Calories120 {Calories}--
Total Carbohydrates4 g1%
Sugar2 g--
Calories from Fat20 {Calories}--
Total Fat2 g3%
Dietary Fiber0 g--
Protein22 g--
Saturated Fat1 g5%
Sodium80 mg3%
Trans Fat0 g--
Cholesterol20 mg7%
Big Multi-Source Blend32000 mg--
Refined Protein Blend0 NP--
Amino Acid Derivatives Blend0 NP--
Nitrated BCAA Blend0 NP--
Glutamine Analogues Blend0 NP--
Big Digestive Enzyme Blend0 NP--

Other ingredients: Caramel, Sucralose, natural & nature's equivalent flavor

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

World's First Myo-Augmenting BCAA Nitrate Blend

Phone: 305-593-9296 - Fax: 202-449-8275

MIAMI, FL --- Betancourt Nutrition’s crack team of protein supplement formulators lock themselves inside their in-house cGMP manufacturing lab. Their mission is to develop the “best and the biggest”, a protein supplement so massive in its content of myo-augmenting proteins and amino acid derivatives that it will produce anabolic behaviors quantitatively and qualitatively unlike anything else on the market for years to come.

MULTI-SOURCE REFINED PROTEIN SHAKE WITH UNSURPASSED ANABOLIC BEHAVIOR!

If you’re looking to get bigger with the best, then look no further than the inside of this bottle.

- Multiple mechanisms of anabolic behavior - Supports proteosynthetic power in muscle & non-muscle tissues - The ideal supplement to training and diet for outrageous myo-augmentation - Designed to be addictively delicious by in-house flavor scientists

(chart) Multiple Mechanisms of Action PROTEOSYNTHETIC POWER (arrow up) MYO-AUGMENTATION (arrow out)

Betancourt formulators sourced BIG BLEND(TM)’s ingredients from around the world, country by country, city by city in order to ensure that they could reward you with a long list of features and benefits including but not limited to rapid and sustained increases in tissue essential (EAA) and nonessential amino acid (NEAA) levels, nitrogen balance, nitric oxide production, protein synthesis in muscle and non-muscle tissues, insulin-like growth-factor-1 (IGF-1) production, muscle fiber hypertrophy, muscle mass, muscle strength and muscle thickness. Furthermore, to make sure that BIG BLEND(TM) makes protein shakes that rapidly quench your appetite every time you drink one, Betancourt developed all of its flavors in-house. For additional glutamine, BCAAs or creatine, take Betancourt’s perfectly portable CHEWIES(TM) with you wherever you go. They’re fast becoming North America’s favorite “muscle candy” for serious bodybuilding!

READY TO STIMULATE WHOLE-BODY PROTEIN SYNTHESIS

Seals/Symbols

WHATEVER IT TAKES(R)

LABORATORY TESTED BY nfn

Storage

STORE IN A COOL, DRY PLACE.

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

POWDER DIETARY SUPPLEMENT

Formula

Contains: Milk.

- AMINO ACID DERIVATIVES: Amino acid derivatives like Nitrated BCAAs, N-Acetyl L-Phenylalanine, L-Valine Ethyl Ester HCl, Glutamine Ethyl Ester HCl, L-Leucine Alpha-Ketoglutarate and many more offer unique pharmacokinetic properties of interest to advanced bodybuilding athletes. These ingredients are impossible to obtain from food and are not found in many protein supplements. - DIGESTIVE STIMULATORS: Low-calorie, low-glycemic brown rice bran, carbohydrates and enzymes stimulate your digestive tract and help improve the anabolic efficiency of BIG BLEND's many powerful proteins and amino acids. BIG BLEND(TM) even contains Papaya extract and lactase to ease digestion and pave the way for more rapid absorption and muscle-building utilization.

Enhanced with 22 Proteins Amino Acids & Enzymes!

- Acetyl, AKG, Ester & Nitrate Amino Acid Derivatives - Low-Glycemic Carbohydrate - Protein Hydrolysates - Brown Rice Bran

Suggested/Recommended/Usage/Directions

RECOMMENDED DOSAGE: Mix 1 serving of BIG BLEND(TM) with cold water to the desired thickness in a shaker cup or blender. Consume immediately after your weight-lifting workout. Repeat 2 hours later. On days that you don’t work out (rest days), consume 1 serving of BIG BLEND(TM) in the morning and 1 serving before bed.

