Bilberry Extract Ingredients & Drug Interactions
by Flora
What is this page for?
First and foremost: checking Bilberry Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Bilberry Extract is a dietary supplement by Flora with 2 active ingredients. Its ingredients are commonly taken for antioxidant support, heart health, brain and memory health.Based on those ingredients, 277 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bilberry fruit extract, Blueberry powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Bilberry Extract by Flora
Ask about any prescription or over-the-counter medication and we check it for interactions with Bilberry Extract by Flora — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Bilberry Extract by Flora
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains 2 active ingredients: blueberry powder and bilberry fruit extract. Blueberries are common food berries; bilberry is a related European species, and both are rich in anthocyanins — compounds that give them their deep color and are thought to have antioxidant properties.
The inactive ingredients are microcrystalline cellulose (a binder), magnesium stearate (a flow agent), and a vegetarian capsule shell.
Does it work?
Not established
The evidence for what this product actually does is thin. Blueberry powder is rated possibly ineffective for high blood pressure, but for age-related thinking problems, anxiety, athletic performance, and high cholesterol, we don't have enough reliable data to say whether it works.
Bilberry fruit extract is also rated possibly ineffective for night vision — despite the old reputation — and we lack solid evidence for cognitive decline, age-related macular degeneration, atherosclerosis, high cholesterol, or poor circulation. If you're considering this for one of those uses, the science doesn't yet back it up.
How safe is it?
Well-documented data
Both blueberry and bilberry are generally well tolerated when eaten as food. Blueberry powder may cause constipation, diarrhea, nausea, or vomiting — one trial found that a quarter of participants taking freeze-dried blueberries dropped out in the first week due to stomach upset.
Bilberry is also well tolerated but can cause dark-colored stools, flatulence, and GI discomfort; in one study, half the patients reported dark green stools after 4 weeks. For pregnancy and breastfeeding, both ingredients are rated likely safe, but concentrated supplements — especially bilberry — haven't been well studied at high doses in these situations.
If you're pregnant or nursing, talk with your doctor or pharmacist before starting a concentrated extract.
Meds to double-check
Moderate interaction found
Before you start Flora's Bilberry Extract, check with your doctor or pharmacist if you take any blood thinners or antiplatelet drugs (like warfarin, clopidogrel, or aspirin for heart health) — bilberry fruit extract carries a Moderate-severity risk of increased bleeding. You should also confirm it's safe with any diabetes medication, as both ingredients theoretically raise the risk of low blood sugar.
If you take erlotinib or any drug metabolized by CYP2E1 enzymes, discuss it first, and let your doctor know about any anti-inflammatory or anxiety medication you're on.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
This product may be worth considering if you want to try a traditional herbal extract, but the evidence that it works for common uses — better night vision, sharper thinking, heart health — is absent or weak. More important: if you take blood thinners, diabetes medications, or any prescription drug, check with your doctor or pharmacist before you start, because both ingredients interact with a significant number of medications.
Even if the evidence isn't ironclad, the risk is real enough to warrant a conversation.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 25, 2017.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Bilberry Extract, straight from the product label.
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Bilberry Extract by Flora, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Blueberry powder | 100 mg | -- |
| Bilberry fruit extract | 220 mg | -- |
Other ingredients: Microcrystalline Cellulose, Magnesium Stearate, Vegetarian Capsule
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
Flora's premium Bilberry Extract plus blueberry is an ultra concentrated bilberry extract containing 55 mg anthocyanidins per capsule.
25% standardized anthocyanidins with freeze-dried blueberry powder
General Statements
Anthocyanidins are antioxidants that help support a healthy circulatory system and maintain cell integrity. Bilberry is commonly used to reduce the effects of occasional eye strain.
Premium herbal formulas
Product of Canada Printed in Canada
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
FDA Statement of Identity
Dietary Supplement
General
61346-R01
Suggested/Recommended/Usage/Directions
Suggested Use: Take 1 capsule in the morning and 1 capsule in the evening with meals.
Storage
Store in a cool, dry place.
Precautions
Security sealed for your protection. Do not use if seal is missing or damaged.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Bilberry Extract by Flora label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Bilberry Extract by Flora
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Blueberry powder
Interacts with88 drugs
Blueberries are a nutritious fruit rich in antioxidants called anthocyanins, and eating them as part of a balanced diet is healthy and safe for most p...