Brand IP Statement(s)

Two months and more than a dozen pilot batches later, they emerge from the lab with new BIG BLEND(TM).

Each serving of new BIG BLEND(TM) contains a myo-augmenting blend of refined proteins and amino acid derivatives from a mind-blowing 22 different sources, all fortified by a low-calorie, low-glycemic infrastructure of brown rice bran, proteolytic enzymes and carbohydrates. With each ingredient having several potential mechanisms of action, BIG BLEND(TM) is capable of an incredibly diverse array of anabolic behaviors once it gets inside your body. The muscle-building possibilities are virtually endless. Importantly, BIG BLEND(TM) supports maximal rates of protein synthesis in the whole body --muscle as well as non-muscle tissues- and It tastes as big as it acts!

Each gram of BIG BLEND(TM) contains ingredients never before found in a single scoop:

- MULTI-SPECIES PROTEINS: BIG BLEND(TM) prepares your stretched and strained muscle fibers for a perfect “anabolic storm” by feeding them precision-processed proteins extracted from Casein, Milk, Brown Rice and Whey. All have been carefully blended together to protect their bioactivity and shelf life.

Precautions

KEEP OUT OF REACH OF CHILDREN.

WARNING: BIG BLEND(TM) is intended for use as a supplement to the diet only. Do not use for weight loss or as your only source of calories. BIG BLEND(TM) contains ingredients derived from milk, eggs and rice. Because it is packaged by weight rather than volume, some settling of the contents of this bottle may occur.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

BIG BLEND Proteosynthetic Vanilla Cappuccino by Betancourt Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

BIG BLEND Proteosynthetic Vanilla Cappuccino label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in BIG BLEND Proteosynthetic Vanilla Cappuccino by Betancourt Nutrition

These are the 10 active ingredients this product is made of. Select any to open its full monograph.

Serving size32 Gram(s) Dosage formPowder Servings per container35 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sugar

2 g per serving

Dietary Fiber

Interacts with
2,025 drugs
0 g per serving

Black psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. I...

Dietary Fiber monograph & interactions

Protein

22 g per serving

Sodium

Interacts with
205 drugs
80 mg per serving

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

Big Multi-Source Blend

32000 mg per serving

Refined Protein Blend

0 NP per serving Form: Casein phosphopeptides 19%, Egg Albumin, Milk Protein concentrate, Rice protein, Whey Protein concentrate, Whey Protein Isolate

Amino Acid Derivatives Blend

0 NP per serving Form: L-Leucine Alpha Ketoglutarate, L-Leucine Ethyl Ester Hydrochloride, L-Leucine Pyroglutamate, L-Lysine Hydrochloride, L-Norvaline, L-Phenylalanine Methyl Ester Hydrochloride, L-Valine Ethyl Ester Hydrochloride, Lactalbumin Hydrolysate, N-Acetyl L-Glutamine, N-Acetyl L-Phenylalanine

Nitrated BCAA Blend

0 NP per serving Form: L-Isoleucine Nitrate, L-Leucine Nitrate, L-Valine Nitrate

Glutamine Analogues Blend

Interacts with
50 drugs
0 NP per serving Form: Akgenuine(TM), L-Glutamine Alpha Ketoglutarate

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle c...

Glutamine Analogues Blend monograph & interactions

Big Digestive Enzyme Blend

0 NP per serving Form: Amylopectin, Brown Rice Bran, Carrageenan, Cellulose Gum, Lactase, Papain, Papaya, Protease, Waxy Maize, Xanthan Gum

Other (inactive) ingredients: Caramel, Sucralose, Natural & nature's equivalent flavor. These complete the product’s ingredient list but are not active constituents.

Interaction report

BIG BLEND Proteosynthetic Vanilla Cappuccino by Betancourt Nutrition Drug Interactions

Want to check YOUR meds against BIG BLEND Proteosynthetic Vanilla Cappuccino?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2,038Drugs
275 Moderate 1,763 Minor

Ingredients driving the most interactions

Dietary Fiber 2,025
Sodium 205
Glutamine Analogues Blend 50

Individual Drug Interactions

The ingredients in BIG BLEND Proteosynthetic Vanilla Cappuccino interact with 2,038 drugs. Click any drug to see the details.

3 of the 10 ingredients in BIG BLEND Proteosynthetic Vanilla Cappuccino interact with drugs. Each result below shows which ingredient is responsible. Dietary Fiber Sodium Glutamine Analogues Blend

Each ingredient & the kinds of drugs it affects

For each ingredient in BIG BLEND Proteosynthetic Vanilla Cappuccino with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Dietary Fiber7 drug types · 2,025 drugs

Carbamazepine (Tegretol)

Theoretically, black psyllium might reduce the effects of carbamazepine and increase the risk for convulsions.
Theoretically, black psyllium might reduce carbamazepine absorption. A preliminary study using blond psyllium reported decreased carbamazepine bioavailability due to binding of the drug to psyllium, as well as reduction of available fluid in the gut for dissolution of the drug. This interaction may also occur with black psyllium.

Likelihood Probable Evidence D
Lithium

Theoretically, taking black psyllium at the same time as lithium might reduce lithium absorption.
The fiber in black psyllium might reduce lithium absorption and plasma levels. Some case reports describe a reduction in plasma lithium levels with concomitant administration of blond psyllium. This was reversed when psyllium was stopped. This interaction may also occur with black psyllium.

Likelihood Probable Evidence D
Metformin (Glucophage)

Theoretically, black psyllium might increase the therapeutic and adverse effects of metformin.
Animal research shows that concurrent consumption of blond psyllium with metformin slows and increases the absorption of metformin. This interaction may also occur with black psyllium. To avoid changes in absorption, take psyllium 30-60 minutes after metformin.

Likelihood Possible Evidence D
Olanzapine (Zyprexa)

Theoretically, taking black psyllium at the same time as olanzapine might reduce olanzapine absorption.
The fiber in black psyllium might decrease the absorption of olanzapine. A single case report describes a reduction in the effectiveness of olanzapine when it was concomitantly administered with an unspecified type of psyllium 3 grams orally twice daily. This effect was reversed when psyllium was stopped.

Likelihood Possible Evidence D
Digoxin (Lanoxin)

Theoretically, taking black psyllium at the same time as digoxin might reduce digoxin absorption and decrease digoxin levels.
Psyllium might bind digoxin in the gut. However, some clinical evidence suggests that psyllium does not impact digoxin absorption.

Likelihood Unlikely Evidence B
Ethinyl Estradiol

Theoretically, taking black psyllium at the same time as ethinyl estradiol might alter levels of estradiol.
Concurrent use of blond psyllium with ethinyl estradiol results in a slight increase in the extent of ethinyl estradiol absorption and a slower rate of absorption. This is unlikely to be clinically significant.

Likelihood Unlikely Evidence D
Oral Drugs

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Psyllium seems to have variable effects on drug absorption. To avoid changes in absorption, take psyllium 30-60 minutes after oral medications. Animal research shows that blond psyllium delays and increases the absorption of metformin and ethinyl estradiol. Case reports and animal research suggest that blond psyllium might reduce absorption of lithium, digoxin, olanzapine, and carbamazepine. Finally, some pharmacokinetic studies show that psyllium does not affect the absorption of levothyroxine or warfarin. Although many of these studies evaluated blond psyllium, the fiber content in black psyllium may have similar effects.

Likelihood Possible Evidence B
Dietary Fiber full monograph & interactions

Sodium7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium full monograph & interactions

Glutamine Analogues Blend1 drug type · 50 drugs

Anticonvulsants

Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Glutamine is metabolized to the excitatory neurotransmitter glutamate. Glutamate might have antagonistic effects with anticonvulsant drugs. However, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D
Glutamine Analogues Blend full monograph & interactions
The maker

Brand information

Manufacturer and brand details for BIG BLEND Proteosynthetic Vanilla Cappuccino, from the product label.