Blueberry powder monograph & interactionsBilberry fruit extract
Interacts with275 drugs
Bilberry is a blueberry-like fruit rich in antioxidant plant compounds called anthocyanins, and it has a long history of traditional use for eye healt...
Bilberry fruit extract monograph & interactionsOther (inactive) ingredients: Microcrystalline Cellulose, Magnesium Stearate, Vegetarian Capsule. These complete the product’s ingredient list but are not active constituents.
Bilberry Extract by Flora Drug Interactions
HelloPharmacist Interaction Report
Flora's Bilberry Extract contains two active ingredients — blueberry powder and bilberry fruit extract — and both have documented interactions with medications.
The most serious concern is bilberry fruit extract with blood thinners and antiplatelet drugs (anticoagulants and antiplatelet medications), rated Moderate severity. Bilberry can inhibit platelet aggregation, which theoretically increases your bleeding risk if you're on these medications.
Read the full breakdown — every affected drug type, severity by severity
Bilberry fruit extract also carries Moderate-severity interactions with antidiabetes drugs (a risk of low blood sugar), CYP2E1 substrate drugs (which may become less effective), and erlotinib, a cancer medication. Blueberry powder adds Minor-severity interactions with antidiabetes drugs, flurbiprofen (an anti-inflammatory), and buspirone (an anxiety medication), each with a theoretical risk of increased blood levels or low blood sugar.
Altogether, these interactions span 277 individual medications.
Neither ingredient's interactions have been definitively reported in human studies — most are based on lab or animal research — but the potential is real, especially with blood thinners and diabetes medications. Check your exact medications with the tool on this page before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Bilberry Extract?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Bilberry Extract interact with 277 drugs. Click any drug to see the details.
2 of the 2 ingredients in Bilberry Extract interact with drugs. Each result below shows which ingredient is responsible. Bilberry fruit extract Blueberry powder
AbciximabReoPro
How Abciximab interacts with Bilberry Extract — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Bilberry Fruit Extract + Abciximab interactionAbrocitinibCibinqo
How Abrocitinib interacts with Bilberry Extract — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Bilberry Fruit Extract + Abrocitinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Bilberry Extract — through 2 ingredients. Tap an ingredient for the detail:
Bilberry Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, bilberry leaf or fruit extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Bilberry Fruit Extract + Acarbose interactionBlueberry PowderAntidiabetes Drugs Minor
Interaction Summary
Theoretically, blueberries or blueberry leaf extracts might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Blueberry Powder + Acarbose interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Bilberry Extract — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Bilberry Fruit Extract + Acenocoumarol interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Bilberry Extract — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Bilberry Fruit Extract + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Bilberry Extract — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractAnticoagulant/antiplatelet Drugs, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Bilberry Fruit Extract + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Bilberry Extract — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractAnticoagulant/antiplatelet Drugs, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Bilberry Fruit Extract + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Bilberry Extract — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Bilberry Fruit Extract + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Bilberry Extract — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Bilberry Fruit Extract + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Bilberry Extract — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Bilberry Fruit Extract + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Bilberry Extract — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Bilberry Fruit Extract + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Bilberry Extract — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Bilberry Fruit Extract + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Bilberry Extract — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Bilberry Fruit Extract + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Bilberry Extract — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Bilberry Fruit Extract + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Bilberry Extract — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Bilberry Fruit Extract + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Bilberry Extract — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Bilberry Fruit Extract + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Bilberry Extract — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Bilberry Fruit Extract + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Bilberry Extract — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Bilberry Fruit Extract + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Bilberry Extract — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Bilberry Fruit Extract + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Bilberry Extract — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Bilberry Fruit Extract + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Bilberry Extract — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Bilberry Fruit Extract + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Bilberry Extract — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Bilberry Fruit Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Bilberry Extract — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Bilberry Fruit Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Bilberry Extract — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Bilberry Fruit Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with Bilberry Extract — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Bilberry Fruit Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
How Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interacts with Bilberry Extract — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Bilberry Fruit Extract + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid
How Acetaminophen, Chlorpheniramine, Phenylephrine interacts with Bilberry Extract — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Bilberry Fruit Extract + Acetaminophen, Chlorpheniramine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR
How Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interacts with Bilberry Extract — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Bilberry Fruit Extract + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylpropanolamineAlumadrine, Conex, Sinadrin Max Strength, Sinulin
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine interacts with Bilberry Extract — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Bilberry Fruit Extract + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interacts with Bilberry Extract — through 1 ingredient. Tap an ingredient for the detail:
Bilberry Fruit ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Read the full Bilberry Fruit Extract + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Bilberry Extract with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Bilberry fruit extract
Anticoagulant/Antiplatelet Drugs
Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro, animal, and clinical research suggest that anthocyanidin extracts from bilberry can inhibit platelet aggregation.