Betancourt Nutrition

See all Betancourt Nutrition products
Name
Betancourt Nutrition, Inc.
Street Address
14620 NW 60th Ave.
City
Miami Lakes
State
Florida
ZipCode
33014
Phone Number
800-443-4153
Web Address
www.betancourtnutrition.com
Pharmacist Counseling Corner

BIG BLEND Proteosynthetic Vanilla Cappuccino by Betancourt Nutrition: Common Questions

Does BIG BLEND Proteosynthetic Vanilla Cappuccino by Betancourt Nutrition interact with any medications?
Yes. Based on its ingredients, BIG BLEND Proteosynthetic Vanilla Cappuccino has a known interaction with 2,038 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
BIG BLEND Proteosynthetic Vanilla Cappuccino contains 10 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe for me if I take blood pressure medication?
That depends on your exact drug and your doctor's sodium limits. This powder contains sodium, which can make blood pressure drugs less effective or require you to take more of them. Talk with your pharmacist or doctor before using it—they can tell you whether it fits your treatment plan.
What are the side effects of glutamine in this product?
In trials and case reports, glutamine caused belching, bloating, constipation, diarrhea, nausea, vomiting, and headache. Two people with bipolar disorder also reported mania or hypomania, so mention this product to your doctor if you have a mood disorder.
Will this help my protein intake?
It's a protein powder, so it will contribute protein to your diet, but the exact amount from each of the seven ingredients isn't broken out on the label. Your nutrition goals are best discussed with a dietitian who knows your whole diet.
Is it safe to take while pregnant or breastfeeding?
Sodium is likely safe in pregnancy and lactation, and glutamine is likely safe in pregnancy. The data on glutamine safety while breastfeeding is limited, so talk with your OB or midwife before using this product during nursing.
Can I use this if I have kidney disease?
Glutamine should only be used under medical supervision if you have kidney or liver disease because it's processed by those organs. Sodium intake is also usually restricted in kidney disease. Check with your nephrologist or pharmacist before starting.
What is glutamine for?
Glutamine is an amino acid your body makes. It's shown to help with sickle cell disease and may help with weight loss from HIV/AIDS, recovery after surgery, and critical illness. In this product, it's part of the amino acid support blend.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if BIG BLEND Proteosynthetic Vanilla Cappuccino is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

BIG BLEND Proteosynthetic Vanilla Cappuccino label
Go deeper

The Full Monographs Behind BIG BLEND Proteosynthetic Vanilla Cappuccino’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Black Psyllium

Interacts with 2,025 drugs

Black psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. It is best known and most studied for rel...

Read the full Black Psyllium monograph → Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph → Herb & supplement monograph

Glutamine

Interacts with 50 drugs

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle cell disease complications, but for most...