Antidiabetes Drugs
Theoretically, bilberry leaf or fruit extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research suggests that bilberry leaf extract might have blood glucose-lowering activity. Also, one small clinical trial in patients with type 2 diabetes shows that taking bilberry fruit extract 470 mg as a single dose prior to an oral glucose tolerance test lowers plasma glucose levels when compared with placebo.
Cytochrome P450 2E1 (Cyp2E1) Substrates
Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Animal research shows that exposure to small concentrations of bilberry extract in drinking water for around one month increased CYP2E1 activity by 31%. However, exposure over a 2-month period did not increase CYP2E1 activity. This effect has not been reported in humans.
Erlotinib (Tarceva)
Theoretically, bilberry fruit extract might reduce the efficacy of erlotinib.
In vitro research suggests that bilberry fruit extract and its constituents, delphinidin and delphinidin-3-O-glucoside, inhibit the activity of erlotinib. This interaction has not been reported in humans.
Blueberry powder
Antidiabetes Drugs
Theoretically, blueberries or blueberry leaf extracts might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal and in vitro research suggests that blueberry and/or blueberry leaf extracts can lower blood glucose levels.
Buspirone (Buspar)
Theoretically, blueberry juice might increase blood levels of buspirone.
In vitro research shows that blueberry juice can inhibit the metabolism of buspirone, possibly by inhibiting cytochrome P450 3A (CYP3A) enzymes. However, pharmacokinetic research in humans shows that drinking 300 mL of blueberry juice 30 minutes before taking buspirone hydrochloride 10 mg does not significantly affect the concentration or clearance of buspirone.
Flurbiprofen (Ansaid, Others)
Theoretically, blueberry juice might increase blood levels of flurbiprofen.
In vitro research shows that blueberry juice can inhibit the metabolism of flurbiprofen, possibly by inhibiting cytochrome P450 2C9 (CYP2C9) enzymes. However, pharmacokinetic research in humans shows that drinking 300 mL of blueberry juice 30 minutes before taking flurbiprofen 100 mg does not significantly affect the concentration or clearance of flurbiprofen.
Brand information
Manufacturer and brand details for Bilberry Extract, from the product label.
Flora
See all Flora products- Name
- Flora, Inc.
- Street Address
- 805 E. Badger Rd.
- City
- Lynden
- State
- WA
- ZipCode
- 98264
- Phone Number
- 1.800.446.2110
- Web Address
- www.florahealth.com
Bilberry Extract by Flora: Common Questions
Does Bilberry Extract by Flora interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will this help my night vision?
Can I take this if I'm pregnant or breastfeeding?
What side effects might I see?
Does this really help with memory or brain fog?
Is this safe to take every day?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Bilberry Extract is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Bilberry Extract’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Blueberry
Interacts with 88 drugsBlueberries are a nutritious fruit rich in antioxidants called anthocyanins, and eating them as part of a balanced diet is healthy and safe for most people. Concentrated supplements are mark...
Read the full Blueberry monograph → Herb & supplement monographBilberry
Interacts with 275 drugsBilberry is a blueberry-like fruit rich in antioxidant plant compounds called anthocyanins, and it has a long history of traditional use for eye health, circulation, and mild diarrhea. While...
Read the full Bilberry monograph →Sources & How We Checked
Bilberry Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 21 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Blueberry 7 references
- Cignarella A, Nastasi M, Cavalli E, Puglisi L. Novel lipid-lowering properties of Vaccinium myrtillus L. leaves, a traditional antidiabetic treatment, in several models of rat dyslipidaemia: a comparison with ciprofibrate. Thromb Res 1996;84:311-22. PubMed
- Wang SY, Lin HS. Antioxidant activity in fruits and leaves of blackberry, raspberry, and strawberry varies with cultivar and developmental stage. J Agric Food Chem 2000;48:140-6.. PubMed
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