Read the full Glutamine monograph →
Sources

Sources & How We Checked

BIG BLEND Proteosynthetic Vanilla Cappuccino's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 69 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Black Psyllium 18 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  3. Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
  4. Etman M. Effect of a bulk forming laxative on the bioavailablility of carbamazepine in man. Drug Dev Ind Pharm 1995;21:1901-6.
  5. Perlman BB. Interaction between lithium salts and ispaghula husk. Lancet 1990;335:416.
  6. Vaswani SK, Hamilton RG, Valentine MD, Adkinson NF. Psyllium laxative-induced anaphylaxis, asthma, and rhinitis. Allergy 1996;51:266-8. PubMed
  7. Lantner RR, Espiritu BR, Zumerchik P, Tobin MC. Anaphylaxis following ingestion of a psyllium-containing cereal. JAMA 1990;264:2534-6. DOI
  8. Kaplan MJ. Anaphylactic reaction to "Heartwise." N Engl J Med 1990;323:1072-3. DOI
  9. Nordstrom M, Melander A, Robertsson E, Steen B. Influence of wheat bran and of a bulk-forming ispaghula cathartic on the bioavailability of digoxin in geriatric in-patients. Drug Nutr Interact 1987;5:67-9..
  10. Robinson DS, Benjamin DM, McCormack JJ. Interaction of warfarin and nonsystemic gastrointestinal drugs. Clin Pharmacol Ther 1971;12:491-5. PubMed
  11. Garcia JJ, Fernandez N, Diez MJ, et al. Influence of two dietary fibers in the oral bioavailability and other pharmacokinetic parameters of ethinyloestradiol. Contraception 2000;62:253-7. PubMed
  12. Fernandez N, Lopez C, Díez R, et al. Drug interactions with the dietary fiber Plantago ovata husk. Expert Opin Drug Metab Toxicol 2012;8(11):1377-86.
  13. Semen plantaginis in: WHO Monographs on Selected Medicinal Plants, volume 1. World Health Organization, Geneva, 1999. Available at http://apps.who.int/medicinedocs/en/d/Js2200e/. Accessed November 26, 1026.
  14. Code of Federal Regulations, Title 21 (21CFR 101.17). Food labeling warning, notice, and safe handling statements. Available at www.ecfr.gov/cgi-bin/text-idx?SID=20f647d3b74161501f46564b915b4048&mc=true&node=se21.2.101_117&rgn=div8. Accessed December 3, 2
  15. Code of Federal Regulations, Title 21 (21CFR 201.319). Specific labeling requirements - water-soluble gums, hydrophilic gums, and hydrophilic mucilloids. Available at www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=201.319. Accessed Dece
  16. Diez R, Garcia JJ, Diez MJ, Sierra M, Sahagun AM, Fernandez N. Influence of Plantago ovata husk (dietary fiber) on the bioavailability and other pharmacokinetic parameters of metformin in diabetic rabbits. BMC Complement Altern Med. 2017 Jun 7;17(1):298. PubMed
  17. Chiu AC, Sherman SI. Effects of pharmacological fiber supplements on levothyroxine absorption. Thyroid. 1998;8(8):667-71. PubMed
  18. Merrick C, Madden CA, Capurso NA. A Case of Blunted Orally Disintegrating Olanzapine Effect Due to Coadministered Psyllium. J Clin Psychiatry 2021;82(2):20cr13633. PubMed

See these in context on the Black Psyllium monograph →

Sodium 40 references
  1. Garabedian-Ruffalo SM, Ruffalo RL. Drug and nutrient interactions. Am Fam Physician 1986;33:165-74.
  2. Food and Drug Administration Science Background: Safety of Sodium Phosphates Oral Solution. September 17, 2001. Available at: http://www.fda.gov/cder/drug/safety/sodiumphospate.htm
  3. Coton T, Mallaret C, Coilliot C, Carre D, Guisset M. Severe acute ulcerated gastritis induced by salt. Presse Med 2009;38(3):499-500. PubMed
  4. Frings-Meuthen P, Buehlmeier J, Baecker N, et al. High sodium chloride intake exacerbates immobilization-induced bone resorption and protein losses. J Appl Physiol 2011;111(2):537-542. PubMed
  5. Frings-Meuthen P, Baecker N, Heer M. Low-grade metabolic acidosis may be the cause of sodium chloride-induced exaggerated bone resorption. J Bone Miner Res 2008;23(4):517-524. PubMed
  6. Alam S, Johnson AG. A meta-analysis of randomised controlled trials (RCT) among healthy normotensive and essential hypertensive elderly patients to determine the effect of high salt (NaCl) diet of blood pressure. J Hum Hypertens 1999;13(6):367-74.
  7. Boudville N, Ward S, Benaroia M, House AA. Increased sodium intake correlates with greater use of antihypertensive agents by subjects with chronic kidney disease. Am J Hypertens 2005;18(10):1300-5. PubMed
  8. Bennett WM. Drug interactions and consequences of sodium restriction. Am J Clin Nutr 1997;65(2 Suppl):678S-681S. PubMed
  9. Okusa MD, Crystal LJ. Clinical manifestations and management of acute lithium intoxication. Am J Med 1994;97(4):383-9. PubMed
  10. Food and Nutrition Board, Institute of Medicine. Dietary reference intakes for water, potassium, sodium, chloride, and sulfate. Washington, DC: National Academy Press, 2005. Available at: http://www.nap.edu/openbook.php?record_id=10925. DOI
  11. D'Elia L, Rossi G, Ippolito R, Cappuccio FP, Strazzullo P. Habitual salt intake and risk of gastric cancer: a meta-analysis of prospective studies. Clin Nutr 2012;31(4):489-98. PubMed
  12. Goldsmith SR. Hyponatremia in heart failure: time for a trial. J Card Fail 2013;19(6):398-400. PubMed
  13. Willocks L, Brettle R, Keen J, Valentine C, Pinching AJ. Formulations of didanosine (ddI) and salt overload. Lancet 1992;339(8786):190.
  14. Chen L, Zhang Z, Chen W, Whelton PK, Appel LJ. Lower Sodium Intake and Risk of Headaches: Results From the Trial of Nonpharmacologic Interventions in the Elderly. Am J Public Health. 2016;106(7):1270-5. PubMed
  15. Cook NR, Appel LJ, Whelton PK. Lower levels of sodium intake and reduced cardiovascular risk. Circulation. 2014;129(9):981-9. PubMed
  16. Cook NR, Appel LJ, Whelton PK. Sodium Intake and All-Cause Mortality Over 20 Years in the Trials of Hypertension Prevention. J Am Coll Cardiol. 2016;68(15):1609-1617. PubMed
  17. Mente A, O'Donnell M, Rangarajan S, et al. Associations of urinary sodium excretion with cardiovascular events in individuals with and without hypertension: a pooled analysis of data from four studies. Lancet. 2016;388(10043):465-75. PubMed
  18. Moosavian SP, Haghighatdoost F, Surkan PJ, Azadbakht L. Salt and obesity: a systematic review and meta-analysis of observational studies. Int J Food Sci Nutr. 2017;68(3):265-277. PubMed
  19. O'Donnell M, Mente A, Rangarajan S, et al. Urinary sodium and potassium excretion, mortality, and cardiovascular events. N Engl J Med. 2014;371(7):612-23. DOI
  20. Poggio R, Gutierrez L, Matta MG, Elorriaga N, Irazola V, Rubinstein A. Daily sodium consumption and CVD mortality in the general population: systematic review and meta-analysis of prospective studies. Public Health Nutr. 2015;18(4):695-704. PubMed
  21. Stallings VA, Harrison M, Oria M; Committee to Review the Dietary Reference Intakes for Sodium and Potassium, Food and Nutrition Board, Health and Medicine Division, National Academies of Sciences, Engineering, and Medicine. Washington (DC): National Acad
  22. Mahtani KR, Heneghan C, Onakpoya I, et al. Reduced Salt Intake for Heart Failure: A Systematic Review. JAMA Intern Med. 2018 Dec 1;178(12):1693-1700. PubMed
  23. Yancy CW. Sodium Restriction in Heart Failure: Too Much Uncertainty-Do the Trials. JAMA Intern Med. 2018 Dec 1;178(12):1700-1701. PubMed
  24. He FJ, Campbell NRC, Ma Y, MacGregor GA, Cogswell ME, Cook NR. Errors in estimating usual sodium intake by the Kawasaki formula alter its relationship with mortality: implications for public health. Int J Epidemiol. 2018;47(6):1784-1795. PubMed
  25. Murthy K, Ondrey GJ, Malkani N, et al. THE EFFECTS OF HYPONATREMIA ON BONE DENSITY AND FRACTURES: A SYSTEMATIC REVIEW AND META-ANALYSIS. Endocr Pract. 2019;25(4):366-378. PubMed
  26. Messerli FH, Hofstetter L, Syrogiannouli L, et al. Sodium intake, life expectancy, and all-cause mortality. Eur Heart J 2021;42(21):2103-2112. PubMed
  27. Graudal NA, Hubeck-Graudal T, Jurgens G. Effects of low sodium diet versus high sodium diet on blood pressure, renin, aldosterone, catecholamines, cholesterol, and triglyceride. Cochrane Database Syst Rev 2020;12(12):CD004022. PubMed
  28. Giatti S, Santos RB, Aielo AN, et al. Association of sodium with obstructive sleep apnea. The ELSA-Brasil study. Ann Am Thorac Soc 2021;18(3):502-510. PubMed
  29. Nan X, Lu H, Wu J, et al. The interactive association between sodium intake, alcohol consumption and hypertension among elderly in northern China: a cross-sectional study. BMC Geriatr 2021;21(1):135. PubMed
  30. Kyozuka H, Fukusda T, Murata T, et al. Impact of preconception sodium intake on hypertensive disorders of pregnancy: The Japan Environment and Children's study. Pregnancy Hypertens 2021;23:66-72. PubMed
  31. Zhao L, Ogden CL, Yang Q, et al. Association of usual sodium intake with obesity among US children and adolescents, NHANES 2009-2016. Obesity (Silver Spring) 2021;29(3):587-594. PubMed
  32. Ma Y, He FJ, Sun Q, et al. 24-Hour urinary sodium and potassium excretion and cardiovascular risk. N Engl J Med 2022;386(3):252-263. PubMed
  33. Liu J, Yang X, Zhang P, et al. Association of urinary sodium excretion and left ventricular hypertrophy in people with type 2 diabetes mellitus: A cross-sectional study. Front Endocrinol (Lausanne) 2021;12:728493. PubMed
  34. Filippini T, Malavolti M, Whelton PK, Vinceti M. Sodium intake and risk of hypertension: A systematic review and dose-response meta-analysis of observational cohort studies. Curr Hypertens Rep 2022;24(5):133-144. PubMed
  35. Wang DD, Li Y, Nguyen XT, et al. Dietary sodium and potassium intake and risk of non-fatal cardiovascular diseases: The million veteran program. Nutrients 2022;14(5):1121. PubMed
  36. Kwak JH, Park CH, Eun CS, et al. The associations of dietary intake of high sodium and low zinc with gastric cancer mortality: A prospective cohort study in Korea. Nutr Cancer 2022;74(10):3501-3508. PubMed
  37. George S, Maiti R, Mishra BR, Jena M, Mohapatra D. Effect of regulated add-on sodium chloride intake on stabilization of serum lithium concentration in bipolar disorder: A randomized controlled trial. Bipolar Disord 2023;25(1):66-75. PubMed
  38. Zhou TL, Schütten MTJ, Kroon AA, et al. Urinary Sodium Excretion and Salt Intake Are Not Associated With Blood Pressure Variability in a White General Population. J Am Heart Assoc 2023;12(1):e026578. PubMed
  39. Gan L, Zhao B, Inoue-Choi M, et al. Sex-specific associations between sodium and potassium intake and overall and cause-specific mortality: a large prospective U.S. cohort study, systematic review, and updated meta-analysis of cohort studies. BMC Med 2024 PubMed
  40. Liu D, Tian Y, Wang R, et al. Sodium, potassium intake, and all-cause mortality: confusion and new findings. BMC Public Health 2024;24(1):180. PubMed

See these in context on the Sodium monograph →

Glutamine 11 references
  1. Miller AL. Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev 1999;4:239-48..
  2. Bozzetti F, Biganzoli L, Gavazzi C, et al. Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study. Nutrition 1997;13:748-51.. PubMed
  3. Mebane AH. L-Glutamine and mania. Am J Psychiatry 984;141:1302-3.
  4. Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000;130:1007S-15S.. PubMed
  5. Garlick PJ. Assessment of the safety of glutamine and other amino acids. J Nutr 2001;131:2556S-61S.. PubMed
  6. Chapman AG. Glutamate and epilepsy. J Nutr 2000;130:1043S-5S.. PubMed
  7. Ziegler TR. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J Nutr 2001;131:2578S-84S.. PubMed
  8. Laviano A, Molfino A, Lacaria MT, Canelli A, De Leo S, Preziosa I, Rossi Fanelli F. Glutamine supplementation favors weight loss in nondieting obese female patients. A pilot study. Eur J Clin Nutr. 2014 Nov;68(11):1264-6. PubMed
  9. Endari (l-glutamine) [package insert]. Torrance, CA: Emmaus Medical,Inc; 2017.
  10. Niihara Y, Miller ST, Kanter J, et al. A Phase 3 Trial of l-Glutamine in Sickle Cell Disease. N Engl J Med 2018;379(3):226-35. doi: 10.1056/NEJMoa1715971.
  11. Ogden HB, Child RB, Fallowfield JL, et al. Gastrointestinal Tolerance of Low, Medium and High Dose Acute Oral l-Glutamine Supplementation in Healthy Adults: A Pilot Study. Nutrients. 2020;12(10):2953. PubMed

See these in context on the Glutamine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team